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Protein

Amyloid protein-binding protein 2

Gene

APPBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.1 Publication

GO - Molecular functioni

  • microtubule motor activity Source: ProtInc

GO - Biological processi

  • intracellular protein transport Source: ProtInc
  • intracellular transport Source: MGI
  • metabolic process Source: GOC
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid protein-binding protein 2
Alternative name(s):
Amyloid beta precursor protein-binding protein 2
Short name:
APP-BP2
Protein interacting with APP tail 1
Gene namesi
Name:APPBP2
Synonyms:KIAA0228, PAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:622. APPBP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic vesicle membrane Source: MGI
  • microtubule Source: UniProtKB-KW
  • microtubule associated complex Source: ProtInc
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24912.

Polymorphism and mutation databases

DMDMi50400598.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Amyloid protein-binding protein 2PRO_0000106259Add
BLAST

Post-translational modificationi

Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.

Proteomic databases

MaxQBiQ92624.
PaxDbiQ92624.
PRIDEiQ92624.

PTM databases

PhosphoSiteiQ92624.

Expressioni

Gene expression databases

BgeeiQ92624.
CleanExiHS_APPBP2.
ExpressionAtlasiQ92624. baseline and differential.
GenevisibleiQ92624. HS.

Interactioni

Subunit structurei

Binds APP.

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H6693EBI-743771,EBI-10307430
AHCYP235263EBI-743771,EBI-1053240
AK3Q9UIJ73EBI-743771,EBI-3916527
ANKRD10Q8IUW13EBI-743771,EBI-10261416
ANKRD10Q9NXR53EBI-743771,EBI-10316475
ARMCX5Q6P1M93EBI-743771,EBI-10252512
C16orf35Q9BTE23EBI-743771,EBI-10298364
C1orf50Q9BV193EBI-743771,EBI-2874661
C6orf226Q5I0X43EBI-743771,EBI-10244057
CALM3B4DJ513EBI-743771,EBI-10171450
CCNL1Q9UK583EBI-743771,EBI-2836773
CDK16Q005363EBI-743771,EBI-726261
CLCN1P355233EBI-743771,EBI-10206780
COL24A1Q17RW23EBI-743771,EBI-2529266
CORO2BQ9UQ033EBI-743771,EBI-723376
CSNK1G2P783683EBI-743771,EBI-748380
CTC1Q2NKJ33EBI-743771,EBI-2562802
DCDP816053EBI-743771,EBI-395625
DHRS2Q132683EBI-743771,EBI-354324
DPEP1P164443EBI-743771,EBI-749514
ERO1LQ96HE73EBI-743771,EBI-2564539
FAM19A4Q96LR43EBI-743771,EBI-10290841
FSTL1Q128415EBI-743771,EBI-2349801
FXYD7P585493EBI-743771,EBI-10216171
GALNT3Q14435-23EBI-743771,EBI-10232904
GCSAMQ8N6F73EBI-743771,EBI-10267082
GSTP1P092113EBI-743771,EBI-353467
HIPK4Q8NE633EBI-743771,EBI-6381114
HIST1H2AKA4FTV93EBI-743771,EBI-10173457
HSPA4P349323EBI-743771,EBI-356933
IKBKEQ141644EBI-743771,EBI-307369
KIF6Q6ZMV93EBI-743771,EBI-751100
KLF11O149013EBI-743771,EBI-948266
KLHL35Q6PF153EBI-743771,EBI-9477654
LANCL2Q9NS863EBI-743771,EBI-2510837
LONRF3Q496Y03EBI-743771,EBI-2690768
LUC7L2Q9Y3833EBI-743771,EBI-352851
LUZP4Q9P1273EBI-743771,EBI-10198848
MUL1Q969V53EBI-743771,EBI-744120
NFYAP235113EBI-743771,EBI-389739
PCTK1Q9BRL43EBI-743771,EBI-10296950
PPP1R8Q129723EBI-743771,EBI-716633
PRKAA2P546463EBI-743771,EBI-1383852
PRKACBP226943EBI-743771,EBI-2679622
PYROXD2Q8N2H33EBI-743771,EBI-3919450
RNF128Q8TEB73EBI-743771,EBI-2341619
RNF34Q969K33EBI-743771,EBI-2340642
RRS1Q150504EBI-743771,EBI-749186
SELIQ8WU573EBI-743771,EBI-751012
SELVP597973EBI-743771,EBI-10216195
SLC22A6Q4U2R83EBI-743771,EBI-749741
SLC25A23Q9BV353EBI-743771,EBI-2933255
SNX5Q9Y5X33EBI-743771,EBI-715760
ST8SIA5O154663EBI-743771,EBI-10182857
SYNRGQ9UMZ23EBI-743771,EBI-7240490
SYT11Q9BT883EBI-743771,EBI-751770
TAF11Q155443EBI-743771,EBI-1027005
TBL3Q127884EBI-743771,EBI-715766
TCF25Q9BQ703EBI-743771,EBI-745182
UBE2R2Q712K33EBI-743771,EBI-2340879
UGGT2Q9NYU13EBI-743771,EBI-1054215
WASP427683EBI-743771,EBI-346375
WDR24Q96S154EBI-743771,EBI-746424
ZC3H10Q96K803EBI-743771,EBI-742550
ZNF747Q9BV973EBI-743771,EBI-4395497

Protein-protein interaction databases

BioGridi115769. 99 interactions.
IntActiQ92624. 79 interactions.
MINTiMINT-1443955.
STRINGi9606.ENSP00000083182.

