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Protein

Ankyrin repeat and SAM domain-containing protein 1A

Gene

ANKS1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000064999-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SAM domain-containing protein 1A
Alternative name(s):
Odin
Gene namesi
Name:ANKS1A
Synonyms:ANKS1, KIAA0229, ODIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20961. ANKS1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi23294.
OpenTargetsiENSG00000064999.
PharmGKBiPA134958476.

Polymorphism and mutation databases

BioMutaiANKS1A.
DMDMi62511243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000669212 – 1134Ankyrin repeat and SAM domain-containing protein 1AAdd BLAST1133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei620PhosphoserineCombined sources1
Modified residuei622PhosphoserineCombined sources1
Modified residuei624PhosphoserineBy similarity1
Modified residuei626PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei663PhosphoserineCombined sources1
Modified residuei666PhosphoserineBy similarity1
Modified residuei677PhosphoserineCombined sources1
Modified residuei887PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues in response to EGF and PDGF.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92625.
MaxQBiQ92625.
PaxDbiQ92625.
PeptideAtlasiQ92625.
PRIDEiQ92625.

PTM databases

iPTMnetiQ92625.
PhosphoSitePlusiQ92625.

Expressioni

Tissue specificityi

Widely expressed (at protein level).

Gene expression databases

BgeeiENSG00000064999.
CleanExiHS_ANKS1A.
GenevisibleiQ92625. HS.

Organism-specific databases

HPAiHPA036768.
HPA036769.

Interactioni

Subunit structurei

Interacts with EPHA8; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination (By similarity). Interacts (via SAM domain) with EPHA2 (via SAM domain).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005335EBI-1048612,EBI-297353
ERBB2P046262EBI-1048612,EBI-641062

Protein-protein interaction databases

BioGridi116889. 26 interactors.
IntActiQ92625. 15 interactors.
MINTiMINT-1493202.
STRINGi9606.ENSP00000353518.

Structurei

Secondary structure

11134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi701 – 708Combined sources8
Helixi711 – 713Combined sources3
Helixi714 – 719Combined sources6
Turni728 – 730Combined sources3
Helixi735 – 741Combined sources7
Helixi746 – 757Combined sources12
Beta strandi759 – 761Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LMRNMR-A691-770[»]
2MYQNMR-A715-757[»]
ProteinModelPortaliQ92625.
SMRiQ92625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati79 – 108ANK 1Add BLAST30
Repeati112 – 141ANK 2Add BLAST30
Repeati148 – 177ANK 3Add BLAST30
Repeati181 – 210ANK 4Add BLAST30
Repeati214 – 243ANK 5Add BLAST30
Repeati246 – 275ANK 6Add BLAST30
Domaini696 – 762SAM 1PROSITE-ProRule annotationAdd BLAST67
Domaini770 – 837SAM 2PROSITE-ProRule annotationAdd BLAST68
Domaini936 – 1091PIDPROSITE-ProRule annotationAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 55Gly-richAdd BLAST54

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 PID domain.PROSITE-ProRule annotation
Contains 2 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000033973.
HOVERGENiHBG050506.
InParanoidiQ92625.
OMAiHLERMLF.
OrthoDBiEOG091G00YV.
PhylomeDBiQ92625.
TreeFamiTF320582.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 4 hits.
2.30.29.30. 1 hit.
InterProiIPR033635. ANKS1.
IPR033637. ANKS1A.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR24174. PTHR24174. 2 hits.
PTHR24174:SF4. PTHR24174:SF4. 2 hits.
PfamiPF12796. Ank_2. 3 hits.
PF00640. PID. 1 hit.
PF00536. SAM_1. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00462. PTB. 1 hit.
SM00454. SAM. 2 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS01179. PID. 1 hit.
PS50105. SAM_DOMAIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92625-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKEQELLEA ARTGHLPAVE KLLSGKRLSS GFGGGGGGGS GGGGGGSGGG
60 70 80 90 100
GGGLGSSSHP LSSLLSMWRG PNVNCVDSTG YTPLHHAALN GHKDVVEVLL
110 120 130 140 150
RNDALTNVAD SKGCYPLHLA AWKGDAQIVR LLIHQGPSHT RVNEQNNDNE
160 170 180 190 200
TALHCAAQYG HTEVVKVLLE ELTDPTMRNN KFETPLDLAA LYGRLEVVKM
210 220 230 240 250
LLNAHPNLLS CNTKKHTPLH LAARNGHKAV VQVLLDAGMD SNYQTEMGSA
260 270 280 290 300
LHEAALFGKT DVVQILLAAG TDVNIKDNHG LTALDTVREL PSQKSQQIAA
310 320 330 340 350
LIEDHMTGKR STKEVDKTPP PQPPLISSMD SISQKSQGDV EKAVTELIID
360 370 380 390 400
FDANAEEEGP YEALYNAISC HSLDSMASGR SSDQDSTNKE AEAAGVKPAG
410 420 430 440 450
VRPRERPPPP AKPPPDEEEE DHIDKKYFPL TASEVLSMRP RIHGSAAREE
460 470 480 490 500
DEHPYELLLT AETKKVVLVD GKTKDHRRSS SSRSQDSAEG QDGQVPEQFS
510 520 530 540 550
GLLHGSSPVC EVGQDPFQLL CTAGQSHPDG SPQQGACHKA SMQLEETGVH
560 570 580 590 600
APGASQPSAL DQSKRVGYLT GLPTTNSRSH PETLTHTASP HPGGAEEGDR
610 620 630 640 650
SGARSRAPPT SKPKAELKLS RSLSKSDSDL LTCSPTEDAT MGSRSESLSN
660 670 680 690 700
CSIGKKRLEK SPSFASEWDE IEKIMSSIGE GIDFSQERQK ISGLRTLEQS
710 720 730 740 750
VGEWLESIGL QQYESKLLLN GFDDVHFLGS NVMEEQDLRD IGISDPQHRR
760 770 780 790 800
KLLQAARSLP KVKALGYDGN SPPSVPSWLD SLGLQDYVHS FLSSGYSSID
810 820 830 840 850
TVKNLWELEL VNVLKVQLLG HRKRIIASLA DRPYEEPPQK PPRFSQLRCQ
860 870 880 890 900
DLLSQTSSPL SQNDSCTGRS ADLLLPPGDT GRRRHDSLHD PAAPSRAERF
910 920 930 940 950
RIQEEHREAK LTLRPPSLAA PYAPVQSWQH QPEKLIFESC GYEANYLGSM
960 970 980 990 1000
LIKDLRGTES TQDACAKMRK STEHMKKIPT IILSITYKGV KFIDASNKNV
1010 1020 1030 1040 1050
IAEHEIRNIS CAAQDPEDLC TFAYITKDLQ TSHHYCHVFS TVDVNLTYEI
1060 1070 1080 1090 1100
ILTLGQAFEV AYQLALQAQK SRATGASAAE MIETKSSKPV PKPRVGVRKS
1110 1120 1130
ALEPPDMDQD AQSHASVSWV VDPKPDSKRS LSTN
Length:1,134
Mass (Da):123,108
Last modified:January 23, 2007 - v4
Checksum:iE519844AD56EE414
GO
Isoform 2 (identifier: Q92625-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-320: HMTGKRSTKEVDKTPP → LDTLQFYFISCPFQGL
     321-1134: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):33,882
Checksum:i596CAD2B08649EB4
GO

Sequence cautioni

The sequence BAA13218 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048282355A → D.Corresponds to variant rs6930932dbSNPEnsembl.1
Natural variantiVAR_021168694L → S.Combined sources3 PublicationsCorresponds to variant rs820085dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056512305 – 320HMTGK…DKTPP → LDTLQFYFISCPFQGL in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_056513321 – 1134Missing in isoform 2. 1 PublicationAdd BLAST814

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86982 mRNA. Translation: BAA13218.1. Different initiation.
AK298987 mRNA. Translation: BAG61080.1.
AL138721, AL033520, AL591002 Genomic DNA. Translation: CAI12437.1.
AL591002, AL033520, AL138721 Genomic DNA. Translation: CAI15138.1.
AL033520, AL138721, AL591002 Genomic DNA. Translation: CAI20281.1.
CH471081 Genomic DNA. Translation: EAX03804.1.
BC132832 mRNA. Translation: AAI32833.1.
CCDSiCCDS4798.1. [Q92625-1]
RefSeqiNP_056060.2. NM_015245.2. [Q92625-1]
UniGeneiHs.656492.

Genome annotation databases

EnsembliENST00000360359; ENSP00000353518; ENSG00000064999. [Q92625-1]
GeneIDi23294.
KEGGihsa:23294.
UCSCiuc003ojx.5. human. [Q92625-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86982 mRNA. Translation: BAA13218.1. Different initiation.
AK298987 mRNA. Translation: BAG61080.1.
AL138721, AL033520, AL591002 Genomic DNA. Translation: CAI12437.1.
AL591002, AL033520, AL138721 Genomic DNA. Translation: CAI15138.1.
AL033520, AL138721, AL591002 Genomic DNA. Translation: CAI20281.1.
CH471081 Genomic DNA. Translation: EAX03804.1.
BC132832 mRNA. Translation: AAI32833.1.
CCDSiCCDS4798.1. [Q92625-1]
RefSeqiNP_056060.2. NM_015245.2. [Q92625-1]
UniGeneiHs.656492.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LMRNMR-A691-770[»]
2MYQNMR-A715-757[»]
ProteinModelPortaliQ92625.
SMRiQ92625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116889. 26 interactors.
IntActiQ92625. 15 interactors.
MINTiMINT-1493202.
STRINGi9606.ENSP00000353518.

PTM databases

iPTMnetiQ92625.
PhosphoSitePlusiQ92625.

Polymorphism and mutation databases

BioMutaiANKS1A.
DMDMi62511243.

Proteomic databases

EPDiQ92625.
MaxQBiQ92625.
PaxDbiQ92625.
PeptideAtlasiQ92625.
PRIDEiQ92625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360359; ENSP00000353518; ENSG00000064999. [Q92625-1]
GeneIDi23294.
KEGGihsa:23294.
UCSCiuc003ojx.5. human. [Q92625-1]

Organism-specific databases

CTDi23294.
DisGeNETi23294.
GeneCardsiANKS1A.
HGNCiHGNC:20961. ANKS1A.
HPAiHPA036768.
HPA036769.
MIMi608994. gene.
neXtProtiNX_Q92625.
OpenTargetsiENSG00000064999.
PharmGKBiPA134958476.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0507. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000033973.
HOVERGENiHBG050506.
InParanoidiQ92625.
OMAiHLERMLF.
OrthoDBiEOG091G00YV.
PhylomeDBiQ92625.
TreeFamiTF320582.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000064999-MONOMER.

Miscellaneous databases

ChiTaRSiANKS1A. human.
GeneWikiiANKS1A.
GenomeRNAii23294.
PROiQ92625.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064999.
CleanExiHS_ANKS1A.
GenevisibleiQ92625. HS.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 4 hits.
2.30.29.30. 1 hit.
InterProiIPR033635. ANKS1.
IPR033637. ANKS1A.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR24174. PTHR24174. 2 hits.
PTHR24174:SF4. PTHR24174:SF4. 2 hits.
PfamiPF12796. Ank_2. 3 hits.
PF00640. PID. 1 hit.
PF00536. SAM_1. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00462. PTB. 1 hit.
SM00454. SAM. 2 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS01179. PID. 1 hit.
PS50105. SAM_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANS1A_HUMAN
AccessioniPrimary (citable) accession number: Q92625
Secondary accession number(s): A2RUC1
, B4DQW8, Q5JYI9, Q5SYR2, Q86WQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 150 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.