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Q92616

- GCN1L_HUMAN

UniProt

Q92616 - GCN1L_HUMAN

Protein

Translational activator GCN1

Gene

GCN1L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 6 (18 May 2010)
      Previous versions | rss
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    Functioni

    Acts as a translation activator that mediates translational control and perform an EF3-related function on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity.By similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. translation factor activity, nucleic acid binding Source: UniProtKB

    GO - Biological processi

    1. regulation of translation Source: UniProtKB-KW
    2. translation Source: GOC

    Keywords - Biological processi

    Translation regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translational activator GCN1
    Short name:
    HsGCN1
    Alternative name(s):
    GCN1-like protein 1
    Gene namesi
    Name:GCN1L1
    Synonyms:KIAA0219
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:4199. GCN1L1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. membrane Source: UniProtKB
    3. ribosome Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28616.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 26712670Translational activator GCN1PRO_0000087443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei786 – 7861Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ92616.
    PaxDbiQ92616.
    PRIDEiQ92616.

    PTM databases

    PhosphoSiteiQ92616.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ92616.
    BgeeiQ92616.
    GenevestigatoriQ92616.

    Organism-specific databases

    HPAiHPA018799.
    HPA019648.
    HPA024367.

    Interactioni

    Subunit structurei

    Interacts with IMPACT; prevents the interaction with GCN2 protein kinase (EIF2AK1-4).By similarity

    Protein-protein interaction databases

    BioGridi116181. 63 interactions.
    IntActiQ92616. 28 interactions.
    MINTiMINT-1144027.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92616.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati257 – 29438HEAT 1Add
    BLAST
    Repeati295 – 33137HEAT 2Add
    BLAST
    Repeati460 – 50344HEAT 3Add
    BLAST
    Repeati1078 – 111538HEAT 4Add
    BLAST
    Repeati1290 – 133243HEAT 5Add
    BLAST
    Repeati1335 – 137238HEAT 6Add
    BLAST
    Repeati1455 – 149238HEAT 7Add
    BLAST
    Repeati1493 – 153038HEAT 8Add
    BLAST
    Repeati1534 – 157138HEAT 9Add
    BLAST
    Repeati1573 – 160937HEAT 10Add
    BLAST
    Repeati1611 – 164838HEAT 11Add
    BLAST
    Repeati1653 – 169038HEAT 12Add
    BLAST
    Repeati1773 – 181038HEAT 13Add
    BLAST
    Repeati1812 – 184837HEAT 14Add
    BLAST
    Repeati1921 – 195838HEAT 15Add
    BLAST
    Repeati1959 – 199638HEAT 16Add
    BLAST
    Repeati2001 – 203838HEAT 17Add
    BLAST
    Repeati2039 – 207638HEAT 18Add
    BLAST
    Repeati2188 – 222538HEAT 19Add
    BLAST
    Repeati2259 – 229638HEAT 20Add
    BLAST
    Repeati2339 – 238042HEAT 21Add
    BLAST
    Repeati2422 – 245938HEAT 22Add
    BLAST
    Repeati2560 – 258324HEAT 23Add
    BLAST
    Repeati2588 – 262538HEAT 24Add
    BLAST

    Sequence similaritiesi

    Belongs to the GCN1 family.Curated
    Contains 24 HEAT repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG325174.
    HOVERGENiHBG081550.
    InParanoidiQ92616.
    OMAiGLMELHM.
    OrthoDBiEOG7H4DSM.
    PhylomeDBiQ92616.
    TreeFamiTF105398.

