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Protein

La-related protein 4B

Gene

LARP4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates mRNA translation.1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

  • positive regulation of translation Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
La-related protein 4B
Alternative name(s):
La ribonucleoprotein domain family member 4B
La ribonucleoprotein domain family member 5
La-related protein 5
Gene namesi
Name:LARP4B
Synonyms:KIAA0217, LARP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:28987. LARP4B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic stress granule Source: UniProtKB
  • cytosol Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • polysomal ribosome Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi23185.
OpenTargetsiENSG00000107929.
PharmGKBiPA165548762.

Polymorphism and mutation databases

DMDMi134034150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811391 – 738La-related protein 4BAdd BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei244PhosphoserineBy similarity1
Modified residuei404Omega-N-methylarginineCombined sources1
Modified residuei419Omega-N-methylarginineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei451PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1
Modified residuei493Omega-N-methylarginineBy similarity1
Modified residuei498PhosphoserineBy similarity1
Modified residuei518PhosphothreonineCombined sources1
Modified residuei524PhosphoserineCombined sources1
Modified residuei556PhosphoserineCombined sources1
Modified residuei566PhosphothreonineCombined sources1
Modified residuei568PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei718PhosphoserineCombined sources1
Modified residuei724N6-acetyllysineCombined sources1
Modified residuei727PhosphoserineCombined sources1
Modified residuei732PhosphothreonineBy similarity1
Modified residuei736PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ92615.
MaxQBiQ92615.
PaxDbiQ92615.
PeptideAtlasiQ92615.
PRIDEiQ92615.

PTM databases

iPTMnetiQ92615.
PhosphoSitePlusiQ92615.

Expressioni

Gene expression databases

BgeeiENSG00000107929.
CleanExiHS_LARP5.
ExpressionAtlasiQ92615. baseline and differential.
GenevisibleiQ92615. HS.

Organism-specific databases

HPAiHPA036566.
HPA042738.

Interactioni

Subunit structurei

Interacts with PABPC1 (PubMed:20573744, Ref. 23). Interacts with RACK1 (PubMed:20573744). Associates with polysomes via the 40S ribosomal subunit (PubMed:20573744).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116795. 98 interactors.
ELMiQ92615.
IntActiQ92615. 24 interactors.
STRINGi9606.ENSP00000326128.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PTHX-ray1.70B55-69[»]
ProteinModelPortaliQ92615.
SMRiQ92615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 239HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST90
Domaini240 – 307RRMAdd BLAST68

Phylogenomic databases

eggNOGiENOG410IN3Y. Eukaryota.
ENOG4111REM. LUCA.
GeneTreeiENSGT00530000063417.
HOGENOMiHOG000004803.
HOVERGENiHBG055137.
InParanoidiQ92615.
KOiK18763.
OMAiNGYRPLD.
OrthoDBiEOG091G03E9.
PhylomeDBiQ92615.
TreeFamiTF321960.

Family and domain databases

CDDicd12706. RRM_LARP5. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR006630. La_HTH.
IPR034900. LARP5_RRM.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF05383. La. 1 hit.
SMARTiView protein in SMART
SM00715. LA. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50961. HTH_LA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSDQDAKVV AEPQTQRVQE GKDSAHLMNG PISQTTSQTS SIPPLSQVPA
60 70 80 90 100
TKVSELNPNA EVWGAPVLHL EASSAADGVS AAWEEVAGHH ADRGPQGSDA
110 120 130 140 150
NGDGDQGHEN AALPDPQESD PADMNALALG PSEYDSLPEN SETGGNESQP
160 170 180 190 200
DSQEDPREVL KKTLEFCLSR ENLASDMYLI SQMDSDQYVP ITTVANLDHI
210 220 230 240 250
KKLSTDVDLI VEVLRSLPLV QVDEKGEKVR PNQNRCIVIL REISESTPVE
260 270 280 290 300
EVEALFKGDN LPKFINCEFA YNDNWFITFE TEADAQQAYK YLREEVKTFQ
310 320 330 340 350
GKPIKARIKA KAIAINTFLP KNGFRPLDVS LYAQQRYATS FYFPPMYSPQ
360 370 380 390 400
QQFPLYSLIT PQTWSATHSY LDPPLVTPFP NTGFINGFTS PAFKPAASPL
410 420 430 440 450
TSLRQYPPRS RNPSKSHLRH AIPSAERGPG LLESPSIFNF TADRLINGVR
460 470 480 490 500
SPQTRQAGQT RTRIQNPSAY AKREAGPGRV EPGSLESSPG LGRGRKNSFG
510 520 530 540 550
YRKKREEKFT SSQTQSPTPP KPPSPSFELG LSSFPPLPGA AGNLKTEDLF
560 570 580 590 600
ENRLSSLIIG PSKERTLSAD ASVNTLPVVV SREPSVPASC AVSATYERSP
610 620 630 640 650
SPAHLPDDPK VAEKQRETHS VDRLPSALTA TACKSVQVNG AATELRKPSY
660 670 680 690 700
AEICQRTSKE PPSSPLQPQK EQKPNTVGCG KEEKKLAEPA ERYREPPALK
710 720 730
STPGAPRDQR RPAGGRPSPS AMGKRLSREQ STPPKSPQ
Length:738
Mass (Da):80,552
Last modified:March 20, 2007 - v3
Checksum:iA0E5D44ECA58265D
GO

Sequence cautioni

The sequence BAA13207 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86971 mRNA. Translation: BAA13207.2. Different initiation.
AK292946 mRNA. Translation: BAF85635.1.
AL359878, AL157709 Genomic DNA. Translation: CAI13663.2.
AL157709, AL359878 Genomic DNA. Translation: CAI39596.2.
AL359878 Genomic DNA. Translation: CAI13661.1.
AL359878 Genomic DNA. Translation: CAI13662.1.
CH471072 Genomic DNA. Translation: EAW86530.1.
BC131630 mRNA. Translation: AAI31631.1.
BC152443 mRNA. Translation: AAI52444.1.
CR749653 mRNA. Translation: CAH18446.1.
CCDSiCCDS31131.1.
RefSeqiNP_055970.1. NM_015155.2.
UniGeneiHs.159069.
Hs.215766.

Genome annotation databases

EnsembliENST00000316157; ENSP00000326128; ENSG00000107929.
ENST00000612396; ENSP00000482767; ENSG00000107929.
GeneIDi23185.
KEGGihsa:23185.
UCSCiuc031ptb.1. human.

Similar proteinsi

Entry informationi

Entry nameiLAR4B_HUMAN
AccessioniPrimary (citable) accession number: Q92615
Secondary accession number(s): A7MD20
, Q5T3R3, Q5T3R4, Q5T3R5, Q68CY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: August 30, 2017
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references