Q92633 (LPAR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysophosphatidic acid receptor 1
Short name=LPA receptor 1
Short name=LPA-1

Alternative name(s):
Lysophosphatidic acid receptor Edg-2

Gene names

Name:	LPAR1
Synonyms:	EDG2, LPA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G12/G13, and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Ref.6
Subunit structure	Interacts with RALA and ADRBK1. Ref.6
Subcellular location	Cell surface. Cell membrane; Multi-pass membrane protein. Note: Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles. Ref.6
Tissue specificity	Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPK activity Inferred from electronic annotation. Source: Compara activation of phospholipase C activity Traceable author statement PubMed 9804623. Source: ProtInc bleb assembly Inferred from electronic annotation. Source: Compara cellular response to oxygen levels Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Traceable author statement PubMed 9804623. Source: ProtInc elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Inferred from electronic annotation. Source: Compara myelination Inferred from electronic annotation. Source: Compara negative regulation of neuron projection development Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from expression pattern PubMed 12761501. Source: UniProtKB positive regulation of Rho protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of dendritic spine development Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell chemotaxis Inferred from electronic annotation. Source: Compara
Cellular_component	cell surface Inferred from direct assay Ref.6. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: Compara dendritic shaft Inferred from electronic annotation. Source: Compara dendritic spine Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 8922387. Source: ProtInc lysophosphatidic acid receptor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Lysophosphatidic acid receptor 1		PRO_0000069417
Regions
	Topological domain	1 – 50	50	Extracellular Potential
	Transmembrane	51 – 75	25	Helical; Name=1; Potential
	Topological domain	76 – 82	7	Cytoplasmic Potential
	Transmembrane	83 – 111	29	Helical; Name=2; Potential
	Topological domain	112 – 125	14	Extracellular Potential
	Transmembrane	126 – 144	19	Helical; Name=3; Potential
	Topological domain	145 – 163	19	Cytoplasmic Potential
	Transmembrane	164 – 189	26	Helical; Name=4; Potential
	Topological domain	190 – 205	16	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Name=5; Potential
	Topological domain	227 – 258	32	Cytoplasmic Potential
	Transmembrane	259 – 280	22	Helical; Name=6; Potential
	Topological domain	281 – 294	14	Extracellular Potential
	Transmembrane	295 – 315	21	Helical; Name=7; Potential
	Topological domain	316 – 364	49	Cytoplasmic Potential
Amino acid modifications
	Lipidation	327	1	S-palmitoyl cysteine By similarity
	Glycosylation	27	1	N-linked (GlcNAc...) Potential
	Glycosylation	35	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	77	1	N → S. Corresponds to variant rs11542862 [ dbSNP | Ensembl ].		VAR_049414
Experimental info
	Sequence conflict	340	1	G → S in AAC51139. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q92633 [UniParc]. Last modified December 6, 2002. Version 3. Checksum: 4CA6262FD00DFE74	FASTA	364	41,109
	10 20 30 40 50 60 MAAISTSIPV ISQPQFTAMN EPQCFYNESI AFFYNRSGKH LATEWNTVSK LVMGLGITVC 70 80 90 100 110 120 IFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL AYFYLMFNTG PNTRRLTVST 130 140 150 160 170 180 WLLRQGLIDT SLTASVANLL AIAIERHITV FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA 190 200 210 220 230 240 IPSVGWNCIC DIENCSNMAP LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS 250 260 270 280 290 300 RHSSGPRRNR DTMMSLLKTV VIVLGAFIIC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA 310 320 330 340 350 360 EFNSAMNPII YSYRDKEMSA TFRQILCCQR SENPTGPTEG SDRSASSLNH TILAGVHSND HSVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid." An S., Dickens M.A., Bleu T., Hallmark O.G., Goetzl E.J. Biochem. Biophys. Res. Commun. 231:619-622(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Lysophosphatidic acid: G-protein signalling and cellular responses." Moolenaar W.H., Kranenburg O., Postma F.R., Zondag G.C.M. Curr. Opin. Cell Biol. 9:168-173(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus and Testis.
[5]	"Lysophosphatidic acid receptors." Contos J.J.A., Ishii I., Chun J. Mol. Pharmacol. 58:1188-1196(2000) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[6]	"Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK." Aziziyeh A.I., Li T.T., Pape C., Pampillo M., Chidiac P., Possmayer F., Babwah A.V., Bhattacharya M. Cell. Signal. 21:1207-1217(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RALA AND ADRBK1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U80811 mRNA. Translation: AAC51139.1. Y09479 mRNA. Translation: CAA70686.1. Y09479 mRNA. Translation: CAA70687.1. U78192 mRNA. Translation: AAC00530.1. AY322546 mRNA. Translation: AAP84359.1. BC030615 mRNA. Translation: AAH30615.1. BC036034 mRNA. Translation: AAH36034.1.
IPI	IPI01010769.
PIR	JC5293.
RefSeq	NP_001392.2. NM_001401.3. NP_476500.1. NM_057159.2.
UniGene	Hs.126667.
3D structure databases
ProteinModelPortal	Q92633.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92633. 1 interaction.
STRING	9606.ENSP00000351755.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q92633.
Polymorphism databases
DMDM	26454626.
Proteomic databases
PaxDb	Q92633.
PRIDE	Q92633.
Protocols and materials databases
DNASU	1902.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358883; ENSP00000351755; ENSG00000198121. ENST00000374430; ENSP00000363552; ENSG00000198121. ENST00000374431; ENSP00000363553; ENSG00000198121.
GeneID	1902.
KEGG	hsa:1902.
UCSC	uc004bfa.3. human.
Organism-specific databases
CTD	1902.
GeneCards	GC09M113635.
HGNC	HGNC:3166. LPAR1.
MIM	602282. gene.
neXtProt	NX_Q92633.
PharmGKB	PA162394187.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274798.
HOVERGEN	HBG103071.
InParanoid	Q92633.
KO	K04289.
OrthoDB	EOG4P2Q2J.
PhylomeDB	Q92633.
Enzyme and pathway databases
Pathway_Interaction_DB	lysophospholipid_pathway. LPA receptor mediated events.
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q92633.
Bgee	Q92633.
CleanEx	HS_LPAR1.
Genevestigator	Q92633.
GermOnline	ENSG00000198121. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR004065. LPA_rcpt. IPR002277. LPA_rcpt_EDG2. [Graphical view]
PANTHER	PTHR22750:SF12. PTHR22750:SF12. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01148. EDG2RECEPTOR. PR00237. GPCRRHODOPSN. PR01527. LPARECEPTOR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q92633.
ChEMBL	CHEMBL3819.
ChiTaRS	LPAR1. human.
GenomeRNAi	1902.
NextBio	7747.
SOURCE	Search...

Entry information

Entry name

LPAR1_HUMAN

Accession

Primary (citable) accession number: Q92633
Secondary accession number(s): O00656, O00722, P78351

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 6, 2002
Last modified:	May 1, 2013
This is version 122 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.