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Q92665 (RT31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S31, mitochondrial

Short name=MRP-S31
Short name=S31mt
Alternative name(s):
Imogen 38
Gene names
Name:MRPS31
Synonyms:IMOGN38
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Subcellular location

Mitochondrion Ref.6.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

STAT3P407632EBI-720602,EBI-518675

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 6565Mitochondrion Potential
Chain66 – 39533028S ribosomal protein S31, mitochondrial
PRO_0000030594

Natural variations

Natural variant2411T → M.
Corresponds to variant rs1854421 [ dbSNP | Ensembl ].
VAR_052049
Natural variant2791D → N. Ref.1
Corresponds to variant rs13508 [ dbSNP | Ensembl ].
VAR_061812

Experimental info

Sequence conflict801T → I in AAH22045. Ref.5
Sequence conflict1321T → A in AAH22045. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q92665 [UniParc].

Last modified February 7, 2006. Version 3.
Checksum: 01ED04983ED56818

FASTA39545,318
        10         20         30         40         50         60 
MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA RTKNNIQRYF 

        70         80         90        100        110        120 
GTNSVICSKK DKQSVRTEET SKETSESQDS EKENTKKDLL GIIKGMKVEL STVNVRTTKP 

       130        140        150        160        170        180 
PKRRPLKSLE ATLGRLRRAT EYAPKKRIEP LSPELVAAAS AVADSLPFDK QTTKSELLSQ 

       190        200        210        220        230        240 
LQQHEEESRA QRDAKRPKIS FSNIISDMKV ARSATARVRS RPELRIQFDE GYDNYPGQEK 

       250        260        270        280        290        300 
TDDLKKRKNI FTGKRLNIFD MMAVTKEAPE TDTSPSLWDV EFAKQLATVN EQPLQNGFEE 

       310        320        330        340        350        360 
LIQWTKEGKL WEFPINNEAG FDDDGSEFHE HIFLEKHLES FPKQGPIRHF MELVTCGLSK 

       370        380        390 
NPYLSVKQKV EHIEWFRNYF NEKKDILKES NIQFN 

« Hide

References

« Hide 'large scale' references
[1]"Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient."
Arden S.D., Roep B.O., Neophytou P.I., Usac E.F., Duinkerken G., de Vries R.R.P., Hutton J.C.
J. Clin. Invest. 97:551-561(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-279.
Tissue: Skin.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[6]"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z68747 mRNA. Translation: CAA92951.1.
AK315248 mRNA. Translation: BAG37670.1.
AL355132, AL161614 Genomic DNA. Translation: CAH70977.1.
AL161614, AL355132 Genomic DNA. Translation: CAH72771.1.
CH471075 Genomic DNA. Translation: EAX08629.1.
BC022045 mRNA. Translation: AAH22045.1.
CCDSCCDS9372.1.
RefSeqNP_005821.2. NM_005830.3.
UniGeneHs.596607.

3D structure databases

ProteinModelPortalQ92665.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115534. 15 interactions.
IntActQ92665. 8 interactions.
MINTMINT-1420773.
STRING9606.ENSP00000315397.

PTM databases

PhosphoSiteQ92665.

Polymorphism databases

DMDM93186129.

Proteomic databases

MaxQBQ92665.
PaxDbQ92665.
PeptideAtlasQ92665.
PRIDEQ92665.

Protocols and materials databases

DNASU10240.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323563; ENSP00000315397; ENSG00000102738.
GeneID10240.
KEGGhsa:10240.
UCSCuc001uxm.4. human.

Organism-specific databases

CTD10240.
GeneCardsGC13M041303.
HGNCHGNC:16632. MRPS31.
HPAHPA039083.
HPA046344.
MIM611992. gene.
neXtProtNX_Q92665.
PharmGKBPA31019.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG74634.
HOGENOMHOG000232111.
HOVERGENHBG036128.
InParanoidQ92665.
KOK17410.
OMAEELIQWT.
OrthoDBEOG7DJSMH.
PhylomeDBQ92665.
TreeFamTF324305.

Gene expression databases

BgeeQ92665.
CleanExHS_MRPS31.
GenevestigatorQ92665.

Family and domain databases

InterProIPR026299. MRP-S31.
[Graphical view]
PANTHERPTHR13231. PTHR13231. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi10240.
NextBio38792.
PROQ92665.
SOURCESearch...

Entry information

Entry nameRT31_HUMAN
AccessionPrimary (citable) accession number: Q92665
Secondary accession number(s): B2RCS3, Q5VYC8, Q8WTV8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: February 7, 2006
Last modified: July 9, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM