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Q92665

- RT31_HUMAN

UniProt

Q92665 - RT31_HUMAN

Protein

28S ribosomal protein S31, mitochondrial

Gene

MRPS31

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. protein domain specific binding Source: UniProtKB
    4. structural constituent of ribosome Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S31, mitochondrial
    Short name:
    MRP-S31
    Short name:
    S31mt
    Alternative name(s):
    Imogen 38
    Gene namesi
    Name:MRPS31
    Synonyms:IMOGN38
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:16632. MRPS31.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial small ribosomal subunit Source: InterPro
    2. mitochondrion Source: HPA
    3. nucleolus Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31019.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6565MitochondrionSequence AnalysisAdd
    BLAST
    Chaini66 – 39533028S ribosomal protein S31, mitochondrialPRO_0000030594Add
    BLAST

    Proteomic databases

    MaxQBiQ92665.
    PaxDbiQ92665.
    PeptideAtlasiQ92665.
    PRIDEiQ92665.

    PTM databases

    PhosphoSiteiQ92665.

    Expressioni

    Gene expression databases

    BgeeiQ92665.
    CleanExiHS_MRPS31.
    GenevestigatoriQ92665.

    Organism-specific databases

    HPAiHPA039083.
    HPA046344.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    STAT3P407632EBI-720602,EBI-518675

    Protein-protein interaction databases

    BioGridi115534. 14 interactions.
    IntActiQ92665. 8 interactions.
    MINTiMINT-1420773.
    STRINGi9606.ENSP00000315397.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92665.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG74634.
    HOGENOMiHOG000232111.
    HOVERGENiHBG036128.
    InParanoidiQ92665.
    KOiK17410.
    OMAiEELIQWT.
    OrthoDBiEOG7DJSMH.
    PhylomeDBiQ92665.
    TreeFamiTF324305.

    Family and domain databases

    InterProiIPR026299. MRP-S31.
    [Graphical view]
    PANTHERiPTHR13231. PTHR13231. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92665-1 [UniParc]FASTAAdd to Basket

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    MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA    50
    RTKNNIQRYF GTNSVICSKK DKQSVRTEET SKETSESQDS EKENTKKDLL 100
    GIIKGMKVEL STVNVRTTKP PKRRPLKSLE ATLGRLRRAT EYAPKKRIEP 150
    LSPELVAAAS AVADSLPFDK QTTKSELLSQ LQQHEEESRA QRDAKRPKIS 200
    FSNIISDMKV ARSATARVRS RPELRIQFDE GYDNYPGQEK TDDLKKRKNI 250
    FTGKRLNIFD MMAVTKEAPE TDTSPSLWDV EFAKQLATVN EQPLQNGFEE 300
    LIQWTKEGKL WEFPINNEAG FDDDGSEFHE HIFLEKHLES FPKQGPIRHF 350
    MELVTCGLSK NPYLSVKQKV EHIEWFRNYF NEKKDILKES NIQFN 395
    Length:395
    Mass (Da):45,318
    Last modified:February 7, 2006 - v3
    Checksum:i01ED04983ED56818
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 801T → I in AAH22045. (PubMed:15489334)Curated
    Sequence conflicti132 – 1321T → A in AAH22045. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti241 – 2411T → M.
    Corresponds to variant rs1854421 [ dbSNP | Ensembl ].
    VAR_052049
    Natural varianti279 – 2791D → N.1 Publication
    Corresponds to variant rs13508 [ dbSNP | Ensembl ].
    VAR_061812

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z68747 mRNA. Translation: CAA92951.1.
    AK315248 mRNA. Translation: BAG37670.1.
    AL355132, AL161614 Genomic DNA. Translation: CAH70977.1.
    AL161614, AL355132 Genomic DNA. Translation: CAH72771.1.
    CH471075 Genomic DNA. Translation: EAX08629.1.
    BC022045 mRNA. Translation: AAH22045.1.
    CCDSiCCDS9372.1.
    RefSeqiNP_005821.2. NM_005830.3.
    UniGeneiHs.596607.

    Genome annotation databases

    EnsembliENST00000323563; ENSP00000315397; ENSG00000102738.
    GeneIDi10240.
    KEGGihsa:10240.
    UCSCiuc001uxm.4. human.

    Polymorphism databases

    DMDMi93186129.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z68747 mRNA. Translation: CAA92951.1 .
    AK315248 mRNA. Translation: BAG37670.1 .
    AL355132 , AL161614 Genomic DNA. Translation: CAH70977.1 .
    AL161614 , AL355132 Genomic DNA. Translation: CAH72771.1 .
    CH471075 Genomic DNA. Translation: EAX08629.1 .
    BC022045 mRNA. Translation: AAH22045.1 .
    CCDSi CCDS9372.1.
    RefSeqi NP_005821.2. NM_005830.3.
    UniGenei Hs.596607.

    3D structure databases

    ProteinModelPortali Q92665.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115534. 14 interactions.
    IntActi Q92665. 8 interactions.
    MINTi MINT-1420773.
    STRINGi 9606.ENSP00000315397.

    PTM databases

    PhosphoSitei Q92665.

    Polymorphism databases

    DMDMi 93186129.

    Proteomic databases

    MaxQBi Q92665.
    PaxDbi Q92665.
    PeptideAtlasi Q92665.
    PRIDEi Q92665.

    Protocols and materials databases

    DNASUi 10240.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323563 ; ENSP00000315397 ; ENSG00000102738 .
    GeneIDi 10240.
    KEGGi hsa:10240.
    UCSCi uc001uxm.4. human.

    Organism-specific databases

    CTDi 10240.
    GeneCardsi GC13M041303.
    HGNCi HGNC:16632. MRPS31.
    HPAi HPA039083.
    HPA046344.
    MIMi 611992. gene.
    neXtProti NX_Q92665.
    PharmGKBi PA31019.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74634.
    HOGENOMi HOG000232111.
    HOVERGENi HBG036128.
    InParanoidi Q92665.
    KOi K17410.
    OMAi EELIQWT.
    OrthoDBi EOG7DJSMH.
    PhylomeDBi Q92665.
    TreeFami TF324305.

    Miscellaneous databases

    GenomeRNAii 10240.
    NextBioi 38792.
    PROi Q92665.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q92665.
    CleanExi HS_MRPS31.
    Genevestigatori Q92665.

    Family and domain databases

    InterProi IPR026299. MRP-S31.
    [Graphical view ]
    PANTHERi PTHR13231. PTHR13231. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient."
      Arden S.D., Roep B.O., Neophytou P.I., Usac E.F., Duinkerken G., de Vries R.R.P., Hutton J.C.
      J. Clin. Invest. 97:551-561(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-279.
      Tissue: Skin.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    6. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT31_HUMAN
    AccessioniPrimary (citable) accession number: Q92665
    Secondary accession number(s): B2RCS3, Q5VYC8, Q8WTV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3