ID   K0232_HUMAN             Reviewed;        1395 AA.
AC   Q92628; A7E2D2;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 5.
DT   24-JAN-2024, entry version 153.
DE   RecName: Full=Uncharacterized protein KIAA0232;
GN   Name=KIAA0232;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA   Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA   Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT   "Prediction of the coding sequences of unidentified human genes. VI. The
RT   coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of
RT   cDNA clones from cell line KG-1 and brain.";
RL   DNA Res. 3:321-329(1996).
RN   [2]
RP   SEQUENCE REVISION TO 535.
RX   PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT   networks.";
RL   Cell 127:635-648(2006).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-814; SER-1080 AND SER-1338,
RP   AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA13221.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; D86985; BAA13221.3; ALT_INIT; mRNA.
DR   EMBL; AC106045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC150286; AAI50287.1; -; mRNA.
DR   CCDS; CCDS43209.1; -.
DR   RefSeq; NP_001094060.1; NM_001100590.1.
DR   RefSeq; NP_055558.2; NM_014743.2.
DR   AlphaFoldDB; Q92628; -.
DR   BioGRID; 115122; 78.
DR   IntAct; Q92628; 39.
DR   MINT; Q92628; -.
DR   STRING; 9606.ENSP00000303928; -.
DR   GlyConnect; 2088; 3 N-Linked glycans (1 site).
DR   GlyCosmos; Q92628; 1 site, 6 glycans.
DR   GlyGen; Q92628; 3 sites, 6 N-linked glycans (1 site), 1 O-linked glycan (2 sites).
DR   iPTMnet; Q92628; -.
DR   PhosphoSitePlus; Q92628; -.
DR   BioMuta; KIAA0232; -.
DR   DMDM; 296439501; -.
DR   EPD; Q92628; -.
DR   jPOST; Q92628; -.
DR   MassIVE; Q92628; -.
DR   MaxQB; Q92628; -.
DR   PaxDb; 9606-ENSP00000303928; -.
DR   PeptideAtlas; Q92628; -.
DR   ProteomicsDB; 75383; -.
DR   Antibodypedia; 51996; 29 antibodies from 7 providers.
DR   DNASU; 9778; -.
DR   Ensembl; ENST00000307659.6; ENSP00000303928.5; ENSG00000170871.12.
DR   Ensembl; ENST00000425103.5; ENSP00000413739.1; ENSG00000170871.12.
DR   GeneID; 9778; -.
DR   KEGG; hsa:9778; -.
DR   MANE-Select; ENST00000307659.6; ENSP00000303928.5; NM_014743.3; NP_055558.2.
DR   UCSC; uc003gjq.5; human.
DR   AGR; HGNC:28992; -.
DR   CTD; 9778; -.
DR   DisGeNET; 9778; -.
DR   GeneCards; KIAA0232; -.
DR   HGNC; HGNC:28992; KIAA0232.
DR   HPA; ENSG00000170871; Low tissue specificity.
DR   MIM; 619237; gene.
DR   neXtProt; NX_Q92628; -.
DR   OpenTargets; ENSG00000170871; -.
DR   PharmGKB; PA162392816; -.
DR   VEuPathDB; HostDB:ENSG00000170871; -.
DR   eggNOG; ENOG502QQF7; Eukaryota.
DR   GeneTree; ENSGT00390000018549; -.
DR   HOGENOM; CLU_005177_0_0_1; -.
DR   InParanoid; Q92628; -.
DR   OMA; KDIWMAI; -.
DR   OrthoDB; 5350455at2759; -.
DR   PhylomeDB; Q92628; -.
DR   TreeFam; TF328400; -.
DR   PathwayCommons; Q92628; -.
DR   SignaLink; Q92628; -.
DR   BioGRID-ORCS; 9778; 14 hits in 1159 CRISPR screens.
DR   ChiTaRS; KIAA0232; human.
DR   GenomeRNAi; 9778; -.
DR   Pharos; Q92628; Tdark.
DR   PRO; PR:Q92628; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q92628; Protein.
DR   Bgee; ENSG00000170871; Expressed in Brodmann (1909) area 23 and 212 other cell types or tissues.
DR   ExpressionAtlas; Q92628; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR027871; DUF4603.
DR   PANTHER; PTHR17611:SF3; HYPOTHETICAL PROTEIN LOC680039; 1.
DR   PANTHER; PTHR17611; UNCHARACTERIZED; 1.
DR   Pfam; PF15376; DUF4603; 1.
DR   Genevisible; Q92628; HS.
PE   1: Evidence at protein level;
KW   ATP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome.
FT   CHAIN           1..1395
FT                   /note="Uncharacterized protein KIAA0232"
FT                   /id="PRO_0000050738"
FT   REGION          146..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          205..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1110..1132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1346..1395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..262
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..284
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..306
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..345
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..361
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..391
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1361..1375
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         89..96
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         814
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         1080
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         1194
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80U59"
FT   MOD_RES         1338
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   CONFLICT        535
FT                   /note="N -> K (in Ref. 1; BAA13221 and 4; AAI50287)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1395 AA;  154789 MW;  3667D0D816A51F35 CRC64;
     MYPICTVVVD GLPSESSSSS YPGPVSVSEM SLLHALGPVQ TWLGQELEKC GIDAMIYTRY
     VLSLLLHDSY DYDLQEQEND IFLGWEKGAY KKWGKSKKKC SDLTLEEMKK QAAVQCLRSA
     SDESSGIETL VEELCSRLKD LQSKQEEKIH KKLEGSPSPE AELSPPAKDQ VEMYYEAFPP
     LSEKPVCLQE IMTVWNKSKV CSYSSSSSSS TAPPASTDTS SPKDCNSESE VTKERSSEVP
     TTVHEKTQSK SKNEKENKFS NGTIEEKPAL YKKQIRHKPE GKIRPRSWSS GSSEAGSSSS
     GNQGELKASM KYVKVRHKAR EIRNKKGRNG QSRLSLKHGE KAERNIHTGS SSSSSSGSVK
     QLCKRGKRPL KEIGRKDPGS TEGKDLYMEN RKDTEYKEEP LWYTEPIAEY FVPLSRKSKL
     ETTYRNRQDT SDLTSEAVEE LSESVHGLCI SNNNLHKTYL AAGTFIDGHF VEMPAVINED
     IDLTGTSLCS LPEDNKYLDD IHLSELTHFY EVDIDQSMLD PGASETMQGE SRILNMIRQK
     SKENTDFEAE CCIVLDGMEL QGERAIWTDS TSSVGAEGLF LQDLGNLAQF WECCSSSSGD
     ADGESFGGDS PVRLSPILDS TVLNSHLLAG NQELFSDINE GSGINSCFSV FEVQCSNSVL
     PFSFETLNLG NENTDSSANM LGKTQSRLLI WTKNSAFEEN EHCSNLSTRT CSPWSHSEET
     RSDNETLNIQ FEESTQFNAE DINYVVPRVS SNYVDEELLD FLQDETCQQN SRTLGEIPTL
     VFKKTSKLES VCGIQLEQKT ENKNFETTQV CNESPHGDGY SSGVIKDIWT KMADTNSVAT
     VEIERTDAEL FSADVNNYCC CLDAEAELET LQEPDKAVRR SEYHLWEGQK ESLEKRAFAS
     SELSNVDGGD YTTPSKPWDV AQDKENTFIL GGVYGELKTF NSDGEWAVVP PSHTKGSLLQ
     CAASDVVTIA GTDVFMTPGN SFAPGHRQLW KPFVSFEQND QPKSGENGLN KGFSFIFHED
     LLGACGNFQV EDPGLEYSFS SFDLSNPFSQ VLHVECSFEP EGIASFSPSF KPKSILCSDS
     DSEVFHPRIC GVDRTQYRAI RISPRTHFRP ISASELSPGG GSESEFESEK DEANIPIPSQ
     VDIFEDPQAD LKPLEEDAEK EGHYYGKSEL ESGKFLPRLK KSGMEKSAQT SLDSQEESTG
     ILSVGKQNQC LECSMNESLE IDLESSEANC KIMAQCEEEI NNFCGCKAGC QFPAYEDNPV
     SSGQLEEFPV LNTDIQGMNR SQEKQTWWEK ALYSPLFPAS ECEECYTNAK GESGLEEYPD
     AKETPSNEER LLDFNRVSSV YEARCTGERD SGAKSDGFRG KMCSSASSTS EETGSEGGGE
     WVGPSEEELF SRTHL
//