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Protein

Tetratricopeptide repeat protein 9A

Gene

TTC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133985-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 9A
Short name:
TPR repeat protein 9A
Gene namesi
Name:TTC9
Synonyms:KIAA0227, TTC9A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20267. TTC9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi23508.
OpenTargetsiENSG00000133985.
PharmGKBiPA134905515.

Polymorphism and mutation databases

BioMutaiTTC9.
DMDMi296453008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063901 – 222Tetratricopeptide repeat protein 9AAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92623.
MaxQBiQ92623.
PaxDbiQ92623.
PeptideAtlasiQ92623.
PRIDEiQ92623.

PTM databases

iPTMnetiQ92623.
PhosphoSitePlusiQ92623.

Expressioni

Gene expression databases

BgeeiENSG00000133985.
CleanExiHS_TTC9.
ExpressionAtlasiQ92623. baseline and differential.
GenevisibleiQ92623. HS.

Organism-specific databases

HPAiHPA047082.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256367.

Structurei

3D structure databases

ProteinModelPortaliQ92623.
SMRiQ92623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 89TPR 1Add BLAST34
Repeati125 – 160TPR 2Add BLAST36
Repeati161 – 194TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the TTC9 family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IWRH. Eukaryota.
ENOG4111HXI. LUCA.
GeneTreeiENSGT00390000016022.
HOGENOMiHOG000012996.
HOVERGENiHBG062451.
InParanoidiQ92623.
OMAiCHGRHEA.
OrthoDBiEOG091G0WNS.
PhylomeDBiQ92623.
TreeFamiTF331917.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKGSAAGA KGNPSPPAAG EGQRPPPPLC VPGGGGGAPA RGQVGAAAEP
60 70 80 90 100
AELIRRAHEF KSQGAQCYKD KKFREAIGKY HRALLELKGL LPPPGERERD
110 120 130 140 150
SRPASPAGAL KPGRLSEEQS KTVEAIEIDC YNSLAACLLQ AELVNYERVK
160 170 180 190 200
EYCLKVLKKE GENFKALYRS GVAFYHLGDY DKALYYLKEA RTQQPTDTNV
210 220
IRYIQLTEMK LSRCSQREKE AM
Length:222
Mass (Da):24,379
Last modified:May 18, 2010 - v3
Checksum:i0D003880776EA85F
GO

Sequence cautioni

The sequence AAH47950 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA13216 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060330103P → A.Combined sources2 PublicationsCorresponds to variant rs4902834dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86980 mRNA. Translation: BAA13216.1. Different initiation.
AC004816 Genomic DNA. No translation available.
AL357153 Genomic DNA. No translation available.
BC047950 mRNA. Translation: AAH47950.1. Different initiation.
CCDSiCCDS45132.1.
RefSeqiNP_056166.1. NM_015351.1.
UniGeneiHs.79170.

Genome annotation databases

EnsembliENST00000256367; ENSP00000256367; ENSG00000133985.
GeneIDi23508.
KEGGihsa:23508.
UCSCiuc001xmi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86980 mRNA. Translation: BAA13216.1. Different initiation.
AC004816 Genomic DNA. No translation available.
AL357153 Genomic DNA. No translation available.
BC047950 mRNA. Translation: AAH47950.1. Different initiation.
CCDSiCCDS45132.1.
RefSeqiNP_056166.1. NM_015351.1.
UniGeneiHs.79170.

3D structure databases

ProteinModelPortaliQ92623.
SMRiQ92623.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256367.

PTM databases

iPTMnetiQ92623.
PhosphoSitePlusiQ92623.

Polymorphism and mutation databases

BioMutaiTTC9.
DMDMi296453008.

Proteomic databases

EPDiQ92623.
MaxQBiQ92623.
PaxDbiQ92623.
PeptideAtlasiQ92623.
PRIDEiQ92623.

Protocols and materials databases

DNASUi23508.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256367; ENSP00000256367; ENSG00000133985.
GeneIDi23508.
KEGGihsa:23508.
UCSCiuc001xmi.2. human.

Organism-specific databases

CTDi23508.
DisGeNETi23508.
GeneCardsiTTC9.
H-InvDBHIX0011778.
HGNCiHGNC:20267. TTC9.
HPAiHPA047082.
MIMi610488. gene.
neXtProtiNX_Q92623.
OpenTargetsiENSG00000133985.
PharmGKBiPA134905515.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWRH. Eukaryota.
ENOG4111HXI. LUCA.
GeneTreeiENSGT00390000016022.
HOGENOMiHOG000012996.
HOVERGENiHBG062451.
InParanoidiQ92623.
OMAiCHGRHEA.
OrthoDBiEOG091G0WNS.
PhylomeDBiQ92623.
TreeFamiTF331917.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133985-MONOMER.

Miscellaneous databases

GenomeRNAii23508.
PROiQ92623.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133985.
CleanExiHS_TTC9.
ExpressionAtlasiQ92623. baseline and differential.
GenevisibleiQ92623. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC9A_HUMAN
AccessioniPrimary (citable) accession number: Q92623
Secondary accession number(s): Q86WT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.