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Protein

28S ribosomal protein S31, mitochondrial

Gene

MRPS31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102738-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S31, mitochondrial
Short name:
MRP-S31
Short name:
S31mt
Alternative name(s):
Imogen 38
Gene namesi
Name:MRPS31
Synonyms:IMOGN38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:16632. MRPS31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi10240.
OpenTargetsiENSG00000102738.
PharmGKBiPA31019.

Polymorphism and mutation databases

BioMutaiMRPS31.
DMDMi93186129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 65MitochondrionSequence analysisAdd BLAST65
ChainiPRO_000003059466 – 39528S ribosomal protein S31, mitochondrialAdd BLAST330

Proteomic databases

EPDiQ92665.
MaxQBiQ92665.
PaxDbiQ92665.
PeptideAtlasiQ92665.
PRIDEiQ92665.

PTM databases

iPTMnetiQ92665.
PhosphoSitePlusiQ92665.

Expressioni

Gene expression databases

BgeeiENSG00000102738.
CleanExiHS_MRPS31.
GenevisibleiQ92665. HS.

Organism-specific databases

HPAiHPA039083.
HPA046344.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-720602,EBI-518675

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115534. 71 interactors.
IntActiQ92665. 16 interactors.
MINTiMINT-1420773.
STRINGi9606.ENSP00000315397.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AY1-395[»]
ProteinModelPortaliQ92665.
SMRiQ92665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IHXJ. Eukaryota.
ENOG4111GGB. LUCA.
GeneTreeiENSGT00390000010017.
HOGENOMiHOG000232111.
HOVERGENiHBG036128.
InParanoidiQ92665.
KOiK17410.
OMAiKESNIQF.
OrthoDBiEOG091G0LP5.
PhylomeDBiQ92665.
TreeFamiTF324305.

Family and domain databases

InterProiIPR026299. MRP-S31.
[Graphical view]
PANTHERiPTHR13231. PTHR13231. 1 hit.
PfamiPF15433. MRP-S31. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA
60 70 80 90 100
RTKNNIQRYF GTNSVICSKK DKQSVRTEET SKETSESQDS EKENTKKDLL
110 120 130 140 150
GIIKGMKVEL STVNVRTTKP PKRRPLKSLE ATLGRLRRAT EYAPKKRIEP
160 170 180 190 200
LSPELVAAAS AVADSLPFDK QTTKSELLSQ LQQHEEESRA QRDAKRPKIS
210 220 230 240 250
FSNIISDMKV ARSATARVRS RPELRIQFDE GYDNYPGQEK TDDLKKRKNI
260 270 280 290 300
FTGKRLNIFD MMAVTKEAPE TDTSPSLWDV EFAKQLATVN EQPLQNGFEE
310 320 330 340 350
LIQWTKEGKL WEFPINNEAG FDDDGSEFHE HIFLEKHLES FPKQGPIRHF
360 370 380 390
MELVTCGLSK NPYLSVKQKV EHIEWFRNYF NEKKDILKES NIQFN
Length:395
Mass (Da):45,318
Last modified:February 7, 2006 - v3
Checksum:i01ED04983ED56818
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80T → I in AAH22045 (PubMed:15489334).Curated1
Sequence conflicti132T → A in AAH22045 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052049241T → M.Corresponds to variant rs1854421dbSNPEnsembl.1
Natural variantiVAR_061812279D → N.1 PublicationCorresponds to variant rs13508dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68747 mRNA. Translation: CAA92951.1.
AK315248 mRNA. Translation: BAG37670.1.
AL355132, AL161614 Genomic DNA. Translation: CAH70977.1.
AL161614, AL355132 Genomic DNA. Translation: CAH72771.1.
CH471075 Genomic DNA. Translation: EAX08629.1.
BC022045 mRNA. Translation: AAH22045.1.
CCDSiCCDS9372.1.
RefSeqiNP_005821.2. NM_005830.3.
UniGeneiHs.596607.

Genome annotation databases

EnsembliENST00000323563; ENSP00000315397; ENSG00000102738.
GeneIDi10240.
KEGGihsa:10240.
UCSCiuc001uxm.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68747 mRNA. Translation: CAA92951.1.
AK315248 mRNA. Translation: BAG37670.1.
AL355132, AL161614 Genomic DNA. Translation: CAH70977.1.
AL161614, AL355132 Genomic DNA. Translation: CAH72771.1.
CH471075 Genomic DNA. Translation: EAX08629.1.
BC022045 mRNA. Translation: AAH22045.1.
CCDSiCCDS9372.1.
RefSeqiNP_005821.2. NM_005830.3.
UniGeneiHs.596607.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AY1-395[»]
ProteinModelPortaliQ92665.
SMRiQ92665.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115534. 71 interactors.
IntActiQ92665. 16 interactors.
MINTiMINT-1420773.
STRINGi9606.ENSP00000315397.

PTM databases

iPTMnetiQ92665.
PhosphoSitePlusiQ92665.

Polymorphism and mutation databases

BioMutaiMRPS31.
DMDMi93186129.

Proteomic databases

EPDiQ92665.
MaxQBiQ92665.
PaxDbiQ92665.
PeptideAtlasiQ92665.
PRIDEiQ92665.

Protocols and materials databases

DNASUi10240.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323563; ENSP00000315397; ENSG00000102738.
GeneIDi10240.
KEGGihsa:10240.
UCSCiuc001uxm.5. human.

Organism-specific databases

CTDi10240.
DisGeNETi10240.
GeneCardsiMRPS31.
HGNCiHGNC:16632. MRPS31.
HPAiHPA039083.
HPA046344.
MIMi611992. gene.
neXtProtiNX_Q92665.
OpenTargetsiENSG00000102738.
PharmGKBiPA31019.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHXJ. Eukaryota.
ENOG4111GGB. LUCA.
GeneTreeiENSGT00390000010017.
HOGENOMiHOG000232111.
HOVERGENiHBG036128.
InParanoidiQ92665.
KOiK17410.
OMAiKESNIQF.
OrthoDBiEOG091G0LP5.
PhylomeDBiQ92665.
TreeFamiTF324305.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102738-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

GenomeRNAii10240.
PROiQ92665.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102738.
CleanExiHS_MRPS31.
GenevisibleiQ92665. HS.

Family and domain databases

InterProiIPR026299. MRP-S31.
[Graphical view]
PANTHERiPTHR13231. PTHR13231. 1 hit.
PfamiPF15433. MRP-S31. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT31_HUMAN
AccessioniPrimary (citable) accession number: Q92665
Secondary accession number(s): B2RCS3, Q5VYC8, Q8WTV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: February 7, 2006
Last modified: November 30, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.