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Q92665

- RT31_HUMAN

UniProt

Q92665 - RT31_HUMAN

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Protein

28S ribosomal protein S31, mitochondrial

Gene

MRPS31

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein domain specific binding Source: UniProtKB
  3. structural constituent of ribosome Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S31, mitochondrial
Short name:
MRP-S31
Short name:
S31mt
Alternative name(s):
Imogen 38
Gene namesi
Name:MRPS31
Synonyms:IMOGN38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:16632. MRPS31.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial small ribosomal subunit Source: InterPro
  2. mitochondrion Source: HPA
  3. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6565MitochondrionSequence AnalysisAdd
BLAST
Chaini66 – 39533028S ribosomal protein S31, mitochondrialPRO_0000030594Add
BLAST

Proteomic databases

MaxQBiQ92665.
PaxDbiQ92665.
PeptideAtlasiQ92665.
PRIDEiQ92665.

PTM databases

PhosphoSiteiQ92665.

Expressioni

Gene expression databases

BgeeiQ92665.
CleanExiHS_MRPS31.
GenevestigatoriQ92665.

Organism-specific databases

HPAiHPA039083.
HPA046344.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-720602,EBI-518675

Protein-protein interaction databases

BioGridi115534. 47 interactions.
IntActiQ92665. 8 interactions.
MINTiMINT-1420773.
STRINGi9606.ENSP00000315397.

Structurei

3D structure databases

ProteinModelPortaliQ92665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG74634.
GeneTreeiENSGT00390000010017.
HOGENOMiHOG000232111.
HOVERGENiHBG036128.
InParanoidiQ92665.
KOiK17410.
OMAiEELIQWT.
OrthoDBiEOG7DJSMH.
PhylomeDBiQ92665.
TreeFamiTF324305.

Family and domain databases

InterProiIPR026299. MRP-S31.
[Graphical view]
PANTHERiPTHR13231. PTHR13231. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92665-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA
60 70 80 90 100
RTKNNIQRYF GTNSVICSKK DKQSVRTEET SKETSESQDS EKENTKKDLL
110 120 130 140 150
GIIKGMKVEL STVNVRTTKP PKRRPLKSLE ATLGRLRRAT EYAPKKRIEP
160 170 180 190 200
LSPELVAAAS AVADSLPFDK QTTKSELLSQ LQQHEEESRA QRDAKRPKIS
210 220 230 240 250
FSNIISDMKV ARSATARVRS RPELRIQFDE GYDNYPGQEK TDDLKKRKNI
260 270 280 290 300
FTGKRLNIFD MMAVTKEAPE TDTSPSLWDV EFAKQLATVN EQPLQNGFEE
310 320 330 340 350
LIQWTKEGKL WEFPINNEAG FDDDGSEFHE HIFLEKHLES FPKQGPIRHF
360 370 380 390
MELVTCGLSK NPYLSVKQKV EHIEWFRNYF NEKKDILKES NIQFN
Length:395
Mass (Da):45,318
Last modified:February 7, 2006 - v3
Checksum:i01ED04983ED56818
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801T → I in AAH22045. (PubMed:15489334)Curated
Sequence conflicti132 – 1321T → A in AAH22045. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti241 – 2411T → M.
Corresponds to variant rs1854421 [ dbSNP | Ensembl ].
VAR_052049
Natural varianti279 – 2791D → N.1 Publication
Corresponds to variant rs13508 [ dbSNP | Ensembl ].
VAR_061812

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68747 mRNA. Translation: CAA92951.1.
AK315248 mRNA. Translation: BAG37670.1.
AL355132, AL161614 Genomic DNA. Translation: CAH70977.1.
AL161614, AL355132 Genomic DNA. Translation: CAH72771.1.
CH471075 Genomic DNA. Translation: EAX08629.1.
BC022045 mRNA. Translation: AAH22045.1.
CCDSiCCDS9372.1.
RefSeqiNP_005821.2. NM_005830.3.
UniGeneiHs.596607.

Genome annotation databases

EnsembliENST00000323563; ENSP00000315397; ENSG00000102738.
GeneIDi10240.
KEGGihsa:10240.
UCSCiuc001uxm.4. human.

Polymorphism databases

DMDMi93186129.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68747 mRNA. Translation: CAA92951.1 .
AK315248 mRNA. Translation: BAG37670.1 .
AL355132 , AL161614 Genomic DNA. Translation: CAH70977.1 .
AL161614 , AL355132 Genomic DNA. Translation: CAH72771.1 .
CH471075 Genomic DNA. Translation: EAX08629.1 .
BC022045 mRNA. Translation: AAH22045.1 .
CCDSi CCDS9372.1.
RefSeqi NP_005821.2. NM_005830.3.
UniGenei Hs.596607.

3D structure databases

ProteinModelPortali Q92665.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115534. 47 interactions.
IntActi Q92665. 8 interactions.
MINTi MINT-1420773.
STRINGi 9606.ENSP00000315397.

PTM databases

PhosphoSitei Q92665.

Polymorphism databases

DMDMi 93186129.

Proteomic databases

MaxQBi Q92665.
PaxDbi Q92665.
PeptideAtlasi Q92665.
PRIDEi Q92665.

Protocols and materials databases

DNASUi 10240.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323563 ; ENSP00000315397 ; ENSG00000102738 .
GeneIDi 10240.
KEGGi hsa:10240.
UCSCi uc001uxm.4. human.

Organism-specific databases

CTDi 10240.
GeneCardsi GC13M041303.
HGNCi HGNC:16632. MRPS31.
HPAi HPA039083.
HPA046344.
MIMi 611992. gene.
neXtProti NX_Q92665.
PharmGKBi PA31019.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74634.
GeneTreei ENSGT00390000010017.
HOGENOMi HOG000232111.
HOVERGENi HBG036128.
InParanoidi Q92665.
KOi K17410.
OMAi EELIQWT.
OrthoDBi EOG7DJSMH.
PhylomeDBi Q92665.
TreeFami TF324305.

Enzyme and pathway databases

Reactomei REACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

GenomeRNAii 10240.
NextBioi 38792.
PROi Q92665.
SOURCEi Search...

Gene expression databases

Bgeei Q92665.
CleanExi HS_MRPS31.
Genevestigatori Q92665.

Family and domain databases

InterProi IPR026299. MRP-S31.
[Graphical view ]
PANTHERi PTHR13231. PTHR13231. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient."
    Arden S.D., Roep B.O., Neophytou P.I., Usac E.F., Duinkerken G., de Vries R.R.P., Hutton J.C.
    J. Clin. Invest. 97:551-561(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-279.
    Tissue: Skin.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT31_HUMAN
AccessioniPrimary (citable) accession number: Q92665
Secondary accession number(s): B2RCS3, Q5VYC8, Q8WTV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: February 7, 2006
Last modified: November 26, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3