SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q92614

- MY18A_HUMAN

UniProt

Q92614 - MY18A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Unconventional myosin-XVIIIa
Gene
MYO18A, KIAA0216, MYSPDZ
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi498 – 5058ATP Reviewed prediction

GO - Molecular functioni

  1. ADP binding Source: UniProtKB
  2. ATP binding Source: UniProtKB
  3. DNA binding Source: InterPro
  4. actin filament binding Source: UniProtKB
  5. motor activity Source: InterPro
  6. poly(A) RNA binding Source: UniProtKB
  7. protein binding Source: IntAct

GO - Biological processi

  1. DNA metabolic process Source: InterPro
  2. Golgi organization Source: UniProtKB
  3. Golgi vesicle budding Source: UniProtKB
  4. actomyosin structure organization Source: UniProtKB
  5. cell migration Source: UniProtKB
  6. negative regulation of apoptotic process Source: ProtInc
  7. positive regulation of protein secretion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121141. Signaling by FGFR1 fusion mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XVIIIa
Alternative name(s):
Molecule associated with JAK3 N-terminus
Short name:
MAJN
Myosin containing a PDZ domain
Gene namesi
Name:MYO18A
Synonyms:KIAA0216, MYSPDZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:31104. MYO18A.

Subcellular locationi

Isoform 1 : Endoplasmic reticulum-Golgi intermediate compartment By similarity. Cytoplasmcytoskeleton
Note: Colocalizes with actin.2 Publications
Isoform 2 : Cytoplasm
Note: Lacks the PDZ domain. Diffusely localized in the cytoplasm.2 Publications
Golgi apparatus. Golgi apparatustrans-Golgi network
Note: Recruited to the Golgi apparatus by GOLPH3.2 Publications

GO - Cellular componenti

  1. Golgi membrane Source: GOC
  2. actomyosin Source: UniProtKB
  3. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
  4. myosin complex Source: UniProtKB-KW
  5. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi114 – 1152RG → AA: No effect on interaction with actin. 1 Publication
Mutagenesisi117 – 1182VL → AA: Abolishes interaction with actin. 1 Publication

Organism-specific databases

PharmGKBiPA134978348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20542054Unconventional myosin-XVIIIa
PRO_0000123476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721Phosphoserine By similarity
Modified residuei83 – 831Phosphoserine1 Publication
Modified residuei140 – 1401Phosphoserine2 Publications
Modified residuei164 – 1641Phosphoserine By similarity
Modified residuei1070 – 10701Phosphoserine1 Publication
Modified residuei1970 – 19701Phosphoserine3 Publications
Modified residuei1974 – 19741Phosphoserine2 Publications
Modified residuei1998 – 19981Phosphoserine1 Publication
Modified residuei2002 – 20021Phosphoserine1 Publication
Modified residuei2007 – 20071Phosphoserine1 Publication
Modified residuei2020 – 20201Phosphoserine2 Publications
Modified residuei2041 – 20411Phosphoserine4 Publications
Modified residuei2043 – 20431Phosphoserine4 Publications
Modified residuei2045 – 20451Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ92614.
PaxDbiQ92614.
PRIDEiQ92614.

PTM databases

PhosphoSiteiQ92614.

Expressioni

Gene expression databases

ArrayExpressiQ92614.
BgeeiQ92614.
CleanExiHS_MYO18A.
GenevestigatoriQ92614.

Organism-specific databases

HPAiHPA019646.
HPA021121.

Interactioni

Subunit structurei

Homodimer. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A. Binds F-actin; regulated by ADP and GOLPH3. Interacts with GOLPH3; the interaction is direct and may link Golgi membranes to the actin cytoskeleton. Interacts with JAK3.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLPH3Q9H4A66EBI-949059,EBI-2465479

Protein-protein interaction databases

BioGridi134384. 7 interactions.
IntActiQ92614. 17 interactions.
STRINGi9606.ENSP00000346291.

Structurei

3D structure databases

ProteinModelPortaliQ92614.
SMRiQ92614. Positions 223-307, 342-1247.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 31192PDZ
Add
BLAST
Domaini405 – 1185781Myosin motor
Add
BLAST
Domaini1188 – 121730IQ
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 398398Mediates nucleotide-independent binding to F-actin and interaction with GOLPH3
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1246 – 1971726 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi114 – 1185Interaction with actin

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 2520Lys-rich
Add
BLAST

Domaini

The myosin motor domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent binding to actin (1 Publication).1 Publication

Sequence similaritiesi

Contains 1 IQ domain.
Contains 1 PDZ (DHR) domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
HOGENOMiHOG000113701.
HOVERGENiHBG052543.
InParanoidiQ92614.
KOiK10362.
PhylomeDBiQ92614.
TreeFamiTF339614.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF00063. Myosin_head. 2 hits.
PF01576. Myosin_tail_1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92614-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR     50
SSKRESKTRL EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA 100
SSSDDLKGEE GSFRGSVLQR AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA 150
SETSTPSEHS AAPSPQVEVR TLEGQLVQHP GPGIPRPGHR SRAPELVTKK 200
FPVDLRLPPV VPLPPPTLRE LELQRRPTGD FGFSLRRTTM LDRGPEGQAC 250
RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG 300
DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDAKTEEQI AAEEAWNETE 350
KVWLVHRDGF SLASQLKSEE LNLPEGKVRV KLDHDGAILD VDEDDVEKAN 400
APSCDRLEDL ASLVYLNESS VLHTLRQRYG ASLLHTYAGP SLLVLGPRGA 450
PAVYSEKVMH MFKGCRREDM APHIYAVAQT AYRAMLMSRQ DQSIILLGSS 500
GSGKTTSCQH LVQYLATIAG ISGNKVFSVE KWQALYTLLE AFGNSPTIIN 550
GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 600
LLACGDGTLR TELHLNHLAE NNVFGIVPLA KPEEKQKAAQ QFSKLQAAMK 650
VLGISPDEQK ACWFILAAIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY 700
LLGCSLEELS SAIFKHQHKG GTLQRSTSFR QGPEESGLGD GTGPKLSALE 750
CLEGMAAGLY SELFTLLVSL VNRALKSSQH SLCSMMIVDT PGFQNPEQGG 800
SARGASFEEL CHNYTQDRLQ RLFHERTFVQ ELERYKEENI ELAFDDLEPP 850
TDDSVAAVDQ ASHQSLVRSL ARTDEARGLL WLLEEEALVP GASEDTLLER 900
LFSYYGPQEG DKKGQSPLLH SSKPHHFLLG HSHGTNWVEY NVTGWLNYTK 950
QNPATQNAPR LLQDSQKKII SNLFLGRAGS ATVLSGSIAG LEGGSQLALR 1000
RATSMRKTFT TGMAAVKKKS LCIQMKLQVD ALIDTIKKSK LHFVHCFLPV 1050
AEGWAGEPRS ASSRRVSSSS ELDLPSGDHC EAGLLQLDVP LLRTQLRGSR 1100
LLDAMRMYRQ GYPDHMVFSE FRRRFDVLAP HLTKKHGRNY IVVDERRAVE 1150
ELLECLDLEK SSCCMGLSRV FFRAGTLARL EEQRDEQTSR NLTLFQAACR 1200
GYLARQHFKK RKIQDLAIRC VQKNIKKNKG VKDWPWWKLF TTVRPLIEVQ 1250
LSEEQIRNKD EEIQQLRSKL EKAEKERNEL RLNSDRLESR ISELTSELTD 1300
ERNTGESASQ LLDAETAERL RAEKEMKELQ TQYDALKKQM EVMEMEVMEA 1350
RLIRAAEING EVDDDDAGGE WRLKYERAVR EVDFTKKRLQ QEFEDKLEVE 1400
QQNKRQLERR LGDLQADSEE SQRALQQLKK KCQRLTAELQ DTKLHLEGQQ 1450
VRNHELEKKQ RRFDSELSQA HEEAQREKLQ REKLQREKDM LLAEAFSLKQ 1500
QLEEKDMDIA GFTQKVVSLE AELQDISSQE SKDEASLAKV KKQLRDLEAK 1550
VKDQEEELDE QAGTIQMLEQ AKLRLEMEME RMRQTHSKEM ESRDEEVEEA 1600
RQSCQKKLKQ MEVQLEEEYE DKQKVLREKR ELEGKLATLS DQVNRRDFES 1650
EKRLRKDLKR TKALLADAQL MLDHLKNSAP SKREIAQLKN QLEESEFTCA 1700
AAVKARKAME VEIEDLHLQI DDIAKAKTAL EEQLSRLQRE KNEIQNRLEE 1750
DQEDMNELMK KHKAAVAQAS RDLAQINDLQ AQLEEANKEK QELQEKLQAL 1800
QSQVEFLEQS MVDKSLVSRQ EAKIRELETR LEFERTQVKR LESLASRLKE 1850
NMEKLTEERD QRIAAENREK EQNKRLQRQL RDTKEEMGEL ARKEAEASRK 1900
KHELEMDLES LEAANQSLQA DLKLAFKRIG DLQAAIEDEM ESDENEDLIN 1950
SLQDMVTKYQ KRKNKLEGDS DVDSELEDRV DGVKSWLSKN KGPSKAASDD 2000
GSLKSSSPTS YWKSLAPDRS DDEHDPLDNT SRPRYSHSYL SDSDTEAKLT 2050
ETNA 2054
Length:2,054
Mass (Da):233,115
Last modified:July 25, 2003 - v3
Checksum:i52BFA0AA273E18F7
GO
Isoform 2 (identifier: Q92614-2) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: SD → MR

Show »
Length:1,723
Mass (Da):196,438
Checksum:iA0764A2A6D54D6EC
GO
Isoform 3 (identifier: Q92614-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1571-1607: Missing.
     1952-1966: Missing.

Note: No experimental confirmation available.

Show »
Length:2,002
Mass (Da):226,690
Checksum:i89350E07C2CF8B03
GO
Isoform 4 (identifier: Q92614-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1952-1966: Missing.

Note: No experimental confirmation available.

Show »
Length:2,039
Mass (Da):231,240
Checksum:i70DDB5F30E54B9C3
GO
Isoform 5 (identifier: Q92614-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-458: Missing.
     1952-1966: Missing.

Show »
Length:1,581
Mass (Da):180,495
Checksum:iDDE7EF34D1A7E515
GO

Sequence cautioni

The sequence BAA13206.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAD66838.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti958 – 9581A → V.2 Publications
Corresponds to variant rs8076604 [ dbSNP | Ensembl ].
VAR_030585

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 458458Missing in isoform 5.
VSP_023058Add
BLAST
Alternative sequencei1 – 331331Missing in isoform 2.
VSP_007869Add
BLAST
Alternative sequencei332 – 3332SD → MR in isoform 2.
VSP_007870
Alternative sequencei1571 – 160737Missing in isoform 3.
VSP_007871Add
BLAST
Alternative sequencei1952 – 196615Missing in isoform 3, isoform 4 and isoform 5.
VSP_007872Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1014 – 10141A → V in BAD66838. 1 Publication
Sequence conflicti1020 – 10201S → P in CAI45931. 1 Publication
Sequence conflicti1757 – 17571E → K in CAI45931. 1 Publication
Sequence conflicti1889 – 18891E → G in CAI45931. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB177858 mRNA. Translation: BAD66836.1.
AB177860 mRNA. Translation: BAD66838.1. Different initiation.
D86970 mRNA. Translation: BAA13206.2. Different initiation.
CR933614 mRNA. Translation: CAI45931.1.
BC039612 mRNA. Translation: AAH39612.1.
CCDSiCCDS45641.1. [Q92614-4]
CCDS45642.1. [Q92614-1]
RefSeqiNP_510880.2. NM_078471.3. [Q92614-1]
NP_976063.1. NM_203318.1. [Q92614-4]
UniGeneiHs.462590.

Genome annotation databases

EnsembliENST00000527372; ENSP00000437073; ENSG00000196535. [Q92614-1]
ENST00000531253; ENSP00000434228; ENSG00000196535. [Q92614-4]
ENST00000533112; ENSP00000435932; ENSG00000196535. [Q92614-3]
GeneIDi399687.
KEGGihsa:399687.
UCSCiuc002hds.2. human. [Q92614-5]
uc002hdt.1. human. [Q92614-1]
uc002hdu.1. human. [Q92614-4]
uc010csa.1. human. [Q92614-3]
uc010wbd.1. human. [Q92614-2]

Polymorphism databases

DMDMi33301318.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB177858 mRNA. Translation: BAD66836.1 .
AB177860 mRNA. Translation: BAD66838.1 . Different initiation.
D86970 mRNA. Translation: BAA13206.2 . Different initiation.
CR933614 mRNA. Translation: CAI45931.1 .
BC039612 mRNA. Translation: AAH39612.1 .
CCDSi CCDS45641.1. [Q92614-4 ]
CCDS45642.1. [Q92614-1 ]
RefSeqi NP_510880.2. NM_078471.3. [Q92614-1 ]
NP_976063.1. NM_203318.1. [Q92614-4 ]
UniGenei Hs.462590.

3D structure databases

ProteinModelPortali Q92614.
SMRi Q92614. Positions 223-307, 342-1247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 134384. 7 interactions.
IntActi Q92614. 17 interactions.
STRINGi 9606.ENSP00000346291.

PTM databases

PhosphoSitei Q92614.

Polymorphism databases

DMDMi 33301318.

