Q92665 (RT31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S31, mitochondrial
Short name=MRP-S31
Short name=S31mt

Alternative name(s):
Imogen 38

Gene names

Name:	MRPS31
Synonyms:	IMOGN38

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion Ref.6.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrial small ribosomal subunit Inferred from electronic annotation. Source: InterPro mitochondrion Traceable author statement Ref.1. Source: ProtInc
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
STAT3	P40763	2	EBI-720602,EBI-518675

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 65	65	Mitochondrion Potential
	Chain	66 – 395	330	28S ribosomal protein S31, mitochondrial		PRO_0000030594
Natural variations
	Natural variant	241	1	T → M. Corresponds to variant rs1854421 [ dbSNP | Ensembl ].		VAR_052049
	Natural variant	279	1	D → N. Ref.1 Corresponds to variant rs13508 [ dbSNP | Ensembl ].		VAR_061812
Experimental info
	Sequence conflict	80	1	T → I in AAH22045. Ref.5
	Sequence conflict	132	1	T → A in AAH22045. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q92665 [UniParc]. Last modified February 7, 2006. Version 3. Checksum: 01ED04983ED56818	FASTA	395	45,318
	10 20 30 40 50 60 MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA RTKNNIQRYF 70 80 90 100 110 120 GTNSVICSKK DKQSVRTEET SKETSESQDS EKENTKKDLL GIIKGMKVEL STVNVRTTKP 130 140 150 160 170 180 PKRRPLKSLE ATLGRLRRAT EYAPKKRIEP LSPELVAAAS AVADSLPFDK QTTKSELLSQ 190 200 210 220 230 240 LQQHEEESRA QRDAKRPKIS FSNIISDMKV ARSATARVRS RPELRIQFDE GYDNYPGQEK 250 260 270 280 290 300 TDDLKKRKNI FTGKRLNIFD MMAVTKEAPE TDTSPSLWDV EFAKQLATVN EQPLQNGFEE 310 320 330 340 350 360 LIQWTKEGKL WEFPINNEAG FDDDGSEFHE HIFLEKHLES FPKQGPIRHF MELVTCGLSK 370 380 390 NPYLSVKQKV EHIEWFRNYF NEKKDILKES NIQFN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient." Arden S.D., Roep B.O., Neophytou P.I., Usac E.F., Duinkerken G., de Vries R.R.P., Hutton J.C. J. Clin. Invest. 97:551-561(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-279. Tissue: Skin.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[6]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z68747 mRNA. Translation: CAA92951.1. AK315248 mRNA. Translation: BAG37670.1. AL355132, AL161614 Genomic DNA. Translation: CAH70977.1. AL161614, AL355132 Genomic DNA. Translation: CAH72771.1. CH471075 Genomic DNA. Translation: EAX08629.1. BC022045 mRNA. Translation: AAH22045.1.
IPI	IPI00294242.
RefSeq	NP_005821.2. NM_005830.3.
UniGene	Hs.596607.
3D structure databases
ProteinModelPortal	Q92665.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92665. 7 interactions.
MINT	MINT-1420773.
STRING	9606.ENSP00000315397.
PTM databases
PhosphoSite	Q92665.
Polymorphism databases
DMDM	93186129.
Proteomic databases
PaxDb	Q92665.
PeptideAtlas	Q92665.
PRIDE	Q92665.
Protocols and materials databases
DNASU	10240.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323563; ENSP00000315397; ENSG00000102738.
GeneID	10240.
KEGG	hsa:10240.
UCSC	uc001uxm.4. human.
Organism-specific databases
CTD	10240.
GeneCards	GC13M041303.
HGNC	HGNC:16632. MRPS31.
HPA	HPA039083. HPA046344.
MIM	611992. gene.
neXtProt	NX_Q92665.
PharmGKB	PA31019.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG74634.
HOGENOM	HOG000232111.
HOVERGEN	HBG036128.
InParanoid	Q92665.
OMA	FEELIQW.
OrthoDB	EOG4HDSVC.
PhylomeDB	Q92665.
Gene expression databases
Bgee	Q92665.
CleanEx	HS_MRPS31.
Genevestigator	Q92665.
GermOnline	ENSG00000102738. Homo sapiens.
Family and domain databases
InterPro	IPR026299. MRP-S31. [Graphical view]
PANTHER	PTHR13231. PTHR13231. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	10240.
NextBio	38792.
SOURCE	Search...

Entry information

Entry name

RT31_HUMAN

Accession

Primary (citable) accession number: Q92665
Secondary accession number(s): B2RCS3, Q5VYC8, Q8WTV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.