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Q92624 (APBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amyloid protein-binding protein 2
Alternative name(s):
Amyloid beta precursor protein-binding protein 2
Short name=APP-BP2
Protein interacting with APP tail 1
Gene names
Name:APPBP2
Synonyms:KIAA0228, PAT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. Ref.1

Subunit structure

Binds APP.

Subcellular location

Nucleus. Cytoplasmcytoskeleton. Membrane; Peripheral membrane protein Potential. Note: Associated with membranes and microtubules. Ref.1 Ref.6

Post-translational modification

Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.

Sequence similarities

Contains 8 TPR repeats.

Sequence caution

The sequence BAA13217.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585Amyloid protein-binding protein 2
PRO_0000106259

Regions

Repeat50 – 8334TPR 1
Repeat120 – 15334TPR 2
Repeat206 – 23934TPR 3
Repeat288 – 32134TPR 4
Repeat333 – 36735TPR 5
Repeat429 – 46234TPR 6
Repeat471 – 50535TPR 7
Repeat514 – 54734TPR 8

Natural variations

Natural variant5611S → N.
Corresponds to variant rs34146848 [ dbSNP | Ensembl ].
VAR_052606

Experimental info

Sequence conflict2961F → L in AAC83973. Ref.1
Sequence conflict3251K → R in AAC83973. Ref.1
Sequence conflict3401S → C in AAC83973. Ref.1
Sequence conflict3541L → V in AAC83973. Ref.1
Sequence conflict3691P → R in AAC83973. Ref.1
Sequence conflict5421N → K in AAC83973. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q92624 [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: 849A120807DA2438

FASTA58566,853
        10         20         30         40         50         60 
MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ GRLCQLGSEF 

        70         80         90        100        110        120 
CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS FSRRCSYIAE SDAAVKEKAI 

       130        140        150        160        170        180 
QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC TLHDEMLHWF RAVECCVRLL HVRNGNCKYH 

       190        200        210        220        230        240 
LGEETFKLAQ TYMDKLSKHG QQANKAALYG ELCALLFAKS HYDEAYKWCI EAMKEITAGL 

       250        260        270        280        290        300 
PVKVVVDVLR QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN 

       310        320        330        340        350        360 
VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF DNALFHAERA 

       370        380        390        400        410        420 
IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ RLLQEAHDLH LSSLQLAKKA 

       430        440        450        460        470        480 
FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE MHIKAIQIKE QLLGQEDYEV ALSVGHLASL 

       490        500        510        520        530        540 
YNYDMNQYEN AEKLYLRSIA IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL 

       550        560        570        580 
SNWNRLRDRQ YSVTDALEDV STSPQSTEEV VQSFLISQNV EGPSC 

« Hide

References

« Hide 'large scale' references
[1]"PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein."
Zheng P., Eastman J., Vande Pol S., Pimplikar S.W.
Proc. Natl. Acad. Sci. U.S.A. 95:14745-14750(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH APP, SUBCELLULAR LOCATION.
Tissue: Cervix carcinoma.
[2]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[6]"The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus."
Gao Y., Pimplikar S.W.
Proc. Natl. Acad. Sci. U.S.A. 98:14979-14984(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEASOMAL DEGRADATION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF017782 mRNA. Translation: AAC83973.1.
D86981 mRNA. Translation: BAA13217.1. Different initiation.
AK292227 mRNA. Translation: BAF84916.1.
CH471179 Genomic DNA. Translation: EAW51406.1.
BC018121 mRNA. Translation: AAH18121.1.
CCDSCCDS32699.1.
RefSeqNP_001269405.1. NM_001282476.1.
NP_006371.2. NM_006380.3.
UniGeneHs.84084.

3D structure databases

ProteinModelPortalQ92624.
SMRQ92624. Positions 342-507.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115769. 29 interactions.
IntActQ92624. 23 interactions.
MINTMINT-1443955.
STRING9606.ENSP00000083182.

PTM databases

PhosphoSiteQ92624.

Polymorphism databases

DMDM50400598.

Proteomic databases

MaxQBQ92624.
PaxDbQ92624.
PRIDEQ92624.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000083182; ENSP00000083182; ENSG00000062725.
GeneID10513.
KEGGhsa:10513.
UCSCuc002iys.1. human.

Organism-specific databases

CTD10513.
GeneCardsGC17M058520.
HGNCHGNC:622. APPBP2.
MIM605324. gene.
neXtProtNX_Q92624.
PharmGKBPA24912.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0457.
HOGENOMHOG000007799.
HOVERGENHBG050527.
InParanoidQ92624.
OMAKLYNSVG.
OrthoDBEOG790G0N.
PhylomeDBQ92624.
TreeFamTF314010.

Gene expression databases

ArrayExpressQ92624.
BgeeQ92624.
CleanExHS_APPBP2.
GenevestigatorQ92624.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
InterProIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PROSITEPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPPBP2. human.
GeneWikiAPPBP2.
GenomeRNAi10513.
NextBio39872.
PROQ92624.
SOURCESearch...

Entry information

Entry nameAPBP2_HUMAN
AccessionPrimary (citable) accession number: Q92624
Secondary accession number(s): A8K862, O95095, Q8WVC9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM