SGCD

Functionⁱ

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

GO - Biological processⁱ

cardiac muscle tissue development Source: GO_Central
heart contraction Source: GO_Central
membrane organization Source: GO_Central
muscle cell development Source: GO_Central
muscle organ development
Source: ProtInc
Traceable author statementⁱ
- 8842738
- 8841194

Complete GO annotation...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Delta-sarcoglycan Short name: Delta-SG Alternative name(s): 35 kDa dystrophin-associated glycoprotein Short name: 35DAG
Gene namesⁱ	Name:SGCD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10807. SGCD.

HGNCⁱ

HGNC:10807. SGCD.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 35	CytoplasmicSequence analysisAdd BLAST	35
Transmembraneⁱ	36 – 56	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	57 – 289	ExtracellularSequence analysisAdd BLAST	233

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-KW
cytoskeleton Source: UniProtKB-SubCell
dystrophin-associated glycoprotein complex
Source: UniProtKB
Inferred from direct assayⁱ
- 17993586
integral component of membrane Source: UniProtKB-KW
plasma membrane
Source: ProtInc
Traceable author statementⁱ
- 8842738
sarcoglycan complex Source: GO_Central
sarcolemma Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Limb-girdle muscular dystrophy 2F (LGMD2F)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive degenerative myopathy initially affecting the proximal limb girdle musculature. Muscle from patients shows a complete loss of delta-sarcoglycan as well as of the others components of the sarcoglycan complex.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_010396	261	E → K in LGMD2F. 1 PublicationCorresponds to variant dbSNP:rs121909297Ensembl.		1

Cardiomyopathy, dilated 1L (CMD1L)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_013181	150	S → A in CMD1L. 1 PublicationCorresponds to variant dbSNP:rs121909298Ensembl.		1

Keywords - Diseaseⁱ

Cardiomyopathy, Disease mutation, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6444.
GeneReviewsⁱ	SGCD.
MalaCards human disease database More...MalaCardsⁱ	SGCD.
MIMⁱ	601287. phenotype. 606685. phenotype.
Open Targets More...OpenTargetsⁱ	ENSG00000170624.
Orphanetⁱ	219. Autosomal recessive limb-girdle muscular dystrophy type 2F. 154. Familial isolated dilated cardiomyopathy.
PharmGKBⁱ	PA35718.

Polymorphism and mutation databases

BioMutaⁱ	SGCD.
DMDMⁱ	212276471.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000175245	1 – 289	Delta-sarcoglycanAdd BLAST		289

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	60	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	108	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	263 ↔ 288	Sequence analysis
Disulfide bondⁱ	265 ↔ 281	Sequence analysis
Glycosylationⁱ	284	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Glycosylated.

Disulfide bonds are present.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92629.
PaxDbⁱ	Q92629.
PeptideAtlas More...PeptideAtlasⁱ	Q92629.
PRIDEⁱ	Q92629.

PTM databases

iPTMnetⁱ	Q92629.
PhosphoSitePlusⁱ	Q92629.

Expressionⁱ

Tissue specificityⁱ

Most strongly expressed in skeletal and cardiac muscle. Also detected in smooth muscle. Weak expression in brain and lung.

Gene expression databases

Bgeeⁱ	ENSG00000170624.
CleanExⁱ	HS_SGCD.
ExpressionAtlasⁱ	Q92629. baseline and differential.
Genevisibleⁱ	Q92629. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026969.

HPAⁱ

HPA026969.

Interactionⁱ

Subunit structureⁱ

Interacts with FLNC and DAG1. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	112342. 7 interactors.
IntActⁱ	Q92629. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-119001.
STRINGⁱ	9606.ENSP00000338343.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92629.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sarcoglycan beta/delta/gamma/zeta family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3950. Eukaryota. ENOG4111GCH. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017950.
HOGENOMⁱ	HOG000007853.
HOVERGENⁱ	HBG008669.
InParanoidⁱ	Q92629.
KEGG Orthology (KO) More...KOⁱ	K12563.
OMAⁱ	IRSRPGN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11VY.
PhylomeDBⁱ	Q92629.
TreeFamⁱ	TF313538.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006875. Sarcoglycan. IPR027661. SGCD.
PANTHERⁱ	PTHR12939:SF9. PTHR12939:SF9. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04790. Sarcoglycan_1. 1 hit.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q92629-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQEQYTHHR STMPGSVGPQ VYKVGIYGWR KRCLYFFVLL LMILILVNLA 
        60         70         80         90        100
MTIWILKVMN FTIDGMGNLR ITEKGLKLEG DSEFLQPLYA KEIQSRPGNA 
       110        120        130        140        150
LYFKSARNVT VNILNDQTKV LTQLITGPKA VEAYGKKFEV KTVSGKLLFS 
       160        170        180        190        200
ADNNEVVVGA ERLRVLGAEG TVFPKSIETP NVRADPFKEL RLESPTRSLV 
       210        220        230        240        250
MEAPKGVEIN AEAGNMEATC RTELRLESKD GEIKLDAAKI RLPRLPHGSY 
       260        270        280 
TPTGTRQKVF EICVCANGRL FLSQAGAGST CQINTSVCL

Length:289

Mass (Da):32,071

Last modified:November 4, 2008 - v2

Checksum:ⁱEB775E2427D260B7

GO

Isoform 2 (identifier: Q92629-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MM

« Hide

        10         20         30         40         50
MMPQEQYTHH RSTMPGSVGP QVYKVGIYGW RKRCLYFFVL LLMILILVNL 
        60         70         80         90        100
AMTIWILKVM NFTIDGMGNL RITEKGLKLE GDSEFLQPLY AKEIQSRPGN 
       110        120        130        140        150
ALYFKSARNV TVNILNDQTK VLTQLITGPK AVEAYGKKFE VKTVSGKLLF 
       160        170        180        190        200
SADNNEVVVG AERLRVLGAE GTVFPKSIET PNVRADPFKE LRLESPTRSL 
       210        220        230        240        250
VMEAPKGVEI NAEAGNMEAT CRTELRLESK DGEIKLDAAK IRLPRLPHGS 
       260        270        280        290
YTPTGTRQKV FEICVCANGR LFLSQAGAGS TCQINTSVCL

Show »

Length:290

Mass (Da):32,203

Checksum:ⁱ905E9A9B75D83682

GO

Isoform 3 (identifier: Q92629-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MM
     233-255: IKLDAAKIRLPRLPHGSYTPTGT → VRDEKDRSSKSYSFNRPTLPITG
     256-289: Missing.

« Hide

        10         20         30         40         50
MMPQEQYTHH RSTMPGSVGP QVYKVGIYGW RKRCLYFFVL LLMILILVNL 
        60         70         80         90        100
AMTIWILKVM NFTIDGMGNL RITEKGLKLE GDSEFLQPLY AKEIQSRPGN 
       110        120        130        140        150
ALYFKSARNV TVNILNDQTK VLTQLITGPK AVEAYGKKFE VKTVSGKLLF 
       160        170        180        190        200
SADNNEVVVG AERLRVLGAE GTVFPKSIET PNVRADPFKE LRLESPTRSL 
       210        220        230        240        250
VMEAPKGVEI NAEAGNMEAT CRTELRLESK DGEVRDEKDR SSKSYSFNRP 

TLPITG

Show »

Length:256

Mass (Da):28,750

Checksum:ⁱ0C8B9E567462F713

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_010429	96	R → Q1 PublicationCorresponds to variant dbSNP:rs45559835Ensembl.	1
Natural variantⁱVAR_013181	150	S → A in CMD1L. 1 PublicationCorresponds to variant dbSNP:rs121909298Ensembl.	1
Natural variantⁱVAR_010396	261	E → K in LGMD2F. 1 PublicationCorresponds to variant dbSNP:rs121909297Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_039245	1	M → MM in isoform 2 and isoform 3. 4 Publications	1
Alternative sequenceⁱVSP_039246	233 – 255	IKLDA…TPTGT → VRDEKDRSSKSYSFNRPTLP ITG in isoform 3. 1 PublicationAdd BLAST	23
Alternative sequenceⁱVSP_039247	256 – 289	Missing in isoform 3. 1 PublicationAdd BLAST	34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X95191 mRNA. Translation: CAA64490.1. U58331 mRNA. Translation: AAC50921.1. AK292794 mRNA. Translation: BAF85483.1. BX537948 mRNA. Translation: CAD97916.1. BC020740 mRNA. Translation: AAH20740.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47325.1. [Q92629-2] CCDS47326.1. [Q92629-3] CCDS47327.1. [Q92629-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_000328.2. NM_000337.5. [Q92629-2] NP_001121681.1. NM_001128209.1. [Q92629-1] NP_758447.1. NM_172244.2. [Q92629-3] XP_005266023.1. XM_005265966.4. [Q92629-2] XP_011532923.1. XM_011534621.2. [Q92629-1] XP_016865212.1. XM_017009723.1. [Q92629-2] XP_016865213.1. XM_017009724.1. [Q92629-2]
UniGeneⁱ	Hs.387207. Hs.644733.

Genome annotation databases

Ensemblⁱ	ENST00000337851; ENSP00000338343; ENSG00000170624. [Q92629-2] ENST00000435422; ENSP00000403003; ENSG00000170624. [Q92629-1] ENST00000517913; ENSP00000429378; ENSG00000170624. [Q92629-3]
GeneIDⁱ	6444.
KEGGⁱ	hsa:6444.
UCSC genome browser More...UCSCⁱ	uc003lwc.5. human. [Q92629-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q92629	G3QYJ8 H2RFS9 Q92629-2	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee)	289	UniRef100_Q92629	Cluster: Delta-sarcoglycan	4

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q92629	G3QYJ8 H2RFS9 Q92629-2 F7DH01 UPI00005E842D A0A096N830 G7MVQ9 G7P6Q5 H9F6I5 UPI00045DCC8D +94	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Monodelphis domestica (Gray short-tailed opossum) Papio anubis (Olive baboon) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Ailuropoda melanoleuca (Giant panda) And more	289	UniRef90_Q92629	Cluster: Delta-sarcoglycan	105
Q92629-3	UPI00093EBDDC UPI00094578AB F6WJI7 UPI0008401A2C UPI0000E20C00	Hipposideros armiger (great roundleaf bat) Rhinolophus sinicus (Chinese rufous horseshoe bat) Callithrix jacchus (White-tufted-ear marmoset) Pan paniscus (Pygmy chimpanzee) (Bonobo)	256	UniRef90_Q92629-3	Cluster: Isoform 3 of Delta-sarcoglycan	6

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q92629	G3QYJ8 H2RFS9 Q92629-2 F7DH01 UPI00005E842D H0XAC6 UPI000273F5BD UPI000943F781 UPI000945A62A UPI000809CD8C +170	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Monodelphis domestica (Gray short-tailed opossum) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Rhinolophus sinicus (Chinese rufous horseshoe bat) Cebus capucinus imitator Aotus nancymaae (Ma's night monkey) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Callithrix jacchus (White-tufted-ear marmoset) And more	289	UniRef50_Q92629	Cluster: Delta-sarcoglycan	181
Q92629-3	UPI00093EBDDC UPI00094578AB F6WJI7 UPI0008401A2C UPI0000E20C00 W5UBY7 UPI0008038479 UPI0007B90C78 UPI0001CF17C5 UPI0007B88FD0 +33	Hipposideros armiger (great roundleaf bat) Rhinolophus sinicus (Chinese rufous horseshoe bat) Callithrix jacchus (White-tufted-ear marmoset) Pan paniscus (Pygmy chimpanzee) (Bonobo) Ictalurus punctatus (Channel catfish) (Silurus punctatus) Sinocyclocheilus anshuiensis Danio rerio (Zebrafish) (Brachydanio rerio) Clupea harengus (Atlantic herring) Cyprinus carpio (Common carp) Nanorana parkeri And more	256	UniRef50_Q92629-3	Cluster: Isoform 3 of Delta-sarcoglycan	44

Cross-referencesⁱ

Web resourcesⁱ

Leiden Muscular Dystrophy pages

SGCD mutations in LGMD2F/CMD1L

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X95191 mRNA. Translation: CAA64490.1. U58331 mRNA. Translation: AAC50921.1. AK292794 mRNA. Translation: BAF85483.1. BX537948 mRNA. Translation: CAD97916.1. BC020740 mRNA. Translation: AAH20740.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47325.1. [Q92629-2] CCDS47326.1. [Q92629-3] CCDS47327.1. [Q92629-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_000328.2. NM_000337.5. [Q92629-2] NP_001121681.1. NM_001128209.1. [Q92629-1] NP_758447.1. NM_172244.2. [Q92629-3] XP_005266023.1. XM_005265966.4. [Q92629-2] XP_011532923.1. XM_011534621.2. [Q92629-1] XP_016865212.1. XM_017009723.1. [Q92629-2] XP_016865213.1. XM_017009724.1. [Q92629-2]
UniGeneⁱ	Hs.387207. Hs.644733.

3D structure databases

ProteinModelPortalⁱ	Q92629.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112342. 7 interactors.
IntActⁱ	Q92629. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-119001.
STRINGⁱ	9606.ENSP00000338343.

PTM databases

iPTMnetⁱ	Q92629.
PhosphoSitePlusⁱ	Q92629.

Polymorphism and mutation databases

BioMutaⁱ	SGCD.
DMDMⁱ	212276471.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92629.
PaxDbⁱ	Q92629.
PeptideAtlas More...PeptideAtlasⁱ	Q92629.
PRIDEⁱ	Q92629.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6444.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000337851; ENSP00000338343; ENSG00000170624. [Q92629-2] ENST00000435422; ENSP00000403003; ENSG00000170624. [Q92629-1] ENST00000517913; ENSP00000429378; ENSG00000170624. [Q92629-3]
GeneIDⁱ	6444.
KEGGⁱ	hsa:6444.
UCSC genome browser More...UCSCⁱ	uc003lwc.5. human. [Q92629-1]

Organism-specific databases

CTDⁱ	6444.
DisGeNET More...DisGeNETⁱ	6444.
GeneCardsⁱ	SGCD.
GeneReviewsⁱ	SGCD.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10807. SGCD.
Human Protein Atlas More...HPAⁱ	HPA026969.
MalaCards human disease database More...MalaCardsⁱ	SGCD.
MIMⁱ	601287. phenotype. 601411. gene. 606685. phenotype.
neXtProtⁱ	NX_Q92629.
Open Targets More...OpenTargetsⁱ	ENSG00000170624.
Orphanetⁱ	219. Autosomal recessive limb-girdle muscular dystrophy type 2F. 154. Familial isolated dilated cardiomyopathy.
PharmGKBⁱ	PA35718.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3950. Eukaryota. ENOG4111GCH. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017950.
HOGENOMⁱ	HOG000007853.
HOVERGENⁱ	HBG008669.
InParanoidⁱ	Q92629.
KEGG Orthology (KO) More...KOⁱ	K12563.
OMAⁱ	IRSRPGN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11VY.
PhylomeDBⁱ	Q92629.
TreeFamⁱ	TF313538.

Miscellaneous databases

ChiTaRSⁱ	SGCD. human.
GeneWikiⁱ	Delta-sarcoglycan. SGCD.
GenomeRNAiⁱ	6444.
Protein Ontology More...PROⁱ	PR:Q92629.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170624.
CleanExⁱ	HS_SGCD.
ExpressionAtlasⁱ	Q92629. baseline and differential.
Genevisibleⁱ	Q92629. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006875. Sarcoglycan. IPR027661. SGCD.
PANTHERⁱ	PTHR12939:SF9. PTHR12939:SF9. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04790. Sarcoglycan_1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SGCD_HUMAN
Accessionⁱ	Q92629Primary (citable) accession number: Q92629 Secondary accession number(s): A8K9S9, Q53XA5, Q99644
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	November 4, 2008
	Last modified:	August 30, 2017
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q92629 (SGCD_HUMAN)

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Delta-sarcoglycan

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (3)ⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