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Q92624

- APBP2_HUMAN

UniProt

Q92624 - APBP2_HUMAN

Protein

Amyloid protein-binding protein 2

Gene

APPBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.1 Publication

    GO - Molecular functioni

    1. microtubule motor activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. intracellular protein transport Source: ProtInc
    2. intracellular transport Source: MGI
    3. metabolic process Source: GOC

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amyloid protein-binding protein 2
    Alternative name(s):
    Amyloid beta precursor protein-binding protein 2
    Short name:
    APP-BP2
    Protein interacting with APP tail 1
    Gene namesi
    Name:APPBP2
    Synonyms:KIAA0228, PAT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:622. APPBP2.

    Subcellular locationi

    Nucleus. Cytoplasmcytoskeleton. Membrane Curated; Peripheral membrane protein Curated
    Note: Associated with membranes and microtubules.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoplasmic vesicle membrane Source: MGI
    3. microtubule Source: UniProtKB-KW
    4. microtubule associated complex Source: ProtInc
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24912.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585Amyloid protein-binding protein 2PRO_0000106259Add
    BLAST

    Post-translational modificationi

    Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.

    Proteomic databases

    MaxQBiQ92624.
    PaxDbiQ92624.
    PRIDEiQ92624.

    PTM databases

    PhosphoSiteiQ92624.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92624.
    BgeeiQ92624.
    CleanExiHS_APPBP2.
    GenevestigatoriQ92624.

    Interactioni

    Subunit structurei

    Binds APP.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KIF6Q6ZMV93EBI-743771,EBI-751100
    MUL1Q969V53EBI-743771,EBI-744120
    NFYAP235113EBI-743771,EBI-389739
    SLC22A6Q4U2R83EBI-743771,EBI-749741
    SYT11Q9BT883EBI-743771,EBI-751770

    Protein-protein interaction databases

    BioGridi115769. 29 interactions.
    IntActiQ92624. 23 interactions.
    MINTiMINT-1443955.
    STRINGi9606.ENSP00000083182.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92624.
    SMRiQ92624. Positions 342-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati50 – 8334TPR 1Add
    BLAST
    Repeati120 – 15334TPR 2Add
    BLAST
    Repeati206 – 23934TPR 3Add
    BLAST
    Repeati288 – 32134TPR 4Add
    BLAST
    Repeati333 – 36735TPR 5Add
    BLAST
    Repeati429 – 46234TPR 6Add
    BLAST
    Repeati471 – 50535TPR 7Add
    BLAST
    Repeati514 – 54734TPR 8Add
    BLAST

    Sequence similaritiesi

    Contains 8 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOGENOMiHOG000007799.
    HOVERGENiHBG050527.
    InParanoidiQ92624.
    OMAiKLYNSVG.
    OrthoDBiEOG790G0N.
    PhylomeDBiQ92624.
    TreeFamiTF314010.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view]
    PROSITEiPS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92624-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ    50
    GRLCQLGSEF CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS 100
    FSRRCSYIAE SDAAVKEKAI QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC 150
    TLHDEMLHWF RAVECCVRLL HVRNGNCKYH LGEETFKLAQ TYMDKLSKHG 200
    QQANKAALYG ELCALLFAKS HYDEAYKWCI EAMKEITAGL PVKVVVDVLR 250
    QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN 300
    VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF 350
    DNALFHAERA IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ 400
    RLLQEAHDLH LSSLQLAKKA FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE 450
    MHIKAIQIKE QLLGQEDYEV ALSVGHLASL YNYDMNQYEN AEKLYLRSIA 500
    IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL SNWNRLRDRQ 550
    YSVTDALEDV STSPQSTEEV VQSFLISQNV EGPSC 585
    Length:585
    Mass (Da):66,853
    Last modified:July 19, 2004 - v2
    Checksum:i849A120807DA2438
    GO

    Sequence cautioni

    The sequence BAA13217.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti296 – 2961F → L in AAC83973. (PubMed:9843960)Curated
    Sequence conflicti325 – 3251K → R in AAC83973. (PubMed:9843960)Curated
    Sequence conflicti340 – 3401S → C in AAC83973. (PubMed:9843960)Curated
    Sequence conflicti354 – 3541L → V in AAC83973. (PubMed:9843960)Curated
    Sequence conflicti369 – 3691P → R in AAC83973. (PubMed:9843960)Curated
    Sequence conflicti542 – 5421N → K in AAC83973. (PubMed:9843960)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti561 – 5611S → N.
    Corresponds to variant rs34146848 [ dbSNP | Ensembl ].
    VAR_052606

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017782 mRNA. Translation: AAC83973.1.
    D86981 mRNA. Translation: BAA13217.1. Different initiation.
    AK292227 mRNA. Translation: BAF84916.1.
    CH471179 Genomic DNA. Translation: EAW51406.1.
    BC018121 mRNA. Translation: AAH18121.1.
    CCDSiCCDS32699.1.
    RefSeqiNP_001269405.1. NM_001282476.1.
    NP_006371.2. NM_006380.3.
    UniGeneiHs.84084.

    Genome annotation databases

    EnsembliENST00000083182; ENSP00000083182; ENSG00000062725.
    GeneIDi10513.
    KEGGihsa:10513.
    UCSCiuc002iys.1. human.

    Polymorphism databases

    DMDMi50400598.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017782 mRNA. Translation: AAC83973.1 .
    D86981 mRNA. Translation: BAA13217.1 . Different initiation.
    AK292227 mRNA. Translation: BAF84916.1 .
    CH471179 Genomic DNA. Translation: EAW51406.1 .
    BC018121 mRNA. Translation: AAH18121.1 .
    CCDSi CCDS32699.1.
    RefSeqi NP_001269405.1. NM_001282476.1.
    NP_006371.2. NM_006380.3.
    UniGenei Hs.84084.

    3D structure databases

    ProteinModelPortali Q92624.
    SMRi Q92624. Positions 342-507.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115769. 29 interactions.
    IntActi Q92624. 23 interactions.
    MINTi MINT-1443955.
    STRINGi 9606.ENSP00000083182.

    PTM databases

    PhosphoSitei Q92624.

    Polymorphism databases

    DMDMi 50400598.

    Proteomic databases

    MaxQBi Q92624.
    PaxDbi Q92624.
    PRIDEi Q92624.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000083182 ; ENSP00000083182 ; ENSG00000062725 .
    GeneIDi 10513.
    KEGGi hsa:10513.
    UCSCi uc002iys.1. human.

    Organism-specific databases

    CTDi 10513.
    GeneCardsi GC17M058520.
    HGNCi HGNC:622. APPBP2.
    MIMi 605324. gene.
    neXtProti NX_Q92624.
    PharmGKBi PA24912.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0457.
    HOGENOMi HOG000007799.
    HOVERGENi HBG050527.
    InParanoidi Q92624.
    OMAi KLYNSVG.
    OrthoDBi EOG790G0N.
    PhylomeDBi Q92624.
    TreeFami TF314010.

    Miscellaneous databases

    ChiTaRSi APPBP2. human.
    GeneWikii APPBP2.
    GenomeRNAii 10513.
    NextBioi 39872.
    PROi Q92624.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92624.
    Bgeei Q92624.
    CleanExi HS_APPBP2.
    Genevestigatori Q92624.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PROSITEi PS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein."
      Zheng P., Eastman J., Vande Pol S., Pimplikar S.W.
      Proc. Natl. Acad. Sci. U.S.A. 95:14745-14750(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH APP, SUBCELLULAR LOCATION.
      Tissue: Cervix carcinoma.
    2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    6. "The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus."
      Gao Y., Pimplikar S.W.
      Proc. Natl. Acad. Sci. U.S.A. 98:14979-14984(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEASOMAL DEGRADATION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAPBP2_HUMAN
    AccessioniPrimary (citable) accession number: Q92624
    Secondary accession number(s): A8K862, O95095, Q8WVC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3