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Q92664

- TF3A_HUMAN

UniProt

Q92664 - TF3A_HUMAN

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Protein

Transcription factor IIIA

Gene

GTF3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri40 – 6425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri70 – 9425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri100 – 12526C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 15423C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri162 – 18625C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21325C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 27126C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 30125C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. gene expression Source: Reactome
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. rRNA transcription Source: ProtInc
  4. transcription from RNA polymerase III promoter Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIA
Short name:
TFIIIA
Gene namesi
Name:GTF3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:4662. GTF3A.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Transcription factor IIIAPRO_0000047080Add
BLAST

Proteomic databases

MaxQBiQ92664.
PaxDbiQ92664.
PRIDEiQ92664.

PTM databases

PhosphoSiteiQ92664.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ92664.
CleanExiHS_GTF3A.
ExpressionAtlasiQ92664. baseline and differential.
GenevestigatoriQ92664.

Organism-specific databases

HPAiHPA007990.

Interactioni

Protein-protein interaction databases

BioGridi109226. 6 interactions.
IntActiQ92664. 6 interactions.
STRINGi9606.ENSP00000370532.

Structurei

3D structure databases

ProteinModelPortaliQ92664.
SMRiQ92664. Positions 38-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri40 – 6425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri70 – 9425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri100 – 12526C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 15423C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri162 – 18625C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21325C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 27126C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 30125C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000232112.
HOVERGENiHBG017915.
InParanoidiQ92664.
KOiK09191.
PhylomeDBiQ92664.
TreeFamiTF333011.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92664-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPPAVVAES VSSLTIADAF IAAGESSAPT PPRPALPRRF ICSFPDCSAN
60 70 80 90 100
YSKAWKLDAH LCKHTGERPF VCDYEGCGKA FIRDYHLSRH ILTHTGEKPF
110 120 130 140 150
VCAANGCDQK FNTKSNLKKH FERKHENQQK QYICSFEDCK KTFKKHQQLK
160 170 180 190 200
IHQCQHTNEP LFKCTQEGCG KHFASPSKLK RHAKAHEGYV CQKGCSFVAK
210 220 230 240 250
TWTELLKHVR ETHKEEILCE VCRKTFKRKD YLKQHMKTHA PERDVCRCPR
260 270 280 290 300
EGCGRTYTTV FNLQSHILSF HEESRPFVCE HAGCGKTFAM KQSLTRHAVV
310 320 330 340 350
HDPDKKKMKL KVKKSREKRS LASHLSGYIP PKRKQGQGLS LCQNGESPNC
360
VEDKMLSTVA VLTLG
Length:365
Mass (Da):41,515
Last modified:February 26, 2008 - v3
Checksum:i261EBDCC550130B9
GO
Isoform 2 (identifier: Q92664-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-188: Missing.
     189-190: YV → LC

Show »
Length:340
Mass (Da):38,779
Checksum:iEAECD6B619A6BC7C
GO

Sequence cautioni

The sequence BAA06988.1 differs from that shown. Reason: Frameshift at positions 319 and 330.
The sequence BAA06988.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561H → N in BAA06988. (PubMed:7789179)Curated
Sequence conflicti319 – 3191R → G in BAA06988. (PubMed:7789179)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti245 – 2451V → L.
Corresponds to variant rs7323 [ dbSNP | Ensembl ].
VAR_014824

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei164 – 18825Missing in isoform 2. 1 PublicationVSP_031525Add
BLAST
Alternative sequencei189 – 1902YV → LC in isoform 2. 1 PublicationVSP_031526

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D32257 mRNA. Translation: BAA06988.1. Sequence problems.
AL137059 Genomic DNA. Translation: CAX15101.1.
U20272 mRNA. Translation: AAA75623.1.
U14134 mRNA. Translation: AAA21873.1.
CCDSiCCDS45019.1. [Q92664-1]
PIRiI38937.
RefSeqiNP_002088.2. NM_002097.2. [Q92664-1]
UniGeneiHs.445977.

Genome annotation databases

EnsembliENST00000381140; ENSP00000370532; ENSG00000122034.
GeneIDi2971.
KEGGihsa:2971.
UCSCiuc001ure.2. human. [Q92664-1]

Polymorphism databases

DMDMi172045838.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D32257 mRNA. Translation: BAA06988.1 . Sequence problems.
AL137059 Genomic DNA. Translation: CAX15101.1 .
U20272 mRNA. Translation: AAA75623.1 .
U14134 mRNA. Translation: AAA21873.1 .
CCDSi CCDS45019.1. [Q92664-1 ]
PIRi I38937.
RefSeqi NP_002088.2. NM_002097.2. [Q92664-1 ]
UniGenei Hs.445977.

3D structure databases

ProteinModelPortali Q92664.
SMRi Q92664. Positions 38-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109226. 6 interactions.
IntActi Q92664. 6 interactions.
STRINGi 9606.ENSP00000370532.

PTM databases

PhosphoSitei Q92664.

Polymorphism databases

DMDMi 172045838.

Proteomic databases

MaxQBi Q92664.
PaxDbi Q92664.
PRIDEi Q92664.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381140 ; ENSP00000370532 ; ENSG00000122034 .
GeneIDi 2971.
KEGGi hsa:2971.
UCSCi uc001ure.2. human. [Q92664-1 ]

Organism-specific databases

CTDi 2971.
GeneCardsi GC13P027998.
H-InvDB HIX0011192.
HIX0130586.
HGNCi HGNC:4662. GTF3A.
HPAi HPA007990.
MIMi 600860. gene.
neXtProti NX_Q92664.
PharmGKBi PA29048.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000232112.
HOVERGENi HBG017915.
InParanoidi Q92664.
KOi K09191.
PhylomeDBi Q92664.
TreeFami TF333011.

Enzyme and pathway databases

Reactomei REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

Miscellaneous databases

ChiTaRSi GTF3A. human.
GeneWikii GTF3A.
GenomeRNAii 2971.
NextBioi 11783.
PROi Q92664.
SOURCEi Search...

Gene expression databases

Bgeei Q92664.
CleanExi HS_GTF3A.
ExpressionAtlasi Q92664. baseline and differential.
Genevestigatori Q92664.

Family and domain databases

Gene3Di 3.30.160.60. 8 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 4 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA."
    Arakawa H., Nagase H., Hayashi N., Ogawa M., Nagata M., Fujiwara T., Takahashi E., Shin S., Nakamura Y.
    Cytogenet. Cell Genet. 70:235-238(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA."
    Drew P.D., Nagle J.W., Canning R.D., Ozato K., Biddison W.E., Becker K.G.
    Gene 159:215-218(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-365 (ISOFORMS 1 AND 2).
    Tissue: Brain.
  4. "Purification and characterization of human transcription factor IIIA."
    Moorefield B., Roeder R.G.
    J. Biol. Chem. 269:20857-20865(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTF3A_HUMAN
AccessioniPrimary (citable) accession number: Q92664
Secondary accession number(s): B7ZBK5, Q12963, Q13097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3