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Protein

Uncharacterized protein KIAA0232

Gene

KIAA0232

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 968ATPSequence Analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA0232
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28992. KIAA0232.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392816.

Polymorphism and mutation databases

BioMutaiKIAA0232.
DMDMi296439501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13951395Uncharacterized protein KIAA0232PRO_0000050738Add
BLAST

Proteomic databases

MaxQBiQ92628.
PaxDbiQ92628.
PRIDEiQ92628.

PTM databases

PhosphoSiteiQ92628.

Expressioni

Gene expression databases

BgeeiQ92628.
CleanExiHS_KIAA0232.
ExpressionAtlasiQ92628. baseline and differential.
GenevisibleiQ92628. HS.

Organism-specific databases

HPAiHPA036891.
HPA036892.

Interactioni

Protein-protein interaction databases

BioGridi115122. 13 interactions.
IntActiQ92628. 5 interactions.
MINTiMINT-1387419.
STRINGi9606.ENSP00000303928.

Structurei

3D structure databases

ProteinModelPortaliQ92628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 207Poly-Ser
Compositional biasi202 – 2109Poly-Ser
Compositional biasi350 – 3589Poly-Ser

Phylogenomic databases

eggNOGiNOG78147.
GeneTreeiENSGT00390000018549.
HOGENOMiHOG000168299.
HOVERGENiHBG081818.
InParanoidiQ92628.
OMAiLQCAASD.
OrthoDBiEOG7DVD95.
PhylomeDBiQ92628.
TreeFamiTF328400.

Family and domain databases

InterProiIPR027871. DUF4603.
[Graphical view]
PfamiPF15376. DUF4603. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPICTVVVD GLPSESSSSS YPGPVSVSEM SLLHALGPVQ TWLGQELEKC
60 70 80 90 100
GIDAMIYTRY VLSLLLHDSY DYDLQEQEND IFLGWEKGAY KKWGKSKKKC
110 120 130 140 150
SDLTLEEMKK QAAVQCLRSA SDESSGIETL VEELCSRLKD LQSKQEEKIH
160 170 180 190 200
KKLEGSPSPE AELSPPAKDQ VEMYYEAFPP LSEKPVCLQE IMTVWNKSKV
210 220 230 240 250
CSYSSSSSSS TAPPASTDTS SPKDCNSESE VTKERSSEVP TTVHEKTQSK
260 270 280 290 300
SKNEKENKFS NGTIEEKPAL YKKQIRHKPE GKIRPRSWSS GSSEAGSSSS
310 320 330 340 350
GNQGELKASM KYVKVRHKAR EIRNKKGRNG QSRLSLKHGE KAERNIHTGS
360 370 380 390 400
SSSSSSGSVK QLCKRGKRPL KEIGRKDPGS TEGKDLYMEN RKDTEYKEEP
410 420 430 440 450
LWYTEPIAEY FVPLSRKSKL ETTYRNRQDT SDLTSEAVEE LSESVHGLCI
460 470 480 490 500
SNNNLHKTYL AAGTFIDGHF VEMPAVINED IDLTGTSLCS LPEDNKYLDD
510 520 530 540 550
IHLSELTHFY EVDIDQSMLD PGASETMQGE SRILNMIRQK SKENTDFEAE
560 570 580 590 600
CCIVLDGMEL QGERAIWTDS TSSVGAEGLF LQDLGNLAQF WECCSSSSGD
610 620 630 640 650
ADGESFGGDS PVRLSPILDS TVLNSHLLAG NQELFSDINE GSGINSCFSV
660 670 680 690 700
FEVQCSNSVL PFSFETLNLG NENTDSSANM LGKTQSRLLI WTKNSAFEEN
710 720 730 740 750
EHCSNLSTRT CSPWSHSEET RSDNETLNIQ FEESTQFNAE DINYVVPRVS
760 770 780 790 800
SNYVDEELLD FLQDETCQQN SRTLGEIPTL VFKKTSKLES VCGIQLEQKT
810 820 830 840 850
ENKNFETTQV CNESPHGDGY SSGVIKDIWT KMADTNSVAT VEIERTDAEL
860 870 880 890 900
FSADVNNYCC CLDAEAELET LQEPDKAVRR SEYHLWEGQK ESLEKRAFAS
910 920 930 940 950
SELSNVDGGD YTTPSKPWDV AQDKENTFIL GGVYGELKTF NSDGEWAVVP
960 970 980 990 1000
PSHTKGSLLQ CAASDVVTIA GTDVFMTPGN SFAPGHRQLW KPFVSFEQND
1010 1020 1030 1040 1050
QPKSGENGLN KGFSFIFHED LLGACGNFQV EDPGLEYSFS SFDLSNPFSQ
1060 1070 1080 1090 1100
VLHVECSFEP EGIASFSPSF KPKSILCSDS DSEVFHPRIC GVDRTQYRAI
1110 1120 1130 1140 1150
RISPRTHFRP ISASELSPGG GSESEFESEK DEANIPIPSQ VDIFEDPQAD
1160 1170 1180 1190 1200
LKPLEEDAEK EGHYYGKSEL ESGKFLPRLK KSGMEKSAQT SLDSQEESTG
1210 1220 1230 1240 1250
ILSVGKQNQC LECSMNESLE IDLESSEANC KIMAQCEEEI NNFCGCKAGC
1260 1270 1280 1290 1300
QFPAYEDNPV SSGQLEEFPV LNTDIQGMNR SQEKQTWWEK ALYSPLFPAS
1310 1320 1330 1340 1350
ECEECYTNAK GESGLEEYPD AKETPSNEER LLDFNRVSSV YEARCTGERD
1360 1370 1380 1390
SGAKSDGFRG KMCSSASSTS EETGSEGGGE WVGPSEEELF SRTHL
Length:1,395
Mass (Da):154,789
Last modified:May 18, 2010 - v5
Checksum:i3667D0D816A51F35
GO

Sequence cautioni

The sequence BAA13221.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti535 – 5351N → K in BAA13221 (PubMed:9039502).Curated
Sequence conflicti535 – 5351N → K in AAI50287 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86985 mRNA. Translation: BAA13221.3. Different initiation.
AC106045 Genomic DNA. No translation available.
BC150286 mRNA. Translation: AAI50287.1.
CCDSiCCDS43209.1.
RefSeqiNP_001094060.1. NM_001100590.1.
NP_055558.2. NM_014743.2.
UniGeneiHs.79276.

Genome annotation databases

EnsembliENST00000307659; ENSP00000303928; ENSG00000170871.
ENST00000425103; ENSP00000413739; ENSG00000170871.
GeneIDi9778.
KEGGihsa:9778.
UCSCiuc003gjq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86985 mRNA. Translation: BAA13221.3. Different initiation.
AC106045 Genomic DNA. No translation available.
BC150286 mRNA. Translation: AAI50287.1.
CCDSiCCDS43209.1.
RefSeqiNP_001094060.1. NM_001100590.1.
NP_055558.2. NM_014743.2.
UniGeneiHs.79276.

3D structure databases

ProteinModelPortaliQ92628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115122. 13 interactions.
IntActiQ92628. 5 interactions.
MINTiMINT-1387419.
STRINGi9606.ENSP00000303928.

PTM databases

PhosphoSiteiQ92628.

Polymorphism and mutation databases

BioMutaiKIAA0232.
DMDMi296439501.

Proteomic databases

MaxQBiQ92628.
PaxDbiQ92628.
PRIDEiQ92628.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307659; ENSP00000303928; ENSG00000170871.
ENST00000425103; ENSP00000413739; ENSG00000170871.
GeneIDi9778.
KEGGihsa:9778.
UCSCiuc003gjq.4. human.

Organism-specific databases

CTDi9778.
GeneCardsiGC04P006783.
HGNCiHGNC:28992. KIAA0232.
HPAiHPA036891.
HPA036892.
neXtProtiNX_Q92628.
PharmGKBiPA162392816.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG78147.
GeneTreeiENSGT00390000018549.
HOGENOMiHOG000168299.
HOVERGENiHBG081818.
InParanoidiQ92628.
OMAiLQCAASD.
OrthoDBiEOG7DVD95.
PhylomeDBiQ92628.
TreeFamiTF328400.

Miscellaneous databases

ChiTaRSiKIAA0232. human.
GenomeRNAii9778.
NextBioi36814.
PROiQ92628.

Gene expression databases

BgeeiQ92628.
CleanExiHS_KIAA0232.
ExpressionAtlasiQ92628. baseline and differential.
GenevisibleiQ92628. HS.

Family and domain databases

InterProiIPR027871. DUF4603.
[Graphical view]
PfamiPF15376. DUF4603. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 535.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiK0232_HUMAN
AccessioniPrimary (citable) accession number: Q92628
Secondary accession number(s): A7E2D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 104 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.