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Reviewed, UniProtKB/Swiss-Prot Q92664 (TF3A_HUMAN)

Last modified November 25, 2008. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Transcription factor IIIA
      Short name=Factor A
      Short name=TFIIIA
Gene names
Name: GTF3A
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes.

Subcellular location

Nucleus.

Tissue specificity

Ubiquitous.

Sequence similarities

Contains 9 C2H2-type zinc fingers.

Caution

It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals.

Sequence caution

The sequence BAA06988.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAA06988.1 differs from that shown. Reason: Frameshift at positions 319 and 330.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92664-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92664-2)

The sequence of this isoform differs from the canonical sequence as follows:
     164-188: Missing.
     189-190: YV → LC

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Transcription factor IIIA
PRO_0000047080

Regions

Zinc finger40 – 6425C2H2-type 1
Zinc finger70 – 9425C2H2-type 2
Zinc finger100 – 12526C2H2-type 3
Zinc finger132 – 15423C2H2-type 4; atypical
Zinc finger162 – 18625C2H2-type 5
Zinc finger189 – 21325C2H2-type 6
Zinc finger217 – 23923C2H2-type 7
Zinc finger246 – 27126C2H2-type 8
Zinc finger277 – 30125C2H2-type 9

Natural variations

Alternative sequence164 – 18825Missing in isoform 2.
VSP_031525
Alternative sequence189 – 1902YV → LC in isoform 2.
VSP_031526
Natural variant2451V → L: dbSNP rs7323.
VAR_014824

Experimental info

Sequence conflict1561H → N in BAA06988. Ref.1
Sequence conflict3191R → G in BAA06988. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: 261EBDCC550130B9

FASTA36541,515
        10         20         30         40         50         60 
MDPPAVVAES VSSLTIADAF IAAGESSAPT PPRPALPRRF ICSFPDCSAN YSKAWKLDAH 

        70         80         90        100        110        120 
LCKHTGERPF VCDYEGCGKA FIRDYHLSRH ILTHTGEKPF VCAANGCDQK FNTKSNLKKH 

       130        140        150        160        170        180 
FERKHENQQK QYICSFEDCK KTFKKHQQLK IHQCQHTNEP LFKCTQEGCG KHFASPSKLK 

       190        200        210        220        230        240 
RHAKAHEGYV CQKGCSFVAK TWTELLKHVR ETHKEEILCE VCRKTFKRKD YLKQHMKTHA 

       250        260        270        280        290        300 
PERDVCRCPR EGCGRTYTTV FNLQSHILSF HEESRPFVCE HAGCGKTFAM KQSLTRHAVV 

       310        320        330        340        350        360 
HDPDKKKMKL KVKKSREKRS LASHLSGYIP PKRKQGQGLS LCQNGESPNC VEDKMLSTVA 


VLTLG 

« Hide

Isoform 2 [UniParc].

Checksum: EAECD6B619A6BC7C
Show »

34038,779

References

[1]"Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA."
Arakawa H., Nagase H., Hayashi N., Ogawa M., Nagata M., Fujiwara T., Takahashi E., Shin S., Nakamura Y.
Cytogenet. Cell Genet. 70:235-238(1995) [PubMed: 7789179] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal brain.
[2]"Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA."
Drew P.D., Nagle J.W., Canning R.D., Ozato K., Biddison W.E., Becker K.G.
Gene 159:215-218(1995) [PubMed: 7622052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-365 (ISOFORMS 1 AND 2).
Tissue: Brain.
[3]"Purification and characterization of human transcription factor IIIA."
Moorefield B., Roeder R.G.
J. Biol. Chem. 269:20857-20865(1994) [PubMed: 8063702] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

D32257 mRNA. Translation: BAA06988.1. Sequence problems.
U20272 mRNA. Translation: AAA75623.1.
U14134 mRNA. Translation: AAA21873.1.
PIRI38937.
RefSeqNP_002088.2.
UniGeneHs.445977

3D structure databases

HSSPHSSP built from PDB template 1TF3 based on UniProtKB P03001.
ModBaseSearch...

Protein-protein interaction databases

IntActQ92664.

Genome annotation databases

EnsemblENSG00000122034. Homo sapiens. [Contig view]
GeneID2971.
KEGGhsa:2971.

Organism-specific databases

H-InvDBHIX0011192.
HIX0059188.
HGNCHGNC:4662. GTF3A.
MIM600860. gene.
PharmGKBPA29048.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ92664.
HOVERGENQ92664.

Enzyme and pathway databases

ReactomeREACT_1788. Transcription.

Gene expression databases

CleanExHS_GTF3A.
GermOnlineENSG00000122034. Homo sapiens.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 6 hits.
PfamPF00096. zf-C2H2. 8 hits.
[Graphical view]
ProDomPD000003. Znf_C2H2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubQ92664.
NextBio11783.
SOURCESearch...

Entry information

Entry nameTF3A_HUMAN
AccessionPrimary (citable) accession number: Q92664
Secondary accession number(s): Q12963, Q13097
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 26, 2008
Last modified: November 25, 2008
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents