Q92616 (GCN1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translational activator GCN1
Short name=HsGCN1

Alternative name(s):
GCN1-like protein 1

Gene names

Name:	GCN1L1
Synonyms:	KIAA0219

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2671 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a translation activator that mediates translational control and perform an EF3-related function on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity By similarity.
Subunit structure	Interacts with IMPACT; prevents the interaction with GCN2 protein kinase (EIF2AK1-4) By similarity.
Tissue specificity	Ubiquitously expressed. Ref.1
Sequence similarities	Belongs to the GCN1 family. Contains 24 HEAT repeats.
Sequence caution	The sequence AAC51648.1 differs from that shown. Reason: Frameshift at position 2657. The sequence AAC83183.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA13209.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Translation regulation
Coding sequence diversity	Polymorphism
Domain	Repeat
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ribosome Non-traceable author statement Ref.7. Source: UniProtKB
Molecular_function	translation factor activity, nucleic acid binding Non-traceable author statement Ref.7. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5
	Chain	2 – 2671	2670	Translational activator GCN1		PRO_0000087443
Regions
	Repeat	257 – 294	38	HEAT 1
	Repeat	295 – 331	37	HEAT 2
	Repeat	460 – 503	44	HEAT 3
	Repeat	1078 – 1115	38	HEAT 4
	Repeat	1290 – 1332	43	HEAT 5
	Repeat	1335 – 1372	38	HEAT 6
	Repeat	1455 – 1492	38	HEAT 7
	Repeat	1493 – 1530	38	HEAT 8
	Repeat	1534 – 1571	38	HEAT 9
	Repeat	1573 – 1609	37	HEAT 10
	Repeat	1611 – 1648	38	HEAT 11
	Repeat	1653 – 1690	38	HEAT 12
	Repeat	1773 – 1810	38	HEAT 13
	Repeat	1812 – 1848	37	HEAT 14
	Repeat	1921 – 1958	38	HEAT 15
	Repeat	1959 – 1996	38	HEAT 16
	Repeat	2001 – 2038	38	HEAT 17
	Repeat	2039 – 2076	38	HEAT 18
	Repeat	2188 – 2225	38	HEAT 19
	Repeat	2259 – 2296	38	HEAT 20
	Repeat	2339 – 2380	42	HEAT 21
	Repeat	2422 – 2459	38	HEAT 22
	Repeat	2560 – 2583	24	HEAT 23
	Repeat	2588 – 2625	38	HEAT 24
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.5
	Modified residue	786	1	Phosphoserine Ref.8
Natural variations
	Natural variant	2155	1	Y → D. Ref.1 Ref.4 Ref.6 Ref.7 Ref.10 Corresponds to variant rs3864938 [ dbSNP | Ensembl ].		VAR_062228
Experimental info
	Sequence conflict	292	1	L → F in BAA13209. Ref.1
	Sequence conflict	292	1	L → F in AAI53882. Ref.4
	Sequence conflict	842	1	A → G in AAC51648. Ref.7
	Sequence conflict	1584	1	A → V in AAC51648. Ref.7
	Sequence conflict	1683	1	A → V in AAC51648. Ref.7
	Sequence conflict	1760	1	F → S in AAD00655. Ref.6
	Sequence conflict	2298	1	A → V in AAC51648. Ref.7
	Sequence conflict	2486	1	S → T in AAD00655. Ref.6
	Sequence conflict	2549	1	A → R in AAC51648. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q92616 [UniParc]. Last modified May 18, 2010. Version 6. Checksum: FC34F50517DCC2A8	FASTA	2,671	292,758
	10 20 30 40 50 60 MAADTQVSET LKRFAGKVTT ASVKERREIL SELGKCVAGK DLPEGAVKGL CKLFCLTLHR 70 80 90 100 110 120 YRDAASRRAL QAAIQQLAEA QPEATAKNLL HSLQSSGIGS KAGVPSKSSG SAALLALTWT 130 140 150 160 170 180 CLLVRIVFPS RAKRQGDIWN KLVEVQCLLL LEVLGGSHKH AVDGAVKKLT KLWKENPGLV 190 200 210 220 230 240 EQYLSAILSL EPNQNYAGML GLLVQFCTSH KEMDVVSQHK SALLDFYMKN ILMSKVKPPK 250 260 270 280 290 300 YLLDSCAPLL RYLSHSEFKD LILPTIQKSL LRSPENVIET ISSLLASVTL DLSQYAMDIV 310 320 330 340 350 360 KGLAGHLKSN SPRLMDEAVL ALRNLARQCS DSSAMESLTK HLFAILGGSE GKLTVVAQKM 370 380 390 400 410 420 SVLSGIGSVS HHVVSGPSSQ VLNGIVAELF IPFLQQEVHE GTLVHAVSVL ALWCNRFTME 430 440 450 460 470 480 VPKKLTEWFK KAFSLKTSTS AVRHAYLQCM LASYRGDTLL QALDLLPLLI QTVEKAASQS 490 500 510 520 530 540 TQVPTITEGV AAALLLLKLS VADSQAEAKL SSFWQLIVDE KKQVFTSEKF LVMASEDALC 550 560 570 580 590 600 TVLHLTERLF LDHPHRLTGN KVQQYHRALV AVLLSRTWHV RRQAQQTVRK LLSSLGGFKL 610 620 630 640 650 660 AHGLLEELKT VLSSHKVLPL EALVTDAGEV TEAGKAYVPP RVLQEALCVI SGVPGLKGDV 670 680 690 700 710 720 TDTEQLAQEM LIISHHPSLV AVQSGLWPAL LARMKIDPEA FITRHLDQII PRMTTQSPLN 730 740 750 760 770 780 QSSMNAMGSL SVLSPDRVLP QLISTITASV QNPALRLVTR EEFAIMQTPA GELYDKSIIQ 790 800 810 820 830 840 SAQQDSIKKA NMKRENKAYS FKEQIIELEL KEEIKKKKGI KEEVQLTSKQ KEMLQAQLDR 850 860 870 880 890 900 EAQVRRRLQE LDGELEAALG LLDIILAKNP SGLTQYIPVL VDSFLPLLKS PLAAPRIKNP 910 920 930 940 950 960 FLSLAACVMP SRLKALGTLV SHVTLRLLKP ECVLDKSWCQ EELSVAVKRA VMLLHTHTIT 970 980 990 1000 1010 1020 SRVGKGEPGA APLSAPAFSL VFPFLKMVLT EMPHHSEEEE EWMAQILQIL TVQAQLRASP 1030 1040 1050 1060 1070 1080 NTPPGRVDEN GPELLPRVAM LRLLTWVIGT GSPRLQVLAS DTLTTLCASS SGDDGCAFAE 1090 1100 1110 1120 1130 1140 QEEVDVLLCA LQSPCASVRE TVLRGLMELH MVLPAPDTDE KNGLNLLRRL WVVKFDKEEE 1150 1160 1170 1180 1190 1200 IRKLAERLWS MMGLDLQPDL CSLLIDDVIY HEAAVRQAGA EALSQAVARY QRQAAEVMGR 1210 1220 1230 1240 1250 1260 LMEIYQEKLY RPPPVLDALG RVISESPPDQ WEARCGLALA LNKLSQYLDS SQVKPLFQFF 1270 1280 1290 1300 1310 1320 VPDALNDRHP DVRKCMLDAA LATLNTHGKE NVNSLLPVFE EFLKNAPNDA SYDAVRQSVV 1330 1340 1350 1360 1370 1380 VLMGSLAKHL DKSDPKVKPI VAKLIAALST PSQQVQESVA SCLPPLVPAI KEDAGGMIQR 1390 1400 1410 1420 1430 1440 LMQQLLESDK YAERKGAAYG LAGLVKGLGI LSLKQQEMMA ALTDAIQDKK NFRRREGALF 1450 1460 1470 1480 1490 1500 AFEMLCTMLG KLFEPYVVHV LPHLLLCFGD GNQYVREAAD DCAKAVMSNL SAHGVKLVLP 1510 1520 1530 1540 1550 1560 SLLAALEEES WRTKAGSVEL LGAMAYCAPK QLSSCLPNIV PKLTEVLTDS HVKVQKAGQQ 1570 1580 1590 1600 1610 1620 ALRQIGSVIR NPEILAIAPV LLDALTDPSR KTQKCLQTLL DTKFVHFIDA PSLALIMPIV 1630 1640 1650 1660 1670 1680 QRAFQDRSTD TRKMAAQIIG NMYSLTDQKD LAPYLPSVTP GLKASLLDPV PEVRTVSAKA 1690 1700 1710 1720 1730 1740 LGAMVKGMGE SCFEDLLPWL METLTYEQSS VDRSGAAQGL AEVMAGLGVE KLEKLMPEIV 1750 1760 1770 1780 1790 1800 ATASKVDIAP HVRDGYIMMF NYLPITFGDK FTPYVGPIIP CILKALADEN EFVRDTALRA 1810 1820 1830 1840 1850 1860 GQRVISMYAE TAIALLLPQL EQGLFDDLWR IRFSSVQLLG DLLFHISGVT GKMTTETASE 1870 1880 1890 1900 1910 1920 DDNFGTAQSN KAIITALGVE RRNRVLAGLY MGRSDTQLVV RQASLHVWKI VVSNTPRTLR 1930 1940 1950 1960 1970 1980 EILPTLFGLL LGFLASTCAD KRTIAARTLG DLVRKLGEKI LPEIIPILEE GLRSQKSDER 1990 2000 2010 2020 2030 2040 QGVCIGLSEI MKSTSRDAVL YFSESLVPTA RKALCDPLEE VREAAAKTFE QLHSTIGHQA 2050 2060 2070 2080 2090 2100 LEDILPFLLK QLDDEEVSEF ALDGLKQVMA IKSRVVLPYL VPKLTTPPVN TRVLAFLSSV 2110 2120 2130 2140 2150 2160 AGDALTRHLG VILPAVMLAL KEKLGTPDEQ LEMANCQAVI LSVEDDTGHR IIIEYLLEAT 2170 2180 2190 2200 2210 2220 RSPEVGMRQA AAIILNIYCS RSKADYTSHL RSLVSGLIRL FNDSSPVVLE ESWDALNAIT 2230 2240 2250 2260 2270 2280 KKLDAGNQLA LIEELHKEIR LIGNESKGEH VPGFCLPKKG VTSILPVLRE GVLTGSPEQK 2290 2300 2310 2320 2330 2340 EEAAKALGLV IRLTSADALR PSVVSITGPL IRILGDRFSW NVKAALLETL SLLLAKVGIA 2350 2360 2370 2380 2390 2400 LKPFLPQLQT TFTKALQDSN RGVRLKAADA LGKLISIHIK VDPLFTELLN GIRAMEDPGV 2410 2420 2430 2440 2450 2460 RDTMLQALRF VIQGAGAKVD AVIRKNIVSL LLSMLGHDED NTRISSAGCL GELCAFLTEE 2470 2480 2490 2500 2510 2520 ELSAVLQQCL LADVSGIDWM VRHGRSLALS VAVNVAPGRL CAGRYSSDVQ EMILSSATAD 2530 2540 2550 2560 2570 2580 RIPIAVSGVR GMGFLMRHHI ETGGGQLPAK LSSLFVKCLQ NPSSDIRLVA EKMIWWANKD 2590 2600 2610 2620 2630 2640 PLPPLDPQAI KPILKALLDN TKDKNTVVRA YSDQAIVNLL KMRQGEEVFQ SLSKILDVAS 2650 2660 2670 LEVLNEVNRR SLKKLASQAD STEQVDDTIL T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY, VARIANT ASP-2155. Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-2155. Tissue: Brain, Liver and Skin.
[5]	Bienvenut W.V. Submitted (MAR-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-13; 69-87; 221-229; 241-251; 314-323; 568-576; 617-635; 822-829; 1201-1208; 1485-1496; 1604-1622; 1735-1745; 1960-1973; 2093-2107; 2151-2161; 2192-2199; 2402-2418 AND 2522-2530, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
[6]	"Transcription map of the 5cM region surrounding the hepatocyte nuclear factor-1a/MODY3 gene on chromosome 12." Yamagata K., Oda N., Furuta H., Vaxillaire M., Southam L., Boriraj V., Chen X., Oda Y., Takeda J., Yamada S., Nishigori H., Lebeau M.M., Lathrop M., Cox R.D., Bell G.I. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-359 AND 1678-2671, VARIANT ASP-2155.
[7]	"Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2." Marton M.J., Vazquez de Aldana C.R., Qiu H., Chakraburtty K., Hinnebusch A.G. Mol. Cell. Biol. 17:4474-4489(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 842-2671, VARIANT ASP-2155. Tissue: Skeletal muscle.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-786, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-2155, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D86973 mRNA. Translation: BAA13209.2. Different initiation. AC004812 Genomic DNA. Translation: AAC83183.1. Sequence problems. BC021129 mRNA. Translation: AAH21129.1. BC032335 mRNA. Translation: AAH32335.1. BC046177 mRNA. Translation: AAH46177.1. BC064346 mRNA. Translation: AAH64346.1. BC153881 mRNA. Translation: AAI53882.1. U88836 mRNA. Translation: AAD00655.1. U88837 mRNA. Translation: AAD00656.1. U77700 mRNA. Translation: AAC51648.1. Frameshift.
IPI	IPI00001159.
RefSeq	NP_006827.1. NM_006836.1.
UniGene	Hs.298716.
3D structure databases
ProteinModelPortal	Q92616.
SMR	Q92616. Positions 1454-1700, 1971-2032.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92616. 20 interactions.
MINT	MINT-1144027.
PTM databases
PhosphoSite	Q92616.
Polymorphism databases
DMDM	296439506.
Proteomic databases
PaxDb	Q92616.
PRIDE	Q92616.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300648; ENSP00000300648; ENSG00000089154.
GeneID	10985.
KEGG	hsa:10985.
UCSC	uc001txo.3. human.
Organism-specific databases
CTD	10985.
GeneCards	GC12M120565.
HGNC	HGNC:4199. GCN1L1.
HPA	HPA018799. HPA019648. HPA024367.
MIM	605614. gene.
neXtProt	NX_Q92616.
PharmGKB	PA28616.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325174.
HOVERGEN	HBG081550.
InParanoid	Q92616.
OMA	KEDAGGM.
OrthoDB	EOG4DV5KB.
Gene expression databases
ArrayExpress	Q92616.
Bgee	Q92616.
Genevestigator	Q92616.
GermOnline	ENSG00000089154. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 8 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. IPR022716. DUF3554. IPR026827. ECM29/GCN1. IPR021133. HEAT_type_2. [Graphical view]
PANTHER	PTHR23346. PTHR23346. 1 hit.
Pfam	PF12074. DUF3554. 1 hit. [Graphical view]
SMART	SM00185. ARM. 3 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 4 hits.
PROSITE	PS50077. HEAT_REPEAT. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GCN1L1. human.
GenomeRNAi	10985.
NextBio	41737.
SOURCE	Search...

Entry information

Entry name

GCN1L_HUMAN

Accession

Primary (citable) accession number: Q92616
Secondary accession number(s): A8KAY1 , O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 115 of the entry and version 6 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.