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Q92614

- MY18A_HUMAN

UniProt

Q92614 - MY18A_HUMAN

Protein

Unconventional myosin-XVIIIa

Gene

MYO18A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 3 (25 Jul 2003)
      Previous versions | rss
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    Functioni

    May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi498 – 5058ATPSequence Analysis

    GO - Molecular functioni

    1. actin filament binding Source: UniProtKB
    2. ADP binding Source: UniProtKB
    3. ATP binding Source: UniProtKB
    4. DNA binding Source: InterPro
    5. motor activity Source: InterPro
    6. poly(A) RNA binding Source: UniProtKB
    7. protein binding Source: IntAct

    GO - Biological processi

    1. actomyosin structure organization Source: UniProtKB
    2. cell migration Source: UniProtKB
    3. DNA metabolic process Source: InterPro
    4. Golgi organization Source: UniProtKB
    5. Golgi vesicle budding Source: UniProtKB
    6. negative regulation of apoptotic process Source: ProtInc
    7. positive regulation of protein secretion Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein, Myosin

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_121141. Signaling by FGFR1 fusion mutants.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Unconventional myosin-XVIIIa
    Alternative name(s):
    Molecule associated with JAK3 N-terminus
    Short name:
    MAJN
    Myosin containing a PDZ domain
    Gene namesi
    Name:MYO18A
    Synonyms:KIAA0216, MYSPDZ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:31104. MYO18A.

    Subcellular locationi

    Isoform 2 : Cytoplasm
    Note: Lacks the PDZ domain. Diffusely localized in the cytoplasm.
    Golgi apparatus. Golgi apparatustrans-Golgi network
    Note: Recruited to the Golgi apparatus by GOLPH3.

    GO - Cellular componenti

    1. actomyosin Source: UniProtKB
    2. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
    3. Golgi membrane Source: GOC
    4. membrane Source: UniProtKB
    5. myosin complex Source: UniProtKB-KW
    6. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Golgi apparatus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi114 – 1152RG → AA: No effect on interaction with actin. 1 Publication
    Mutagenesisi117 – 1182VL → AA: Abolishes interaction with actin. 1 Publication

    Organism-specific databases

    PharmGKBiPA134978348.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20542054Unconventional myosin-XVIIIaPRO_0000123476Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei72 – 721PhosphoserineBy similarity
    Modified residuei83 – 831Phosphoserine1 Publication
    Modified residuei140 – 1401Phosphoserine2 Publications
    Modified residuei164 – 1641PhosphoserineBy similarity
    Modified residuei1070 – 10701Phosphoserine1 Publication
    Modified residuei1970 – 19701Phosphoserine3 Publications
    Modified residuei1974 – 19741Phosphoserine2 Publications
    Modified residuei1998 – 19981Phosphoserine1 Publication
    Modified residuei2002 – 20021Phosphoserine1 Publication
    Modified residuei2007 – 20071Phosphoserine1 Publication
    Modified residuei2020 – 20201Phosphoserine2 Publications
    Modified residuei2041 – 20411Phosphoserine4 Publications
    Modified residuei2043 – 20431Phosphoserine4 Publications
    Modified residuei2045 – 20451Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ92614.
    PaxDbiQ92614.
    PRIDEiQ92614.

    PTM databases

    PhosphoSiteiQ92614.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92614.
    BgeeiQ92614.
    CleanExiHS_MYO18A.
    GenevestigatoriQ92614.

    Organism-specific databases

    HPAiHPA019646.
    HPA021121.

    Interactioni

    Subunit structurei

    Homodimer. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A. Binds F-actin; regulated by ADP and GOLPH3. Interacts with GOLPH3; the interaction is direct and may link Golgi membranes to the actin cytoskeleton. Interacts with JAK3.6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GOLPH3Q9H4A66EBI-949059,EBI-2465479

    Protein-protein interaction databases

    BioGridi134384. 7 interactions.
    IntActiQ92614. 17 interactions.
    STRINGi9606.ENSP00000346291.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92614.
    SMRiQ92614. Positions 223-307, 342-1247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini220 – 31192PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini405 – 1185781Myosin motorAdd
    BLAST
    Domaini1188 – 121730IQPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 398398Mediates nucleotide-independent binding to F-actin and interaction with GOLPH3Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1246 – 1971726Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi114 – 1185Interaction with actin

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 2520Lys-richAdd
    BLAST

    Domaini

    The myosin motor domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent binding to actin (PubMed:23990465).1 Publication

    Sequence similaritiesi

    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000113701.
    HOVERGENiHBG052543.
    InParanoidiQ92614.
    KOiK10362.
    PhylomeDBiQ92614.
    TreeFamiTF339614.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    4.10.270.10. 1 hit.
    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR020587. RecA_monomer-monomer_interface.
    [Graphical view]
    PfamiPF00063. Myosin_head. 2 hits.
    PF01576. Myosin_tail_1. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 3 hits.
    PROSITEiPS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92614-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR     50
    SSKRESKTRL EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA 100
    SSSDDLKGEE GSFRGSVLQR AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA 150
    SETSTPSEHS AAPSPQVEVR TLEGQLVQHP GPGIPRPGHR SRAPELVTKK 200
    FPVDLRLPPV VPLPPPTLRE LELQRRPTGD FGFSLRRTTM LDRGPEGQAC 250
    RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG 300
    DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDAKTEEQI AAEEAWNETE 350
    KVWLVHRDGF SLASQLKSEE LNLPEGKVRV KLDHDGAILD VDEDDVEKAN 400
    APSCDRLEDL ASLVYLNESS VLHTLRQRYG ASLLHTYAGP SLLVLGPRGA 450
    PAVYSEKVMH MFKGCRREDM APHIYAVAQT AYRAMLMSRQ DQSIILLGSS 500
    GSGKTTSCQH LVQYLATIAG ISGNKVFSVE KWQALYTLLE AFGNSPTIIN 550
    GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 600
    LLACGDGTLR TELHLNHLAE NNVFGIVPLA KPEEKQKAAQ QFSKLQAAMK 650
    VLGISPDEQK ACWFILAAIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY 700
    LLGCSLEELS SAIFKHQHKG GTLQRSTSFR QGPEESGLGD GTGPKLSALE 750
    CLEGMAAGLY SELFTLLVSL VNRALKSSQH SLCSMMIVDT PGFQNPEQGG 800
    SARGASFEEL CHNYTQDRLQ RLFHERTFVQ ELERYKEENI ELAFDDLEPP 850
    TDDSVAAVDQ ASHQSLVRSL ARTDEARGLL WLLEEEALVP GASEDTLLER 900
    LFSYYGPQEG DKKGQSPLLH SSKPHHFLLG HSHGTNWVEY NVTGWLNYTK 950
    QNPATQNAPR LLQDSQKKII SNLFLGRAGS ATVLSGSIAG LEGGSQLALR 1000
    RATSMRKTFT TGMAAVKKKS LCIQMKLQVD ALIDTIKKSK LHFVHCFLPV 1050
    AEGWAGEPRS ASSRRVSSSS ELDLPSGDHC EAGLLQLDVP LLRTQLRGSR 1100
    LLDAMRMYRQ GYPDHMVFSE FRRRFDVLAP HLTKKHGRNY IVVDERRAVE 1150
    ELLECLDLEK SSCCMGLSRV FFRAGTLARL EEQRDEQTSR NLTLFQAACR 1200
    GYLARQHFKK RKIQDLAIRC VQKNIKKNKG VKDWPWWKLF TTVRPLIEVQ 1250
    LSEEQIRNKD EEIQQLRSKL EKAEKERNEL RLNSDRLESR ISELTSELTD 1300
    ERNTGESASQ LLDAETAERL RAEKEMKELQ TQYDALKKQM EVMEMEVMEA 1350
    RLIRAAEING EVDDDDAGGE WRLKYERAVR EVDFTKKRLQ QEFEDKLEVE 1400
    QQNKRQLERR LGDLQADSEE SQRALQQLKK KCQRLTAELQ DTKLHLEGQQ 1450
    VRNHELEKKQ RRFDSELSQA HEEAQREKLQ REKLQREKDM LLAEAFSLKQ 1500
    QLEEKDMDIA GFTQKVVSLE AELQDISSQE SKDEASLAKV KKQLRDLEAK 1550
    VKDQEEELDE QAGTIQMLEQ AKLRLEMEME RMRQTHSKEM ESRDEEVEEA 1600
    RQSCQKKLKQ MEVQLEEEYE DKQKVLREKR ELEGKLATLS DQVNRRDFES 1650
    EKRLRKDLKR TKALLADAQL MLDHLKNSAP SKREIAQLKN QLEESEFTCA 1700
    AAVKARKAME VEIEDLHLQI DDIAKAKTAL EEQLSRLQRE KNEIQNRLEE 1750
    DQEDMNELMK KHKAAVAQAS RDLAQINDLQ AQLEEANKEK QELQEKLQAL 1800
    QSQVEFLEQS MVDKSLVSRQ EAKIRELETR LEFERTQVKR LESLASRLKE 1850
    NMEKLTEERD QRIAAENREK EQNKRLQRQL RDTKEEMGEL ARKEAEASRK 1900
    KHELEMDLES LEAANQSLQA DLKLAFKRIG DLQAAIEDEM ESDENEDLIN 1950
    SLQDMVTKYQ KRKNKLEGDS DVDSELEDRV DGVKSWLSKN KGPSKAASDD 2000
    GSLKSSSPTS YWKSLAPDRS DDEHDPLDNT SRPRYSHSYL SDSDTEAKLT 2050
    ETNA 2054
    Length:2,054
    Mass (Da):233,115
    Last modified:July 25, 2003 - v3
    Checksum:i52BFA0AA273E18F7
    GO
    Isoform 2 (identifier: Q92614-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-331: Missing.
         332-333: SD → MR

    Show »
    Length:1,723
    Mass (Da):196,438
    Checksum:iA0764A2A6D54D6EC
    GO
    Isoform 3 (identifier: Q92614-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1571-1607: Missing.
         1952-1966: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:2,002
    Mass (Da):226,690
    Checksum:i89350E07C2CF8B03
    GO
    Isoform 4 (identifier: Q92614-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1952-1966: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:2,039
    Mass (Da):231,240
    Checksum:i70DDB5F30E54B9C3
    GO
    Isoform 5 (identifier: Q92614-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-458: Missing.
         1952-1966: Missing.

    Show »
    Length:1,581
    Mass (Da):180,495
    Checksum:iDDE7EF34D1A7E515
    GO

    Sequence cautioni

    The sequence BAA13206.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAD66838.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1014 – 10141A → V in BAD66838. (PubMed:15491607)Curated
    Sequence conflicti1020 – 10201S → P in CAI45931. (PubMed:17974005)Curated
    Sequence conflicti1757 – 17571E → K in CAI45931. (PubMed:17974005)Curated
    Sequence conflicti1889 – 18891E → G in CAI45931. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti958 – 9581A → V.2 Publications
    Corresponds to variant rs8076604 [ dbSNP | Ensembl ].
    VAR_030585

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 458458Missing in isoform 5. 1 PublicationVSP_023058Add
    BLAST
    Alternative sequencei1 – 331331Missing in isoform 2. CuratedVSP_007869Add
    BLAST
    Alternative sequencei332 – 3332SD → MR in isoform 2. CuratedVSP_007870
    Alternative sequencei1571 – 160737Missing in isoform 3. 1 PublicationVSP_007871Add
    BLAST
    Alternative sequencei1952 – 196615Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsVSP_007872Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB177858 mRNA. Translation: BAD66836.1.
    AB177860 mRNA. Translation: BAD66838.1. Different initiation.
    D86970 mRNA. Translation: BAA13206.2. Different initiation.
    CR933614 mRNA. Translation: CAI45931.1.
    BC039612 mRNA. Translation: AAH39612.1.
    CCDSiCCDS45641.1. [Q92614-4]
    CCDS45642.1. [Q92614-1]
    RefSeqiNP_510880.2. NM_078471.3. [Q92614-1]
    NP_976063.1. NM_203318.1. [Q92614-4]
    UniGeneiHs.462590.

    Genome annotation databases

    EnsembliENST00000527372; ENSP00000437073; ENSG00000196535. [Q92614-1]
    ENST00000531253; ENSP00000434228; ENSG00000196535. [Q92614-4]
    ENST00000533112; ENSP00000435932; ENSG00000196535. [Q92614-3]
    GeneIDi399687.
    KEGGihsa:399687.
    UCSCiuc002hds.2. human. [Q92614-5]
    uc002hdt.1. human. [Q92614-1]
    uc002hdu.1. human. [Q92614-4]
    uc010csa.1. human. [Q92614-3]
    uc010wbd.1. human. [Q92614-2]

    Polymorphism databases

    DMDMi33301318.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB177858 mRNA. Translation: BAD66836.1 .
    AB177860 mRNA. Translation: BAD66838.1 . Different initiation.
    D86970 mRNA. Translation: BAA13206.2 . Different initiation.
    CR933614 mRNA. Translation: CAI45931.1 .
    BC039612 mRNA. Translation: AAH39612.1 .
    CCDSi CCDS45641.1. [Q92614-4 ]
    CCDS45642.1. [Q92614-1 ]
    RefSeqi NP_510880.2. NM_078471.3. [Q92614-1 ]
    NP_976063.1. NM_203318.1. [Q92614-4 ]
    UniGenei Hs.462590.

    3D structure databases

    ProteinModelPortali Q92614.
    SMRi Q92614. Positions 223-307, 342-1247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 134384. 7 interactions.
    IntActi Q92614. 17 interactions.
    STRINGi 9606.ENSP00000346291.

    PTM databases

    PhosphoSitei Q92614.

    Polymorphism databases

    DMDMi 33301318.

    Proteomic databases

    MaxQBi Q92614.
    PaxDbi Q92614.
    PRIDEi Q92614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000527372 ; ENSP00000437073 ; ENSG00000196535 . [Q92614-1 ]
    ENST00000531253 ; ENSP00000434228 ; ENSG00000196535 . [Q92614-4 ]
    ENST00000533112 ; ENSP00000435932 ; ENSG00000196535 . [Q92614-3 ]
    GeneIDi 399687.
    KEGGi hsa:399687.
    UCSCi uc002hds.2. human. [Q92614-5 ]
    uc002hdt.1. human. [Q92614-1 ]
    uc002hdu.1. human. [Q92614-4 ]
    uc010csa.1. human. [Q92614-3 ]
    uc010wbd.1. human. [Q92614-2 ]

    Organism-specific databases

    CTDi 399687.
    GeneCardsi GC17M027400.
    HGNCi HGNC:31104. MYO18A.
    HPAi HPA019646.
    HPA021121.
    MIMi 609517. gene.
    610067. gene.
    neXtProti NX_Q92614.
    PharmGKBi PA134978348.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000113701.
    HOVERGENi HBG052543.
    InParanoidi Q92614.
    KOi K10362.
    PhylomeDBi Q92614.
    TreeFami TF339614.

    Enzyme and pathway databases

    Reactomei REACT_121141. Signaling by FGFR1 fusion mutants.

    Miscellaneous databases

    ChiTaRSi MYO18A. human.
    GeneWikii MYO18A.
    GenomeRNAii 399687.
    NextBioi 105494.
    PROi Q92614.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92614.
    Bgeei Q92614.
    CleanExi HS_MYO18A.
    Genevestigatori Q92614.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    4.10.270.10. 1 hit.
    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR020587. RecA_monomer-monomer_interface.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 2 hits.
    PF01576. Myosin_tail_1. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 3 hits.
    PROSITEi PS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternative splice variants encoding unstable protein domains exist in the human brain."
      Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K.
      J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [MRNA] OF 9-2054 (ISOFORM 1).
      Tissue: Brain.
    2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-958.
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Amygdala.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT VAL-958.
      Tissue: Testis.
    5. "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival."
      Ji H., Zhai Q., Zhu J., Yan M., Sun L., Liu X., Zheng Z.
      Biochem. Biophys. Res. Commun. 270:267-271(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH JAK3.
    6. "Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)."
      Mori K., Furusawa T., Okubo T., Inoue T., Ikawa S., Yanai N., Mori K.J., Obinata M.
      J. Biochem. 133:405-413(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
    7. "The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site."
      Isogawa Y., Kon T., Inoue T., Ohkura R., Yamakawa H., Ohara O., Sutoh K.
      Biochemistry 44:6190-6196(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, HOMODIMERIZATION, INTERACTION WITH ACTIN, MUTAGENESIS OF 114-ARG-GLY-115 AND 117-VAL-LEU-118.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1970 AND SER-1974, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow."
      Tan I., Yong J., Dong J.M., Lim L., Leung T.
      Cell 135:123-136(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH LURAP1 AND CDC42BPA/CDC42BPB.
    10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2020, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1070; SER-1998; SER-2002; SER-2020; SER-2041; SER-2043 AND THR-2045, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1970 AND SER-1974, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    14. "GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding."
      Dippold H.C., Ng M.M., Farber-Katz S.E., Lee S.K., Kerr M.L., Peterman M.C., Sim R., Wiharto P.A., Galbraith K.A., Madhavarapu S., Fuchs G.J., Meerloo T., Farquhar M.G., Zhou H., Field S.J.
      Cell 139:337-351(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN GOLGI MEMBRANE BUDDING, INTERACTION WITH GOLPH3, SUBCELLULAR LOCATION.
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041 AND SER-2043, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-140; SER-2041 AND SER-2043, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-1970; SER-2007; SER-2041 AND SER-2043, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Functional Characterization of Human Myosin-18A and its Interaction with F-actin and GOLPH3."
      Taft M.H., Behrmann E., Munske-Weidemann L.C., Thiel C., Raunser S., Manstein D.J.
      J. Biol. Chem. 288:30029-30041(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GOLPH3, F-ACTIN-BINDING, NUCLEOTIDE-BINDING, DOMAIN.
    20. "GOLPH3L antagonizes GOLPH3 to determine Golgi morphology."
      Ng M.M., Dippold H.C., Buschman M.D., Noakes C.J., Field S.J.
      Mol. Biol. Cell 24:796-808(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GOLPH3.

    Entry informationi

    Entry nameiMY18A_HUMAN
    AccessioniPrimary (citable) accession number: Q92614
    Secondary accession number(s): Q5H9U3
    , Q5W9F9, Q5W9G1, Q8IXP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: July 25, 2003
    Last modified: October 1, 2014
    This is version 147 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3