Q92628 (K0232_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein KIAA0232

Gene names

Name:

KIAA0232

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1395 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence caution

The sequence BAA13221.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1395	1395	Uncharacterized protein KIAA0232		PRO_0000050738
Regions
	Nucleotide binding	89 – 96	8	ATP Potential
	Compositional bias	14 – 20	7	Poly-Ser
	Compositional bias	202 – 210	9	Poly-Ser
	Compositional bias	350 – 358	9	Poly-Ser
Experimental info
	Sequence conflict	535	1	N → K in BAA13221. Ref.1
	Sequence conflict	535	1	N → K in AAI50287. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q92628 [UniParc]. Last modified May 18, 2010. Version 5. Checksum: 3667D0D816A51F35	FASTA	1,395	154,789
	10 20 30 40 50 60 MYPICTVVVD GLPSESSSSS YPGPVSVSEM SLLHALGPVQ TWLGQELEKC GIDAMIYTRY 70 80 90 100 110 120 VLSLLLHDSY DYDLQEQEND IFLGWEKGAY KKWGKSKKKC SDLTLEEMKK QAAVQCLRSA 130 140 150 160 170 180 SDESSGIETL VEELCSRLKD LQSKQEEKIH KKLEGSPSPE AELSPPAKDQ VEMYYEAFPP 190 200 210 220 230 240 LSEKPVCLQE IMTVWNKSKV CSYSSSSSSS TAPPASTDTS SPKDCNSESE VTKERSSEVP 250 260 270 280 290 300 TTVHEKTQSK SKNEKENKFS NGTIEEKPAL YKKQIRHKPE GKIRPRSWSS GSSEAGSSSS 310 320 330 340 350 360 GNQGELKASM KYVKVRHKAR EIRNKKGRNG QSRLSLKHGE KAERNIHTGS SSSSSSGSVK 370 380 390 400 410 420 QLCKRGKRPL KEIGRKDPGS TEGKDLYMEN RKDTEYKEEP LWYTEPIAEY FVPLSRKSKL 430 440 450 460 470 480 ETTYRNRQDT SDLTSEAVEE LSESVHGLCI SNNNLHKTYL AAGTFIDGHF VEMPAVINED 490 500 510 520 530 540 IDLTGTSLCS LPEDNKYLDD IHLSELTHFY EVDIDQSMLD PGASETMQGE SRILNMIRQK 550 560 570 580 590 600 SKENTDFEAE CCIVLDGMEL QGERAIWTDS TSSVGAEGLF LQDLGNLAQF WECCSSSSGD 610 620 630 640 650 660 ADGESFGGDS PVRLSPILDS TVLNSHLLAG NQELFSDINE GSGINSCFSV FEVQCSNSVL 670 680 690 700 710 720 PFSFETLNLG NENTDSSANM LGKTQSRLLI WTKNSAFEEN EHCSNLSTRT CSPWSHSEET 730 740 750 760 770 780 RSDNETLNIQ FEESTQFNAE DINYVVPRVS SNYVDEELLD FLQDETCQQN SRTLGEIPTL 790 800 810 820 830 840 VFKKTSKLES VCGIQLEQKT ENKNFETTQV CNESPHGDGY SSGVIKDIWT KMADTNSVAT 850 860 870 880 890 900 VEIERTDAEL FSADVNNYCC CLDAEAELET LQEPDKAVRR SEYHLWEGQK ESLEKRAFAS 910 920 930 940 950 960 SELSNVDGGD YTTPSKPWDV AQDKENTFIL GGVYGELKTF NSDGEWAVVP PSHTKGSLLQ 970 980 990 1000 1010 1020 CAASDVVTIA GTDVFMTPGN SFAPGHRQLW KPFVSFEQND QPKSGENGLN KGFSFIFHED 1030 1040 1050 1060 1070 1080 LLGACGNFQV EDPGLEYSFS SFDLSNPFSQ VLHVECSFEP EGIASFSPSF KPKSILCSDS 1090 1100 1110 1120 1130 1140 DSEVFHPRIC GVDRTQYRAI RISPRTHFRP ISASELSPGG GSESEFESEK DEANIPIPSQ 1150 1160 1170 1180 1190 1200 VDIFEDPQAD LKPLEEDAEK EGHYYGKSEL ESGKFLPRLK KSGMEKSAQT SLDSQEESTG 1210 1220 1230 1240 1250 1260 ILSVGKQNQC LECSMNESLE IDLESSEANC KIMAQCEEEI NNFCGCKAGC QFPAYEDNPV 1270 1280 1290 1300 1310 1320 SSGQLEEFPV LNTDIQGMNR SQEKQTWWEK ALYSPLFPAS ECEECYTNAK GESGLEEYPD 1330 1340 1350 1360 1370 1380 AKETPSNEER LLDFNRVSSV YEARCTGERD SGAKSDGFRG KMCSSASSTS EETGSEGGGE 1390 WVGPSEEELF SRTHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO 535.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D86985 mRNA. Translation: BAA13221.3. Different initiation. AC106045 Genomic DNA. No translation available. BC150286 mRNA. Translation: AAI50287.1.
IPI	IPI00294215.
RefSeq	NP_001094060.1. NM_001100590.1. NP_055558.2. NM_014743.2.
UniGene	Hs.79276.
3D structure databases
ProteinModelPortal	Q92628.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92628. 3 interactions.
MINT	MINT-1387419.
STRING	9606.ENSP00000303928.
PTM databases
PhosphoSite	Q92628.
Polymorphism databases
DMDM	296439501.
Proteomic databases
PaxDb	Q92628.
PRIDE	Q92628.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307659; ENSP00000303928; ENSG00000170871. ENST00000425103; ENSP00000413739; ENSG00000170871.
GeneID	9778.
KEGG	hsa:9778.
UCSC	uc003gjq.4. human.
Organism-specific databases
CTD	9778.
GeneCards	GC04P006783.
HGNC	HGNC:28992. KIAA0232.
HPA	HPA036891.
neXtProt	NX_Q92628.
PharmGKB	PA162392816.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG78147.
HOGENOM	HOG000168299.
HOVERGEN	HBG081818.
InParanoid	Q92628.
OMA	LQCAASD.
OrthoDB	EOG4TTGH4.
Gene expression databases
ArrayExpress	Q92628.
Bgee	Q92628.
CleanEx	HS_KIAA0232.
Genevestigator	Q92628.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	9778.
NextBio	36814.

Entry information

Entry name

K0232_HUMAN

Accession

Primary (citable) accession number: Q92628
Secondary accession number(s): A7E2D2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 88 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.