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Q92621

- NU205_HUMAN

UniProt

Q92621 - NU205_HUMAN

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Protein

Nuclear pore complex protein Nup205

Gene
NUP205, C7orf14, KIAA0225
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. structural constituent of nuclear pore Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. cytokine-mediated signaling pathway Source: Reactome
  3. glucose transport Source: Reactome
  4. hexose transport Source: Reactome
  5. mitotic cell cycle Source: Reactome
  6. mitotic nuclear envelope disassembly Source: Reactome
  7. mRNA transport Source: UniProtKB-KW
  8. nuclear pore complex assembly Source: UniProtKB
  9. nucleocytoplasmic transport Source: UniProtKB
  10. protein import into nucleus, docking Source: UniProtKB
  11. regulation of glucose transport Source: Reactome
  12. small molecule metabolic process Source: Reactome
  13. transmembrane transport Source: Reactome
  14. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup205
Alternative name(s):
205 kDa nucleoporin
Nucleoporin Nup205
Gene namesi
Name:NUP205
Synonyms:C7orf14, KIAA0225
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:18658. NUP205.

Subcellular locationi

Nucleus membrane; Peripheral membrane protein. Nucleusnuclear pore complex
Note: Localized near the center, on both the cytoplasmic and nuclear side, of the NPC core structure.2 Publications

GO - Cellular componenti

  1. nuclear envelope Source: Reactome
  2. nuclear membrane Source: UniProtKB
  3. nuclear periphery Source: UniProtKB
  4. nuclear pore Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 20122011Nuclear pore complex protein Nup205PRO_0000204859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei3 – 31Phosphothreonine1 Publication
Modified residuei1939 – 19391Phosphoserine3 Publications
Modified residuei1942 – 19421Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ92621.
PaxDbiQ92621.
PRIDEiQ92621.

PTM databases

PhosphoSiteiQ92621.

Expressioni

Gene expression databases

ArrayExpressiQ92621.
BgeeiQ92621.
CleanExiHS_NUP205.
GenevestigatoriQ92621.

Organism-specific databases

HPAiHPA024574.

Interactioni

Subunit structurei

Part of the nuclear pore complex (NPC). Forms a complex with NUP53, NUP93, NUP155 and lamin B. Does not interact with TPR.2 Publications

Protein-protein interaction databases

BioGridi116777. 29 interactions.
IntActiQ92621. 12 interactions.
MINTiMINT-2813123.
STRINGi9606.ENSP00000285968.

Structurei

3D structure databases

ProteinModelPortaliQ92621.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG317247.
HOGENOMiHOG000044863.
HOVERGENiHBG052682.
InParanoidiQ92621.
KOiK14310.
OMAiVECLDNE.
OrthoDBiEOG715Q36.
PhylomeDBiQ92621.
TreeFamiTF313397.

Family and domain databases

InterProiIPR021827. Nup186/Nup192/Nup205.
[Graphical view]
PfamiPF11894. DUF3414. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92621-1 [UniParc]FASTAAdd to Basket

« Hide

MATPLAVNSA ASLWGPYKDI WHKVGNALWR RQPEAVHLLD KILKKHKPDF     50
ISLFKNPPKN VQQHEKVQKA STEGVAIQGQ QGTRLLPEQL IKEAFILSDL 100
FDIGELAAVE LLLAGEHQQP HFPGLTRGLV AVLLYWDGKR CIANSLKALI 150
QSRRGKTWTL ELSPELASMT TRFTDELMEQ GLTYKVLTLV SQIDVNNEFE 200
KLQRERGLGS EKHRKEVSDL IKECRQSLAE SLFAWACQSP LGKEDTLLLI 250
GHLERVTVEA NGSLDAVNLA LLMALLYCFD ISFIEQSTEE RDDMIHQLPL 300
LTEKQYIATI HSRLQDSQLW KLPGLQATVR LAWALALRGI SQLPDVTALA 350
EFTEADEAMA ELAIADNVFL FLMESVVVSE YFYQEEFYIR RVHNLITDFL 400
ALMPMKVKQL RNRADEDARM IHMSMQMGNE PPISLRRDLE HLMLLIGELY 450
KKNPFHLELA LEYWCPTEPL QTPTIMGSYL GVAHQRPPQR QVVLSKFVRQ 500
MGDLLPPTIY IPYLKMLQGL ANGPQCAHYC FSLLKVNGSS HVENIQGAGG 550
SPVSWEHFFH SLMLYHEHLR KDLPSADSVQ YRHLPSRGIT QKEQDGLIAF 600
LQLTSTIITW SENARLALCE HPQWTPVVVI LGLLQCSIPP VLKAELLKTL 650
AAFGKSPEIA ASLWQSLEYT QILQTVRIPS QRQAIGIEVE LNEIESRCEE 700
YPLTRAFCQL ISTLVESSFP SNLGAGLRPP GFDPYLQFLR DSVFLRFRTR 750
AYRRAAEKWE VAEVVLEVFY KLLRDYEPQL EDFVDQFVEL QGEEIIAYKP 800
PGFSLMYHLL NESPMLELAL SLLEEGVKQL DTYAPFPGKK HLEKAVQHCL 850
ALLNLTLQKE NLFMDLLRES QLALIVCPLE QLLQGINPRT KKADNVVNIA 900
RYLYHGNTNP ELAFESAKIL CCISCNSNIQ IKLVGDFTHD QSISQKLMAG 950
FVECLDCEDA EEFVRLEEGS ELEKKLVAIR HETRIHILNL LITSLECNPP 1000
NLALYLLGFE LKKPVSTTNL QDPGVLGCPR TCLHAILNIL EKGTEGRTGP 1050
VAVRESPQLA ELCYQVIYQL CACSDTSGPT MRYLRTSQDF LFSQLQYLPF 1100
SNKEYEISML NQMSWLMKTA SIELRVTSLN RQRSHTQRLL HLLLDDMPVK 1150
PYSDGEGGIE DENRSVSGFL HFDTATKVRR KILNILDSID FSQEIPEPLQ 1200
LDFFDRAQIE QVIANCEHKN LRGQTVCNVK LLHRVLVAEV NALQGMAAIG 1250
QRPLLMEEIS TVLQYVVGRN KLLQCLHAKR HALESWRQLV EIILTACPQD 1300
LIQAEDRQLI IRDILQDVHD KILDDEAAQE LMPVVAGAVF TLTAHLSQAV 1350
LTEQKETSVL GPAEAHYAFM LDSCFTSPPP EENPLVGFAS IGDSSLYIIL 1400
KKLLDFILKT GGGFQRVRTH LYGSLLYYLQ IAQRPDEPDT LEAAKKTMWE 1450
RLTAPEDVFS KLQRENIAII ESYGAALMEV VCRDACDGHE IGRMLALALL 1500
DRIVSVDKQQ QWLLYLSNSG YLKVLVDSLV EDDRTLQSLL TPQPPLLKAL 1550
YTYESKMAFL TRVAKIQQGA LELLRSGVIV RLAQCQVYDM RPETDPQSMF 1600
GMRDPPMFIP TPVDRYRQIL LPALQLCQVI LTSSMAQHLQ AAGQVLQFLI 1650
SHSDTIQAIL RCQDVSAGSL QELALLTGII SKAALPGILS ELDVDVNEGS 1700
LMELQGHIGR FQRQCLGLLS RFGGSDRLRQ FKFQDDNVEG DKVSKKDEIE 1750
LAMQQICANV MEYCQSLMLQ SSPTFQHAVC LFTPSLSETV NRDGPRQDTQ 1800
APVVPYWRLP GLGIIIYLLK QSANDFFSYY DSHRQSVSKL QNVEQLPPDE 1850
IKELCQSVMP AGVDKISTAQ KYVLARRRLV KVINNRAKLL SLCSFIIETC 1900
LFILWRHLEY YLLHCMPTDS QDSLFASRTL FKSRRLQDSF ASETNLDFRS 1950
GLAIVSQHDL DQLQADAINA FGESLQKKLL DIEGLYSKVR SRYSFIQALV 2000
RRIRGLLRIS RN 2012
Length:2,012
Mass (Da):227,922
Last modified:May 18, 2010 - v3
Checksum:iF3B268881000FBAA
GO

