Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 516

Gene

ZNF516

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 56C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri62 – 84C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 197C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri200 – 223C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri248 – 270C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri760 – 783C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1098 – 1120C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 516Imported
Gene namesi
Name:ZNF516Imported
Synonyms:KIAA0222Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000101493.10.
HGNCiHGNC:28990. ZNF516.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9658.
OpenTargetsiENSG00000101493.
PharmGKBiPA134992707.

Polymorphism and mutation databases

BioMutaiZNF516.
DMDMi14548318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476341 – 1163Zinc finger protein 516Add BLAST1163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki681Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1043Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1062Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ92618.
MaxQBiQ92618.
PaxDbiQ92618.
PeptideAtlasiQ92618.
PRIDEiQ92618.

PTM databases

iPTMnetiQ92618.
PhosphoSitePlusiQ92618.

Expressioni

Gene expression databases

BgeeiENSG00000101493.
CleanExiHS_ZNF516.
ExpressionAtlasiQ92618. baseline and differential.
GenevisibleiQ92618. HS.

Organism-specific databases

HPAiHPA015792.

Interactioni

Subunit structurei

Interacts with PRDM16; the interaction is direct and may play a role in the transcription of brown adipose tissue-specific genes.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115016. 11 interactors.
CORUMiQ92618.
IntActiQ92618. 5 interactors.
MINTiMINT-1728539.
STRINGi9606.ENSP00000394757.

Structurei

3D structure databases

ProteinModelPortaliQ92618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 431Mediates promoter DNA-binding and activation of transcriptionBy similarityAdd BLAST431

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 56C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri62 – 84C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 197C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri200 – 223C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri248 – 270C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri760 – 783C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1098 – 1120C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000155800.
HOVERGENiHBG079384.
InParanoidiQ92618.
OMAiRDHITAQ.
OrthoDBiEOG091G00XJ.
PhylomeDBiQ92618.
TreeFamiTF332241.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.1050.10. 1 hit.
InterProiView protein in InterPro
IPR026939. At2g23090-like.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 10 hits.
SUPFAMiSSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequencei

Sequence statusi: Complete.

Q92618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRNREAEME LRRGPSPTRA GRGHEVDGDK ATCHTCCICG KSFPFQSSLS
60 70 80 90 100
QHMRKHTGEK PYKCPYCDHR ASQKGNLKIH IRSHRTGTLI QGHEPEAGEA
110 120 130 140 150
PLGEMRASEG LDACASPTKS ASACNRLLNG ASQADGARVL NGASQADSGR
160 170 180 190 200
VLLRSSKKGA EGSACAPGEA KAAVQCSFCK SQFERKKDLE LHVHQAHKPF
210 220 230 240 250
KCRLCSYATL REESLLSHIE RDHITAQGPG SGEACVENGK PELSPGEFPC
260 270 280 290 300
EVCGQAFSQT WFLKAHMKKH RGSFDHGCHI CGRRFKEPWF LKNHMKAHGP
310 320 330 340 350
KTGSKNRPKS ELDPIATINN VVQEEVIVAG LSLYEVCAKC GNLFTNLDSL
360 370 380 390 400
NAHNAIHRRV EASRTRAPAE EGAEGPSDTK QFFLQCLNLR PSAAGDSCPG
410 420 430 440 450
TQAGRRVAEL DPVNSYQAWQ LATRGKVAEP AEYLKYGAWD EALAGDVAFD
460 470 480 490 500
KDRREYVLVS QEKRKREQDA PAAQGPPRKR ASGPGDPAPA GHLDPRSAAR
510 520 530 540 550
PNRRAAATTG QGKSSECFEC GKIFRTYHQM VLHSRVHRRA RRERDSDGDR
560 570 580 590 600
AARARCGSLS EGDSASQPSS PGSACAAADS PGSGLADEAA EDSGEEGAPE
610 620 630 640 650
PAPGGQPRRC CFSEEVTSTE LSSGDQSHKM GDNASERDTG ESKAGIAASV
660 670 680 690 700
SILENSSRET SRRQEQHRFS MDLKMPAFHP KQEVPVPGDG VEFPSSTGAE
710 720 730 740 750
GQTGHPAEKL SDLHNKEHSG GGKRALAPDL MPLDLSARST RDDPSNKETA
760 770 780 790 800
SSLQAALVVH PCPYCSHKTY YPEVLWMHKR IWHRVSCNSV APPWIQPNGY
810 820 830 840 850
KSIRSNLVFL SRSGRTGPPP ALGGKECQPL LLARFTRTQV PGGMPGSKSG
860 870 880 890 900
SSPLGVVTKA ASMPKNKESH SGGPCALWAP GPDGYRQTKP CHGQEPHGAA
910 920 930 940 950
TQGPLAKPRQ EASSKPVPAP GGGGFSRSAT PTPTVIARAG AQPSANSKPV
960 970 980 990 1000
EKFGVPPAGA GFAPTNKHSA PDSLKAKFSA QPQGPPPAKG EGGAPPLPPR
1010 1020 1030 1040 1050
EPPSKAAQEL RTLATCAAGS RGDAALQAQP GVAGAPPVLH SIKQEPVAEG
1060 1070 1080 1090 1100
HEKRLDILNI FKTYIPKDFA TLYQGWGVSG PGLEHRGTLR TQARPGEFVC
1110 1120 1130 1140 1150
IECGKSFHQP GHLRAHMRAH SVVFESDGPR GSEVHTTSAD APKQGRDHSN
1160
TGTVQTVPLR KGT
Length:1,163
Mass (Da):124,289
Last modified:February 1, 1997 - v1
Checksum:i9D6DDDE2D70236A4
GO

Sequence cautioni

The sequence BAA13211 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0528524N → S. Corresponds to variant dbSNP:rs3752097Ensembl.1
Natural variantiVAR_052853239G → S. Corresponds to variant dbSNP:rs12961584Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86975 mRNA. Translation: BAA13211.2. Different initiation.
CCDSiCCDS74234.1.
RefSeqiNP_055458.1. NM_014643.3.
XP_011524571.1. XM_011526269.1.
XP_011524572.1. XM_011526270.2.
XP_011524573.1. XM_011526271.2.
XP_011524574.1. XM_011526272.2.
XP_011524575.1. XM_011526273.2.
XP_011524576.1. XM_011526274.2.
XP_011524577.1. XM_011526275.2.
XP_016881586.1. XM_017026097.1.
UniGeneiHs.436973.

Genome annotation databases

EnsembliENST00000443185; ENSP00000394757; ENSG00000101493.
GeneIDi9658.
KEGGihsa:9658.
UCSCiuc032hhr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN516_HUMAN
AccessioniPrimary (citable) accession number: Q92618
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: February 1, 1997
Last modified: October 25, 2017
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families