Reviewed,
UniProtKB/Swiss-Prot Q92625 (ANS1A_HUMAN)
Last modified
February 9, 2010.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ankyrin repeat and SAM domain-containing protein 1A Alternative name(s): Odin | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1134 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play a negative role in growth factor receptor signaling pathways. |
| Subcellular location | Cytoplasm. Note: Cytoplasmic before and after growth factor treatment. |
| Tissue specificity | Widely expressed (at protein level). |
| Post-translational modification | Phosphorylated on tyrosine residues in response to EGF and PDGF By similarity. Ref.6 Ref.7 Ref.8 Ref.10 Ref.11 |
| Sequence similarities | Contains 6 ANK repeats. Contains 1 PID domain. Contains 2 SAM (sterile alpha motif) domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Domain | ANK repeat Repeat |
| PTM | Acetylation Phosphoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||
| Chain | 2 – 1134 | 1133 | Ankyrin repeat and SAM domain-containing protein 1A | PRO_0000066921 | |||||
Regions | |||||||||
| Repeat | 79 – 108 | 30 | ANK 1 | ||||||
| Repeat | 112 – 141 | 30 | ANK 2 | ||||||
| Repeat | 148 – 177 | 30 | ANK 3 | ||||||
| Repeat | 181 – 210 | 30 | ANK 4 | ||||||
| Repeat | 214 – 243 | 30 | ANK 5 | ||||||
| Repeat | 246 – 275 | 30 | ANK 6 | ||||||
| Domain | 696 – 762 | 67 | SAM 1 | ||||||
| Domain | 770 – 837 | 68 | SAM 2 | ||||||
| Domain | 936 – 1091 | 156 | PID | ||||||
| Compositional bias | 2 – 55 | 54 | Gly-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylglycine Ref.5 | ||||||
| Modified residue | 318 | 1 | Phosphothreonine Ref.8 | ||||||
| Modified residue | 622 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 624 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 626 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 628 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 647 | 1 | Phosphoserine Ref.8 Ref.10 | ||||||
| Modified residue | 661 | 1 | Phosphoserine Ref.8 Ref.10 | ||||||
| Modified residue | 663 | 1 | Phosphoserine Ref.6 Ref.10 Ref.11 | ||||||
| Modified residue | 666 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 677 | 1 | Phosphoserine Ref.11 | ||||||
| Modified residue | 887 | 1 | Phosphoserine Ref.7 | ||||||
Natural variations | |||||||||
| Natural variant | 355 | 1 | A → D: dbSNP rs6930932. | VAR_048282 | |||||
| Natural variant | 694 | 1 | L → S: dbSNP rs820085. Ref.1 Ref.3 Ref.4 | VAR_021168 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-694. Tissue: Bone marrow. |
| [2] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-694. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-694. |
| [5] | "Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases." Pandey A., Blagoev B., Kratchmarova I., Fernandez M., Nielsen M., Kristiansen T.Z., Ohara O., Podtelejnikov A.V., Roche S., Lodish H.F., Mann M. Oncogene 21:8029-8036(2002) [PubMed: 12439753] [Abstract] Cited for: PROTEIN SEQUENCE OF 540-564, ACETYLATION AT GLY-2, MASS SPECTROMETRY, CHARACTERIZATION. Tissue: Cervix carcinoma. |
| [6] | "Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663, MASS SPECTROMETRY. Tissue: Platelet. |
| [7] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-887, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-318; SER-622; SER-626; SER-647 AND SER-661, MASS SPECTROMETRY. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [10] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-647; SER-661 AND SER-663, MASS SPECTROMETRY. |
| [11] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663 AND SER-677, MASS SPECTROMETRY. Tissue: T-cell. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D86982 mRNA. Translation: BAA13218.1. Different initiation. AL138721, AL033520, AL591002 Genomic DNA. Translation: CAI12437.1. AL591002, AL033520, AL138721 Genomic DNA. Translation: CAI15138.1. AL033520, AL138721, AL591002 Genomic DNA. Translation: CAI20281.1. CH471081 Genomic DNA. Translation: EAX03804.1. BC132832 mRNA. Translation: AAI32833.1. |
| IPI | IPI00395663. |
| RefSeq | NP_056060.2. |
| UniGene | Hs.656492 |
3D structure databases | |
| SMR | Q92625. Positions 5-267, 72-289, 692-760, 766-861, 914-1067. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q92625. 1 interaction. |
| STRING | Q92625. |
PTM databases | |
| PhosphoSite | Q92625. |
Proteomic databases | |
| PeptideAtlas | Q92625. |
| PRIDE | Q92625. |
Genome annotation databases | |
| Ensembl | ENST00000360359; ENSP00000353518; ENSG00000064999; Homo sapiens. [Genome view] |
| GeneID | 23294. |
| KEGG | hsa:23294. |
| UCSC | uc003ojx.2. human. |
Organism-specific databases | |
| CTD | 23294. |
| GeneCards | GC06P034966. |
| HGNC | HGNC:20961. ANKS1A. |
| MIM | 608994. gene. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG446292. |
| HOVERGEN | Q92625. |
| InParanoid | Q92625. |
| OMA | CSIGKKR. |
| PhylomeDB | Q92625. |
Gene expression databases | |
| ArrayExpress | Q92625. |
| Bgee | Q92625. |
| CleanEx | HS_ANKS1A. |
| Genevestigator | Q92625. |
| GermOnline | ENSG00000064999. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR011993. PH_type. IPR006020. PTyr_interaction_dom. IPR001660. SAM. IPR010993. SAM_homology. IPR013761. SAM_type. IPR021129. SAM_type1. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:1.10.150.50. SAM_type. 2 hits. |
| Pfam | PF00023. Ank. 6 hits. PF00640. PID. 1 hit. PF00536. SAM_1. 2 hits. [Graphical view] |
| SMART | SM00248. ANK. 6 hits. SM00462. PTB. 1 hit. SM00454. SAM. 2 hits. [Graphical view] |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 6 hits. PS01179. PID. 1 hit. PS50105. SAM_DOMAIN. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 45120. |
| SOURCE | Search... |
Entry information
| Entry name | ANS1A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q92625 Secondary accession number(s): A2RUC1 Q86WQ7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