Sequence cautioni

The sequence BAA13214.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331P → S.
Corresponds to variant rs7797639 [ dbSNP | Ensembl ].
VAR_050567
Natural varianti1356 – 13561E → Q.3 Publications
Corresponds to variant rs7810767 [ dbSNP | Ensembl ].
VAR_050568

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86978 mRNA. Translation: BAA13214.1. Different initiation.
AC093107 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83855.1.
BC044255 mRNA. Translation: AAH44255.1.
BC136624 mRNA. Translation: AAI36625.1.
BC146784 mRNA. Translation: AAI46785.1.
CCDSiCCDS34759.1.
RefSeqiNP_055950.1. NM_015135.2.
UniGeneiHs.743250.

Genome annotation databases

EnsembliENST00000285968; ENSP00000285968; ENSG00000155561.
GeneIDi23165.
KEGGihsa:23165.
UCSCiuc003vsw.3. human.

Polymorphism databases

DMDMi296439283.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86978 mRNA. Translation: BAA13214.1 . Different initiation.
AC093107 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83855.1 .
BC044255 mRNA. Translation: AAH44255.1 .
BC136624 mRNA. Translation: AAI36625.1 .
BC146784 mRNA. Translation: AAI46785.1 .
CCDSi CCDS34759.1.
RefSeqi NP_055950.1. NM_015135.2.
UniGenei Hs.743250.

3D structure databases

ProteinModelPortali Q92621.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116777. 29 interactions.
IntActi Q92621. 12 interactions.
MINTi MINT-2813123.
STRINGi 9606.ENSP00000285968.

PTM databases

PhosphoSitei Q92621.

Polymorphism databases

DMDMi 296439283.

Proteomic databases

MaxQBi Q92621.
PaxDbi Q92621.
PRIDEi Q92621.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285968 ; ENSP00000285968 ; ENSG00000155561 .
GeneIDi 23165.
KEGGi hsa:23165.
UCSCi uc003vsw.3. human.

Organism-specific databases

CTDi 23165.
GeneCardsi GC07P135242.
HGNCi HGNC:18658. NUP205.
HPAi HPA024574.
MIMi 614352. gene.
neXtProti NX_Q92621.
PharmGKBi PA38624.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317247.
HOGENOMi HOG000044863.
HOVERGENi HBG052682.
InParanoidi Q92621.
KOi K14310.
OMAi VECLDNE.
OrthoDBi EOG715Q36.
PhylomeDBi Q92621.
TreeFami TF313397.

Enzyme and pathway databases

Reactomei REACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Miscellaneous databases

GeneWikii NUP205.
GenomeRNAii 23165.
NextBioi 44556.
PROi Q92621.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92621.
Bgeei Q92621.
CleanExi HS_NUP205.
Genevestigatori Q92621.

Family and domain databases

InterProi IPR021827. Nup186/Nup192/Nup205.
[Graphical view ]
Pfami PF11894. DUF3414. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-1356.
    Tissue: Bone marrow.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-1356.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-1356.
    Tissue: Skin.
  5. "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly."
    Grandi P., Dang T., Pane N., Shevchenko A., Mann M., Forbes D., Hurt E.
    Mol. Biol. Cell 8:2017-2038(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 85-92; 572-581; 1452-1461 AND 1494-1502, CHARACTERIZATION.
  6. "Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex."
    Hase M.E., Cordes V.C.
    Mol. Biol. Cell 14:1923-1940(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF INTERACTION WITH TPR, SUBCELLULAR LOCATION.
  7. "Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket."
    Krull S., Thyberg J., Bjorkroth B., Rackwitz H.R., Cordes V.C.
    Mol. Biol. Cell 15:4261-4277(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE NUCLEAR PORE COMPLEX, SUBCELLULAR LOCATION.
  8. "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex."
    Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W.
    Mol. Biol. Cell 16:2382-2394(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH LAMIN B; NUP53; NUP93 AND NUP155.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3 AND SER-1939, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939 AND SER-1942, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939 AND SER-1942, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNU205_HUMAN
AccessioniPrimary (citable) accession number: Q92621
Secondary accession number(s): A6H8X3, Q86YC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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