ID   NPIB3_HUMAN             Reviewed;        1050 AA.
AC   Q92617; O43332; Q504Q6; Q59F29; Q6GMR1; Q6P7T2; Q6PIE2; Q6RH21;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 5.
DT   24-JAN-2024, entry version 155.
DE   RecName: Full=Nuclear pore complex-interacting protein family member B3;
DE   AltName: Full=Nuclear pore complex-interacting protein-like 3;
DE   AltName: Full=Protein pps22-1;
GN   Name=NPIPB3; Synonyms=KIAA0220, NPIPL3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Bone marrow;
RX   PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA   Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA   Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT   "Prediction of the coding sequences of unidentified human genes. VI. The
RT   coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of
RT   cDNA clones from cell line KG-1 and brain.";
RL   DNA Res. 3:321-329(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC   TISSUE=Spleen;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), AND
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 690-1050 (ISOFORM 1).
RC   TISSUE=Lymph, Mammary carcinoma, Pancreas, and PNS;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 917-1050 (ISOFORM 6).
RA   Huang Y.-P., Cheng J., Yang Y.-J.;
RT   "Cloning and identification of a new protein coding gene pps22-1 binding
RT   with promoter DNA of pre-pre-S gene of hepatitis B virus.";
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- INTERACTION:
CC       Q92617; P59634: 6; Xeno; NbExp=3; IntAct=EBI-2866234, EBI-25489038;
CC       Q92617-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12346419, EBI-16439278;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=6;
CC       Name=1;
CC         IsoId=Q92617-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q92617-2; Sequence=VSP_021837;
CC       Name=3;
CC         IsoId=Q92617-3; Sequence=VSP_021833, VSP_021838;
CC       Name=4;
CC         IsoId=Q92617-4; Sequence=VSP_021832, VSP_021836;
CC       Name=5;
CC         IsoId=Q92617-5; Sequence=VSP_021834, VSP_021835, VSP_021839;
CC       Name=6;
CC         IsoId=Q92617-6; Sequence=VSP_033367;
CC   -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA13210.2; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAD92869.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D86974; BAA13210.2; ALT_SEQ; mRNA.
DR   EMBL; AB209632; BAD92869.1; ALT_INIT; Transcribed_RNA.
DR   EMBL; AC008740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC036263; AAH36263.1; -; mRNA.
DR   EMBL; BC061522; AAH61522.1; -; mRNA.
DR   EMBL; BC073943; AAH73943.1; -; mRNA.
DR   EMBL; BC094882; AAH94882.1; -; mRNA.
DR   EMBL; AY498718; AAS48701.1; -; mRNA.
DR   AlphaFoldDB; Q92617; -.
DR   BioGRID; 116739; 5.
DR   IntAct; Q92617; 4.
DR   iPTMnet; Q92617; -.
DR   PhosphoSitePlus; Q92617; -.
DR   BioMuta; NPIPB3; -.
DR   DMDM; 215274263; -.
DR   jPOST; Q92617; -.
DR   MassIVE; Q92617; -.
DR   PeptideAtlas; Q92617; -.
DR   ProteomicsDB; 75370; -. [Q92617-6]
DR   Antibodypedia; 67318; 7 antibodies from 5 providers.
DR   Ensembl; ENST00000542817.1; ENSP00000444096.1; ENSG00000169246.17. [Q92617-4]
DR   UCSC; uc059rux.1; human. [Q92617-1]
DR   AGR; HGNC:28989; -.
DR   GeneCards; NPIPB3; -.
DR   HGNC; HGNC:28989; NPIPB3.
DR   HPA; ENSG00000169246; Low tissue specificity.
DR   neXtProt; NX_Q92617; -.
DR   OpenTargets; ENSG00000169246; -.
DR   PharmGKB; PA164724182; -.
DR   VEuPathDB; HostDB:ENSG00000169246; -.
DR   GeneTree; ENSGT00540000072033; -.
DR   HOGENOM; CLU_780666_0_0_1; -.
DR   InParanoid; Q92617; -.
DR   OMA; YLCFSIM; -.
DR   PhylomeDB; Q92617; -.
DR   PathwayCommons; Q92617; -.
DR   Reactome; R-HSA-9692916; SARS-CoV-1 activates/modulates innate immune responses.
DR   SignaLink; Q92617; -.
DR   BioGRID-ORCS; 23117; 32 hits in 234 CRISPR screens.
DR   ChiTaRS; NPIPB3; human.
DR   GenomeRNAi; 23117; -.
DR   Pharos; Q92617; Tdark.
DR   PRO; PR:Q92617; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q92617; Protein.
DR   Bgee; ENSG00000169246; Expressed in right uterine tube and 96 other cell types or tissues.
DR   ExpressionAtlas; Q92617; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005635; C:nuclear envelope; TAS:Reactome.
DR   InterPro; IPR048893; NPB13-like_MII_rpt.
DR   InterPro; IPR009443; NPIP.
DR   PANTHER; PTHR15438; NUCLEAR PORE COMPLEX INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR15438:SF14; NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER A1-RELATED; 1.
DR   Pfam; PF20885; NPB13-l_MII_rpt; 2.
DR   Pfam; PF06409; NPIP; 2.
DR   Genevisible; Q92617; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..1050
FT                   /note="Nuclear pore complex-interacting protein family
FT                   member B3"
FT                   /id="PRO_0000050735"
FT   TRANSMEM        63..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          241..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          785..1050
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..262
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        935..1050
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..216
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_021832"
FT   VAR_SEQ         1..40
FT                   /note="MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRK -> MFCCLGYE
FT                   WLSGGCKTWHSAW (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_021833"
FT   VAR_SEQ         290..327
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_021834"
FT   VAR_SEQ         413..576
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_021835"
FT   VAR_SEQ         515..928
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_021836"
FT   VAR_SEQ         515..886
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_021837"
FT   VAR_SEQ         577..868
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_021838"
FT   VAR_SEQ         785..826
FT                   /note="ERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPA -> GRFHPQ
FT                   RMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG (in isoform 5)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_021839"
FT   VAR_SEQ         947..974
FT                   /note="Missing (in isoform 6)"
FT                   /evidence="ECO:0000303|Ref.5"
FT                   /id="VSP_033367"
FT   CONFLICT        21
FT                   /note="T -> S (in Ref. 4; AAH36263)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        138
FT                   /note="G -> V (in Ref. 4; AAH36263)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        388
FT                   /note="P -> L (in Ref. 4; AAH36263)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        521
FT                   /note="A -> P (in Ref. 1; BAA13210)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        526
FT                   /note="A -> APPSA (in Ref. 1; BAA13210)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        584
FT                   /note="Missing (in Ref. 2; BAD92869)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        610..612
FT                   /note="HLP -> YLL (in Ref. 1; BAA13210)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        617
FT                   /note="G -> F (in Ref. 1; BAA13210)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        621..623
FT                   /note="PQQ -> HQP (in Ref. 1; BAA13210)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        622..623
FT                   /note="QQ -> ER (in Ref. 2; BAD92869)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        664
FT                   /note="Q -> E (in Ref. 2; BAD92869)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        675
FT                   /note="V -> I (in Ref. 1; BAA13210)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        707
FT                   /note="Q -> R (in Ref. 1; BAA13210 and 2; BAD92869)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        766
FT                   /note="P -> T (in Ref. 1; BAA13210)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        825
FT                   /note="P -> S (in Ref. 4; AAH73943)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1050 AA;  116847 MW;  342657B7685C9167 CRC64;
     MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
     LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
     ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
     KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
     NRMGHQPPPP TQQHSITDNS LSLKTPPECL LTPLPPSADD NLKTPPECVL TPLPPSADDN
     LKTPPECVLT PLPPSADDNL KTPPECLLTP LPPSADDNLK TPPECLLTPL PPSALPSAPP
     SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
     PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL
     PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT ALPPSADDNI KTPAERLRGP
     LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAFHPQ RMIISRHLPS VSSLPFHPQL
     HPQQMIISRH LPSVCGGRFH PQQMIISRHL PSVSSLPFHP QLHPQQMIIS RHLPSVCGGR
     FHPQRMIISR HLPSVSSLPF HPQLHPQQMI ISRHLPSVCG GRFHPQQMII SRHLPSVSSL
     PFHPQLHPQQ MIISRHLPSV CGGRFHPQRM IISRHLPSVS SLPFHPQLHP QQMIISRHLP
     SVCGERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAERLR GPLPPSADDN
     LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD DNLKTPSERQ LTPLPPSAPP
     SADDNIKTPA ERLRGPLPPS ADDNLKTPPL ATQEAEAEKP RKPKRQRAAE MEPPPEPKRR
     RVGDVEPSRK PKRRRAADVE PSSPEPKRRR VGDVEPSRKP KRRRAADVEP SSPEPKRRRV
     GDVEPSRKPK RRRAADVEPS LPEPKRRRLS
//