Myosin-XVIIIa - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
    Myosin-XVIIIa
Alternative name(s):
    Myosin containing a PDZ domain
    Molecule associated with JAK3 N-terminus
      Short name=MAJN

Gene names

Name:	MYO18A
Synonyms:	KIAA0216, MYSPDZ

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	2054 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May be involved in the maintenance of the stromal cell architectures required for cell to cell contact By similarity.
Subunit structure	Homodimer. Interacts with JAK3 and actin. Ref.5 Ref.7
Subcellular location	Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment By similarity. Cytoplasm › cytoskeleton. Note: Colocalizes with actin. Ref.7 Isoform 2: Cytoplasm. Note: Lacks the PDZ domain. Diffusely localized in the cytoplasm. Ref.7
Sequence similarities	Contains 1 IQ domain. Contains 1 myosin head-like domain. Contains 1 PDZ (DHR) domain.
Caution	The TIAF1 protein is coded in the 3'-UTR region of MYO18A.

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Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein Myosin
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA metabolic process Inferred from electronic annotation. Source: InterPro anti-apoptosis Traceable author statement. Source: ProtInc
Cellular component	ER-Golgi intermediate compartment Inferred from electronic annotation. Source: UniProtKB-SubCell Golgi apparatus Inferred from direct assay. Source: HPA myosin complex Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay. Source: HPA
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA-dependent ATPase activity Inferred from electronic annotation. Source: InterPro identical protein binding Inferred from physical interaction. Source: IntAct motor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-949059,EBI-949059

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Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92614-1) Also known as: Alpha; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Colocalizes with actin. Ref.7

Isoform 2 (identifier: Q92614-2) Also known as: Beta; The sequence of this isoform differs from the canonical sequence as follows: 1-331: Missing. 332-333: SD → MR
Note: Lacks the PDZ domain. Diffusely localized in the cytoplasm. Ref.7

Isoform 3 (identifier: Q92614-3) The sequence of this isoform differs from the canonical sequence as follows: 1571-1607: Missing. 1952-1966: Missing.
Note: No experimental confirmation available.

Isoform 4 (identifier: Q92614-4) The sequence of this isoform differs from the canonical sequence as follows: 1952-1966: Missing.
Note: No experimental confirmation available.

Isoform 5 (identifier: Q92614-5) The sequence of this isoform differs from the canonical sequence as follows: 1-458: Missing. 1952-1966: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2054

2054

Myosin-XVIIIa

PRO_0000123476

Regions

Domain

220 – 311

92

PDZ

Domain

420 – 1186

767

Myosin head-like

Domain

1188 – 1217

30

IQ

Nucleotide binding

498 – 505

8

ATP Potential

Coiled coil

1246 – 1971

726

Potential

Motif

114 – 118

5

Interaction with actin

Amino acid modifications

Modified residue

72

1

Phosphoserine By similarity

Modified residue

74

1

Phosphoserine By similarity

Modified residue

83

1

Phosphoserine By similarity

Modified residue

102

1

Phosphoserine By similarity

Modified residue

140

1

Phosphoserine Ref.9

Modified residue

164

1

Phosphoserine By similarity

Modified residue

234

1

Phosphoserine Ref.9

Modified residue

1039

1

Phosphoserine Ref.10

Modified residue

1063

1

Phosphoserine Ref.10

Modified residue

1067

1

Phosphoserine Ref.12 Ref.13

Modified residue

1070

1

Phosphoserine Ref.13

Modified residue

1942

1

Phosphoserine Ref.9 Ref.13

Modified residue

1951

1

Phosphoserine Ref.13

Modified residue

1970

1

Phosphoserine Ref.9 Ref.13 Ref.14

Modified residue

1974

1

Phosphoserine Ref.9 Ref.13 Ref.14

Modified residue

1998

1

Phosphoserine Ref.13

Modified residue

2002

1

Phosphoserine Ref.13

Modified residue

2007

1

Phosphoserine Ref.13

Modified residue

2020

1

Phosphoserine Ref.9 Ref.13

Modified residue

2036

1

Phosphoserine By similarity

Modified residue

2041

1

Phosphoserine Ref.13 Ref.8 Ref.11 Ref.16

Modified residue

2043

1

Phosphoserine Ref.13 Ref.8 Ref.11 Ref.16

Modified residue

2045

1

Phosphothreonine Ref.13

Natural variations

Alternative sequence

1 – 458

458

Missing in isoform 5.

VSP_023058

Alternative sequence

1 – 331

331

Missing in isoform 2.

VSP_007869

Alternative sequence

332 – 333

2

SD → MR in isoform 2.

VSP_007870

Alternative sequence

1571 – 1607

37

Missing in isoform 3.

VSP_007871

Alternative sequence

1952 – 1966

15

Missing in isoform 3, isoform 4 and isoform 5.

VSP_007872

Natural variant

958

1

A → V: dbSNP rs8076604. Ref.2 Ref.4

VAR_030585

Experimental info

Mutagenesis

114 – 115

2

RG → AA: No effect on interaction with actin. Ref.7

Mutagenesis

117 – 118

2

VL → AA: Abolishes interaction with actin. Ref.7

Sequence conflict

1014

1

A → V in BAD66838. Ref.1

Sequence conflict

1020

1

S → P in CAI45931. Ref.3

Sequence conflict

1757

1

E → K in CAI45931. Ref.3

Sequence conflict

1889

1

E → G in CAI45931. Ref.3

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 (Alpha) [UniParc]. Last modified July 25, 2003. Version 3. Checksum: 52BFA0AA273E18F7 Show »	FASTA	2,054	233,115
10 20 30 40 50 60 MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR SSKRESKTRL 70 80 90 100 110 120 EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 130 140 150 160 170 180 AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLVQHP 190 200 210 220 230 240 GPGIPRPGHR SRAPELVTKK FPVDLRLPPV VPLPPPTLRE LELQRRPTGD FGFSLRRTTM 250 260 270 280 290 300 LDRGPEGQAC RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG 310 320 330 340 350 360 DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDAKTEEQI AAEEAWNETE KVWLVHRDGF 370 380 390 400 410 420 SLASQLKSEE LNLPEGKVRV KLDHDGAILD VDEDDVEKAN APSCDRLEDL ASLVYLNESS 430 440 450 460 470 480 VLHTLRQRYG ASLLHTYAGP SLLVLGPRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT 490 500 510 520 530 540 AYRAMLMSRQ DQSIILLGSS GSGKTTSCQH LVQYLATIAG ISGNKVFSVE KWQALYTLLE 550 560 570 580 590 600 AFGNSPTIIN GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 610 620 630 640 650 660 LLACGDGTLR TELHLNHLAE NNVFGIVPLA KPEEKQKAAQ QFSKLQAAMK VLGISPDEQK 670 680 690 700 710 720 ACWFILAAIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY LLGCSLEELS SAIFKHQHKG 730 740 750 760 770 780 GTLQRSTSFR QGPEESGLGD GTGPKLSALE CLEGMAAGLY SELFTLLVSL VNRALKSSQH 790 800 810 820 830 840 SLCSMMIVDT PGFQNPEQGG SARGASFEEL CHNYTQDRLQ RLFHERTFVQ ELERYKEENI 850 860 870 880 890 900 ELAFDDLEPP TDDSVAAVDQ ASHQSLVRSL ARTDEARGLL WLLEEEALVP GASEDTLLER 910 920 930 940 950 960 LFSYYGPQEG DKKGQSPLLH SSKPHHFLLG HSHGTNWVEY NVTGWLNYTK QNPATQNAPR 970 980 990 1000 1010 1020 LLQDSQKKII SNLFLGRAGS ATVLSGSIAG LEGGSQLALR RATSMRKTFT TGMAAVKKKS 1030 1040 1050 1060 1070 1080 LCIQMKLQVD ALIDTIKKSK LHFVHCFLPV AEGWAGEPRS ASSRRVSSSS ELDLPSGDHC 1090 1100 1110 1120 1130 1140 EAGLLQLDVP LLRTQLRGSR LLDAMRMYRQ GYPDHMVFSE FRRRFDVLAP HLTKKHGRNY 1150 1160 1170 1180 1190 1200 IVVDERRAVE ELLECLDLEK SSCCMGLSRV FFRAGTLARL EEQRDEQTSR NLTLFQAACR 1210 1220 1230 1240 1250 1260 GYLARQHFKK RKIQDLAIRC VQKNIKKNKG VKDWPWWKLF TTVRPLIEVQ LSEEQIRNKD 1270 1280 1290 1300 1310 1320 EEIQQLRSKL EKAEKERNEL RLNSDRLESR ISELTSELTD ERNTGESASQ LLDAETAERL 1330 1340 1350 1360 1370 1380 RAEKEMKELQ TQYDALKKQM EVMEMEVMEA RLIRAAEING EVDDDDAGGE WRLKYERAVR 1390 1400 1410 1420 1430 1440 EVDFTKKRLQ QEFEDKLEVE QQNKRQLERR LGDLQADSEE SQRALQQLKK KCQRLTAELQ 1450 1460 1470 1480 1490 1500 DTKLHLEGQQ VRNHELEKKQ RRFDSELSQA HEEAQREKLQ REKLQREKDM LLAEAFSLKQ 1510 1520 1530 1540 1550 1560 QLEEKDMDIA GFTQKVVSLE AELQDISSQE SKDEASLAKV KKQLRDLEAK VKDQEEELDE 1570 1580 1590 1600 1610 1620 QAGTIQMLEQ AKLRLEMEME RMRQTHSKEM ESRDEEVEEA RQSCQKKLKQ MEVQLEEEYE 1630 1640 1650 1660 1670 1680 DKQKVLREKR ELEGKLATLS DQVNRRDFES EKRLRKDLKR TKALLADAQL MLDHLKNSAP 1690 1700 1710 1720 1730 1740 SKREIAQLKN QLEESEFTCA AAVKARKAME VEIEDLHLQI DDIAKAKTAL EEQLSRLQRE 1750 1760 1770 1780 1790 1800 KNEIQNRLEE DQEDMNELMK KHKAAVAQAS RDLAQINDLQ AQLEEANKEK QELQEKLQAL 1810 1820 1830 1840 1850 1860 QSQVEFLEQS MVDKSLVSRQ EAKIRELETR LEFERTQVKR LESLASRLKE NMEKLTEERD 1870 1880 1890 1900 1910 1920 QRIAAENREK EQNKRLQRQL RDTKEEMGEL ARKEAEASRK KHELEMDLES LEAANQSLQA 1930 1940 1950 1960 1970 1980 DLKLAFKRIG DLQAAIEDEM ESDENEDLIN SLQDMVTKYQ KRKNKLEGDS DVDSELEDRV 1990 2000 2010 2020 2030 2040 DGVKSWLSKN KGPSKAASDD GSLKSSSPTS YWKSLAPDRS DDEHDPLDNT SRPRYSHSYL 2050 SDSDTEAKLT ETNA « Hide
Isoform 2 (Beta). Checksum: A0764A2A6D54D6EC Show »	FASTA	1,723	196,438
10 20 30 40 50 60 MRAKTEEQIA AEEAWNETEK VWLVHRDGFS LASQLKSEEL NLPEGKVRVK LDHDGAILDV 70 80 90 100 110 120 DEDDVEKANA PSCDRLEDLA SLVYLNESSV LHTLRQRYGA SLLHTYAGPS LLVLGPRGAP 130 140 150 160 170 180 AVYSEKVMHM FKGCRREDMA PHIYAVAQTA YRAMLMSRQD QSIILLGSSG SGKTTSCQHL 190 200 210 220 230 240 VQYLATIAGI SGNKVFSVEK WQALYTLLEA FGNSPTIING NATRFSQILS LDFDQAGQVA 250 260 270 280 290 300 SASIQTMLLE KLRVARRPAS EATFNVFYYL LACGDGTLRT ELHLNHLAEN NVFGIVPLAK 310 320 330 340 350 360 PEEKQKAAQQ FSKLQAAMKV LGISPDEQKA CWFILAAIYH LGAAGATKEA AEAGRKQFAR 370 380 390 400 410 420 HEWAQKAAYL LGCSLEELSS AIFKHQHKGG TLQRSTSFRQ GPEESGLGDG TGPKLSALEC 430 440 450 460 470 480 LEGMAAGLYS ELFTLLVSLV NRALKSSQHS LCSMMIVDTP GFQNPEQGGS ARGASFEELC 490 500 510 520 530 540 HNYTQDRLQR LFHERTFVQE LERYKEENIE LAFDDLEPPT DDSVAAVDQA SHQSLVRSLA 550 560 570 580 590 600 RTDEARGLLW LLEEEALVPG ASEDTLLERL FSYYGPQEGD KKGQSPLLHS SKPHHFLLGH 610 620 630 640 650 660 SHGTNWVEYN VTGWLNYTKQ NPATQNAPRL LQDSQKKIIS NLFLGRAGSA TVLSGSIAGL 670 680 690 700 710 720 EGGSQLALRR ATSMRKTFTT GMAAVKKKSL CIQMKLQVDA LIDTIKKSKL HFVHCFLPVA 730 740 750 760 770 780 EGWAGEPRSA SSRRVSSSSE LDLPSGDHCE AGLLQLDVPL LRTQLRGSRL LDAMRMYRQG 790 800 810 820 830 840 YPDHMVFSEF RRRFDVLAPH LTKKHGRNYI VVDERRAVEE LLECLDLEKS SCCMGLSRVF 850 860 870 880 890 900 FRAGTLARLE EQRDEQTSRN LTLFQAACRG YLARQHFKKR KIQDLAIRCV QKNIKKNKGV 910 920 930 940 950 960 KDWPWWKLFT TVRPLIEVQL SEEQIRNKDE EIQQLRSKLE KAEKERNELR LNSDRLESRI 970 980 990 1000 1010 1020 SELTSELTDE RNTGESASQL LDAETAERLR AEKEMKELQT QYDALKKQME VMEMEVMEAR 1030 1040 1050 1060 1070 1080 LIRAAEINGE VDDDDAGGEW RLKYERAVRE VDFTKKRLQQ EFEDKLEVEQ QNKRQLERRL 1090 1100 1110 1120 1130 1140 GDLQADSEES QRALQQLKKK CQRLTAELQD TKLHLEGQQV RNHELEKKQR RFDSELSQAH 1150 1160 1170 1180 1190 1200 EEAQREKLQR EKLQREKDML LAEAFSLKQQ LEEKDMDIAG FTQKVVSLEA ELQDISSQES 1210 1220 1230 1240 1250 1260 KDEASLAKVK KQLRDLEAKV KDQEEELDEQ AGTIQMLEQA KLRLEMEMER MRQTHSKEME 1270 1280 1290 1300 1310 1320 SRDEEVEEAR QSCQKKLKQM EVQLEEEYED KQKVLREKRE LEGKLATLSD QVNRRDFESE 1330 1340 1350 1360 1370 1380 KRLRKDLKRT KALLADAQLM LDHLKNSAPS KREIAQLKNQ LEESEFTCAA AVKARKAMEV 1390 1400 1410 1420 1430 1440 EIEDLHLQID DIAKAKTALE EQLSRLQREK NEIQNRLEED QEDMNELMKK HKAAVAQASR 1450 1460 1470 1480 1490 1500 DLAQINDLQA QLEEANKEKQ ELQEKLQALQ SQVEFLEQSM VDKSLVSRQE AKIRELETRL 1510 1520 1530 1540 1550 1560 EFERTQVKRL ESLASRLKEN MEKLTEERDQ RIAAENREKE QNKRLQRQLR DTKEEMGELA 1570 1580 1590 1600 1610 1620 RKEAEASRKK HELEMDLESL EAANQSLQAD LKLAFKRIGD LQAAIEDEME SDENEDLINS 1630 1640 1650 1660 1670 1680 LQDMVTKYQK RKNKLEGDSD VDSELEDRVD GVKSWLSKNK GPSKAASDDG SLKSSSPTSY 1690 1700 1710 1720 WKSLAPDRSD DEHDPLDNTS RPRYSHSYLS DSDTEAKLTE TNA « Hide
Isoform 3. Checksum: 89350E07C2CF8B03 Show »	FASTA	2,002	226,690
10 20 30 40 50 60 MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR SSKRESKTRL 70 80 90 100 110 120 EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 130 140 150 160 170 180 AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLVQHP 190 200 210 220 230 240 GPGIPRPGHR SRAPELVTKK FPVDLRLPPV VPLPPPTLRE LELQRRPTGD FGFSLRRTTM 250 260 270 280 290 300 LDRGPEGQAC RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG 310 320 330 340 350 360 DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDAKTEEQI AAEEAWNETE KVWLVHRDGF 370 380 390 400 410 420 SLASQLKSEE LNLPEGKVRV KLDHDGAILD VDEDDVEKAN APSCDRLEDL ASLVYLNESS 430 440 450 460 470 480 VLHTLRQRYG ASLLHTYAGP SLLVLGPRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT 490 500 510 520 530 540 AYRAMLMSRQ DQSIILLGSS GSGKTTSCQH LVQYLATIAG ISGNKVFSVE KWQALYTLLE 550 560 570 580 590 600 AFGNSPTIIN GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 610 620 630 640 650 660 LLACGDGTLR TELHLNHLAE NNVFGIVPLA KPEEKQKAAQ QFSKLQAAMK VLGISPDEQK 670 680 690 700 710 720 ACWFILAAIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY LLGCSLEELS SAIFKHQHKG 730 740 750 760 770 780 GTLQRSTSFR QGPEESGLGD GTGPKLSALE CLEGMAAGLY SELFTLLVSL VNRALKSSQH 790 800 810 820 830 840 SLCSMMIVDT PGFQNPEQGG SARGASFEEL CHNYTQDRLQ RLFHERTFVQ ELERYKEENI 850 860 870 880 890 900 ELAFDDLEPP TDDSVAAVDQ ASHQSLVRSL ARTDEARGLL WLLEEEALVP GASEDTLLER 910 920 930 940 950 960 LFSYYGPQEG DKKGQSPLLH SSKPHHFLLG HSHGTNWVEY NVTGWLNYTK QNPATQNAPR 970 980 990 1000 1010 1020 LLQDSQKKII SNLFLGRAGS ATVLSGSIAG LEGGSQLALR RATSMRKTFT TGMAAVKKKS 1030 1040 1050 1060 1070 1080 LCIQMKLQVD ALIDTIKKSK LHFVHCFLPV AEGWAGEPRS ASSRRVSSSS ELDLPSGDHC 1090 1100 1110 1120 1130 1140 EAGLLQLDVP LLRTQLRGSR LLDAMRMYRQ GYPDHMVFSE FRRRFDVLAP HLTKKHGRNY 1150 1160 1170 1180 1190 1200 IVVDERRAVE ELLECLDLEK SSCCMGLSRV FFRAGTLARL EEQRDEQTSR NLTLFQAACR 1210 1220 1230 1240 1250 1260 GYLARQHFKK RKIQDLAIRC VQKNIKKNKG VKDWPWWKLF TTVRPLIEVQ LSEEQIRNKD 1270 1280 1290 1300 1310 1320 EEIQQLRSKL EKAEKERNEL RLNSDRLESR ISELTSELTD ERNTGESASQ LLDAETAERL 1330 1340 1350 1360 1370 1380 RAEKEMKELQ TQYDALKKQM EVMEMEVMEA RLIRAAEING EVDDDDAGGE WRLKYERAVR 1390 1400 1410 1420 1430 1440 EVDFTKKRLQ QEFEDKLEVE QQNKRQLERR LGDLQADSEE SQRALQQLKK KCQRLTAELQ 1450 1460 1470 1480 1490 1500 DTKLHLEGQQ VRNHELEKKQ RRFDSELSQA HEEAQREKLQ REKLQREKDM LLAEAFSLKQ 1510 1520 1530 1540 1550 1560 QLEEKDMDIA GFTQKVVSLE AELQDISSQE SKDEASLAKV KKQLRDLEAK VKDQEEELDE 1570 1580 1590 1600 1610 1620 QAGTIQMLEQ LKQMEVQLEE EYEDKQKVLR EKRELEGKLA TLSDQVNRRD FESEKRLRKD 1630 1640 1650 1660 1670 1680 LKRTKALLAD AQLMLDHLKN SAPSKREIAQ LKNQLEESEF TCAAAVKARK AMEVEIEDLH 1690 1700 1710 1720 1730 1740 LQIDDIAKAK TALEEQLSRL QREKNEIQNR LEEDQEDMNE LMKKHKAAVA QASRDLAQIN 1750 1760 1770 1780 1790 1800 DLQAQLEEAN KEKQELQEKL QALQSQVEFL EQSMVDKSLV SRQEAKIREL ETRLEFERTQ 1810 1820 1830 1840 1850 1860 VKRLESLASR LKENMEKLTE ERDQRIAAEN REKEQNKRLQ RQLRDTKEEM GELARKEAEA 1870 1880 1890 1900 1910 1920 SRKKHELEMD LESLEAANQS LQADLKLAFK RIGDLQAAIE DEMESDENED LINSEGDSDV 1930 1940 1950 1960 1970 1980 DSELEDRVDG VKSWLSKNKG PSKAASDDGS LKSSSPTSYW KSLAPDRSDD EHDPLDNTSR 1990 2000 PRYSHSYLSD SDTEAKLTET NA « Hide
Isoform 4. Checksum: 70DDB5F30E54B9C3 Show »	FASTA	2,039	231,240
10 20 30 40 50 60 MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR SSKRESKTRL 70 80 90 100 110 120 EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 130 140 150 160 170 180 AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLVQHP 190 200 210 220 230 240 GPGIPRPGHR SRAPELVTKK FPVDLRLPPV VPLPPPTLRE LELQRRPTGD FGFSLRRTTM 250 260 270 280 290 300 LDRGPEGQAC RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG 310 320 330 340 350 360 DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDAKTEEQI AAEEAWNETE KVWLVHRDGF 370 380 390 400 410 420 SLASQLKSEE LNLPEGKVRV KLDHDGAILD VDEDDVEKAN APSCDRLEDL ASLVYLNESS 430 440 450 460 470 480 VLHTLRQRYG ASLLHTYAGP SLLVLGPRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT 490 500 510 520 530 540 AYRAMLMSRQ DQSIILLGSS GSGKTTSCQH LVQYLATIAG ISGNKVFSVE KWQALYTLLE 550 560 570 580 590 600 AFGNSPTIIN GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 610 620 630 640 650 660 LLACGDGTLR TELHLNHLAE NNVFGIVPLA KPEEKQKAAQ QFSKLQAAMK VLGISPDEQK 670 680 690 700 710 720 ACWFILAAIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY LLGCSLEELS SAIFKHQHKG 730 740 750 760 770 780 GTLQRSTSFR QGPEESGLGD GTGPKLSALE CLEGMAAGLY SELFTLLVSL VNRALKSSQH 790 800 810 820 830 840 SLCSMMIVDT PGFQNPEQGG SARGASFEEL CHNYTQDRLQ RLFHERTFVQ ELERYKEENI 850 860 870 880 890 900 ELAFDDLEPP TDDSVAAVDQ ASHQSLVRSL ARTDEARGLL WLLEEEALVP GASEDTLLER 910 920 930 940 950 960 LFSYYGPQEG DKKGQSPLLH SSKPHHFLLG HSHGTNWVEY NVTGWLNYTK QNPATQNAPR 970 980 990 1000 1010 1020 LLQDSQKKII SNLFLGRAGS ATVLSGSIAG LEGGSQLALR RATSMRKTFT TGMAAVKKKS 1030 1040 1050 1060 1070 1080 LCIQMKLQVD ALIDTIKKSK LHFVHCFLPV AEGWAGEPRS ASSRRVSSSS ELDLPSGDHC 1090 1100 1110 1120 1130 1140 EAGLLQLDVP LLRTQLRGSR LLDAMRMYRQ GYPDHMVFSE FRRRFDVLAP HLTKKHGRNY 1150 1160 1170 1180 1190 1200 IVVDERRAVE ELLECLDLEK SSCCMGLSRV FFRAGTLARL EEQRDEQTSR NLTLFQAACR 1210 1220 1230 1240 1250 1260 GYLARQHFKK RKIQDLAIRC VQKNIKKNKG VKDWPWWKLF TTVRPLIEVQ LSEEQIRNKD 1270 1280 1290 1300 1310 1320 EEIQQLRSKL EKAEKERNEL RLNSDRLESR ISELTSELTD ERNTGESASQ LLDAETAERL 1330 1340 1350 1360 1370 1380 RAEKEMKELQ TQYDALKKQM EVMEMEVMEA RLIRAAEING EVDDDDAGGE WRLKYERAVR 1390 1400 1410 1420 1430 1440 EVDFTKKRLQ QEFEDKLEVE QQNKRQLERR LGDLQADSEE SQRALQQLKK KCQRLTAELQ 1450 1460 1470 1480 1490 1500 DTKLHLEGQQ VRNHELEKKQ RRFDSELSQA HEEAQREKLQ REKLQREKDM LLAEAFSLKQ 1510 1520 1530 1540 1550 1560 QLEEKDMDIA GFTQKVVSLE AELQDISSQE SKDEASLAKV KKQLRDLEAK VKDQEEELDE 1570 1580 1590 1600 1610 1620 QAGTIQMLEQ AKLRLEMEME RMRQTHSKEM ESRDEEVEEA RQSCQKKLKQ MEVQLEEEYE 1630 1640 1650 1660 1670 1680 DKQKVLREKR ELEGKLATLS DQVNRRDFES EKRLRKDLKR TKALLADAQL MLDHLKNSAP 1690 1700 1710 1720 1730 1740 SKREIAQLKN QLEESEFTCA AAVKARKAME VEIEDLHLQI DDIAKAKTAL EEQLSRLQRE 1750 1760 1770 1780 1790 1800 KNEIQNRLEE DQEDMNELMK KHKAAVAQAS RDLAQINDLQ AQLEEANKEK QELQEKLQAL 1810 1820 1830 1840 1850 1860 QSQVEFLEQS MVDKSLVSRQ EAKIRELETR LEFERTQVKR LESLASRLKE NMEKLTEERD 1870 1880 1890 1900 1910 1920 QRIAAENREK EQNKRLQRQL RDTKEEMGEL ARKEAEASRK KHELEMDLES LEAANQSLQA 1930 1940 1950 1960 1970 1980 DLKLAFKRIG DLQAAIEDEM ESDENEDLIN SEGDSDVDSE LEDRVDGVKS WLSKNKGPSK 1990 2000 2010 2020 2030 AASDDGSLKS SSPTSYWKSL APDRSDDEHD PLDNTSRPRY SHSYLSDSDT EAKLTETNA « Hide
Isoform 5. Checksum: DDE7EF34D1A7E515 Show »	FASTA	1,581	180,495
10 20 30 40 50 60 MHMFKGCRRE DMAPHIYAVA QTAYRAMLMS RQDQSIILLG SSGSGKTTSC QHLVQYLATI 70 80 90 100 110 120 AGISGNKVFS VEKWQALYTL LEAFGNSPTI INGNATRFSQ ILSLDFDQAG QVASASIQTM 130 140 150 160 170 180 LLEKLRVARR PASEATFNVF YYLLACGDGT LRTELHLNHL AENNVFGIVP LAKPEEKQKA 190 200 210 220 230 240 AQQFSKLQAA MKVLGISPDE QKACWFILAA IYHLGAAGAT KEAAEAGRKQ FARHEWAQKA 250 260 270 280 290 300 AYLLGCSLEE LSSAIFKHQH KGGTLQRSTS FRQGPEESGL GDGTGPKLSA LECLEGMAAG 310 320 330 340 350 360 LYSELFTLLV SLVNRALKSS QHSLCSMMIV DTPGFQNPEQ GGSARGASFE ELCHNYTQDR 370 380 390 400 410 420 LQRLFHERTF VQELERYKEE NIELAFDDLE PPTDDSVAAV DQASHQSLVR SLARTDEARG 430 440 450 460 470 480 LLWLLEEEAL VPGASEDTLL ERLFSYYGPQ EGDKKGQSPL LHSSKPHHFL LGHSHGTNWV 490 500 510 520 530 540 EYNVTGWLNY TKQNPATQNA PRLLQDSQKK IISNLFLGRA GSATVLSGSI AGLEGGSQLA 550 560 570 580 590 600 LRRATSMRKT FTTGMAAVKK KSLCIQMKLQ VDALIDTIKK SKLHFVHCFL PVAEGWAGEP 610 620 630 640 650 660 RSASSRRVSS SSELDLPSGD HCEAGLLQLD VPLLRTQLRG SRLLDAMRMY RQGYPDHMVF 670 680 690 700 710 720 SEFRRRFDVL APHLTKKHGR NYIVVDERRA VEELLECLDL EKSSCCMGLS RVFFRAGTLA 730 740 750 760 770 780 RLEEQRDEQT SRNLTLFQAA CRGYLARQHF KKRKIQDLAI RCVQKNIKKN KGVKDWPWWK 790 800 810 820 830 840 LFTTVRPLIE VQLSEEQIRN KDEEIQQLRS KLEKAEKERN ELRLNSDRLE SRISELTSEL 850 860 870 880 890 900 TDERNTGESA SQLLDAETAE RLRAEKEMKE LQTQYDALKK QMEVMEMEVM EARLIRAAEI 910 920 930 940 950 960 NGEVDDDDAG GEWRLKYERA VREVDFTKKR LQQEFEDKLE VEQQNKRQLE RRLGDLQADS 970 980 990 1000 1010 1020 EESQRALQQL KKKCQRLTAE LQDTKLHLEG QQVRNHELEK KQRRFDSELS QAHEEAQREK 1030 1040 1050 1060 1070 1080 LQREKLQREK DMLLAEAFSL KQQLEEKDMD IAGFTQKVVS LEAELQDISS QESKDEASLA 1090 1100 1110 1120 1130 1140 KVKKQLRDLE AKVKDQEEEL DEQAGTIQML EQAKLRLEME MERMRQTHSK EMESRDEEVE 1150 1160 1170 1180 1190 1200 EARQSCQKKL KQMEVQLEEE YEDKQKVLRE KRELEGKLAT LSDQVNRRDF ESEKRLRKDL 1210 1220 1230 1240 1250 1260 KRTKALLADA QLMLDHLKNS APSKREIAQL KNQLEESEFT CAAAVKARKA MEVEIEDLHL 1270 1280 1290 1300 1310 1320 QIDDIAKAKT ALEEQLSRLQ REKNEIQNRL EEDQEDMNEL MKKHKAAVAQ ASRDLAQIND 1330 1340 1350 1360 1370 1380 LQAQLEEANK EKQELQEKLQ ALQSQVEFLE QSMVDKSLVS RQEAKIRELE TRLEFERTQV 1390 1400 1410 1420 1430 1440 KRLESLASRL KENMEKLTEE RDQRIAAENR EKEQNKRLQR QLRDTKEEMG ELARKEAEAS 1450 1460 1470 1480 1490 1500 RKKHELEMDL ESLEAANQSL QADLKLAFKR IGDLQAAIED EMESDENEDL INSEGDSDVD 1510 1520 1530 1540 1550 1560 SELEDRVDGV KSWLSKNKGP SKAASDDGSL KSSSPTSYWK SLAPDRSDDE HDPLDNTSRP 1570 1580 RYSHSYLSDS DTEAKLTETN A « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alternative splice variants encoding unstable protein domains exist in the human brain." Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K. J. Mol. Biol. 343:1207-1220(2004) [PubMed: 15491607] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [MRNA] OF 9-2054 (ISOFORM 1). Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-958. Tissue: Brain.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Amygdala.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT VAL-958. Tissue: Testis.
[5]	"A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival." Ji H., Zhai Q., Zhu J., Yan M., Sun L., Liu X., Zheng Z. Biochem. Biophys. Res. Commun. 270:267-271(2000) [PubMed: 10733938] [Abstract] Cited for: INTERACTION WITH JAK3.
[6]	"Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)." Mori K., Furusawa T., Okubo T., Inoue T., Ikawa S., Yanai N., Mori K.J., Obinata M. J. Biochem. 133:405-413(2003) [PubMed: 12761286] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
[7]	"The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site." Isogawa Y., Kon T., Inoue T., Ohkura R., Yamakawa H., Ohara O., Sutoh K. Biochemistry 44:6190-6196(2005) [PubMed: 15835906] [Abstract] Cited for: SUBCELLULAR LOCATION, HOMODIMERIZATION, INTERACTION WITH ACTIN, MUTAGENESIS OF 114-ARG-GLY-115 AND 117-VAL-LEU-118.
[8]	"Global phosphoproteome of HT-29 human colon adenocarcinoma cells." Kim J.-E., Tannenbaum S.R., White F.M. J. Proteome Res. 4:1339-1346(2005) [PubMed: 16083285] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041 AND SER-2043, MASS SPECTROMETRY.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-234; SER-1942; SER-1970; SER-1974 AND SER-2020, MASS SPECTROMETRY. Tissue: Epithelium.
[10]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1039 AND SER-1063, MASS SPECTROMETRY.