Proteomic databases

MaxQBi Q92614.
PaxDbi Q92614.
PRIDEi Q92614.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000527372 ; ENSP00000437073 ; ENSG00000196535 . [Q92614-1 ]
ENST00000531253 ; ENSP00000434228 ; ENSG00000196535 . [Q92614-4 ]
ENST00000533112 ; ENSP00000435932 ; ENSG00000196535 . [Q92614-3 ]
GeneIDi 399687.
KEGGi hsa:399687.
UCSCi uc002hds.2. human. [Q92614-5 ]
uc002hdt.1. human. [Q92614-1 ]
uc002hdu.1. human. [Q92614-4 ]
uc010csa.1. human. [Q92614-3 ]
uc010wbd.1. human. [Q92614-2 ]

Organism-specific databases

CTDi 399687.
GeneCardsi GC17M027400.
HGNCi HGNC:31104. MYO18A.
HPAi HPA019646.
HPA021121.
MIMi 609517. gene.
610067. gene.
neXtProti NX_Q92614.
PharmGKBi PA134978348.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5022.
HOGENOMi HOG000113701.
HOVERGENi HBG052543.
InParanoidi Q92614.
KOi K10362.
PhylomeDBi Q92614.
TreeFami TF339614.

Enzyme and pathway databases

Reactomei REACT_121141. Signaling by FGFR1 fusion mutants.

Miscellaneous databases

ChiTaRSi MYO18A. human.
GeneWikii MYO18A.
GenomeRNAii 399687.
NextBioi 105494.
PROi Q92614.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92614.
Bgeei Q92614.
CleanExi HS_MYO18A.
Genevestigatori Q92614.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
4.10.270.10. 1 hit.
InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view ]
Pfami PF00063. Myosin_head. 2 hits.
PF01576. Myosin_tail_1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Alternative splice variants encoding unstable protein domains exist in the human brain."
    Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K.
    J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [MRNA] OF 9-2054 (ISOFORM 1).
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-958.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Amygdala.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT VAL-958.
    Tissue: Testis.
  5. "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival."
    Ji H., Zhai Q., Zhu J., Yan M., Sun L., Liu X., Zheng Z.
    Biochem. Biophys. Res. Commun. 270:267-271(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH JAK3.
  6. "Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)."
    Mori K., Furusawa T., Okubo T., Inoue T., Ikawa S., Yanai N., Mori K.J., Obinata M.
    J. Biochem. 133:405-413(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
  7. "The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site."
    Isogawa Y., Kon T., Inoue T., Ohkura R., Yamakawa H., Ohara O., Sutoh K.
    Biochemistry 44:6190-6196(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, HOMODIMERIZATION, INTERACTION WITH ACTIN, MUTAGENESIS OF 114-ARG-GLY-115 AND 117-VAL-LEU-118.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1970 AND SER-1974, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow."
    Tan I., Yong J., Dong J.M., Lim L., Leung T.
    Cell 135:123-136(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH LURAP1 AND CDC42BPA/CDC42BPB.
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2020, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1070; SER-1998; SER-2002; SER-2020; SER-2041; SER-2043 AND THR-2045, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1970 AND SER-1974, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  14. "GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding."
    Dippold H.C., Ng M.M., Farber-Katz S.E., Lee S.K., Kerr M.L., Peterman M.C., Sim R., Wiharto P.A., Galbraith K.A., Madhavarapu S., Fuchs G.J., Meerloo T., Farquhar M.G., Zhou H., Field S.J.
    Cell 139:337-351(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN GOLGI MEMBRANE BUDDING, INTERACTION WITH GOLPH3, SUBCELLULAR LOCATION.
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041 AND SER-2043, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-140; SER-2041 AND SER-2043, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-1970; SER-2007; SER-2041 AND SER-2043, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Functional Characterization of Human Myosin-18A and its Interaction with F-actin and GOLPH3."
    Taft M.H., Behrmann E., Munske-Weidemann L.C., Thiel C., Raunser S., Manstein D.J.
    J. Biol. Chem. 288:30029-30041(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GOLPH3, F-ACTIN-BINDING, NUCLEOTIDE-BINDING, DOMAIN.
  20. "GOLPH3L antagonizes GOLPH3 to determine Golgi morphology."
    Ng M.M., Dippold H.C., Buschman M.D., Noakes C.J., Field S.J.
    Mol. Biol. Cell 24:796-808(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GOLPH3.

Entry informationi

Entry nameiMY18A_HUMAN
AccessioniPrimary (citable) accession number: Q92614
Secondary accession number(s): Q5H9U3
, Q5W9F9, Q5W9G1, Q8IXP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: September 3, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi