Q92637 (FCGRB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
High affinity immunoglobulin gamma Fc receptor IB
Short name=IgG Fc receptor IB

Alternative name(s):
Fc-gamma RIB
Short name=FcRIB
Short name=hFcgammaRIB

Gene names

Name:	FCGR1B
Synonyms:	IGFRB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response. Ref.1 Ref.5
Subcellular location	Cell membrane; Single-pass type I membrane protein Ref.1.
Induction	Up-regulated by IFNG/IFN-gamma. Ref.1 Ref.2
Sequence similarities	Belongs to the immunoglobulin superfamily. FCGR1 family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Ligand	IgG-binding protein
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular_component	clathrin-coated endocytic vesicle membrane Traceable author statement. Source: Reactome early endosome membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	immunoglobulin receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92637-1)

Also known as: b2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92637-2)

The sequence of this isoform differs from the canonical sequence as follows:
     188-223: GLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKEL → ELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGL
     224-280: Missing.

Isoform 3 (identifier: Q92637-3)

Also known as: b3;

The sequence of this isoform differs from the canonical sequence as follows:
     11-102: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 280	265	High affinity immunoglobulin gamma Fc receptor IB		PRO_0000331462
Regions
	Topological domain	16 – 198	183	Extracellular Potential
	Transmembrane	199 – 219	21	Helical; Potential
	Topological domain	220 – 280	61	Cytoplasmic Potential
	Domain	22 – 101	80	Ig-like C2-type 1
	Domain	95 – 184	90	Ig-like C2-type 2
Amino acid modifications
	Glycosylation	59	1	N-linked (GlcNAc...) Potential
	Glycosylation	152	1	N-linked (GlcNAc...) Potential
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
	Disulfide bond	43 ↔ 85		By similarity
	Disulfide bond	124 ↔ 168		By similarity
Natural variations
	Alternative sequence	11 – 102	92	Missing in isoform 3.		VSP_033215
	Alternative sequence	188 – 223	36	GLQLP…IRKEL → ELFPAPVLNASVTSPLLEGN LVTLSCETKLLLQRPGL in isoform 2.		VSP_033216
	Alternative sequence	224 – 280	57	Missing in isoform 2.		VSP_033217
Experimental info
	Sequence conflict	154	1	T → A in AAA35826. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (b2) [UniParc]. Last modified February 1, 1997. Version 1. Checksum: C6C6C45AE3D345C6	FASTA	280	32,232
	10 20 30 40 50 60 MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG SSSTQWFLNG 70 80 90 100 110 120 TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI HRGWLLLQVS SRVFMEGEPL 130 140 150 160 170 180 ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN SNLTILKTNI SHNGTYHCSG MGKHRYTSAG 190 200 210 220 230 240 ISQYTVKGLQ LPTPVWFHVL FYLAVGIMFL VNTVLWVTIR KELKRKKKWN LEISLDSGHE 250 260 270 280 KKVISSLQED RHLEEELKCQ EQKEEQLQEG VHRKEPQGAT
	Isoform 2 [UniParc]. Checksum: A7C9280734DB02A9	FASTA	224	25,203
	10 20 30 40 50 60 MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG SSSTQWFLNG 70 80 90 100 110 120 TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI HRGWLLLQVS SRVFMEGEPL 130 140 150 160 170 180 ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN SNLTILKTNI SHNGTYHCSG MGKHRYTSAG 190 200 210 220 ISQYTVKELF PAPVLNASVT SPLLEGNLVT LSCETKLLLQ RPGL
	Isoform 3 (b3) [UniParc]. Checksum: F46517B3279ABEF9	FASTA	188	22,136
	10 20 30 40 50 60 MWFLTTLLLW GWLLLQVSSR VFMEGEPLAL RCHAWKDKLV YNVLYYRNGK AFKFFHWNSN 70 80 90 100 110 120 LTILKTNISH NGTYHCSGMG KHRYTSAGIS QYTVKGLQLP TPVWFHVLFY LAVGIMFLVN 130 140 150 160 170 180 TVLWVTIRKE LKRKKKWNLE ISLDSGHEKK VISSLQEDRH LEEELKCQEQ KEEQLQEGVH RKEPQGAT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel Fc gamma receptor I family gene products in human mononuclear cells." Porges A.J., Redecha P.B., Doebele R., Pan L.C., Salmon J.E., Kimberly R.P. J. Clin. Invest. 90:2102-2109(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY IFNG. Tissue: Blood.
[2]	"Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure." Benech P.D., Sastry K.N., Iyer R.R., Eichbaum Q.G., Raveh D.P., Ezekowitz R.A. J. Exp. Med. 176:1115-1123(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION BY IFNG.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21." Maresco D.L., Chang E., Theil K.S., Francke U., Anderson C.L. Cytogenet. Cell Genet. 73:157-163(1996) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts." Ernst L.K., Duchemin A.-M., Miller K.L., Anderson C.L. Mol. Immunol. 35:943-954(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, ALTERNATIVE SPLICING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L03419 mRNA. Translation: AAA35825.1. L03420 mRNA. Translation: AAA35826.1. S45709 , S45704, S45705, S45707, S45708 Genomic DNA. Translation: AAD13842.1. AL357493 Genomic DNA. No translation available.
IPI	IPI00294221. IPI00383647. IPI00890744.
PIR	I55577.
RefSeq	NP_001004340.2. NM_001004340.3. NP_001017986.1. NM_001017986.3. NP_001231839.1. NM_001244910.1.
UniGene	Hs.534956. Hs.77424.
3D structure databases
HSSP	HSSP built from PDB template 1FNL based on UniProtKB O75015.
ProteinModelPortal	Q92637.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000358391.
PTM databases
PhosphoSite	Q92637.
Polymorphism databases
DMDM	74760649.
Proteomic databases
PaxDb	Q92637.
PRIDE	Q92637.
Protocols and materials databases
DNASU	2210.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369383; ENSP00000358390; ENSG00000198019. ENST00000369384; ENSP00000358391; ENSG00000198019. ENST00000577333; ENSP00000464601; ENSG00000263850.
GeneID	2210.
KEGG	hsa:2210.
UCSC	uc001eip.3. human. uc001eiq.3. human. uc009whr.2. human.
Organism-specific databases
CTD	2210.
GeneCards	GC01M120926.
H-InvDB	HIX0028931.
HGNC	HGNC:3614. FCGR1B.
MIM	601502. gene.
neXtProt	NX_Q92637.
PharmGKB	PA28061.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG277652.
HOGENOM	HOG000251632.
HOVERGEN	HBG051602.
InParanoid	Q92637.
OMA	LWCEGPR.
OrthoDB	EOG498V21.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	Q92637.
CleanEx	HS_FCGR1B.
Genevestigator	Q92637.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
SMART	SM00409. IG. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2210.
NextBio	8951.
SOURCE	Search...

Entry information

Entry name

FCGRB_HUMAN

Accession

Primary (citable) accession number: Q92637
Secondary accession number(s): Q7KZ13, Q92638

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.