Q92619 (HMHA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Minor histocompatibility protein HA-1

Cleaved into the following chain:

1. Minor histocompatibility antigen HA-1
   Short name=mHag HA-1

Gene names

Name:	HMHA1
Synonyms:	KIAA0223

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1136 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTPase activator for the Rho-type GTPases Potential. Ref.10 Ref.11 Ref.13 Ref.15 Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. Ref.10 Ref.11 Ref.13 Ref.15
Subunit structure	HA-1 forms a complex with MHC class I HLA-A*0201.
Tissue specificity	Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cancerous and non-cancerous tissue. Ref.12 Ref.14
Polymorphism	The HA-1H allele is presented on the cell surface and recognized by CTL, whereas the HA-1R allele is poorly represented by HLA-A and non-immunogenic, although HA-1R allelic frequency is the highest.
Miscellaneous	Infusion of lymphocyte from mHag HA-1-negative donors results in a durable remission in mHag HA-1-positive patients with leukemia or multiple myeloma.
Sequence similarities	Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Rho-GAP domain.
Sequence caution	The sequence BAA13212.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92619-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92619-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MFSRKKRELMKTPSISKKNRAGSPSPQPSG → MSRGQRVLKG...CPRDLPLPPE

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1136	1136	Minor histocompatibility protein HA-1		PRO_0000330312
	Peptide	137 – 145	9	Minor histocompatibility antigen HA-1 Ref.9		PRO_0000330313
Regions
	Domain	761 – 974	214	Rho-GAP
	Zinc finger	702 – 747	46	Phorbol-ester/DAG-type
	Coiled coil	376 – 412	37	Potential
	Coiled coil	440 – 499	60	Potential
Amino acid modifications
	Modified residue	23	1	Phosphoserine Ref.16 Ref.19
	Modified residue	25	1	Phosphoserine Ref.16
	Modified residue	73	1	Phosphoserine Ref.19
	Modified residue	93	1	Phosphoserine Ref.19
	Modified residue	99	1	Phosphoserine Ref.18 Ref.19
	Modified residue	569	1	Phosphoserine Ref.18 Ref.19
	Modified residue	578	1	Phosphoserine By similarity
	Modified residue	619	1	Phosphoserine Ref.19
	Modified residue	1027	1	Phosphoserine By similarity
	Modified residue	1030	1	Phosphoserine By similarity
	Modified residue	1032	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 30	30	MFSRK…PQPSG → MSRGQRVLKGLLGWVCTWTW AWRARLGARGCGLHVLCPRD LPLPPE in isoform 2.		VSP_044707
	Natural variant	139	1	R → H in allele HA-1H; induction of CTL recognition for epitope HA-1. Ref.5 Ref.7 Ref.8 Ref.9 Ref.21 Ref.22 Corresponds to variant rs1801284 [ dbSNP | Ensembl ].		VAR_042693
	Natural variant	259	1	E → D. Ref.5 Corresponds to variant rs2074442 [ dbSNP | Ensembl ].		VAR_042694
	Natural variant	439	1	S → G. Ref.5 Corresponds to variant rs7251797 [ dbSNP | Ensembl ].		VAR_042695
	Natural variant	515	1	M → I. Corresponds to variant rs36084354 [ dbSNP | Ensembl ].		VAR_042696
	Natural variant	886	1	A → P. Corresponds to variant rs34569196 [ dbSNP | Ensembl ].		VAR_042697
Experimental info
	Sequence conflict	648	1	S → F in BAG62086. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 29, 2008. Version 2. Checksum: 9536787B3B1EE16D	FASTA	1,136	124,614
	10 20 30 40 50 60 MFSRKKRELM KTPSISKKNR AGSPSPQPSG ELPRKDGADA VFPGPSLEPP AGSSGVKATG 70 80 90 100 110 120 TLKRPTSLSR HASAAGFPLS GAASWTLGRS HRSPLTAASP GELPTEGAGP DVVEDISHLL 130 140 150 160 170 180 ADVARFAEGL EKLKECVLRD DLLEARRPRA HECLGEALRV MHQIISKYPL LNTVETLTAA 190 200 210 220 230 240 GTLIAKVKAF HYESNNDLEK QEFEKALETI AVAFSSTVSE FLMGEVDSST LLAVPPGDSS 250 260 270 280 290 300 QSMESLYGPG SEGTPPSLED CDAGCLPAEE VDVLLQRCEG GVDAALLYAK NMAKYMKDLI 310 320 330 340 350 360 SYLEKRTTLE MEFAKGLQKI AHNCRQSVMQ EPHMPLLSIY SLALEQDLEF GHSMVQAVGT 370 380 390 400 410 420 LQTQTFMQPL TLRRLEHEKR RKEIKEAWHR AQRKLQEAES NLRKAKQGYV QRCEDHDKAR 430 440 450 460 470 480 FLVAKAEEEQ AGSAPGAGST ATKTLDKRRR LEEEAKNKAE EAMATYRTCV ADAKTQKQEL 490 500 510 520 530 540 EDTKVTALRQ IQEVIRQSDQ TIKSATISYY QMMHMQTAPL PVHFQMLCES SKLYDPGQQY 550 560 570 580 590 600 ASHVRQLQRD QEPDVHYDFE PHVSANAWSP VMRARKSSFN VSDVARPEAA GSPPEEGGCT 610 620 630 640 650 660 EGTPAKDHRA GRGHQVHKSW PLSISDSDSG LDPGPGAGDF KKFERTSSSG TMSSTEELVD 670 680 690 700 710 720 PDGGAGASAF EQADLNGMTP ELPVAVPSGP FRHEGLSKAA RTHRLRKLRT PAKCRECNSY 730 740 750 760 770 780 VYFQGAECEE CCLACHKKCL ETLAIQCGHK KLQGRLQLFG QDFSHAARSA PDGVPFIVKK 790 800 810 820 830 840 CVCEIERRAL RTKGIYRVNG VKTRVEKLCQ AFENGKELVE LSQASPHDIS NVLKLYLRQL 850 860 870 880 890 900 PEPLISFRLY HELVGLAKDS LKAEAEAKAA SRGRQDGSES EAVAVALAGR LRELLRDLPP 910 920 930 940 950 960 ENRASLQYLL RHLRRIVEVE QDNKMTPGNL GIVFGPTLLR PRPTEATVSL SSLVDYPHQA 970 980 990 1000 1010 1020 RVIETLIVHY GLVFEEEPEE TPGGQDESSN QRAEVVVQVP YLEAGEAVVY PLQEAAADGC 1030 1040 1050 1060 1070 1080 RESRVVSNDS DSDLEEASEL LSSSEASALG HLSFLEQQQS EASLEVASGS HSGSEEQLEA 1090 1100 1110 1120 1130 TAREDGDGDE DGPAQQLSGF NTNQSNNVLQ APLPPMRLRG GRMTLGSCRE RQPEFV
	Isoform 2 [UniParc]. Checksum: E3144EE985E43A96	FASTA	1,152	126,497
	10 20 30 40 50 60 MSRGQRVLKG LLGWVCTWTW AWRARLGARG CGLHVLCPRD LPLPPEELPR KDGADAVFPG 70 80 90 100 110 120 PSLEPPAGSS GVKATGTLKR PTSLSRHASA AGFPLSGAAS WTLGRSHRSP LTAASPGELP 130 140 150 160 170 180 TEGAGPDVVE DISHLLADVA RFAEGLEKLK ECVLRDDLLE ARRPRAHECL GEALRVMHQI 190 200 210 220 230 240 ISKYPLLNTV ETLTAAGTLI AKVKAFHYES NNDLEKQEFE KALETIAVAF SSTVSEFLMG 250 260 270 280 290 300 EVDSSTLLAV PPGDSSQSME SLYGPGSEGT PPSLEDCDAG CLPAEEVDVL LQRCEGGVDA 310 320 330 340 350 360 ALLYAKNMAK YMKDLISYLE KRTTLEMEFA KGLQKIAHNC RQSVMQEPHM PLLSIYSLAL 370 380 390 400 410 420 EQDLEFGHSM VQAVGTLQTQ TFMQPLTLRR LEHEKRRKEI KEAWHRAQRK LQEAESNLRK 430 440 450 460 470 480 AKQGYVQRCE DHDKARFLVA KAEEEQAGSA PGAGSTATKT LDKRRRLEEE AKNKAEEAMA 490 500 510 520 530 540 TYRTCVADAK TQKQELEDTK VTALRQIQEV IRQSDQTIKS ATISYYQMMH MQTAPLPVHF 550 560 570 580 590 600 QMLCESSKLY DPGQQYASHV RQLQRDQEPD VHYDFEPHVS ANAWSPVMRA RKSSFNVSDV 610 620 630 640 650 660 ARPEAAGSPP EEGGCTEGTP AKDHRAGRGH QVHKSWPLSI SDSDSGLDPG PGAGDFKKFE 670 680 690 700 710 720 RTSSSGTMSS TEELVDPDGG AGASAFEQAD LNGMTPELPV AVPSGPFRHE GLSKAARTHR 730 740 750 760 770 780 LRKLRTPAKC RECNSYVYFQ GAECEECCLA CHKKCLETLA IQCGHKKLQG RLQLFGQDFS 790 800 810 820 830 840 HAARSAPDGV PFIVKKCVCE IERRALRTKG IYRVNGVKTR VEKLCQAFEN GKELVELSQA 850 860 870 880 890 900 SPHDISNVLK LYLRQLPEPL ISFRLYHELV GLAKDSLKAE AEAKAASRGR QDGSESEAVA 910 920 930 940 950 960 VALAGRLREL LRDLPPENRA SLQYLLRHLR RIVEVEQDNK MTPGNLGIVF GPTLLRPRPT 970 980 990 1000 1010 1020 EATVSLSSLV DYPHQARVIE TLIVHYGLVF EEEPEETPGG QDESSNQRAE VVVQVPYLEA 1030 1040 1050 1060 1070 1080 GEAVVYPLQE AAADGCRESR VVSNDSDSDL EEASELLSSS EASALGHLSF LEQQQSEASL 1090 1100 1110 1120 1130 1140 EVASGSHSGS EEQLEATARE DGDGDEDGPA QQLSGFNTNQ SNNVLQAPLP PMRLRGGRMT 1150 LGSCRERQPE FV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene." Kaminski W.E., Piehler A., Schmitz G. Biochem. Biophys. Res. Commun. 278:782-789(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS HIS-139; ASP-259 AND GLY-439.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Testis.
[7]	"Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA)." Arostegui J.I., Gallardo D., Rodriguez-Luaces M., Querol S., Madrigal J.A., Garcia-Lopez J., Granena A. Tissue Antigens 56:69-76(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 82-140, VARIANT HIS-139.
[8]	"Sequence diversity within the HA-1 gene as detected by melting temperature assay without oligonucleotide probes." Graziano C., Giorgi M., Malentacchi C., Mattiuz P.L., Porfirio B. BMC Med. Genet. 6:36-36(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 82-140, VARIANT HIS-139.
[9]	"The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism." den Haan J.M., Meadows L.M., Wang W., Pool J., Blokland E., Bishop T.L., Reinhardus C., Shabanowitz J., Offringa R., Hunt D.F., Engelhard V.H., Goulmy E. Science 279:1054-1057(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 137-145, MASS SPECTROMETRY, VARIANT HIS-139.
[10]	"Minor histocompatibility antigens HA-1-, -2-, and -4-, and HY-specific cytotoxic T-cell clones inhibit human hematopoietic progenitor cell growth by a mechanism that is dependent on direct cell-cell contact." Marijt W.A.F., Veenhof W.F.J., Goulmy E., Willemze R., van Rood J.J., Falkenburg J.H.F. Blood 82:3778-3785(1993) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation." Goulmy E., Schipper R., Pool J., Blokland E., Falkenburg J.H., Vossen J., Gratwohl A., Vogelsang G.B., van Houwelingen H.C., van Rood J.J. N. Engl. J. Med. 334:281-285(1996) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[12]	"Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells." van Lochem E., van der Keur M., Mommaas A.M., de Gast G.C., Goulmy E. Transpl. Immunol. 4:151-157(1996) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[13]	"HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation." Rufer N., Wolpert E., Helg C., Tiercy J.-M., Gratwohl A., Chapuis B., Jeannet M., Goulmy E., Roosnek E. Transplantation 66:910-916(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[14]	"Expression of minor histocompatibility antigen, HA-1, in solid tumor cells." Fujii N., Hiraki A., Ikeda K., Ohmura Y., Nozaki I., Shinagawa K., Ishimaru F., Kiura K., Shimizu N., Tanimoto M., Harada M. Transplantation 73:1137-1141(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[15]	"Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia." Marijt W.A.E., Heemskerk M.H.M., Kloosterboer F.M., Goulmy E., Kester M.G.D., van der Hoorn M.A.W.G., van Luxemburg-Heys S.A.P., Hoogeboom M., Mutis T., Drijfhout J.W., van Rood J.J., Willemze R., Falkenburg J.H.F. Proc. Natl. Acad. Sci. U.S.A. 100:2742-2747(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[16]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-25, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[18]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND SER-569, MASS SPECTROMETRY. Tissue: T-cell.
[19]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-73; SER-93; SER-99; SER-569 AND SER-619, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[20]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[21]	"Definition of the gene encoding the minor histocompatibility antigen HA-1 and typing for HA-1 from genomic DNA." Tseng L.-H., Lin M.-T., Martin P.J., Pei J., Smith A.G., Hansen J.A. Tissue Antigens 52:305-311(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HIS-139.
[22]	"Therapeutic and diagnostic applications of minor histocompatibility antigen HA-1 and HA-2 disparities in allogeneic hematopoietic stem cell transplantation: a survey of different populations." Di Terlizzi S., Zino E., Mazzi B., Magnani C., Tresoldi C., Perna S.K., Bregni M., Rossini S., Ciceri F., Bordignon C., Bonini C., Fleischhauer K. Biol. Blood Marrow Transplant. 12:95-101(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HIS-139.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF308066 , AF308045, AF308046, AF308047, AF308048, AF308049, AF308050, AF308051, AF308052, AF308053, AF308054, AF308055, AF308056, AF308057, AF308058, AF308059, AF308060, AF308061, AF308062, AF308063, AF308064, AF308065, AF311102 Genomic DNA. Translation: AAN04658.1.
D86976 mRNA. Translation: BAA13212.1. Different initiation.
AK300341 mRNA. Translation: BAG62086.1.
AC004151 Genomic DNA. Translation: AAC03237.1.
AC011558 Genomic DNA. No translation available.
AC093066 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69551.1.
BC048129 mRNA. Translation: AAH48129.1.
BC065223 mRNA. Translation: AAH65223.1.
AF207595 Genomic DNA. Translation: AAG02014.1.
AF207596 Genomic DNA. Translation: AAG02015.1.
AF207597 Genomic DNA. Translation: AAG02016.1.
AF236756 Genomic DNA. Translation: AAF91292.1.

IPI

IPI00022471.
IPI00943093.

PIR

D59433.

RefSeq

NP_001245257.1. NM_001258328.1.
NP_036424.2. NM_012292.3.

UniGene

Hs.465521.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3D25	X-ray	1.30	C	137-145	[»]

ProteinModelPortal

Q92619.

ModBase

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Protein-protein interaction databases

IntAct

Q92619. 2 interactions.

PTM databases

PhosphoSite

Q92619.

Polymorphism databases

DMDM

187471158.

Proteomic databases

PaxDb

Q92619.

PRIDE

Q92619.

Protocols and materials databases

StructuralBiologyKnowledgebase

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Genome annotation databases

Ensembl

ENST00000313093; ENSP00000316772; ENSG00000180448.
ENST00000539243; ENSP00000439601; ENSG00000180448.

GeneID

23526.

KEGG

hsa:23526.

UCSC

uc002lqz.1. human.

Organism-specific databases

CTD

23526.

GeneCards

GC19P001066.

H-InvDB

HIX0014570.

HGNC

HGNC:17102. HMHA1.

HPA

HPA019816.

MIM

601155. gene.

neXtProt

NX_Q92619.

PharmGKB

PA128394633.

HUGE

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GenAtlas

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Phylogenomic databases

eggNOG

NOG310169.

HOVERGEN

HBG107979.

InParanoid

Q92619.

OMA

HECLGEA.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

Q92619.

Bgee

Q92619.

Genevestigator

Q92619.

Family and domain databases

Gene3D

1.10.555.10. 1 hit.

InterPro

IPR001060. FCH_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]

Pfam

PF00620. RhoGAP. 1 hit.
[Graphical view]

SMART

SM00109. C1. 1 hit.
SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]

SUPFAM

SSF48350. Rho_GAP. 1 hit.

PROSITE

PS50238. RHOGAP. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

HMHA1. human.

EvolutionaryTrace

Q92619.

GenomeRNAi

23526.

NextBio

45988.

SOURCE

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Entry information

Entry name

HMHA1_HUMAN

Accession

Primary (citable) accession number: Q92619
Secondary accession number(s): B4DTS4 , F6QP70, Q6P189, Q7LE26, Q86WS1, Q8HX84, Q9GJN9, Q9GJP0, Q9GJP1, Q9MY24

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.