    Family and domain databases

    Gene3Di1.25.10.10. 8 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR022716. DUF3554.
    IPR026827. ECM29/GCN1.
    IPR021133. HEAT_type_2.
    [Graphical view]
    PANTHERiPTHR23346. PTHR23346. 1 hit.
    PfamiPF12074. DUF3554. 1 hit.
    [Graphical view]
    SMARTiSM00185. ARM. 3 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 7 hits.
    PROSITEiPS50077. HEAT_REPEAT. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92616-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAADTQVSET LKRFAGKVTT ASVKERREIL SELGKCVAGK DLPEGAVKGL     50
    CKLFCLTLHR YRDAASRRAL QAAIQQLAEA QPEATAKNLL HSLQSSGIGS 100
    KAGVPSKSSG SAALLALTWT CLLVRIVFPS RAKRQGDIWN KLVEVQCLLL 150
    LEVLGGSHKH AVDGAVKKLT KLWKENPGLV EQYLSAILSL EPNQNYAGML 200
    GLLVQFCTSH KEMDVVSQHK SALLDFYMKN ILMSKVKPPK YLLDSCAPLL 250
    RYLSHSEFKD LILPTIQKSL LRSPENVIET ISSLLASVTL DLSQYAMDIV 300
    KGLAGHLKSN SPRLMDEAVL ALRNLARQCS DSSAMESLTK HLFAILGGSE 350
    GKLTVVAQKM SVLSGIGSVS HHVVSGPSSQ VLNGIVAELF IPFLQQEVHE 400
    GTLVHAVSVL ALWCNRFTME VPKKLTEWFK KAFSLKTSTS AVRHAYLQCM 450
    LASYRGDTLL QALDLLPLLI QTVEKAASQS TQVPTITEGV AAALLLLKLS 500
    VADSQAEAKL SSFWQLIVDE KKQVFTSEKF LVMASEDALC TVLHLTERLF 550
    LDHPHRLTGN KVQQYHRALV AVLLSRTWHV RRQAQQTVRK LLSSLGGFKL 600
    AHGLLEELKT VLSSHKVLPL EALVTDAGEV TEAGKAYVPP RVLQEALCVI 650
    SGVPGLKGDV TDTEQLAQEM LIISHHPSLV AVQSGLWPAL LARMKIDPEA 700
    FITRHLDQII PRMTTQSPLN QSSMNAMGSL SVLSPDRVLP QLISTITASV 750
    QNPALRLVTR EEFAIMQTPA GELYDKSIIQ SAQQDSIKKA NMKRENKAYS 800
    FKEQIIELEL KEEIKKKKGI KEEVQLTSKQ KEMLQAQLDR EAQVRRRLQE 850
    LDGELEAALG LLDIILAKNP SGLTQYIPVL VDSFLPLLKS PLAAPRIKNP 900
    FLSLAACVMP SRLKALGTLV SHVTLRLLKP ECVLDKSWCQ EELSVAVKRA 950
    VMLLHTHTIT SRVGKGEPGA APLSAPAFSL VFPFLKMVLT EMPHHSEEEE 1000
    EWMAQILQIL TVQAQLRASP NTPPGRVDEN GPELLPRVAM LRLLTWVIGT 1050
    GSPRLQVLAS DTLTTLCASS SGDDGCAFAE QEEVDVLLCA LQSPCASVRE 1100
    TVLRGLMELH MVLPAPDTDE KNGLNLLRRL WVVKFDKEEE IRKLAERLWS 1150
    MMGLDLQPDL CSLLIDDVIY HEAAVRQAGA EALSQAVARY QRQAAEVMGR 1200
    LMEIYQEKLY RPPPVLDALG RVISESPPDQ WEARCGLALA LNKLSQYLDS 1250
    SQVKPLFQFF VPDALNDRHP DVRKCMLDAA LATLNTHGKE NVNSLLPVFE 1300
    EFLKNAPNDA SYDAVRQSVV VLMGSLAKHL DKSDPKVKPI VAKLIAALST 1350
    PSQQVQESVA SCLPPLVPAI KEDAGGMIQR LMQQLLESDK YAERKGAAYG 1400
    LAGLVKGLGI LSLKQQEMMA ALTDAIQDKK NFRRREGALF AFEMLCTMLG 1450
    KLFEPYVVHV LPHLLLCFGD GNQYVREAAD DCAKAVMSNL SAHGVKLVLP 1500
    SLLAALEEES WRTKAGSVEL LGAMAYCAPK QLSSCLPNIV PKLTEVLTDS 1550
    HVKVQKAGQQ ALRQIGSVIR NPEILAIAPV LLDALTDPSR KTQKCLQTLL 1600
    DTKFVHFIDA PSLALIMPIV QRAFQDRSTD TRKMAAQIIG NMYSLTDQKD 1650
    LAPYLPSVTP GLKASLLDPV PEVRTVSAKA LGAMVKGMGE SCFEDLLPWL 1700
    METLTYEQSS VDRSGAAQGL AEVMAGLGVE KLEKLMPEIV ATASKVDIAP 1750
    HVRDGYIMMF NYLPITFGDK FTPYVGPIIP CILKALADEN EFVRDTALRA 1800
    GQRVISMYAE TAIALLLPQL EQGLFDDLWR IRFSSVQLLG DLLFHISGVT 1850
    GKMTTETASE DDNFGTAQSN KAIITALGVE RRNRVLAGLY MGRSDTQLVV 1900
    RQASLHVWKI VVSNTPRTLR EILPTLFGLL LGFLASTCAD KRTIAARTLG 1950
    DLVRKLGEKI LPEIIPILEE GLRSQKSDER QGVCIGLSEI MKSTSRDAVL 2000
    YFSESLVPTA RKALCDPLEE VREAAAKTFE QLHSTIGHQA LEDILPFLLK 2050
    QLDDEEVSEF ALDGLKQVMA IKSRVVLPYL VPKLTTPPVN TRVLAFLSSV 2100
    AGDALTRHLG VILPAVMLAL KEKLGTPDEQ LEMANCQAVI LSVEDDTGHR 2150
    IIIEYLLEAT RSPEVGMRQA AAIILNIYCS RSKADYTSHL RSLVSGLIRL 2200
    FNDSSPVVLE ESWDALNAIT KKLDAGNQLA LIEELHKEIR LIGNESKGEH 2250
    VPGFCLPKKG VTSILPVLRE GVLTGSPEQK EEAAKALGLV IRLTSADALR 2300
    PSVVSITGPL IRILGDRFSW NVKAALLETL SLLLAKVGIA LKPFLPQLQT 2350
    TFTKALQDSN RGVRLKAADA LGKLISIHIK VDPLFTELLN GIRAMEDPGV 2400
    RDTMLQALRF VIQGAGAKVD AVIRKNIVSL LLSMLGHDED NTRISSAGCL 2450
    GELCAFLTEE ELSAVLQQCL LADVSGIDWM VRHGRSLALS VAVNVAPGRL 2500
    CAGRYSSDVQ EMILSSATAD RIPIAVSGVR GMGFLMRHHI ETGGGQLPAK 2550
    LSSLFVKCLQ NPSSDIRLVA EKMIWWANKD PLPPLDPQAI KPILKALLDN 2600
    TKDKNTVVRA YSDQAIVNLL KMRQGEEVFQ SLSKILDVAS LEVLNEVNRR 2650
    SLKKLASQAD STEQVDDTIL T 2671
    Length:2,671
    Mass (Da):292,758
    Last modified:May 18, 2010 - v6
    Checksum:iFC34F50517DCC2A8
    GO

    Sequence cautioni

    The sequence AAC51648.1 differs from that shown. Reason: Frameshift at position 2657.
    The sequence BAA13209.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAC83183.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti292 – 2921L → F in BAA13209. (PubMed:9039502)Curated
    Sequence conflicti292 – 2921L → F in AAI53882. (PubMed:15489334)Curated
    Sequence conflicti842 – 8421A → G in AAC51648. (PubMed:9234705)Curated
    Sequence conflicti1584 – 15841A → V in AAC51648. (PubMed:9234705)Curated
    Sequence conflicti1683 – 16831A → V in AAC51648. (PubMed:9234705)Curated
    Sequence conflicti1760 – 17601F → S in AAD00655. 1 PublicationCurated
    Sequence conflicti2298 – 22981A → V in AAC51648. (PubMed:9234705)Curated
    Sequence conflicti2486 – 24861S → T in AAD00655. 1 PublicationCurated
    Sequence conflicti2549 – 25491A → R in AAC51648. (PubMed:9234705)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2155 – 21551Y → D.5 Publications
    Corresponds to variant rs3864938 [ dbSNP | Ensembl ].
    VAR_062228

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86973 mRNA. Translation: BAA13209.2. Different initiation.
    AC004812 Genomic DNA. Translation: AAC83183.1. Sequence problems.
    BC021129 mRNA. Translation: AAH21129.1.
    BC032335 mRNA. Translation: AAH32335.1.
    BC046177 mRNA. Translation: AAH46177.1.
    BC064346 mRNA. Translation: AAH64346.1.
    BC153881 mRNA. Translation: AAI53882.1.
    U88836 mRNA. Translation: AAD00655.1.
    U88837 mRNA. Translation: AAD00656.1.
    U77700 mRNA. Translation: AAC51648.1. Frameshift.
    CCDSiCCDS41847.1.
    RefSeqiNP_006827.1. NM_006836.1.
    UniGeneiHs.298716.

    Genome annotation databases

    EnsembliENST00000300648; ENSP00000300648; ENSG00000089154.
    GeneIDi10985.
    KEGGihsa:10985.
    UCSCiuc001txo.3. human.

    Polymorphism databases

    DMDMi296439506.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86973 mRNA. Translation: BAA13209.2 . Different initiation.
    AC004812 Genomic DNA. Translation: AAC83183.1 . Sequence problems.
    BC021129 mRNA. Translation: AAH21129.1 .
    BC032335 mRNA. Translation: AAH32335.1 .
    BC046177 mRNA. Translation: AAH46177.1 .
    BC064346 mRNA. Translation: AAH64346.1 .
    BC153881 mRNA. Translation: AAI53882.1 .
    U88836 mRNA. Translation: AAD00655.1 .
    U88837 mRNA. Translation: AAD00656.1 .
    U77700 mRNA. Translation: AAC51648.1 . Frameshift.
    CCDSi CCDS41847.1.
    RefSeqi NP_006827.1. NM_006836.1.
    UniGenei Hs.298716.

    3D structure databases

    ProteinModelPortali Q92616.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116181. 63 interactions.
    IntActi Q92616. 28 interactions.
    MINTi MINT-1144027.

    PTM databases

    PhosphoSitei Q92616.

    Polymorphism databases

    DMDMi 296439506.

    Proteomic databases

    MaxQBi Q92616.
    PaxDbi Q92616.
    PRIDEi Q92616.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300648 ; ENSP00000300648 ; ENSG00000089154 .
    GeneIDi 10985.
    KEGGi hsa:10985.
    UCSCi uc001txo.3. human.

    Organism-specific databases

    CTDi 10985.
    GeneCardsi GC12M120565.
    HGNCi HGNC:4199. GCN1L1.
    HPAi HPA018799.
    HPA019648.
    HPA024367.
    MIMi 605614. gene.
    neXtProti NX_Q92616.
    PharmGKBi PA28616.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325174.
    HOVERGENi HBG081550.
    InParanoidi Q92616.
    OMAi GLMELHM.
    OrthoDBi EOG7H4DSM.
    PhylomeDBi Q92616.
    TreeFami TF105398.

    Miscellaneous databases

    ChiTaRSi GCN1L1. human.
    GeneWikii GCN1L1.
    GenomeRNAii 10985.
    NextBioi 41737.
    PROi Q92616.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92616.
    Bgeei Q92616.
    Genevestigatori Q92616.

    Family and domain databases

    Gene3Di 1.25.10.10. 8 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR022716. DUF3554.
    IPR026827. ECM29/GCN1.
    IPR021133. HEAT_type_2.
    [Graphical view ]
    PANTHERi PTHR23346. PTHR23346. 1 hit.
    Pfami PF12074. DUF3554. 1 hit.
    [Graphical view ]
    SMARTi SM00185. ARM. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 7 hits.
    PROSITEi PS50077. HEAT_REPEAT. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY, VARIANT ASP-2155.
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-2155.
      Tissue: Brain, Liver and Skin.
    5. Bienvenut W.V.
      Submitted (MAR-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13; 69-87; 221-229; 241-251; 314-323; 568-576; 617-635; 822-829; 1201-1208; 1485-1496; 1604-1622; 1735-1745; 1960-1973; 2093-2107; 2151-2161; 2192-2199; 2402-2418 AND 2522-2530, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    6. "Transcription map of the 5cM region surrounding the hepatocyte nuclear factor-1a/MODY3 gene on chromosome 12."
      Yamagata K., Oda N., Furuta H., Vaxillaire M., Southam L., Boriraj V., Chen X., Oda Y., Takeda J., Yamada S., Nishigori H., Lebeau M.M., Lathrop M., Cox R.D., Bell G.I.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-359 AND 1678-2671, VARIANT ASP-2155.
    7. "Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2."
      Marton M.J., Vazquez de Aldana C.R., Qiu H., Chakraburtty K., Hinnebusch A.G.
      Mol. Cell. Biol. 17:4474-4489(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 842-2671, VARIANT ASP-2155.
      Tissue: Skeletal muscle.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-786, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-2155, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGCN1L_HUMAN
    AccessioniPrimary (citable) accession number: Q92616
    Secondary accession number(s): A8KAY1
    , O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 128 of the entry and version 6 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3