[11]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041 AND SER-2043, MASS SPECTROMETRY. Tissue: Platelet.
[12]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1067, MASS SPECTROMETRY.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1067; SER-1070; SER-1942; SER-1951; SER-1970; SER-1974; SER-1998; SER-2002; SER-2007; SER-2020; SER-2041; SER-2043 AND THR-2045, MASS SPECTROMETRY.
[14]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1970 AND SER-1974, MASS SPECTROMETRY. Tissue: Liver.
[15]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[16]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041 AND SER-2043, MASS SPECTROMETRY. Tissue: T-cell.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AB177858 mRNA. Translation: BAD66836.1. AB177860 mRNA. Translation: BAD66838.1. Different initiation. D86970 mRNA. Translation: BAA13206.2. Different initiation. CR933614 mRNA. Translation: CAI45931.1. BC039612 mRNA. Translation: AAH39612.1.
IPI	IPI00334410. IPI00760846. IPI00760925. IPI00827840. IPI00828082.
RefSeq	NP_510880.2. NP_976063.1.
3D structure databases
SMR	Q92614. Positions 217-309, 342-1214.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92614. 8 interactions.
STRING	Q92614.
PTM databases
PhosphoSite	Q92614.
Proteomic databases
PRIDE	Q92614.
Genome annotation databases
Ensembl	ENST00000354329; ENSP00000346291; ENSG00000196535; Homo sapiens. [Genome view]
GeneID	399687.
KEGG	hsa:399687.
UCSC	uc002hds.1. human. uc002hdt.1. human. uc002hdu.1. human. uc010csa.1. human.
Organism-specific databases
CTD	399687.
GeneCards	GC17M024425.
H-InvDB	HIX0013671.
HGNC	HGNC:31104. MYO18A.
HPA	HPA019646. HPA021121.
MIM	609517. gene. 610067. gene.
PharmGKB	PA134978348.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG402832.
HOVERGEN	Q92614.
InParanoid	Q92614.
OMA	LFHERTF.
PhylomeDB	Q92614.
Gene expression databases
ArrayExpress	Q92614.
Bgee	Q92614.
CleanEx	HS_MYO18A.
Genevestigator	Q92614.
GermOnline	ENSG00000196535. Homo sapiens.
Family and domain databases
InterPro	IPR000048. IQ_CaM_bd_region. IPR001609. Myosin_head_motor_dom. IPR002928. Myosin_tail. IPR001478. PDZ/DHR/GLGF. IPR020587. RecA_monomer-monomer_interface. [Graphical view]
Pfam	PF00063. Myosin_head. 2 hits. PF01576. Myosin_tail_1. 1 hit. PF00595. PDZ. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00015. IQ. 1 hit. SM00242. MYSc. 1 hit. SM00228. PDZ. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. 1 hit. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	105494.
SOURCE	Search...

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Entry information

Entry name

MY18A_HUMAN

Accession

Primary (citable) accession number: Q92614
Secondary accession number(s): Q5H9U3

Q8IXP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	July 25, 2003
Last modified:	January 19, 2010
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

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