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Reviewed, UniProtKB/Swiss-Prot Q92621 (NU205_HUMAN)

Last modified December 15, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Nuclear pore complex protein Nup205
Alternative name(s):
    Nucleoporin Nup205
    205 kDa nucleoporin
Gene names
Name: NUP205
Synonyms: C7orf14, KIAA0225
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length2012 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subunit structure

Interacts with NUP93 and NUP35/NUP53. Ref.4

Subcellular location

Nucleus › nuclear pore complex Potential.

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Ontologies

Keywords
   Biological processProtein transport
Translocation
Transport
mRNA transport
   Cellular componentNuclear pore complex
Nucleus
   Coding sequence diversityPolymorphism
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processmRNA transport

Inferred from electronic annotation. Source: UniProtKB-KW

protein import into nucleus, docking Ref.3

Traceable author statement. Source: UniProtKB

transmembrane transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnuclear pore Ref.3

Non-traceable author statement. Source: UniProtKB

   Molecular functionprotein binding Ref.3

Inferred from physical interaction. Source: UniProtKB

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

MAGED1Q9Y5V31EBI-1045046,EBI-716006
PHB2Q996231EBI-1045046,EBI-358348
PHLDA3Q9Y5J51EBI-1045046,EBI-1055859

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 20122011Nuclear pore complex protein Nup205
PRO_0000204859

Amino acid modifications

Modified residue21N-acetylalanine Ref.8
Modified residue31Phosphothreonine Ref.6
Modified residue11651Phosphoserine Ref.5
Modified residue19391Phosphoserine Ref.6 Ref.9
Modified residue19421Phosphoserine Ref.9

Natural variations

Natural variant331P → S: dbSNP rs7797639.
VAR_050567
Natural variant13561Q → E: dbSNP rs7810767.
VAR_050568

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Sequences

Sequence LengthMass (Da)Tools
Q92621-1 [UniParc].

Last modified January 16, 2004. Version 2.
Checksum: FF92FCE40E723F16

FASTA2,012227,921
        10         20         30         40         50         60 
MATPLAVNSA ASLWGPYKDI WHKVGNALWR RQPEAVHLLD KILKKHKPDF ISLFKNPPKN 

        70         80         90        100        110        120 
VQQHEKVQKA STEGVAIQGQ QGTRLLPEQL IKEAFILSDL FDIGELAAVE LLLAGEHQQP 

       130        140        150        160        170        180 
HFPGLTRGLV AVLLYWDGKR CIANSLKALI QSRRGKTWTL ELSPELASMT TRFTDELMEQ 

       190        200        210        220        230        240 
GLTYKVLTLV SQIDVNNEFE KLQRERGLGS EKHRKEVSDL IKECRQSLAE SLFAWACQSP 

       250        260        270        280        290        300 
LGKEDTLLLI GHLERVTVEA NGSLDAVNLA LLMALLYCFD ISFIEQSTEE RDDMIHQLPL 

       310        320        330        340        350        360 
LTEKQYIATI HSRLQDSQLW KLPGLQATVR LAWALALRGI SQLPDVTALA EFTEADEAMA 

       370        380        390        400        410        420 
ELAIADNVFL FLMESVVVSE YFYQEEFYIR RVHNLITDFL ALMPMKVKQL RNRADEDARM 

       430        440        450        460        470        480 
IHMSMQMGNE PPISLRRDLE HLMLLIGELY KKNPFHLELA LEYWCPTEPL QTPTIMGSYL 

       490        500        510        520        530        540 
GVAHQRPPQR QVVLSKFVRQ MGDLLPPTIY IPYLKMLQGL ANGPQCAHYC FSLLKVNGSS 

       550        560        570        580        590        600 
HVENIQGAGG SPVSWEHFFH SLMLYHEHLR KDLPSADSVQ YRHLPSRGIT QKEQDGLIAF 

       610        620        630        640        650        660 
LQLTSTIITW SENARLALCE HPQWTPVVVI LGLLQCSIPP VLKAELLKTL AAFGKSPEIA 

       670        680        690        700        710        720 
ASLWQSLEYT QILQTVRIPS QRQAIGIEVE LNEIESRCEE YPLTRAFCQL ISTLVESSFP 

       730        740        750        760        770        780 
SNLGAGLRPP GFDPYLQFLR DSVFLRFRTR AYRRAAEKWE VAEVVLEVFY KLLRDYEPQL 

       790        800        810        820        830        840 
EDFVDQFVEL QGEEIIAYKP PGFSLMYHLL NESPMLELAL SLLEEGVKQL DTYAPFPGKK 

       850        860        870        880        890        900 
HLEKAVQHCL ALLNLTLQKE NLFMDLLRES QLALIVCPLE QLLQGINPRT KKADNVVNIA 

       910        920        930        940        950        960 
RYLYHGNTNP ELAFESAKIL CCISCNSNIQ IKLVGDFTHD QSISQKLMAG FVECLDCEDA 

       970        980        990       1000       1010       1020 
EEFVRLEEGS ELEKKLVAIR HETRIHILNL LITSLECNPP NLALYLLGFE LKKPVSTTNL 

      1030       1040       1050       1060       1070       1080 
QDPGVLGCPR TCLHAILNIL EKGTEGRTGP VAVRESPQLA ELCYQVIYQL CACSDTSGPT 

      1090       1100       1110       1120       1130       1140 
MRYLRTSQDF LFSQLQYLPF SNKEYEISML NQMSWLMKTA SIELRVTSLN RQRSHTQRLL 

      1150       1160       1170       1180       1190       1200 
HLLLDDMPVK PYSDGEGGIE DENRSVSGFL HFDTATKVRR KILNILDSID FSQEIPEPLQ 

      1210       1220       1230       1240       1250       1260 
LDFFDRAQIE QVIANCEHKN LRGQTVCNVK LLHRVLVAEV NALQGMAAIG QRPLLMEEIS 

      1270       1280       1290       1300       1310       1320 
TVLQYVVGRN KLLQCLHAKR HALESWRQLV EIILTACPQD LIQAEDRQLI IRDILQDVHD 

      1330       1340       1350       1360       1370       1380 
KILDDEAAQE LMPVVAGAVF TLTAHLSQAV LTEQKQTSVL GPAEAHYAFM LDSCFTSPPP 

      1390       1400       1410       1420       1430       1440 
EENPLVGFAS IGDSSLYIIL KKLLDFILKT GGGFQRVRTH LYGSLLYYLQ IAQRPDEPDT 

      1450       1460       1470       1480       1490       1500 
LEAAKKTMWE RLTAPEDVFS KLQRENIAII ESYGAALMEV VCRDACDGHE IGRMLALALL 

      1510       1520       1530       1540       1550       1560 
DRIVSVDKQQ QWLLYLSNSG YLKVLVDSLV EDDRTLQSLL TPQPPLLKAL YTYESKMAFL 

      1570       1580       1590       1600       1610       1620 
TRVAKIQQGA LELLRSGVIV RLAQCQVYDM RPETDPQSMF GMRDPPMFIP TPVDRYRQIL 

      1630       1640       1650       1660       1670       1680 
LPALQLCQVI LTSSMAQHLQ AAGQVLQFLI SHSDTIQAIL RCQDVSAGSL QELALLTGII 

      1690       1700       1710       1720       1730       1740 
SKAALPGILS ELDVDVNEGS LMELQGHIGR FQRQCLGLLS RFGGSDRLRQ FKFQDDNVEG 

      1750       1760       1770       1780       1790       1800 
DKVSKKDEIE LAMQQICANV MEYCQSLMLQ SSPTFQHAVC LFTPSLSETV NRDGPRQDTQ 

      1810       1820       1830       1840       1850       1860 
APVVPYWRLP GLGIIIYLLK QSANDFFSYY DSHRQSVSKL QNVEQLPPDE IKELCQSVMP 

      1870       1880       1890       1900       1910       1920 
AGVDKISTAQ KYVLARRRLV KVINNRAKLL SLCSFIIETC LFILWRHLEY YLLHCMPTDS 

      1930       1940       1950       1960       1970       1980 
QDSLFASRTL FKSRRLQDSF ASETNLDFRS GLAIVSQHDL DQLQADAINA FGESLQKKLL 

      1990       2000       2010 
DIEGLYSKVR SRYSFIQALV RRIRGLLRIS RN

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References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1181-2012.
Tissue: Skin.
[3]"Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly."
Grandi P., Dang T., Pane N., Shevchenko A., Mann M., Forbes D., Hurt E.
Mol. Biol. Cell 8:2017-2038(1997) [PubMed: 9348540] [Abstract]
Cited for: PROTEIN SEQUENCE OF 85-92; 572-581; 1452-1461 AND 1494-1502, CHARACTERIZATION.
[4]"Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex."
Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W.
Mol. Biol. Cell 16:2382-2394(2005) [PubMed: 15703211] [Abstract]
Cited for: INTERACTION WITH NUP35.
[5]"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis."
Wang B., Malik R., Nigg E.A., Korner R.
Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1165, MASS SPECTROMETRY.
[6]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3 AND SER-1939, MASS SPECTROMETRY.
[7]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY.
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939 AND SER-1942, MASS SPECTROMETRY.
Tissue: T-cell.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D86978 mRNA. Translation: BAA13214.1. Different initiation.
BC044255 mRNA. Translation: AAH44255.1.
IPIIPI00783781.
RefSeqNP_055950.1.
UniGeneHs.632299

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ92621. 6 interactions.
STRINGQ92621.

PTM databases

PhosphoSiteQ92621.

Proteomic databases

PRIDEQ92621.

Genome annotation databases

EnsemblENST00000285968; ENSP00000285968; ENSG00000155561; Homo sapiens. [Genome view]
GeneID23165.
KEGGhsa:23165.
UCSCuc003vsw.1. human.

Organism-specific databases

CTD23165.
GeneCardsGC07P134893.
HGNCHGNC:18658. NUP205.
HPAHPA024574.
PharmGKBPA38624.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG713607.
HOVERGENQ92621.
InParanoidQ92621.

Enzyme and pathway databases

ReactomeREACT_6185. HIV Infection.

Gene expression databases

ArrayExpressQ92621.
BgeeQ92621.
CleanExHS_NUP205.
GenevestigatorQ92621.
GermOnlineENSG00000155561. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio44556.

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Entry information

Entry nameNU205_HUMAN
AccessionPrimary (citable) accession number: Q92621
Secondary accession number(s): Q86YC1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: December 15, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents