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Protein

eIF-2-alpha kinase activator GCN1

Gene

GCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
  • protein kinase regulator activity Source: InterPro
  • ribosome binding Source: InterPro
  • translation factor activity, RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Stress response, Translation regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089154-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
eIF-2-alpha kinase activator GCN1By similarity
Alternative name(s):
GCN1 eIF-2-alpha kinase activator homologImported
GCN1-like protein 1By similarity
General control of amino-acid synthesis 1-like protein 1By similarity
Translational activator GCN1By similarity
Short name:
HsGCN1
Gene namesi
Name:GCN1Imported
Synonyms:GCN1L1By similarity, KIAA0219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:4199. GCN1.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Associates with ribosomes in undifferentiated neuroblastoma cells and increases after neuronal differentiation.By similarity

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • membrane Source: UniProtKB
  • polysome Source: UniProtKB
  • ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10985.
PharmGKBiPA28616.

Chemistry databases

ChEMBLiCHEMBL3706558.

Polymorphism and mutation databases

BioMutaiGCN1L1.
DMDMi296439506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000874432 – 2671eIF-2-alpha kinase activator GCN1Add BLAST2670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei729PhosphoserineCombined sources1
Modified residuei786PhosphoserineCombined sources1
Modified residuei2276PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92616.
MaxQBiQ92616.
PaxDbiQ92616.
PeptideAtlasiQ92616.
PRIDEiQ92616.

PTM databases

iPTMnetiQ92616.
PhosphoSitePlusiQ92616.
SwissPalmiQ92616.

Expressioni

Tissue specificityi

Ubiquitously expressed (PubMed:9039502). Expressed in skeletal muscules, ovary and testis (PubMed:9234705).2 Publications

Gene expression databases

BgeeiENSG00000089154.
GenevisibleiQ92616. HS.

Organism-specific databases

HPAiHPA018799.
HPA019648.
HPA024367.

Interactioni

Subunit structurei

Interacts with EIF2AK4/GCN2; this interaction stimulates the EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Interacts with IMPACT; this prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity.By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi116181. 100 interactors.
IntActiQ92616. 47 interactors.
MINTiMINT-1144027.
STRINGi9606.ENSP00000300648.

Structurei

3D structure databases

ProteinModelPortaliQ92616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati140 – 178HEAT 1Sequence analysisAdd BLAST39
Repeati257 – 293HEAT 2Sequence analysisAdd BLAST37
Repeati294 – 331HEAT 3Sequence analysisAdd BLAST38
Repeati385 – 423HEAT 4Sequence analysisAdd BLAST39
Repeati425 – 459HEAT 5Sequence analysisAdd BLAST35
Repeati460 – 503HEAT 6Sequence analysisAdd BLAST44
Repeati560 – 597HEAT 7Sequence analysisAdd BLAST38
Repeati599 – 636HEAT 8Sequence analysisAdd BLAST38
Repeati697 – 732HEAT 9Sequence analysisAdd BLAST36
Repeati733 – 770HEAT 10Sequence analysisAdd BLAST38
Repeati879 – 925HEAT 11Sequence analysisAdd BLAST47
Repeati979 – 1016HEAT 12Sequence analysisAdd BLAST38
Repeati1035 – 1072HEAT 13Sequence analysisAdd BLAST38
Repeati1078 – 1115HEAT 14Sequence analysisAdd BLAST38
Repeati1155 – 1192HEAT 15Sequence analysisAdd BLAST38
Repeati1210 – 1250HEAT 16Sequence analysisAdd BLAST41
Repeati1251 – 1289HEAT 17Sequence analysisAdd BLAST39
Repeati1290 – 1332HEAT 18Sequence analysisAdd BLAST43
Repeati1335 – 1372HEAT 19Sequence analysisAdd BLAST38
Repeati1374 – 1410HEAT 20Sequence analysisAdd BLAST37
Repeati1413 – 1451HEAT 21Sequence analysisAdd BLAST39
Repeati1455 – 1492HEAT 22Sequence analysisAdd BLAST38
Repeati1493 – 1530HEAT 23Sequence analysisAdd BLAST38
Repeati1534 – 1571HEAT 24Sequence analysisAdd BLAST38
Repeati1573 – 1609HEAT 25Sequence analysisAdd BLAST37
Repeati1611 – 1648HEAT 26Sequence analysisAdd BLAST38
Repeati1653 – 1690HEAT 27Sequence analysisAdd BLAST38
Repeati1692 – 1729HEAT 28Sequence analysisAdd BLAST38
Repeati1731 – 1769HEAT 29Sequence analysisAdd BLAST39
Repeati1773 – 1810HEAT 30Sequence analysisAdd BLAST38
Repeati1812 – 1848HEAT 31Sequence analysisAdd BLAST37
Repeati1921 – 1958HEAT 32Sequence analysisAdd BLAST38
Repeati1959 – 1996HEAT 33Sequence analysisAdd BLAST38
Repeati2001 – 2038HEAT 34Sequence analysisAdd BLAST38
Repeati2039 – 2076HEAT 35Sequence analysisAdd BLAST38
Repeati2078 – 2106HEAT 36Sequence analysisAdd BLAST29
Repeati2107 – 2146HEAT 37Sequence analysisAdd BLAST40
Repeati2147 – 2184HEAT 38Sequence analysisAdd BLAST38
Repeati2188 – 2225HEAT 39Sequence analysisAdd BLAST38
Repeati2259 – 2296HEAT 40Sequence analysisAdd BLAST38
Repeati2301 – 2338HEAT 41Sequence analysisAdd BLAST38
Repeati2339 – 2380HEAT 42Sequence analysisAdd BLAST42
Repeati2382 – 2417HEAT 43Sequence analysisAdd BLAST36
Repeati2422 – 2459HEAT 44Sequence analysisAdd BLAST38
Repeati2546 – 2583HEAT 45Sequence analysisAdd BLAST38
Repeati2588 – 2625HEAT 46Sequence analysisAdd BLAST38
Repeati2627 – 2661HEAT 47; degenerateSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili804 – 863Sequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the GCN1 family.Curated
Contains 47 HEAT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1242. Eukaryota.
ENOG410XPSD. LUCA.
HOVERGENiHBG081550.
InParanoidiQ92616.
OrthoDBiEOG091G008Q.
PhylomeDBiQ92616.
TreeFamiTF105398.

Family and domain databases

Gene3Di1.25.10.10. 8 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026827. Ecm29/Gcn1.
IPR033173. Gcn1.
IPR021133. HEAT_type_2.
[Graphical view]
PANTHERiPTHR23346. PTHR23346. 1 hit.
PTHR23346:SF7. PTHR23346:SF7. 1 hit.
SUPFAMiSSF48371. SSF48371. 7 hits.
PROSITEiPS50077. HEAT_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADTQVSET LKRFAGKVTT ASVKERREIL SELGKCVAGK DLPEGAVKGL
60 70 80 90 100
CKLFCLTLHR YRDAASRRAL QAAIQQLAEA QPEATAKNLL HSLQSSGIGS
110 120 130 140 150
KAGVPSKSSG SAALLALTWT CLLVRIVFPS RAKRQGDIWN KLVEVQCLLL
160 170 180 190 200
LEVLGGSHKH AVDGAVKKLT KLWKENPGLV EQYLSAILSL EPNQNYAGML
210 220 230 240 250
GLLVQFCTSH KEMDVVSQHK SALLDFYMKN ILMSKVKPPK YLLDSCAPLL
260 270 280 290 300
RYLSHSEFKD LILPTIQKSL LRSPENVIET ISSLLASVTL DLSQYAMDIV
310 320 330 340 350
KGLAGHLKSN SPRLMDEAVL ALRNLARQCS DSSAMESLTK HLFAILGGSE
360 370 380 390 400
GKLTVVAQKM SVLSGIGSVS HHVVSGPSSQ VLNGIVAELF IPFLQQEVHE
410 420 430 440 450
GTLVHAVSVL ALWCNRFTME VPKKLTEWFK KAFSLKTSTS AVRHAYLQCM
460 470 480 490 500
LASYRGDTLL QALDLLPLLI QTVEKAASQS TQVPTITEGV AAALLLLKLS
510 520 530 540 550
VADSQAEAKL SSFWQLIVDE KKQVFTSEKF LVMASEDALC TVLHLTERLF
560 570 580 590 600
LDHPHRLTGN KVQQYHRALV AVLLSRTWHV RRQAQQTVRK LLSSLGGFKL
610 620 630 640 650
AHGLLEELKT VLSSHKVLPL EALVTDAGEV TEAGKAYVPP RVLQEALCVI
660 670 680 690 700
SGVPGLKGDV TDTEQLAQEM LIISHHPSLV AVQSGLWPAL LARMKIDPEA
710 720 730 740 750
FITRHLDQII PRMTTQSPLN QSSMNAMGSL SVLSPDRVLP QLISTITASV
760 770 780 790 800
QNPALRLVTR EEFAIMQTPA GELYDKSIIQ SAQQDSIKKA NMKRENKAYS
810 820 830 840 850
FKEQIIELEL KEEIKKKKGI KEEVQLTSKQ KEMLQAQLDR EAQVRRRLQE
860 870 880 890 900
LDGELEAALG LLDIILAKNP SGLTQYIPVL VDSFLPLLKS PLAAPRIKNP
910 920 930 940 950
FLSLAACVMP SRLKALGTLV SHVTLRLLKP ECVLDKSWCQ EELSVAVKRA
960 970 980 990 1000
VMLLHTHTIT SRVGKGEPGA APLSAPAFSL VFPFLKMVLT EMPHHSEEEE
1010 1020 1030 1040 1050
EWMAQILQIL TVQAQLRASP NTPPGRVDEN GPELLPRVAM LRLLTWVIGT
1060 1070 1080 1090 1100
GSPRLQVLAS DTLTTLCASS SGDDGCAFAE QEEVDVLLCA LQSPCASVRE
1110 1120 1130 1140 1150
TVLRGLMELH MVLPAPDTDE KNGLNLLRRL WVVKFDKEEE IRKLAERLWS
1160 1170 1180 1190 1200
MMGLDLQPDL CSLLIDDVIY HEAAVRQAGA EALSQAVARY QRQAAEVMGR
1210 1220 1230 1240 1250
LMEIYQEKLY RPPPVLDALG RVISESPPDQ WEARCGLALA LNKLSQYLDS
1260 1270 1280 1290 1300
SQVKPLFQFF VPDALNDRHP DVRKCMLDAA LATLNTHGKE NVNSLLPVFE
1310 1320 1330 1340 1350
EFLKNAPNDA SYDAVRQSVV VLMGSLAKHL DKSDPKVKPI VAKLIAALST
1360 1370 1380 1390 1400
PSQQVQESVA SCLPPLVPAI KEDAGGMIQR LMQQLLESDK YAERKGAAYG
1410 1420 1430 1440 1450
LAGLVKGLGI LSLKQQEMMA ALTDAIQDKK NFRRREGALF AFEMLCTMLG
1460 1470 1480 1490 1500
KLFEPYVVHV LPHLLLCFGD GNQYVREAAD DCAKAVMSNL SAHGVKLVLP
1510 1520 1530 1540 1550
SLLAALEEES WRTKAGSVEL LGAMAYCAPK QLSSCLPNIV PKLTEVLTDS
1560 1570 1580 1590 1600
HVKVQKAGQQ ALRQIGSVIR NPEILAIAPV LLDALTDPSR KTQKCLQTLL
1610 1620 1630 1640 1650
DTKFVHFIDA PSLALIMPIV QRAFQDRSTD TRKMAAQIIG NMYSLTDQKD
1660 1670 1680 1690 1700
LAPYLPSVTP GLKASLLDPV PEVRTVSAKA LGAMVKGMGE SCFEDLLPWL
1710 1720 1730 1740 1750
METLTYEQSS VDRSGAAQGL AEVMAGLGVE KLEKLMPEIV ATASKVDIAP
1760 1770 1780 1790 1800
HVRDGYIMMF NYLPITFGDK FTPYVGPIIP CILKALADEN EFVRDTALRA
1810 1820 1830 1840 1850
GQRVISMYAE TAIALLLPQL EQGLFDDLWR IRFSSVQLLG DLLFHISGVT
1860 1870 1880 1890 1900
GKMTTETASE DDNFGTAQSN KAIITALGVE RRNRVLAGLY MGRSDTQLVV
1910 1920 1930 1940 1950
RQASLHVWKI VVSNTPRTLR EILPTLFGLL LGFLASTCAD KRTIAARTLG
1960 1970 1980 1990 2000
DLVRKLGEKI LPEIIPILEE GLRSQKSDER QGVCIGLSEI MKSTSRDAVL
2010 2020 2030 2040 2050
YFSESLVPTA RKALCDPLEE VREAAAKTFE QLHSTIGHQA LEDILPFLLK
2060 2070 2080 2090 2100
QLDDEEVSEF ALDGLKQVMA IKSRVVLPYL VPKLTTPPVN TRVLAFLSSV
2110 2120 2130 2140 2150
AGDALTRHLG VILPAVMLAL KEKLGTPDEQ LEMANCQAVI LSVEDDTGHR
2160 2170 2180 2190 2200
IIIEYLLEAT RSPEVGMRQA AAIILNIYCS RSKADYTSHL RSLVSGLIRL
2210 2220 2230 2240 2250
FNDSSPVVLE ESWDALNAIT KKLDAGNQLA LIEELHKEIR LIGNESKGEH
2260 2270 2280 2290 2300
VPGFCLPKKG VTSILPVLRE GVLTGSPEQK EEAAKALGLV IRLTSADALR
2310 2320 2330 2340 2350
PSVVSITGPL IRILGDRFSW NVKAALLETL SLLLAKVGIA LKPFLPQLQT
2360 2370 2380 2390 2400
TFTKALQDSN RGVRLKAADA LGKLISIHIK VDPLFTELLN GIRAMEDPGV
2410 2420 2430 2440 2450
RDTMLQALRF VIQGAGAKVD AVIRKNIVSL LLSMLGHDED NTRISSAGCL
2460 2470 2480 2490 2500
GELCAFLTEE ELSAVLQQCL LADVSGIDWM VRHGRSLALS VAVNVAPGRL
2510 2520 2530 2540 2550
CAGRYSSDVQ EMILSSATAD RIPIAVSGVR GMGFLMRHHI ETGGGQLPAK
2560 2570 2580 2590 2600
LSSLFVKCLQ NPSSDIRLVA EKMIWWANKD PLPPLDPQAI KPILKALLDN
2610 2620 2630 2640 2650
TKDKNTVVRA YSDQAIVNLL KMRQGEEVFQ SLSKILDVAS LEVLNEVNRR
2660 2670
SLKKLASQAD STEQVDDTIL T
Length:2,671
Mass (Da):292,758
Last modified:May 18, 2010 - v6
Checksum:iFC34F50517DCC2A8
GO

Sequence cautioni

The sequence AAC51648 differs from that shown. Reason: Frameshift at position 2657.Curated
The sequence AAC83183 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA13209 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti292L → F in BAA13209 (PubMed:9039502).Curated1
Sequence conflicti292L → F in AAI53882 (PubMed:15489334).Curated1
Sequence conflicti842A → G in AAC51648 (PubMed:9234705).Curated1
Sequence conflicti1584A → V in AAC51648 (PubMed:9234705).Curated1
Sequence conflicti1683A → V in AAC51648 (PubMed:9234705).Curated1
Sequence conflicti1760F → S in AAD00655 (Ref. 6) Curated1
Sequence conflicti2298A → V in AAC51648 (PubMed:9234705).Curated1
Sequence conflicti2486S → T in AAD00655 (Ref. 6) Curated1
Sequence conflicti2549A → R in AAC51648 (PubMed:9234705).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0622282155Y → D.Combined sources4 PublicationsCorresponds to variant rs3864938dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86973 mRNA. Translation: BAA13209.2. Different initiation.
AC004812 Genomic DNA. Translation: AAC83183.1. Sequence problems.
BC021129 mRNA. Translation: AAH21129.1.
BC032335 mRNA. Translation: AAH32335.1.
BC046177 mRNA. Translation: AAH46177.1.
BC064346 mRNA. Translation: AAH64346.1.
BC153881 mRNA. Translation: AAI53882.1.
U88836 mRNA. Translation: AAD00655.1.
U88837 mRNA. Translation: AAD00656.1.
U77700 mRNA. Translation: AAC51648.1. Frameshift.
CCDSiCCDS41847.1.
RefSeqiNP_006827.1. NM_006836.1.
UniGeneiHs.298716.

Genome annotation databases

EnsembliENST00000300648; ENSP00000300648; ENSG00000089154.
GeneIDi10985.
KEGGihsa:10985.
UCSCiuc001txo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86973 mRNA. Translation: BAA13209.2. Different initiation.
AC004812 Genomic DNA. Translation: AAC83183.1. Sequence problems.
BC021129 mRNA. Translation: AAH21129.1.
BC032335 mRNA. Translation: AAH32335.1.
BC046177 mRNA. Translation: AAH46177.1.
BC064346 mRNA. Translation: AAH64346.1.
BC153881 mRNA. Translation: AAI53882.1.
U88836 mRNA. Translation: AAD00655.1.
U88837 mRNA. Translation: AAD00656.1.
U77700 mRNA. Translation: AAC51648.1. Frameshift.
CCDSiCCDS41847.1.
RefSeqiNP_006827.1. NM_006836.1.
UniGeneiHs.298716.

3D structure databases

ProteinModelPortaliQ92616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116181. 100 interactors.
IntActiQ92616. 47 interactors.
MINTiMINT-1144027.
STRINGi9606.ENSP00000300648.

Chemistry databases

ChEMBLiCHEMBL3706558.

PTM databases

iPTMnetiQ92616.
PhosphoSitePlusiQ92616.
SwissPalmiQ92616.

Polymorphism and mutation databases

BioMutaiGCN1L1.
DMDMi296439506.

Proteomic databases

EPDiQ92616.
MaxQBiQ92616.
PaxDbiQ92616.
PeptideAtlasiQ92616.
PRIDEiQ92616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300648; ENSP00000300648; ENSG00000089154.
GeneIDi10985.
KEGGihsa:10985.
UCSCiuc001txo.4. human.

Organism-specific databases

CTDi10985.
DisGeNETi10985.
GeneCardsiGCN1L1.
HGNCiHGNC:4199. GCN1.
HPAiHPA018799.
HPA019648.
HPA024367.
MIMi605614. gene.
neXtProtiNX_Q92616.
PharmGKBiPA28616.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1242. Eukaryota.
ENOG410XPSD. LUCA.
HOVERGENiHBG081550.
InParanoidiQ92616.
OrthoDBiEOG091G008Q.
PhylomeDBiQ92616.
TreeFamiTF105398.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089154-MONOMER.

Miscellaneous databases

ChiTaRSiGCN1L1. human.
GeneWikiiGCN1L1.
GenomeRNAii10985.
PROiQ92616.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089154.
GenevisibleiQ92616. HS.

Family and domain databases

Gene3Di1.25.10.10. 8 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026827. Ecm29/Gcn1.
IPR033173. Gcn1.
IPR021133. HEAT_type_2.
[Graphical view]
PANTHERiPTHR23346. PTHR23346. 1 hit.
PTHR23346:SF7. PTHR23346:SF7. 1 hit.
SUPFAMiSSF48371. SSF48371. 7 hits.
PROSITEiPS50077. HEAT_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCN1_HUMAN
AccessioniPrimary (citable) accession number: Q92616
Secondary accession number(s): A8KAY1
, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 150 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.