Structurei

3D structure databases

ProteinModelPortaliQ92624.
SMRiQ92624. Positions 342-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 8334TPR 1Add
BLAST
Repeati120 – 15334TPR 2Add
BLAST
Repeati206 – 23934TPR 3Add
BLAST
Repeati288 – 32134TPR 4Add
BLAST
Repeati333 – 36735TPR 5Add
BLAST
Repeati429 – 46234TPR 6Add
BLAST
Repeati471 – 50535TPR 7Add
BLAST
Repeati514 – 54734TPR 8Add
BLAST

Sequence similaritiesi

Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00390000010722.
HOGENOMiHOG000007799.
HOVERGENiHBG050527.
InParanoidiQ92624.
OMAiKLYNSVG.
OrthoDBiEOG790G0N.
PhylomeDBiQ92624.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ
60 70 80 90 100
GRLCQLGSEF CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS
110 120 130 140 150
FSRRCSYIAE SDAAVKEKAI QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC
160 170 180 190 200
TLHDEMLHWF RAVECCVRLL HVRNGNCKYH LGEETFKLAQ TYMDKLSKHG
210 220 230 240 250
QQANKAALYG ELCALLFAKS HYDEAYKWCI EAMKEITAGL PVKVVVDVLR
260 270 280 290 300
QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN
310 320 330 340 350
VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF
360 370 380 390 400
DNALFHAERA IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ
410 420 430 440 450
RLLQEAHDLH LSSLQLAKKA FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE
460 470 480 490 500
MHIKAIQIKE QLLGQEDYEV ALSVGHLASL YNYDMNQYEN AEKLYLRSIA
510 520 530 540 550
IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL SNWNRLRDRQ
560 570 580
YSVTDALEDV STSPQSTEEV VQSFLISQNV EGPSC
Length:585
Mass (Da):66,853
Last modified:July 19, 2004 - v2
Checksum:i849A120807DA2438
GO

Sequence cautioni

The sequence BAA13217.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2961F → L in AAC83973 (PubMed:9843960).Curated
Sequence conflicti325 – 3251K → R in AAC83973 (PubMed:9843960).Curated
Sequence conflicti340 – 3401S → C in AAC83973 (PubMed:9843960).Curated
Sequence conflicti354 – 3541L → V in AAC83973 (PubMed:9843960).Curated
Sequence conflicti369 – 3691P → R in AAC83973 (PubMed:9843960).Curated
Sequence conflicti542 – 5421N → K in AAC83973 (PubMed:9843960).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti561 – 5611S → N.
Corresponds to variant rs34146848 [ dbSNP | Ensembl ].
VAR_052606

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017782 mRNA. Translation: AAC83973.1.
D86981 mRNA. Translation: BAA13217.1. Different initiation.
AK292227 mRNA. Translation: BAF84916.1.
CH471179 Genomic DNA. Translation: EAW51406.1.
BC018121 mRNA. Translation: AAH18121.1.
CCDSiCCDS32699.1.
RefSeqiNP_001269405.1. NM_001282476.1.
NP_006371.2. NM_006380.3.
UniGeneiHs.84084.

Genome annotation databases

EnsembliENST00000083182; ENSP00000083182; ENSG00000062725.
GeneIDi10513.
KEGGihsa:10513.
UCSCiuc002iys.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017782 mRNA. Translation: AAC83973.1.
D86981 mRNA. Translation: BAA13217.1. Different initiation.
AK292227 mRNA. Translation: BAF84916.1.
CH471179 Genomic DNA. Translation: EAW51406.1.
BC018121 mRNA. Translation: AAH18121.1.
CCDSiCCDS32699.1.
RefSeqiNP_001269405.1. NM_001282476.1.
NP_006371.2. NM_006380.3.
UniGeneiHs.84084.

3D structure databases

ProteinModelPortaliQ92624.
SMRiQ92624. Positions 342-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115769. 99 interactions.
IntActiQ92624. 79 interactions.
MINTiMINT-1443955.
STRINGi9606.ENSP00000083182.

PTM databases

PhosphoSiteiQ92624.

Polymorphism and mutation databases

DMDMi50400598.

Proteomic databases

MaxQBiQ92624.
PaxDbiQ92624.
PRIDEiQ92624.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000083182; ENSP00000083182; ENSG00000062725.
GeneIDi10513.
KEGGihsa:10513.
UCSCiuc002iys.1. human.

Organism-specific databases

CTDi10513.
GeneCardsiGC17M058520.
HGNCiHGNC:622. APPBP2.
MIMi605324. gene.
neXtProtiNX_Q92624.
PharmGKBiPA24912.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00390000010722.
HOGENOMiHOG000007799.
HOVERGENiHBG050527.
InParanoidiQ92624.
OMAiKLYNSVG.
OrthoDBiEOG790G0N.
PhylomeDBiQ92624.
TreeFamiTF314010.

Miscellaneous databases

ChiTaRSiAPPBP2. human.
GeneWikiiAPPBP2.
GenomeRNAii10513.
NextBioi39872.
PROiQ92624.
SOURCEiSearch...

Gene expression databases

BgeeiQ92624.
CleanExiHS_APPBP2.
ExpressionAtlasiQ92624. baseline and differential.
GenevisibleiQ92624. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein."
    Zheng P., Eastman J., Vande Pol S., Pimplikar S.W.
    Proc. Natl. Acad. Sci. U.S.A. 95:14745-14750(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH APP, SUBCELLULAR LOCATION.
    Tissue: Cervix carcinoma.
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus."
    Gao Y., Pimplikar S.W.
    Proc. Natl. Acad. Sci. U.S.A. 98:14979-14984(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEASOMAL DEGRADATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAPBP2_HUMAN
AccessioniPrimary (citable) accession number: Q92624
Secondary accession number(s): A8K862, O95095, Q8WVC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 22, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.