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Q92626

- PXDN_HUMAN

UniProt

Q92626 - PXDN_HUMAN

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Protein
Peroxidasin homolog
Gene
PXDN, KIAA0230, MG50, PRG2, VPO, VPO1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Displays low peroxidase activity and is likely to participate in H2O2 metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.2 Publications

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.2 Publications

Cofactori

Binds 1 calcium ion per subunit By similarity.1 Publication
Binds 1 heme B (iron-protoporphyrin IX) group covalently per subunit.1 Publication

Kineticsi

  1. KM=0.15 mM for H2O21 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei826 – 8261Heme (covalent; via 2 links) By similarity
Active sitei827 – 8271Proton acceptor By similarity
Metal bindingi828 – 8281Calcium By similarity
Metal bindingi907 – 9071Calcium By similarity
Metal bindingi909 – 9091Calcium; via carbonyl oxygen By similarity
Metal bindingi911 – 9111Calcium By similarity
Metal bindingi913 – 9131Calcium By similarity
Sitei977 – 9771Transition state stabilizer By similarity
Binding sitei980 – 9801Heme (covalent; via 2 links) By similarity
Metal bindingi1074 – 10741Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: UniProtKB
  2. heme binding Source: UniProtKB
  3. interleukin-1 receptor antagonist activity Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. peroxidase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. extracellular matrix organization Source: UniProtKB
  2. hydrogen peroxide catabolic process Source: UniProtKB
  3. immune response Source: UniProtKB
  4. negative regulation of cytokine-mediated signaling pathway Source: GOC
  5. oxidation-reduction process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3355. HsPxd01.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidasin homolog (EC:1.11.1.7)
Alternative name(s):
Melanoma-associated antigen MG50
Vascular peroxidase 1
p53-responsive gene 2 protein
Gene namesi
Name:PXDN
Synonyms:KIAA0230, MG50, PRG2, VPO, VPO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:14966. PXDN.

Subcellular locationi

Secretedextracellular spaceextracellular matrix
Note: Enriched in the peritubular space of fibrotic kidneys.2 Publications

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. extracellular matrix Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti289499. Congenital cataract microcornea with corneal opacity.
PharmGKBiPA128394535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 14791453Peroxidasin homolog
PRO_0000319619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi267 ↔ 317 By similarity
Disulfide bondi363 ↔ 412 By similarity
Disulfide bondi454 ↔ 502 By similarity
Disulfide bondi546 ↔ 594 By similarity
Glycosylationi640 – 6401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi699 – 6991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi719 – 7191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi731 – 7311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi732 ↔ 748 By similarity
Disulfide bondi847 ↔ 857 By similarity
Disulfide bondi851 ↔ 875 By similarity
Glycosylationi865 – 8651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi959 ↔ 970 By similarity
Modified residuei1176 – 11761Phosphotyrosine1 Publication
Disulfide bondi1177 ↔ 1234 By similarity
Glycosylationi1178 – 11781N-linked (GlcNAc...)1 Publication
Modified residuei1180 – 11801Phosphoserine1 Publication
Disulfide bondi1275 ↔ 1301 By similarity
Glycosylationi1280 – 12801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1368 – 13681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1425 – 14251N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ92626.
PaxDbiQ92626.
PRIDEiQ92626.

PTM databases

PhosphoSiteiQ92626.

Expressioni

Tissue specificityi

Expressed at higher levels in heart, lung, ovary, spleen, intestine and placenta, and at lower levels in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Expressed in tumors such as melanoma, breast cancer, ovarian cancer and glioblastoma. A shorter form probably lacking the signal sequence is found in testis and in EB1 cells undergoing p53/TP53-dependent apoptosis.4 Publications

Developmental stagei

Expressed in fetal liver and spleen.1 Publication

Inductioni

By TGFB1 in fibroblasts and up-regulated in apoptotic cells.2 Publications

Gene expression databases

ArrayExpressiQ92626.
BgeeiQ92626.
CleanExiHS_PRG2.
HS_PXDN.
GenevestigatoriQ92626.

Organism-specific databases

HPAiHPA012375.

Interactioni

Protein-protein interaction databases

BioGridi113596. 4 interactions.
IntActiQ92626. 1 interaction.
MINTiMINT-4931004.
STRINGi9606.ENSP00000252804.

Structurei

3D structure databases

ProteinModelPortaliQ92626.
SMRiQ92626. Positions 34-676, 738-1314.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 6337LRRNT
Add
BLAST
Repeati87 – 10822LRR 1
Add
BLAST
Repeati111 – 13222LRR 2
Add
BLAST
Repeati135 – 15622LRR 3
Add
BLAST
Repeati159 – 18022LRR 4
Add
BLAST
Domaini192 – 24554LRRCT
Add
BLAST
Domaini246 – 33287Ig-like C2-type 1
Add
BLAST
Domaini342 – 42887Ig-like C2-type 2
Add
BLAST
Domaini433 – 52088Ig-like C2-type 3
Add
BLAST
Domaini521 – 61090Ig-like C2-type 4
Add
BLAST
Domaini1413 – 147159VWFC
Add
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Contains 1 VWFC domain.

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG262194.
HOGENOMiHOG000016084.
HOVERGENiHBG108312.
InParanoidiQ92626.
OMAiEPVITWN.
OrthoDBiEOG7D2FD6.
PhylomeDBiQ92626.
TreeFamiTF314316.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
2.60.40.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR001007. VWF_C.
[Graphical view]
PfamiPF03098. An_peroxidase. 1 hit.
PF07679. I-set. 4 hits.
PF13855. LRR_8. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00408. IGc2. 4 hits.
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50835. IG_LIKE. 4 hits.
PS51450. LRR. 5 hits.
PS50292. PEROXIDASE_3. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q92626-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAKRSRGPGR RCLLALVLFC AWGTLAVVAQ KPGAGCPSRC LCFRTTVRCM     50
HLLLEAVPAV APQTSILDLR FNRIREIQPG AFRRLRNLNT LLLNNNQIKR 100
IPSGAFEDLE NLKYLYLYKN EIQSIDRQAF KGLASLEQLY LHFNQIETLD 150
PDSFQHLPKL ERLFLHNNRI THLVPGTFNH LESMKRLRLD SNTLHCDCEI 200
LWLADLLKTY AESGNAQAAA ICEYPRRIQG RSVATITPEE LNCERPRITS 250
EPQDADVTSG NTVYFTCRAE GNPKPEIIWL RNNNELSMKT DSRLNLLDDG 300
TLMIQNTQET DQGIYQCMAK NVAGEVKTQE VTLRYFGSPA RPTFVIQPQN 350
TEVLVGESVT LECSATGHPP PRISWTRGDR TPLPVDPRVN ITPSGGLYIQ 400
NVVQGDSGEY ACSATNNIDS VHATAFIIVQ ALPQFTVTPQ DRVVIEGQTV 450
DFQCEAKGNP PPVIAWTKGG SQLSVDRRHL VLSSGTLRIS GVALHDQGQY 500
ECQAVNIIGS QKVVAHLTVQ PRVTPVFASI PSDTTVEVGA NVQLPCSSQG 550
EPEPAITWNK DGVQVTESGK FHISPEGFLT INDVGPADAG RYECVARNTI 600
GSASVSMVLS VNVPDVSRNG DPFVATSIVE AIATVDRAIN STRTHLFDSR 650
PRSPNDLLAL FRYPRDPYTV EQARAGEIFE RTLQLIQEHV QHGLMVDLNG 700
TSYHYNDLVS PQYLNLIANL SGCTAHRRVN NCSDMCFHQK YRTHDGTCNN 750
LQHPMWGASL TAFERLLKSV YENGFNTPRG INPHRLYNGH ALPMPRLVST 800
TLIGTETVTP DEQFTHMLMQ WGQFLDHDLD STVVALSQAR FSDGQHCSNV 850
CSNDPPCFSV MIPPNDSRAR SGARCMFFVR SSPVCGSGMT SLLMNSVYPR 900
EQINQLTSYI DASNVYGSTE HEARSIRDLA SHRGLLRQGI VQRSGKPLLP 950
FATGPPTECM RDENESPIPC FLAGDHRANE QLGLTSMHTL WFREHNRIAT 1000
ELLKLNPHWD GDTIYYETRK IVGAEIQHIT YQHWLPKILG EVGMRTLGEY 1050
HGYDPGINAG IFNAFATAAF RFGHTLVNPL LYRLDENFQP IAQDHLPLHK 1100
AFFSPFRIVN EGGIDPLLRG LFGVAGKMRV PSQLLNTELT ERLFSMAHTV 1150
ALDLAAINIQ RGRDHGIPPY HDYRVYCNLS AAHTFEDLKN EIKNPEIREK 1200
LKRLYGSTLN IDLFPALVVE DLVPGSRLGP TLMCLLSTQF KRLRDGDRLW 1250
YENPGVFSPA QLTQIKQTSL ARILCDNADN ITRVQSDVFR VAEFPHGYGS 1300
CDEIPRVDLR VWQDCCEDCR TRGQFNAFSY HFRGRRSLEF SYQEDKPTKK 1350
TRPRKIPSVG RQGEHLSNST SAFSTRSDAS GTNDFREFVL EMQKTITDLR 1400
TQIKKLESRL STTECVDAGG ESHANNTKWK KDACTICECK DGQVTCFVEA 1450
CPPATCAVPV NIPGACCPVC LQKRAEEKP 1479
Length:1,479
Mass (Da):165,275
Last modified:February 26, 2008 - v2
Checksum:i7A75F533D89C6AAD
GO
Isoform 2 (identifier: Q92626-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     703-727: YHYNDLVSPQYLNLIANLSGCTAHR → QCQSLFFLLHGLSNGVEHASVKSHS
     728-1479: Missing.

Show »
Length:727
Mass (Da):80,329
Checksum:i16391EA8B7F61878
GO

Sequence cautioni

The sequence AAF06354.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA13219.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1198 – 11981R → Q.
Corresponds to variant rs6723697 [ dbSNP | Ensembl ].
VAR_050487
Natural varianti1261 – 12611Q → R.
Corresponds to variant rs6723697 [ dbSNP | Ensembl ].
VAR_039048

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei703 – 72725YHYND…CTAHR → QCQSLFFLLHGLSNGVEHAS VKSHS in isoform 2.
VSP_031516Add
BLAST
Alternative sequencei728 – 1479752Missing in isoform 2.
VSP_031517Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF200348 mRNA. Translation: AAF06354.1. Different initiation.
EF090903 mRNA. Translation: ABO25865.1.
D86983 mRNA. Translation: BAA13219.1. Different initiation.
CH471053 Genomic DNA. Translation: EAX01084.1.
CH471053 Genomic DNA. Translation: EAX01085.1.
BC098579 mRNA. Translation: AAH98579.1.
CCDSiCCDS46221.1. [Q92626-1]
RefSeqiNP_036425.1. NM_012293.1. [Q92626-1]
UniGeneiHs.332197.

Genome annotation databases

EnsembliENST00000252804; ENSP00000252804; ENSG00000130508. [Q92626-1]
GeneIDi7837.
KEGGihsa:7837.
UCSCiuc002qxa.3. human. [Q92626-1]
uc002qxb.1. human. [Q92626-2]

Polymorphism databases

DMDMi172045828.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF200348 mRNA. Translation: AAF06354.1 . Different initiation.
EF090903 mRNA. Translation: ABO25865.1 .
D86983 mRNA. Translation: BAA13219.1 . Different initiation.
CH471053 Genomic DNA. Translation: EAX01084.1 .
CH471053 Genomic DNA. Translation: EAX01085.1 .
BC098579 mRNA. Translation: AAH98579.1 .
CCDSi CCDS46221.1. [Q92626-1 ]
RefSeqi NP_036425.1. NM_012293.1. [Q92626-1 ]
UniGenei Hs.332197.

3D structure databases

ProteinModelPortali Q92626.
SMRi Q92626. Positions 34-676, 738-1314.
ModBasei Search...

Protein-protein interaction databases

BioGridi 113596. 4 interactions.
IntActi Q92626. 1 interaction.
MINTi MINT-4931004.
STRINGi 9606.ENSP00000252804.

Protein family/group databases

PeroxiBasei 3355. HsPxd01.

PTM databases

PhosphoSitei Q92626.

Polymorphism databases

DMDMi 172045828.

Proteomic databases

MaxQBi Q92626.
PaxDbi Q92626.
PRIDEi Q92626.

Protocols and materials databases

DNASUi 7837.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252804 ; ENSP00000252804 ; ENSG00000130508 . [Q92626-1 ]
GeneIDi 7837.
KEGGi hsa:7837.
UCSCi uc002qxa.3. human. [Q92626-1 ]
uc002qxb.1. human. [Q92626-2 ]

Organism-specific databases

CTDi 7837.
GeneCardsi GC02M001635.
HGNCi HGNC:14966. PXDN.
HPAi HPA012375.
MIMi 605158. gene.
neXtProti NX_Q92626.
Orphaneti 289499. Congenital cataract microcornea with corneal opacity.
PharmGKBi PA128394535.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262194.
HOGENOMi HOG000016084.
HOVERGENi HBG108312.
InParanoidi Q92626.
OMAi EPVITWN.
OrthoDBi EOG7D2FD6.
PhylomeDBi Q92626.
TreeFami TF314316.

Miscellaneous databases

ChiTaRSi PXDN. human.
GeneWikii PXDN.
GenomeRNAii 7837.
NextBioi 30238.
PROi Q92626.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92626.
Bgeei Q92626.
CleanExi HS_PRG2.
HS_PXDN.
Genevestigatori Q92626.

Family and domain databases

Gene3Di 1.10.640.10. 2 hits.
2.60.40.10. 4 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF03098. An_peroxidase. 1 hit.
PF07679. I-set. 4 hits.
PF13855. LRR_8. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00408. IGc2. 4 hits.
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50835. IG_LIKE. 4 hits.
PS51450. LRR. 5 hits.
PS50292. PEROXIDASE_3. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene."
    Horikoshi N., Cong J., Kley N., Shenk T.
    Biochem. Biophys. Res. Commun. 261:864-869(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, TISSUE SPECIFICITY.
  2. "A novel melanoma gene (MG50) encoding the interleukin 1 receptor antagonist and six epitopes recognized by human cytolytic T lymphocytes."
    Mitchell M.S., Kan-Mitchell J., Minev B., Edman C., Deans R.J.
    Cancer Res. 60:6448-6456(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "Identification and characterization of VPO1, a new animal heme-containing peroxidase."
    Cheng G., Salerno J.C., Cao Z., Pagano P.J., Lambeth J.D.
    Free Radic. Biol. Med. 45:1682-1694(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), 3D-STRUCTURE MODELING, FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, HEME COFACTOR, TISSUE SPECIFICITY.
  4. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1479 (ISOFORM 2).
    Tissue: Chondrosarcoma.
  7. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1176 AND SER-1180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. Cheng G.
    Unpublished observations (FEB-2008)
    Cited for: SUBCELLULAR LOCATION.
  9. "Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney."
    Peterfi Z., Donko A., Orient A., Sum A., Prokai A., Molnar B., Vereb Z., Rajnavolgyi E., Kovacs K.J., Muller V., Szabo A.J., Geiszt M.
    Am. J. Pathol. 175:725-735(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION BY TGFB1.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1178.
    Tissue: Liver.

Entry informationi

Entry nameiPXDN_HUMAN
AccessioniPrimary (citable) accession number: Q92626
Secondary accession number(s): A8QM65, D6W4Y0, Q4KMG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 3, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi