Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor IIIA

Gene

GTF3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity).By similarity1 Publication

Caution

It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 64C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri70 – 94C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri100 – 125C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri132 – 154C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri162 – 186C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri189 – 213C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri217 – 239C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 271C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri277 – 301C2H2-type 9PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • ribosomal large subunit biogenesis Source: UniProtKB
  • rRNA transcription Source: ProtInc
  • transcription by RNA polymerase III Source: ProtInc

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processRibosome biogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIA
Short name:
TFIIIA
Gene namesi
Name:GTF3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000122034.12
HGNCiHGNC:4662 GTF3A
MIMi600860 gene
neXtProtiNX_Q92664

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2971
OpenTargetsiENSG00000122034
PharmGKBiPA29048

Polymorphism and mutation databases

BioMutaiGTF3A
DMDMi172045838

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470801 – 365Transcription factor IIIAAdd BLAST365

Proteomic databases

EPDiQ92664
MaxQBiQ92664
PaxDbiQ92664
PeptideAtlasiQ92664
PRIDEiQ92664

PTM databases

iPTMnetiQ92664
PhosphoSitePlusiQ92664

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000122034
CleanExiHS_GTF3A
ExpressionAtlasiQ92664 baseline and differential
GenevisibleiQ92664 HS

Organism-specific databases

HPAiHPA007990

Interactioni

Protein-protein interaction databases

BioGridi109226, 5 interactors
CORUMiQ92664
IntActiQ92664, 7 interactors
STRINGi9606.ENSP00000370532

Structurei

3D structure databases

ProteinModelPortaliQ92664
SMRiQ92664
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 64C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri70 – 94C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri100 – 125C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri132 – 154C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri162 – 186C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri189 – 213C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri217 – 239C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 271C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri277 – 301C2H2-type 9PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000232112
HOVERGENiHBG017915
InParanoidiQ92664
KOiK09191
PhylomeDBiQ92664
TreeFamiTF333011

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92664-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPPAVVAES VSSLTIADAF IAAGESSAPT PPRPALPRRF ICSFPDCSAN
60 70 80 90 100
YSKAWKLDAH LCKHTGERPF VCDYEGCGKA FIRDYHLSRH ILTHTGEKPF
110 120 130 140 150
VCAANGCDQK FNTKSNLKKH FERKHENQQK QYICSFEDCK KTFKKHQQLK
160 170 180 190 200
IHQCQHTNEP LFKCTQEGCG KHFASPSKLK RHAKAHEGYV CQKGCSFVAK
210 220 230 240 250
TWTELLKHVR ETHKEEILCE VCRKTFKRKD YLKQHMKTHA PERDVCRCPR
260 270 280 290 300
EGCGRTYTTV FNLQSHILSF HEESRPFVCE HAGCGKTFAM KQSLTRHAVV
310 320 330 340 350
HDPDKKKMKL KVKKSREKRS LASHLSGYIP PKRKQGQGLS LCQNGESPNC
360
VEDKMLSTVA VLTLG
Length:365
Mass (Da):41,515
Last modified:February 26, 2008 - v3
Checksum:i261EBDCC550130B9
GO
Isoform 2 (identifier: Q92664-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-188: Missing.
     189-190: YV → LC

Show »
Length:340
Mass (Da):38,779
Checksum:iEAECD6B619A6BC7C
GO

Sequence cautioni

The sequence BAA06988 differs from that shown. Reason: Frameshift at positions 319 and 330.Curated
The sequence BAA06988 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156H → N in BAA06988 (PubMed:7789179).Curated1
Sequence conflicti319R → G in BAA06988 (PubMed:7789179).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014824245V → L. Corresponds to variant dbSNP:rs7323Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031525164 – 188Missing in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_031526189 – 190YV → LC in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32257 mRNA Translation: BAA06988.1 Sequence problems.
AL137059 Genomic DNA No translation available.
U20272 mRNA Translation: AAA75623.1
U14134 mRNA Translation: AAA21873.1
CCDSiCCDS45019.1 [Q92664-1]
PIRiI38937
RefSeqiNP_002088.2, NM_002097.2 [Q92664-1]
UniGeneiHs.445977

Genome annotation databases

EnsembliENST00000640289; ENSP00000491190; ENSG00000122034 [Q92664-1]
GeneIDi2971
KEGGihsa:2971
UCSCiuc058wav.1 human [Q92664-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTF3A_HUMAN
AccessioniPrimary (citable) accession number: Q92664
Secondary accession number(s): B7ZBK5, Q12963, Q13097
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health