Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q92616 (GCN1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translational activator GCN1

Short name=HsGCN1
Alternative name(s):
GCN1-like protein 1
Gene names
Name:GCN1L1
Synonyms:KIAA0219
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2671 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a translation activator that mediates translational control and perform an EF3-related function on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity By similarity.

Subunit structure

Interacts with IMPACT; prevents the interaction with GCN2 protein kinase (EIF2AK1-4) By similarity.

Tissue specificity

Ubiquitously expressed. Ref.1

Sequence similarities

Belongs to the GCN1 family.

Contains 24 HEAT repeats.

Sequence caution

The sequence AAC51648.1 differs from that shown. Reason: Frameshift at position 2657.

The sequence AAC83183.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAA13209.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 26712670Translational activator GCN1
PRO_0000087443

Regions

Repeat257 – 29438HEAT 1
Repeat295 – 33137HEAT 2
Repeat460 – 50344HEAT 3
Repeat1078 – 111538HEAT 4
Repeat1290 – 133243HEAT 5
Repeat1335 – 137238HEAT 6
Repeat1455 – 149238HEAT 7
Repeat1493 – 153038HEAT 8
Repeat1534 – 157138HEAT 9
Repeat1573 – 160937HEAT 10
Repeat1611 – 164838HEAT 11
Repeat1653 – 169038HEAT 12
Repeat1773 – 181038HEAT 13
Repeat1812 – 184837HEAT 14
Repeat1921 – 195838HEAT 15
Repeat1959 – 199638HEAT 16
Repeat2001 – 203838HEAT 17
Repeat2039 – 207638HEAT 18
Repeat2188 – 222538HEAT 19
Repeat2259 – 229638HEAT 20
Repeat2339 – 238042HEAT 21
Repeat2422 – 245938HEAT 22
Repeat2560 – 258324HEAT 23
Repeat2588 – 262538HEAT 24

Amino acid modifications

Modified residue21N-acetylalanine Ref.5 Ref.9 Ref.11
Modified residue7861Phosphoserine Ref.8

Natural variations

Natural variant21551Y → D. Ref.1 Ref.4 Ref.6 Ref.7 Ref.13
Corresponds to variant rs3864938 [ dbSNP | Ensembl ].
VAR_062228

Experimental info

Sequence conflict2921L → F in BAA13209. Ref.1
Sequence conflict2921L → F in AAI53882. Ref.4
Sequence conflict8421A → G in AAC51648. Ref.7
Sequence conflict15841A → V in AAC51648. Ref.7
Sequence conflict16831A → V in AAC51648. Ref.7
Sequence conflict17601F → S in AAD00655. Ref.6
Sequence conflict22981A → V in AAC51648. Ref.7
Sequence conflict24861S → T in AAD00655. Ref.6
Sequence conflict25491A → R in AAC51648. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q92616 [UniParc].

Last modified May 18, 2010. Version 6.
Checksum: FC34F50517DCC2A8

FASTA2,671292,758
        10         20         30         40         50         60 
MAADTQVSET LKRFAGKVTT ASVKERREIL SELGKCVAGK DLPEGAVKGL CKLFCLTLHR 

        70         80         90        100        110        120 
YRDAASRRAL QAAIQQLAEA QPEATAKNLL HSLQSSGIGS KAGVPSKSSG SAALLALTWT 

       130        140        150        160        170        180 
CLLVRIVFPS RAKRQGDIWN KLVEVQCLLL LEVLGGSHKH AVDGAVKKLT KLWKENPGLV 

       190        200        210        220        230        240 
EQYLSAILSL EPNQNYAGML GLLVQFCTSH KEMDVVSQHK SALLDFYMKN ILMSKVKPPK 

       250        260        270        280        290        300 
YLLDSCAPLL RYLSHSEFKD LILPTIQKSL LRSPENVIET ISSLLASVTL DLSQYAMDIV 

       310        320        330        340        350        360 
KGLAGHLKSN SPRLMDEAVL ALRNLARQCS DSSAMESLTK HLFAILGGSE GKLTVVAQKM 

       370        380        390        400        410        420 
SVLSGIGSVS HHVVSGPSSQ VLNGIVAELF IPFLQQEVHE GTLVHAVSVL ALWCNRFTME 

       430        440        450        460        470        480 
VPKKLTEWFK KAFSLKTSTS AVRHAYLQCM LASYRGDTLL QALDLLPLLI QTVEKAASQS 

       490        500        510        520        530        540 
TQVPTITEGV AAALLLLKLS VADSQAEAKL SSFWQLIVDE KKQVFTSEKF LVMASEDALC 

       550        560        570        580        590        600 
TVLHLTERLF LDHPHRLTGN KVQQYHRALV AVLLSRTWHV RRQAQQTVRK LLSSLGGFKL 

       610        620        630        640        650        660 
AHGLLEELKT VLSSHKVLPL EALVTDAGEV TEAGKAYVPP RVLQEALCVI SGVPGLKGDV 

       670        680        690        700        710        720 
TDTEQLAQEM LIISHHPSLV AVQSGLWPAL LARMKIDPEA FITRHLDQII PRMTTQSPLN 

       730        740        750        760        770        780 
QSSMNAMGSL SVLSPDRVLP QLISTITASV QNPALRLVTR EEFAIMQTPA GELYDKSIIQ 

       790        800        810        820        830        840 
SAQQDSIKKA NMKRENKAYS FKEQIIELEL KEEIKKKKGI KEEVQLTSKQ KEMLQAQLDR 

       850        860        870        880        890        900 
EAQVRRRLQE LDGELEAALG LLDIILAKNP SGLTQYIPVL VDSFLPLLKS PLAAPRIKNP 

       910        920        930        940        950        960 
FLSLAACVMP SRLKALGTLV SHVTLRLLKP ECVLDKSWCQ EELSVAVKRA VMLLHTHTIT 

       970        980        990       1000       1010       1020 
SRVGKGEPGA APLSAPAFSL VFPFLKMVLT EMPHHSEEEE EWMAQILQIL TVQAQLRASP 

      1030       1040       1050       1060       1070       1080 
NTPPGRVDEN GPELLPRVAM LRLLTWVIGT GSPRLQVLAS DTLTTLCASS SGDDGCAFAE 

      1090       1100       1110       1120       1130       1140 
QEEVDVLLCA LQSPCASVRE TVLRGLMELH MVLPAPDTDE KNGLNLLRRL WVVKFDKEEE 

      1150       1160       1170       1180       1190       1200 
IRKLAERLWS MMGLDLQPDL CSLLIDDVIY HEAAVRQAGA EALSQAVARY QRQAAEVMGR 

      1210       1220       1230       1240       1250       1260 
LMEIYQEKLY RPPPVLDALG RVISESPPDQ WEARCGLALA LNKLSQYLDS SQVKPLFQFF 

      1270       1280       1290       1300       1310       1320 
VPDALNDRHP DVRKCMLDAA LATLNTHGKE NVNSLLPVFE EFLKNAPNDA SYDAVRQSVV 

      1330       1340       1350       1360       1370       1380 
VLMGSLAKHL DKSDPKVKPI VAKLIAALST PSQQVQESVA SCLPPLVPAI KEDAGGMIQR 

      1390       1400       1410       1420       1430       1440 
LMQQLLESDK YAERKGAAYG LAGLVKGLGI LSLKQQEMMA ALTDAIQDKK NFRRREGALF 

      1450       1460       1470       1480       1490       1500 
AFEMLCTMLG KLFEPYVVHV LPHLLLCFGD GNQYVREAAD DCAKAVMSNL SAHGVKLVLP 

      1510       1520       1530       1540       1550       1560 
SLLAALEEES WRTKAGSVEL LGAMAYCAPK QLSSCLPNIV PKLTEVLTDS HVKVQKAGQQ 

      1570       1580       1590       1600       1610       1620 
ALRQIGSVIR NPEILAIAPV LLDALTDPSR KTQKCLQTLL DTKFVHFIDA PSLALIMPIV 

      1630       1640       1650       1660       1670       1680 
QRAFQDRSTD TRKMAAQIIG NMYSLTDQKD LAPYLPSVTP GLKASLLDPV PEVRTVSAKA 

      1690       1700       1710       1720       1730       1740 
LGAMVKGMGE SCFEDLLPWL METLTYEQSS VDRSGAAQGL AEVMAGLGVE KLEKLMPEIV 

      1750       1760       1770       1780       1790       1800 
ATASKVDIAP HVRDGYIMMF NYLPITFGDK FTPYVGPIIP CILKALADEN EFVRDTALRA 

      1810       1820       1830       1840       1850       1860 
GQRVISMYAE TAIALLLPQL EQGLFDDLWR IRFSSVQLLG DLLFHISGVT GKMTTETASE 

      1870       1880       1890       1900       1910       1920 
DDNFGTAQSN KAIITALGVE RRNRVLAGLY MGRSDTQLVV RQASLHVWKI VVSNTPRTLR 

      1930       1940       1950       1960       1970       1980 
EILPTLFGLL LGFLASTCAD KRTIAARTLG DLVRKLGEKI LPEIIPILEE GLRSQKSDER 

      1990       2000       2010       2020       2030       2040 
QGVCIGLSEI MKSTSRDAVL YFSESLVPTA RKALCDPLEE VREAAAKTFE QLHSTIGHQA 

      2050       2060       2070       2080       2090       2100 
LEDILPFLLK QLDDEEVSEF ALDGLKQVMA IKSRVVLPYL VPKLTTPPVN TRVLAFLSSV 

      2110       2120       2130       2140       2150       2160 
AGDALTRHLG VILPAVMLAL KEKLGTPDEQ LEMANCQAVI LSVEDDTGHR IIIEYLLEAT 

      2170       2180       2190       2200       2210       2220 
RSPEVGMRQA AAIILNIYCS RSKADYTSHL RSLVSGLIRL FNDSSPVVLE ESWDALNAIT 

      2230       2240       2250       2260       2270       2280 
KKLDAGNQLA LIEELHKEIR LIGNESKGEH VPGFCLPKKG VTSILPVLRE GVLTGSPEQK 

      2290       2300       2310       2320       2330       2340 
EEAAKALGLV IRLTSADALR PSVVSITGPL IRILGDRFSW NVKAALLETL SLLLAKVGIA 

      2350       2360       2370       2380       2390       2400 
LKPFLPQLQT TFTKALQDSN RGVRLKAADA LGKLISIHIK VDPLFTELLN GIRAMEDPGV 

      2410       2420       2430       2440       2450       2460 
RDTMLQALRF VIQGAGAKVD AVIRKNIVSL LLSMLGHDED NTRISSAGCL GELCAFLTEE 

      2470       2480       2490       2500       2510       2520 
ELSAVLQQCL LADVSGIDWM VRHGRSLALS VAVNVAPGRL CAGRYSSDVQ EMILSSATAD 

      2530       2540       2550       2560       2570       2580 
RIPIAVSGVR GMGFLMRHHI ETGGGQLPAK LSSLFVKCLQ NPSSDIRLVA EKMIWWANKD 

      2590       2600       2610       2620       2630       2640 
PLPPLDPQAI KPILKALLDN TKDKNTVVRA YSDQAIVNLL KMRQGEEVFQ SLSKILDVAS 

      2650       2660       2670 
LEVLNEVNRR SLKKLASQAD STEQVDDTIL T 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY, VARIANT ASP-2155.
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-2155.
Tissue: Brain, Liver and Skin.
[5]Bienvenut W.V.
Submitted (MAR-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-13; 69-87; 221-229; 241-251; 314-323; 568-576; 617-635; 822-829; 1201-1208; 1485-1496; 1604-1622; 1735-1745; 1960-1973; 2093-2107; 2151-2161; 2192-2199; 2402-2418 AND 2522-2530, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
[6]"Transcription map of the 5cM region surrounding the hepatocyte nuclear factor-1a/MODY3 gene on chromosome 12."
Yamagata K., Oda N., Furuta H., Vaxillaire M., Southam L., Boriraj V., Chen X., Oda Y., Takeda J., Yamada S., Nishigori H., Lebeau M.M., Lathrop M., Cox R.D., Bell G.I.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-359 AND 1678-2671, VARIANT ASP-2155.
[7]"Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2."
Marton M.J., Vazquez de Aldana C.R., Qiu H., Chakraburtty K., Hinnebusch A.G.
Mol. Cell. Biol. 17:4474-4489(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 842-2671, VARIANT ASP-2155.
Tissue: Skeletal muscle.
[8]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-786, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-2155, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86973 mRNA. Translation: BAA13209.2. Different initiation.
AC004812 Genomic DNA. Translation: AAC83183.1. Sequence problems.
BC021129 mRNA. Translation: AAH21129.1.
BC032335 mRNA. Translation: AAH32335.1.
BC046177 mRNA. Translation: AAH46177.1.
BC064346 mRNA. Translation: AAH64346.1.
BC153881 mRNA. Translation: AAI53882.1.
U88836 mRNA. Translation: AAD00655.1.
U88837 mRNA. Translation: AAD00656.1.
U77700 mRNA. Translation: AAC51648.1. Frameshift.
CCDSCCDS41847.1.
RefSeqNP_006827.1. NM_006836.1.
UniGeneHs.298716.

3D structure databases

ProteinModelPortalQ92616.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116181. 61 interactions.
IntActQ92616. 28 interactions.
MINTMINT-1144027.

PTM databases

PhosphoSiteQ92616.

Polymorphism databases

DMDM296439506.

Proteomic databases

MaxQBQ92616.
PaxDbQ92616.
PRIDEQ92616.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300648; ENSP00000300648; ENSG00000089154.
GeneID10985.
KEGGhsa:10985.
UCSCuc001txo.3. human.

Organism-specific databases

CTD10985.
GeneCardsGC12M120565.
HGNCHGNC:4199. GCN1L1.
HPAHPA018799.
HPA019648.
HPA024367.
MIM605614. gene.
neXtProtNX_Q92616.
PharmGKBPA28616.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325174.
HOVERGENHBG081550.
InParanoidQ92616.
OMAGLMELHM.
OrthoDBEOG7H4DSM.
PhylomeDBQ92616.
TreeFamTF105398.

Gene expression databases

ArrayExpressQ92616.
BgeeQ92616.
GenevestigatorQ92616.

Family and domain databases

Gene3D1.25.10.10. 8 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR022716. DUF3554.
IPR026827. ECM29/GCN1.
IPR021133. HEAT_type_2.
[Graphical view]
PANTHERPTHR23346. PTHR23346. 1 hit.
PfamPF12074. DUF3554. 1 hit.
[Graphical view]
SMARTSM00185. ARM. 3 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 7 hits.
PROSITEPS50077. HEAT_REPEAT. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGCN1L1. human.
GeneWikiGCN1L1.
GenomeRNAi10985.
NextBio41737.
PROQ92616.
SOURCESearch...

Entry information

Entry nameGCN1L_HUMAN
AccessionPrimary (citable) accession number: Q92616
Secondary accession number(s): A8KAY1 expand/collapse secondary AC list , O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 126 of the entry and version 6 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM