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Protein

eIF-2-alpha kinase activator GCN1

Gene

GCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
  • protein kinase regulator activity Source: InterPro
  • ribosome binding Source: InterPro
  • translation factor activity, RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Stress response, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
eIF-2-alpha kinase activator GCN1By similarity
Alternative name(s):
GCN1 eIF-2-alpha kinase activator homologImported
GCN1-like protein 1By similarity
General control of amino-acid synthesis 1-like protein 1By similarity
Translational activator GCN1By similarity
Short name:
HsGCN1
Gene namesi
Name:GCN1Imported
Synonyms:GCN1L1By similarity, KIAA0219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:4199. GCN1.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Associates with ribosomes in undifferentiated neuroblastoma cells and increases after neuronal differentiation.By similarity

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • membrane Source: UniProtKB
  • polysome Source: UniProtKB
  • ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28616.

Polymorphism and mutation databases

BioMutaiGCN1L1.
DMDMi296439506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 26712670eIF-2-alpha kinase activator GCN1PRO_0000087443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources1 Publication
Modified residuei729 – 7291PhosphoserineCombined sources
Modified residuei786 – 7861PhosphoserineCombined sources
Modified residuei2276 – 22761PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92616.
MaxQBiQ92616.
PaxDbiQ92616.
PeptideAtlasiQ92616.
PRIDEiQ92616.

PTM databases

iPTMnetiQ92616.
PhosphoSiteiQ92616.
SwissPalmiQ92616.

Expressioni

Tissue specificityi

Ubiquitously expressed (PubMed:9039502). Expressed in skeletal muscules, ovary and testis (PubMed:9234705).2 Publications

Gene expression databases

BgeeiENSG00000089154.
GenevisibleiQ92616. HS.

Organism-specific databases

HPAiHPA018799.
HPA019648.
HPA024367.

Interactioni

Subunit structurei

Interacts with EIF2AK4/GCN2; this interaction stimulates the EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Interacts with IMPACT; this prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity.By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi116181. 99 interactions.
IntActiQ92616. 46 interactions.
MINTiMINT-1144027.
STRINGi9606.ENSP00000300648.

