Reviewed, UniProtKB/Swiss-Prot Q92636 (FAN_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein FAN
Alternative name(s):
    Factor associated with neutral sphingomyelinase activation
      Short name=Factor associated with N-SMase activation

Gene names

Name:	NSMAF
Synonyms:	FAN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	917 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
Tissue specificity	Ubiquitous.
Sequence similarities	Contains 1 BEACH domain. Contains 1 GRAM domain. Contains 6 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Gene Ontology (GO)
Biological process	ceramide metabolic process Ref.1 Traceable author statement. Source: ProtInc signal transduction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Ref.1 Traceable author statement. Source: ProtInc soluble fraction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	receptor signaling protein activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 917	917	Protein FAN		PRO_0000050975
Regions
	Domain	176 – 247	72	GRAM
	Domain	290 – 575	286	BEACH
	Repeat	628 – 658	31	WD 1
	Repeat	670 – 700	31	WD 2
	Repeat	712 – 740	29	WD 3
	Repeat	761 – 791	31	WD 4
	Repeat	803 – 833	31	WD 5
	Repeat	884 – 914	31	WD 6
	Compositional bias	23 – 28	6	Poly-Leu
Natural variations
	Natural variant	626	1	Y → C: dbSNP rs2228505.		VAR_047023
	Natural variant	850	1	R → T: dbSNP rs1131173. Ref.1		VAR_047024

Sequences

	Sequence		Length	Mass (Da)
	Q92636-1 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 36498B5A1378E49C	FASTA	917	104,372
	10 20 30 40 50 60 MAFIRKKQQE QQLQLYSKER FSLLLLNLEE YYFEQHRANH ILHKGSHHER KIRGSLKICS 70 80 90 100 110 120 KSVIFEPDSI SQPIIKIPLR DCIKIGKHGE NGANRHFTKA KSGGISLIFS QVYFIKEHNV 130 140 150 160 170 180 VAPYKIERGK MEYVFELDVP GKVEDVVETL LQLHRASCLD KLGDQTAMIT AILQSRLART 190 200 210 220 230 240 SFDKNRFQNI SEKLHMECKA EMVTPLVTNP GHVCITDTNL YFQPLNGYPK PVVQITLQDV 250 260 270 280 290 300 RRIYKRRHGL MPLGLEVFCT EDDLCSDIYL KFYEPQDRDD LYFYIATYLE HHVAEHTAES 310 320 330 340 350 360 YMLQWQRGHL SNYQYLLHLN NLADRSCNDL SQYPVFPWII HDYSSSELDL SNPGTFRDLS 370 380 390 400 410 420 KPVGALNKER LERLLTRYQE MPEPKFMYGS HYSSPGYVLF YLVRIAPEYM LCLQNGRFDN 430 440 450 460 470 480 ADRMFNSIAE TWKNCLDGAT DFKELIPEFY GDDVSFLVNS LKLDLGKRQG GQMVDDVELP 490 500 510 520 530 540 PWASSPEDFL QKSKDALESN YVSEHLHEWI DLIFGYKQKG SDAVGAHNVF HPLTYEGGVD 550 560 570 580 590 600 LNSIQDPDEK VAMLTQILEF GQTPKQLFVT PHPRRITPKF KSLSQTSSYN ASMADSPGEE 610 620 630 640 650 660 SFEDLTEESK TLAWNNITKL QLHEHYKIHK EAVTGITVSR NGSSVFTTSQ DSTLKMFSKE 670 680 690 700 710 720 SKMLQRSISF SNMALSSCLL LPGDATVITS SWDNNVYFYS IAFGRRQDTL MGHDDAVSKI 730 740 750 760 770 780 CWHDNRLYSA SWDSTVKVWS GVPAEMPGTK RHHFDLLAEL EHDVSVDTIS LNAASTLLVS 790 800 810 820 830 840 GTKEGTVNIW DLTTATLMHQ IPCHSGIVCD TAFSPDSRHV LSTGTDGCLN VIDVQTGMLI 850 860 870 880 890 900 SSMTSDEPQR CFVWDGNSVL SGSQSGELLV WDLLGAKISE RIQGHTGAVT CIWMNEQCSS 910 IITGGEDRQI IFWKLQY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase." Adam-Klages S., Adam D., Wiegmann K., Struve S., Kolanus W., Schneider-Mergener J., Kroenke M. Cell 86:937-947(1996) [PubMed: 8808629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-850. Tissue: Muscle.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X96586 mRNA. Translation: CAA65405.1. CH471068 Genomic DNA. Translation: EAW86817.1. BC041124 mRNA. Translation: AAH41124.1.
IPI	IPI00328260.
RefSeq	NP_003571.2.
UniGene	Hs.372000
3D structure databases
HSSP	HSSP built from PDB template 1MI1 based on UniProtKB Q8NFP9.
ModBase	Search...
Proteomic databases
PRIDE	Q92636.
Genome annotation databases
Ensembl	ENSG00000035681. Homo sapiens. [Contig view]
GeneID	8439.
KEGG	hsa:8439.
Organism-specific databases
GeneCards	GC08M059658.
H-InvDB	HIX0007527.
HGNC	HGNC:8017. NSMAF.
MIM	603043. gene.
PharmGKB	PA31795.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q92636.
HOVERGEN	Q92636.
OMA	Q92636. FDKNRFQ.
Enzyme and pathway databases
Pathway_Interaction_DB	tnfpathway. TNF receptor signaling pathway.
Gene expression databases
ArrayExpress	Q92636.
Bgee	Q92636.
CleanEx	HS_NSMAF.
GermOnline	ENSG00000035681. Homo sapiens.
Family and domain databases
InterPro	IPR000409. Beige_BEACH. IPR004182. GRAM. IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_region. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:1.10.1540.10. Beige_BEACH. 1 hit. G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF02138. Beach. 1 hit. PF02893. GRAM. 1 hit. PF00400. WD40. 4 hits. [Graphical view]
ProDom	PD000018. WD40. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00568. GRAM. 1 hit. SM00320. WD40. 7 hits. [Graphical view]
PROSITE	PS50197. BEACH. 1 hit. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

FAN_HUMAN

Accession

Primary (citable) accession number: Q92636
Secondary accession number(s): Q8IW26

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 14, 2008
Last modified:	June 16, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)