Q92624 (APBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Amyloid protein-binding protein 2

Alternative name(s):
Amyloid beta precursor protein-binding protein 2
Short name=APP-BP2
Protein interacting with APP tail 1

Gene names

Name:	APPBP2
Synonyms:	KIAA0228, PAT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	585 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. Ref.1
Subunit structure	Binds APP.
Subcellular location	Nucleus. Cytoplasm › cytoskeleton. Membrane; Peripheral membrane protein Potential. Note: Associated with membranes and microtubules. Ref.1 Ref.6
Post-translational modification	Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.
Sequence similarities	Contains 8 TPR repeats.
Sequence caution	The sequence BAA13217.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Cytoskeleton Membrane Microtubule Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat TPR repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transport Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytoplasmic vesicle membrane Inferred from direct assay Ref.1. Source: MGI microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Traceable author statement Ref.1. Source: ProtInc nucleus Non-traceable author statement Ref.6. Source: UniProtKB
Molecular_function	microtubule motor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
KIF6	Q6ZMV9	3	EBI-743771,EBI-751100
MUL1	Q969V5	3	EBI-743771,EBI-744120
NFYA	P23511	3	EBI-743771,EBI-389739
SLC22A6	Q4U2R8	3	EBI-743771,EBI-749741
SYT11	Q9BT88	3	EBI-743771,EBI-751770

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 585	585	Amyloid protein-binding protein 2		PRO_0000106259
Regions
	Repeat	50 – 83	34	TPR 1
	Repeat	120 – 153	34	TPR 2
	Repeat	206 – 239	34	TPR 3
	Repeat	288 – 321	34	TPR 4
	Repeat	333 – 367	35	TPR 5
	Repeat	429 – 462	34	TPR 6
	Repeat	471 – 505	35	TPR 7
	Repeat	514 – 547	34	TPR 8
Natural variations
	Natural variant	561	1	S → N. Corresponds to variant rs34146848 [ dbSNP | Ensembl ].		VAR_052606
Experimental info
	Sequence conflict	296	1	F → L in AAC83973. Ref.1
	Sequence conflict	325	1	K → R in AAC83973. Ref.1
	Sequence conflict	340	1	S → C in AAC83973. Ref.1
	Sequence conflict	354	1	L → V in AAC83973. Ref.1
	Sequence conflict	369	1	P → R in AAC83973. Ref.1
	Sequence conflict	542	1	N → K in AAC83973. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q92624 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 849A120807DA2438	FASTA	585	66,853
	10 20 30 40 50 60 MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ GRLCQLGSEF 70 80 90 100 110 120 CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS FSRRCSYIAE SDAAVKEKAI 130 140 150 160 170 180 QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC TLHDEMLHWF RAVECCVRLL HVRNGNCKYH 190 200 210 220 230 240 LGEETFKLAQ TYMDKLSKHG QQANKAALYG ELCALLFAKS HYDEAYKWCI EAMKEITAGL 250 260 270 280 290 300 PVKVVVDVLR QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN 310 320 330 340 350 360 VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF DNALFHAERA 370 380 390 400 410 420 IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ RLLQEAHDLH LSSLQLAKKA 430 440 450 460 470 480 FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE MHIKAIQIKE QLLGQEDYEV ALSVGHLASL 490 500 510 520 530 540 YNYDMNQYEN AEKLYLRSIA IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL 550 560 570 580 SNWNRLRDRQ YSVTDALEDV STSPQSTEEV VQSFLISQNV EGPSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein." Zheng P., Eastman J., Vande Pol S., Pimplikar S.W. Proc. Natl. Acad. Sci. U.S.A. 95:14745-14750(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH APP, SUBCELLULAR LOCATION. Tissue: Cervix carcinoma.
[2]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[6]	"The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus." Gao Y., Pimplikar S.W. Proc. Natl. Acad. Sci. U.S.A. 98:14979-14984(2001) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEASOMAL DEGRADATION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF017782 mRNA. Translation: AAC83973.1. D86981 mRNA. Translation: BAA13217.1. Different initiation. AK292227 mRNA. Translation: BAF84916.1. CH471179 Genomic DNA. Translation: EAW51406.1. BC018121 mRNA. Translation: AAH18121.1.
IPI	IPI00007393.
RefSeq	NP_006371.2. NM_006380.2.
UniGene	Hs.84084.
3D structure databases
ProteinModelPortal	Q92624.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92624. 23 interactions.
MINT	MINT-1443955.
STRING	9606.ENSP00000083182.
PTM databases
PhosphoSite	Q92624.
Polymorphism databases
DMDM	50400598.
Proteomic databases
PaxDb	Q92624.
PRIDE	Q92624.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000083182; ENSP00000083182; ENSG00000062725.
GeneID	10513.
KEGG	hsa:10513.
UCSC	uc002iys.1. human.
Organism-specific databases
CTD	10513.
GeneCards	GC17M058520.
HGNC	HGNC:622. APPBP2.
MIM	605324. gene.
neXtProt	NX_Q92624.
PharmGKB	PA24912.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0457.
HOGENOM	HOG000007799.
HOVERGEN	HBG050527.
InParanoid	Q92624.
OMA	KLYNSVG.
OrthoDB	EOG451DQ8.
Enzyme and pathway databases
Pathway_Interaction_DB	ar_tf_pathway. Regulation of Androgen receptor activity.
Gene expression databases
Bgee	Q92624.
CleanEx	HS_APPBP2.
Genevestigator	Q92624.
GermOnline	ENSG00000062725. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.10. 2 hits.
InterPro	IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
PROSITE	PS50005. TPR. 2 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	APPBP2. human.
GenomeRNAi	10513.
NextBio	39872.
SOURCE	Search...

Entry information

Entry name

APBP2_HUMAN

Accession

Primary (citable) accession number: Q92624
Secondary accession number(s): A8K862, O95095, Q8WVC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.