Structurei

3D structure databases

ProteinModelPortaliQ92616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati140 – 17839HEAT 1Sequence analysisAdd
BLAST
Repeati257 – 29337HEAT 2Sequence analysisAdd
BLAST
Repeati294 – 33138HEAT 3Sequence analysisAdd
BLAST
Repeati385 – 42339HEAT 4Sequence analysisAdd
BLAST
Repeati425 – 45935HEAT 5Sequence analysisAdd
BLAST
Repeati460 – 50344HEAT 6Sequence analysisAdd
BLAST
Repeati560 – 59738HEAT 7Sequence analysisAdd
BLAST
Repeati599 – 63638HEAT 8Sequence analysisAdd
BLAST
Repeati697 – 73236HEAT 9Sequence analysisAdd
BLAST
Repeati733 – 77038HEAT 10Sequence analysisAdd
BLAST
Repeati879 – 92547HEAT 11Sequence analysisAdd
BLAST
Repeati979 – 101638HEAT 12Sequence analysisAdd
BLAST
Repeati1035 – 107238HEAT 13Sequence analysisAdd
BLAST
Repeati1078 – 111538HEAT 14Sequence analysisAdd
BLAST
Repeati1155 – 119238HEAT 15Sequence analysisAdd
BLAST
Repeati1210 – 125041HEAT 16Sequence analysisAdd
BLAST
Repeati1251 – 128939HEAT 17Sequence analysisAdd
BLAST
Repeati1290 – 133243HEAT 18Sequence analysisAdd
BLAST
Repeati1335 – 137238HEAT 19Sequence analysisAdd
BLAST
Repeati1374 – 141037HEAT 20Sequence analysisAdd
BLAST
Repeati1413 – 145139HEAT 21Sequence analysisAdd
BLAST
Repeati1455 – 149238HEAT 22Sequence analysisAdd
BLAST
Repeati1493 – 153038HEAT 23Sequence analysisAdd
BLAST
Repeati1534 – 157138HEAT 24Sequence analysisAdd
BLAST
Repeati1573 – 160937HEAT 25Sequence analysisAdd
BLAST
Repeati1611 – 164838HEAT 26Sequence analysisAdd
BLAST
Repeati1653 – 169038HEAT 27Sequence analysisAdd
BLAST
Repeati1692 – 172938HEAT 28Sequence analysisAdd
BLAST
Repeati1731 – 176939HEAT 29Sequence analysisAdd
BLAST
Repeati1773 – 181038HEAT 30Sequence analysisAdd
BLAST
Repeati1812 – 184837HEAT 31Sequence analysisAdd
BLAST
Repeati1921 – 195838HEAT 32Sequence analysisAdd
BLAST
Repeati1959 – 199638HEAT 33Sequence analysisAdd
BLAST
Repeati2001 – 203838HEAT 34Sequence analysisAdd
BLAST
Repeati2039 – 207638HEAT 35Sequence analysisAdd
BLAST
Repeati2078 – 210629HEAT 36Sequence analysisAdd
BLAST
Repeati2107 – 214640HEAT 37Sequence analysisAdd
BLAST
Repeati2147 – 218438HEAT 38Sequence analysisAdd
BLAST
Repeati2188 – 222538HEAT 39Sequence analysisAdd
BLAST
Repeati2259 – 229638HEAT 40Sequence analysisAdd
BLAST
Repeati2301 – 233838HEAT 41Sequence analysisAdd
BLAST
Repeati2339 – 238042HEAT 42Sequence analysisAdd
BLAST
Repeati2382 – 241736HEAT 43Sequence analysisAdd
BLAST
Repeati2422 – 245938HEAT 44Sequence analysisAdd
BLAST
Repeati2546 – 258338HEAT 45Sequence analysisAdd
BLAST
Repeati2588 – 262538HEAT 46Sequence analysisAdd
BLAST
Repeati2627 – 266135HEAT 47; degenerateSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili804 – 86360Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the GCN1 family.Curated
Contains 47 HEAT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1242. Eukaryota.
ENOG410XPSD. LUCA.
HOVERGENiHBG081550.
InParanoidiQ92616.
OrthoDBiEOG091G008Q.
PhylomeDBiQ92616.
TreeFamiTF105398.

