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Protein

28S ribosomal protein S31, mitochondrial

Gene

MRPS31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S31, mitochondrial
Short name:
MRP-S31
Short name:
S31mt
Alternative name(s):
Imogen 38
Gene namesi
Name:MRPS31
Synonyms:IMOGN38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:16632. MRPS31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31019.

Polymorphism and mutation databases

BioMutaiMRPS31.
DMDMi93186129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6565MitochondrionSequence AnalysisAdd
BLAST
Chaini66 – 39533028S ribosomal protein S31, mitochondrialPRO_0000030594Add
BLAST

Proteomic databases

MaxQBiQ92665.
PaxDbiQ92665.
PeptideAtlasiQ92665.
PRIDEiQ92665.

PTM databases

PhosphoSiteiQ92665.

Expressioni

Gene expression databases

BgeeiQ92665.
CleanExiHS_MRPS31.
GenevisibleiQ92665. HS.

Organism-specific databases

HPAiHPA039083.
HPA046344.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-720602,EBI-518675

Protein-protein interaction databases

BioGridi115534. 46 interactions.
IntActiQ92665. 9 interactions.
MINTiMINT-1420773.
STRINGi9606.ENSP00000315397.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AY1-395[»]
ProteinModelPortaliQ92665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG74634.
GeneTreeiENSGT00390000010017.
HOGENOMiHOG000232111.
HOVERGENiHBG036128.
InParanoidiQ92665.
KOiK17410.
OMAiPVNNEAG.
OrthoDBiEOG7DJSMH.
PhylomeDBiQ92665.
TreeFamiTF324305.

Family and domain databases

InterProiIPR026299. MRP-S31.
[Graphical view]
PANTHERiPTHR13231. PTHR13231. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA
60 70 80 90 100
RTKNNIQRYF GTNSVICSKK DKQSVRTEET SKETSESQDS EKENTKKDLL
110 120 130 140 150
GIIKGMKVEL STVNVRTTKP PKRRPLKSLE ATLGRLRRAT EYAPKKRIEP
160 170 180 190 200
LSPELVAAAS AVADSLPFDK QTTKSELLSQ LQQHEEESRA QRDAKRPKIS
210 220 230 240 250
FSNIISDMKV ARSATARVRS RPELRIQFDE GYDNYPGQEK TDDLKKRKNI
260 270 280 290 300
FTGKRLNIFD MMAVTKEAPE TDTSPSLWDV EFAKQLATVN EQPLQNGFEE
310 320 330 340 350
LIQWTKEGKL WEFPINNEAG FDDDGSEFHE HIFLEKHLES FPKQGPIRHF
360 370 380 390
MELVTCGLSK NPYLSVKQKV EHIEWFRNYF NEKKDILKES NIQFN
Length:395
Mass (Da):45,318
Last modified:February 7, 2006 - v3
Checksum:i01ED04983ED56818
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801T → I in AAH22045 (PubMed:15489334).Curated
Sequence conflicti132 – 1321T → A in AAH22045 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti241 – 2411T → M.
Corresponds to variant rs1854421 [ dbSNP | Ensembl ].
VAR_052049
Natural varianti279 – 2791D → N.1 Publication
Corresponds to variant rs13508 [ dbSNP | Ensembl ].
VAR_061812

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68747 mRNA. Translation: CAA92951.1.
AK315248 mRNA. Translation: BAG37670.1.
AL355132, AL161614 Genomic DNA. Translation: CAH70977.1.
AL161614, AL355132 Genomic DNA. Translation: CAH72771.1.
CH471075 Genomic DNA. Translation: EAX08629.1.
BC022045 mRNA. Translation: AAH22045.1.
CCDSiCCDS9372.1.
RefSeqiNP_005821.2. NM_005830.3.
UniGeneiHs.596607.

Genome annotation databases

EnsembliENST00000323563; ENSP00000315397; ENSG00000102738.
GeneIDi10240.
KEGGihsa:10240.
UCSCiuc001uxm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68747 mRNA. Translation: CAA92951.1.
AK315248 mRNA. Translation: BAG37670.1.
AL355132, AL161614 Genomic DNA. Translation: CAH70977.1.
AL161614, AL355132 Genomic DNA. Translation: CAH72771.1.
CH471075 Genomic DNA. Translation: EAX08629.1.
BC022045 mRNA. Translation: AAH22045.1.
CCDSiCCDS9372.1.
RefSeqiNP_005821.2. NM_005830.3.
UniGeneiHs.596607.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AY1-395[»]
ProteinModelPortaliQ92665.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115534. 46 interactions.
IntActiQ92665. 9 interactions.
MINTiMINT-1420773.
STRINGi9606.ENSP00000315397.

PTM databases

PhosphoSiteiQ92665.

Polymorphism and mutation databases

BioMutaiMRPS31.
DMDMi93186129.

Proteomic databases

MaxQBiQ92665.
PaxDbiQ92665.
PeptideAtlasiQ92665.
PRIDEiQ92665.

Protocols and materials databases

DNASUi10240.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323563; ENSP00000315397; ENSG00000102738.
GeneIDi10240.
KEGGihsa:10240.
UCSCiuc001uxm.4. human.

Organism-specific databases

CTDi10240.
GeneCardsiGC13M041303.
HGNCiHGNC:16632. MRPS31.
HPAiHPA039083.
HPA046344.
MIMi611992. gene.
neXtProtiNX_Q92665.
PharmGKBiPA31019.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG74634.
GeneTreeiENSGT00390000010017.
HOGENOMiHOG000232111.
HOVERGENiHBG036128.
InParanoidiQ92665.
KOiK17410.
OMAiPVNNEAG.
OrthoDBiEOG7DJSMH.
PhylomeDBiQ92665.
TreeFamiTF324305.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

GenomeRNAii10240.
NextBioi38792.
PROiQ92665.
SOURCEiSearch...

Gene expression databases

BgeeiQ92665.
CleanExiHS_MRPS31.
GenevisibleiQ92665. HS.

Family and domain databases

InterProiIPR026299. MRP-S31.
[Graphical view]
PANTHERiPTHR13231. PTHR13231. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient."
    Arden S.D., Roep B.O., Neophytou P.I., Usac E.F., Duinkerken G., de Vries R.R.P., Hutton J.C.
    J. Clin. Invest. 97:551-561(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-279.
    Tissue: Skin.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRT31_HUMAN
AccessioniPrimary (citable) accession number: Q92665
Secondary accession number(s): B2RCS3, Q5VYC8, Q8WTV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: February 7, 2006
Last modified: July 22, 2015
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.