Q92615 (LAR4B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
La-related protein 4B

Alternative name(s):
La ribonucleoprotein domain family member 4B
La ribonucleoprotein domain family member 5
La-related protein 5

Gene names

Name:	LARP4B
Synonyms:	KIAA0217, LARP5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	738 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 1 HTH La-type RNA-binding domain. Contains 1 RRM (RNA recognition motif) domain.
Sequence caution	The sequence BAA13207.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	RNA-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 738	738	La-related protein 4B		PRO_0000281139
Regions
	Domain	150 – 239	90	HTH La-type RNA-binding
	Domain	240 – 307	68	RRM
Amino acid modifications
	Modified residue	424	1	Phosphoserine Ref.14 Ref.16
	Modified residue	434	1	Phosphoserine Ref.9 Ref.10 Ref.12 Ref.14
	Modified residue	451	1	Phosphoserine Ref.14
	Modified residue	498	1	Phosphoserine By similarity
	Modified residue	516	1	Phosphoserine Ref.14
	Modified residue	518	1	Phosphothreonine Ref.16
	Modified residue	524	1	Phosphoserine Ref.14 Ref.16
	Modified residue	566	1	Phosphothreonine Ref.9
	Modified residue	568	1	Phosphoserine Ref.12
	Modified residue	601	1	Phosphoserine Ref.8 Ref.11 Ref.13
	Modified residue	663	1	Phosphoserine Ref.15
	Modified residue	664	1	Phosphoserine Ref.15
	Modified residue	718	1	Phosphoserine Ref.8
	Modified residue	724	1	N6-acetyllysine Ref.17
	Modified residue	727	1	Phosphoserine Ref.14 Ref.15
	Modified residue	732	1	Phosphothreonine Ref.14 Ref.15
	Modified residue	736	1	Phosphoserine Ref.14 Ref.15

Sequences

	Sequence		Length	Mass (Da)
	Q92615 [UniParc]. Last modified March 20, 2007. Version 3. Checksum: A0E5D44ECA58265D	FASTA	738	80,552
	10 20 30 40 50 60 MTSDQDAKVV AEPQTQRVQE GKDSAHLMNG PISQTTSQTS SIPPLSQVPA TKVSELNPNA 70 80 90 100 110 120 EVWGAPVLHL EASSAADGVS AAWEEVAGHH ADRGPQGSDA NGDGDQGHEN AALPDPQESD 130 140 150 160 170 180 PADMNALALG PSEYDSLPEN SETGGNESQP DSQEDPREVL KKTLEFCLSR ENLASDMYLI 190 200 210 220 230 240 SQMDSDQYVP ITTVANLDHI KKLSTDVDLI VEVLRSLPLV QVDEKGEKVR PNQNRCIVIL 250 260 270 280 290 300 REISESTPVE EVEALFKGDN LPKFINCEFA YNDNWFITFE TEADAQQAYK YLREEVKTFQ 310 320 330 340 350 360 GKPIKARIKA KAIAINTFLP KNGFRPLDVS LYAQQRYATS FYFPPMYSPQ QQFPLYSLIT 370 380 390 400 410 420 PQTWSATHSY LDPPLVTPFP NTGFINGFTS PAFKPAASPL TSLRQYPPRS RNPSKSHLRH 430 440 450 460 470 480 AIPSAERGPG LLESPSIFNF TADRLINGVR SPQTRQAGQT RTRIQNPSAY AKREAGPGRV 490 500 510 520 530 540 EPGSLESSPG LGRGRKNSFG YRKKREEKFT SSQTQSPTPP KPPSPSFELG LSSFPPLPGA 550 560 570 580 590 600 AGNLKTEDLF ENRLSSLIIG PSKERTLSAD ASVNTLPVVV SREPSVPASC AVSATYERSP 610 620 630 640 650 660 SPAHLPDDPK VAEKQRETHS VDRLPSALTA TACKSVQVNG AATELRKPSY AEICQRTSKE 670 680 690 700 710 720 PPSSPLQPQK EQKPNTVGCG KEEKKLAEPA ERYREPPALK STPGAPRDQR RPAGGRPSPS 730 AMGKRLSREQ STPPKSPQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-738. Tissue: Fetal kidney.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601 AND SER-718, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434 AND THR-566, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434 AND SER-568, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424 AND SER-434; SER-451; SER-516; SER-524; SER-727; THR-732 AND SER-736, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663; SER-664; SER-727; THR-732 AND SER-736, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[16]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424; THR-518 AND SER-524, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[17]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-724, MASS SPECTROMETRY.
[18]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D86971 mRNA. Translation: BAA13207.2. Different initiation. AK292946 mRNA. Translation: BAF85635.1. AL359878, AL157709 Genomic DNA. Translation: CAI13663.2. AL157709, AL359878 Genomic DNA. Translation: CAI39596.2. AL359878 Genomic DNA. Translation: CAI13661.1. AL359878 Genomic DNA. Translation: CAI13662.1. CH471072 Genomic DNA. Translation: EAW86530.1. BC131630 mRNA. Translation: AAI31631.1. BC152443 mRNA. Translation: AAI52444.1. CR749653 mRNA. Translation: CAH18446.1.
IPI	IPI00953461.
RefSeq	NP_055970.1. NM_015155.1.
UniGene	Hs.631814. Hs.713649.
3D structure databases
HSSP	HSSP built from PDB template 2CQK based on UniProtKB Q71RC2.
ProteinModelPortal	Q92615.
SMR	Q92615. Positions 152-237.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92615. 1 interaction.
STRING	Q92615.
PTM databases
PhosphoSite	Q92615.
Polymorphism databases
DMDM	134034150.
Proteomic databases
PRIDE	Q92615.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316157; ENSP00000326128; ENSG00000107929.
GeneID	23185.
KEGG	hsa:23185.
UCSC	uc001ifs.1. human.
Organism-specific databases
CTD	23185.
GeneCards	GC10M000851.
H-InvDB	HIX0008584.
HGNC	HGNC:28987. LARP4B.
HPA	HPA036566.
neXtProt	NX_Q92615.
PharmGKB	PA134956777.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13183.
GeneTree	ENSGT00530000063417.
OMA	AKVWGNH.
OrthoDB	EOG4FN4HK.
PhylomeDB	Q92615.
Gene expression databases
ArrayExpress	Q92615.
Bgee	Q92615.
CleanEx	HS_LARP5.
Genevestigator	Q92615.
Family and domain databases
InterPro	IPR006630. Lupus_La_RNA-bd. IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF05383. La. 1 hit. [Graphical view]
SMART	SM00715. LA. 1 hit. SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50961. HTH_LA. 1 hit. PS50102. RRM. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	44651.

Entry information

Entry name

LAR4B_HUMAN

Accession

Primary (citable) accession number: Q92615
Secondary accession number(s): A7MD20 , Q5T3R3, Q5T3R4, Q5T3R5, Q68CY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	January 25, 2012
This is version 92 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.