Family and domain databases

Gene3Di1.25.10.10. 8 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026827. Ecm29/Gcn1.
IPR033173. Gcn1.
IPR021133. HEAT_type_2.
[Graphical view]
PANTHERiPTHR23346. PTHR23346. 1 hit.
PTHR23346:SF7. PTHR23346:SF7. 1 hit.
SUPFAMiSSF48371. SSF48371. 7 hits.
PROSITEiPS50077. HEAT_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADTQVSET LKRFAGKVTT ASVKERREIL SELGKCVAGK DLPEGAVKGL
60 70 80 90 100
CKLFCLTLHR YRDAASRRAL QAAIQQLAEA QPEATAKNLL HSLQSSGIGS
110 120 130 140 150
KAGVPSKSSG SAALLALTWT CLLVRIVFPS RAKRQGDIWN KLVEVQCLLL
160 170 180 190 200
LEVLGGSHKH AVDGAVKKLT KLWKENPGLV EQYLSAILSL EPNQNYAGML
210 220 230 240 250
GLLVQFCTSH KEMDVVSQHK SALLDFYMKN ILMSKVKPPK YLLDSCAPLL
260 270 280 290 300
RYLSHSEFKD LILPTIQKSL LRSPENVIET ISSLLASVTL DLSQYAMDIV
310 320 330 340 350
KGLAGHLKSN SPRLMDEAVL ALRNLARQCS DSSAMESLTK HLFAILGGSE
360 370 380 390 400
GKLTVVAQKM SVLSGIGSVS HHVVSGPSSQ VLNGIVAELF IPFLQQEVHE
410 420 430 440 450
GTLVHAVSVL ALWCNRFTME VPKKLTEWFK KAFSLKTSTS AVRHAYLQCM
460 470 480 490 500
LASYRGDTLL QALDLLPLLI QTVEKAASQS TQVPTITEGV AAALLLLKLS
510 520 530 540 550
VADSQAEAKL SSFWQLIVDE KKQVFTSEKF LVMASEDALC TVLHLTERLF
560 570 580 590 600
LDHPHRLTGN KVQQYHRALV AVLLSRTWHV RRQAQQTVRK LLSSLGGFKL
610 620 630 640 650
AHGLLEELKT VLSSHKVLPL EALVTDAGEV TEAGKAYVPP RVLQEALCVI
660 670 680 690 700
SGVPGLKGDV TDTEQLAQEM LIISHHPSLV AVQSGLWPAL LARMKIDPEA
710 720 730 740 750
FITRHLDQII PRMTTQSPLN QSSMNAMGSL SVLSPDRVLP QLISTITASV
760 770 780 790 800
QNPALRLVTR EEFAIMQTPA GELYDKSIIQ SAQQDSIKKA NMKRENKAYS
810 820 830 840 850
FKEQIIELEL KEEIKKKKGI KEEVQLTSKQ KEMLQAQLDR EAQVRRRLQE
860 870 880 890 900
LDGELEAALG LLDIILAKNP SGLTQYIPVL VDSFLPLLKS PLAAPRIKNP
910 920 930 940 950
FLSLAACVMP SRLKALGTLV SHVTLRLLKP ECVLDKSWCQ EELSVAVKRA
960 970 980 990 1000
VMLLHTHTIT SRVGKGEPGA APLSAPAFSL VFPFLKMVLT EMPHHSEEEE
1010 1020 1030 1040 1050
EWMAQILQIL TVQAQLRASP NTPPGRVDEN GPELLPRVAM LRLLTWVIGT
1060 1070 1080 1090 1100
GSPRLQVLAS DTLTTLCASS SGDDGCAFAE QEEVDVLLCA LQSPCASVRE
1110 1120 1130 1140 1150
TVLRGLMELH MVLPAPDTDE KNGLNLLRRL WVVKFDKEEE IRKLAERLWS
1160 1170 1180 1190 1200
MMGLDLQPDL CSLLIDDVIY HEAAVRQAGA EALSQAVARY QRQAAEVMGR
1210 1220 1230 1240 1250
LMEIYQEKLY RPPPVLDALG RVISESPPDQ WEARCGLALA LNKLSQYLDS
1260 1270 1280 1290 1300
SQVKPLFQFF VPDALNDRHP DVRKCMLDAA LATLNTHGKE NVNSLLPVFE
1310 1320 1330 1340 1350
EFLKNAPNDA SYDAVRQSVV VLMGSLAKHL DKSDPKVKPI VAKLIAALST
1360 1370 1380 1390 1400
PSQQVQESVA SCLPPLVPAI KEDAGGMIQR LMQQLLESDK YAERKGAAYG
1410 1420 1430 1440 1450
LAGLVKGLGI LSLKQQEMMA ALTDAIQDKK NFRRREGALF AFEMLCTMLG
1460 1470 1480 1490 1500
KLFEPYVVHV LPHLLLCFGD GNQYVREAAD DCAKAVMSNL SAHGVKLVLP
1510 1520 1530 1540 1550
SLLAALEEES WRTKAGSVEL LGAMAYCAPK QLSSCLPNIV PKLTEVLTDS
1560 1570 1580 1590 1600
HVKVQKAGQQ ALRQIGSVIR NPEILAIAPV LLDALTDPSR KTQKCLQTLL
1610 1620 1630 1640 1650
DTKFVHFIDA PSLALIMPIV QRAFQDRSTD TRKMAAQIIG NMYSLTDQKD
1660 1670 1680 1690 1700
LAPYLPSVTP GLKASLLDPV PEVRTVSAKA LGAMVKGMGE SCFEDLLPWL
1710 1720 1730 1740 1750
METLTYEQSS VDRSGAAQGL AEVMAGLGVE KLEKLMPEIV ATASKVDIAP
1760 1770 1780 1790 1800
HVRDGYIMMF NYLPITFGDK FTPYVGPIIP CILKALADEN EFVRDTALRA
1810 1820 1830 1840 1850
GQRVISMYAE TAIALLLPQL EQGLFDDLWR IRFSSVQLLG DLLFHISGVT
1860 1870 1880 1890 1900
GKMTTETASE DDNFGTAQSN KAIITALGVE RRNRVLAGLY MGRSDTQLVV
1910 1920 1930 1940 1950
RQASLHVWKI VVSNTPRTLR EILPTLFGLL LGFLASTCAD KRTIAARTLG
1960 1970 1980 1990 2000
DLVRKLGEKI LPEIIPILEE GLRSQKSDER QGVCIGLSEI MKSTSRDAVL
2010 2020 2030 2040 2050
YFSESLVPTA RKALCDPLEE VREAAAKTFE QLHSTIGHQA LEDILPFLLK
2060 2070 2080 2090 2100
QLDDEEVSEF ALDGLKQVMA IKSRVVLPYL VPKLTTPPVN TRVLAFLSSV
2110 2120 2130 2140 2150
AGDALTRHLG VILPAVMLAL KEKLGTPDEQ LEMANCQAVI LSVEDDTGHR
2160 2170 2180 2190 2200
IIIEYLLEAT RSPEVGMRQA AAIILNIYCS RSKADYTSHL RSLVSGLIRL
2210 2220 2230 2240 2250
FNDSSPVVLE ESWDALNAIT KKLDAGNQLA LIEELHKEIR LIGNESKGEH
2260 2270 2280 2290 2300
VPGFCLPKKG VTSILPVLRE GVLTGSPEQK EEAAKALGLV IRLTSADALR
2310 2320 2330 2340 2350
PSVVSITGPL IRILGDRFSW NVKAALLETL SLLLAKVGIA LKPFLPQLQT
2360 2370 2380 2390 2400
TFTKALQDSN RGVRLKAADA LGKLISIHIK VDPLFTELLN GIRAMEDPGV
2410 2420 2430 2440 2450
RDTMLQALRF VIQGAGAKVD AVIRKNIVSL LLSMLGHDED NTRISSAGCL
2460 2470 2480 2490 2500
GELCAFLTEE ELSAVLQQCL LADVSGIDWM VRHGRSLALS VAVNVAPGRL
2510 2520 2530 2540 2550
CAGRYSSDVQ EMILSSATAD RIPIAVSGVR GMGFLMRHHI ETGGGQLPAK
2560 2570 2580 2590 2600
LSSLFVKCLQ NPSSDIRLVA EKMIWWANKD PLPPLDPQAI KPILKALLDN
2610 2620 2630 2640 2650
TKDKNTVVRA YSDQAIVNLL KMRQGEEVFQ SLSKILDVAS LEVLNEVNRR
2660 2670
SLKKLASQAD STEQVDDTIL T
Length:2,671
Mass (Da):292,758
Last modified:May 18, 2010 - v6
Checksum:iFC34F50517DCC2A8
GO

Sequence cautioni

The sequence AAC51648 differs from that shown. Reason: Frameshift at position 2657. Curated
The sequence AAC83183 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAA13209 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti292 – 2921L → F in BAA13209 (PubMed:9039502).Curated
Sequence conflicti292 – 2921L → F in AAI53882 (PubMed:15489334).Curated
Sequence conflicti842 – 8421A → G in AAC51648 (PubMed:9234705).Curated
Sequence conflicti1584 – 15841A → V in AAC51648 (PubMed:9234705).Curated
Sequence conflicti1683 – 16831A → V in AAC51648 (PubMed:9234705).Curated
Sequence conflicti1760 – 17601F → S in AAD00655 (Ref. 6) Curated
Sequence conflicti2298 – 22981A → V in AAC51648 (PubMed:9234705).Curated
Sequence conflicti2486 – 24861S → T in AAD00655 (Ref. 6) Curated
Sequence conflicti2549 – 25491A → R in AAC51648 (PubMed:9234705).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2155 – 21551Y → D.Combined sources4 Publications
Corresponds to variant rs3864938 [ dbSNP | Ensembl ].
VAR_062228

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86973 mRNA. Translation: BAA13209.2. Different initiation.
AC004812 Genomic DNA. Translation: AAC83183.1. Sequence problems.
BC021129 mRNA. Translation: AAH21129.1.
BC032335 mRNA. Translation: AAH32335.1.
BC046177 mRNA. Translation: AAH46177.1.
BC064346 mRNA. Translation: AAH64346.1.
BC153881 mRNA. Translation: AAI53882.1.
U88836 mRNA. Translation: AAD00655.1.
U88837 mRNA. Translation: AAD00656.1.
U77700 mRNA. Translation: AAC51648.1. Frameshift.
CCDSiCCDS41847.1.
RefSeqiNP_006827.1. NM_006836.1.
UniGeneiHs.298716.

Genome annotation databases

EnsembliENST00000300648; ENSP00000300648; ENSG00000089154.
GeneIDi10985.
KEGGihsa:10985.
UCSCiuc001txo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86973 mRNA. Translation: BAA13209.2. Different initiation.
AC004812 Genomic DNA. Translation: AAC83183.1. Sequence problems.
BC021129 mRNA. Translation: AAH21129.1.
BC032335 mRNA. Translation: AAH32335.1.
BC046177 mRNA. Translation: AAH46177.1.
BC064346 mRNA. Translation: AAH64346.1.
BC153881 mRNA. Translation: AAI53882.1.
U88836 mRNA. Translation: AAD00655.1.
U88837 mRNA. Translation: AAD00656.1.
U77700 mRNA. Translation: AAC51648.1. Frameshift.
CCDSiCCDS41847.1.
RefSeqiNP_006827.1. NM_006836.1.
UniGeneiHs.298716.

3D structure databases

ProteinModelPortaliQ92616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116181. 99 interactions.
IntActiQ92616. 46 interactions.
MINTiMINT-1144027.
STRINGi9606.ENSP00000300648.

PTM databases

iPTMnetiQ92616.
PhosphoSiteiQ92616.
SwissPalmiQ92616.

Polymorphism and mutation databases

BioMutaiGCN1L1.
DMDMi296439506.

Proteomic databases

EPDiQ92616.
MaxQBiQ92616.
PaxDbiQ92616.
PeptideAtlasiQ92616.
PRIDEiQ92616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300648; ENSP00000300648; ENSG00000089154.
GeneIDi10985.
KEGGihsa:10985.
UCSCiuc001txo.4. human.

Organism-specific databases

CTDi10985.
GeneCardsiGCN1L1.
HGNCiHGNC:4199. GCN1.
HPAiHPA018799.
HPA019648.
HPA024367.
MIMi605614. gene.
neXtProtiNX_Q92616.
PharmGKBiPA28616.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1242. Eukaryota.
ENOG410XPSD. LUCA.
HOVERGENiHBG081550.
InParanoidiQ92616.
OrthoDBiEOG091G008Q.
PhylomeDBiQ92616.
TreeFamiTF105398.

Miscellaneous databases

ChiTaRSiGCN1L1. human.
GeneWikiiGCN1L1.
GenomeRNAii10985.
PROiQ92616.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089154.
GenevisibleiQ92616. HS.

Family and domain databases

Gene3Di1.25.10.10. 8 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026827. Ecm29/Gcn1.
IPR033173. Gcn1.
IPR021133. HEAT_type_2.
[Graphical view]
PANTHERiPTHR23346. PTHR23346. 1 hit.
PTHR23346:SF7. PTHR23346:SF7. 1 hit.
SUPFAMiSSF48371. SSF48371. 7 hits.
PROSITEiPS50077. HEAT_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCN1_HUMAN
AccessioniPrimary (citable) accession number: Q92616
Secondary accession number(s): A8KAY1
, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 147 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.