Q92614 (MY18A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Unconventional myosin-XVIIIa

Alternative name(s):
Molecule associated with JAK3 N-terminus
Short name=MAJN
Myosin containing a PDZ domain

Gene names

Name:	MYO18A
Synonyms:	KIAA0216, MYSPDZ

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2054 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the maintenance of the stromal cell architectures required for cell to cell contact By similarity. In concert with LURAP1 and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Ref.9
Subunit structure	Homodimer. Interacts with JAK3 and actin. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A. Ref.5 Ref.7 Ref.9
Subcellular location	Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment By similarity. Cytoplasm › cytoskeleton. Note: Colocalizes with actin. Ref.7 Isoform 2: Cytoplasm. Note: Lacks the PDZ domain. Diffusely localized in the cytoplasm. Ref.7
Sequence similarities	Contains 1 IQ domain. Contains 1 myosin head-like domain. Contains 1 PDZ (DHR) domain.
Caution	The TIAF1 protein is coded in the 3'-UTR region of MYO18A.
Sequence caution	The sequence BAA13206.2 differs from that shown. Reason: Erroneous initiation. The sequence BAD66838.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein Myosin
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA metabolic process Inferred from electronic annotation. Source: InterPro actomyosin structure organization Inferred from mutant phenotype Ref.9. Source: UniProtKB cell migration Inferred from mutant phenotype Ref.9. Source: UniProtKB negative regulation of apoptotic process Traceable author statement PubMed 9918798. Source: ProtInc
Cellular_component	actomyosin Inferred from direct assay Ref.9. Source: UniProtKB endoplasmic reticulum-Golgi intermediate compartment Inferred from electronic annotation. Source: UniProtKB-SubCell myosin complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA-dependent ATPase activity Inferred from electronic annotation. Source: InterPro motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GOLPH3	Q9H4A6	4	EBI-949059,EBI-2465479

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92614-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92614-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: SD → MR

Isoform 3 (identifier: Q92614-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1571-1607: Missing.
     1952-1966: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q92614-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1952-1966: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q92614-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-458: Missing.
     1952-1966: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2054	2054	Unconventional myosin-XVIIIa		PRO_0000123476
Regions
	Domain	220 – 311	92	PDZ
	Domain	420 – 1186	767	Myosin head-like
	Domain	1188 – 1217	30	IQ
	Nucleotide binding	498 – 505	8	ATP Potential
	Coiled coil	1246 – 1971	726	Potential
	Motif	114 – 118	5	Interaction with actin
Amino acid modifications
	Modified residue	72	1	Phosphoserine By similarity
	Modified residue	74	1	Phosphoserine By similarity
	Modified residue	83	1	Phosphoserine Ref.15
	Modified residue	102	1	Phosphoserine By similarity
	Modified residue	140	1	Phosphoserine Ref.15 Ref.17
	Modified residue	164	1	Phosphoserine By similarity
	Modified residue	1070	1	Phosphoserine Ref.12
	Modified residue	1970	1	Phosphoserine Ref.8 Ref.13 Ref.17
	Modified residue	1974	1	Phosphoserine Ref.8 Ref.13
	Modified residue	1998	1	Phosphoserine Ref.12
	Modified residue	2002	1	Phosphoserine Ref.12
	Modified residue	2007	1	Phosphoserine Ref.17
	Modified residue	2020	1	Phosphoserine Ref.11 Ref.12
	Modified residue	2036	1	Phosphoserine By similarity
	Modified residue	2041	1	Phosphoserine Ref.12 Ref.14 Ref.15 Ref.17
	Modified residue	2043	1	Phosphoserine Ref.12 Ref.14 Ref.15 Ref.17
	Modified residue	2045	1	Phosphothreonine Ref.12
Natural variations
	Alternative sequence	1 – 458	458	Missing in isoform 5.		VSP_023058
	Alternative sequence	1 – 331	331	Missing in isoform 2.		VSP_007869
	Alternative sequence	332 – 333	2	SD → MR in isoform 2.		VSP_007870
	Alternative sequence	1571 – 1607	37	Missing in isoform 3.		VSP_007871
	Alternative sequence	1952 – 1966	15	Missing in isoform 3, isoform 4 and isoform 5.		VSP_007872
	Natural variant	958	1	A → V. Ref.2 Ref.4 Corresponds to variant rs8076604 [ dbSNP | Ensembl ].		VAR_030585
Experimental info
	Mutagenesis	114 – 115	2	RG → AA: No effect on interaction with actin. Ref.7
	Mutagenesis	117 – 118	2	VL → AA: Abolishes interaction with actin. Ref.7
	Sequence conflict	1014	1	A → V in BAD66838. Ref.1
	Sequence conflict	1020	1	S → P in CAI45931. Ref.3
	Sequence conflict	1757	1	E → K in CAI45931. Ref.3
	Sequence conflict	1889	1	E → G in CAI45931. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha) [UniParc]. Last modified July 25, 2003. Version 3. Checksum: 52BFA0AA273E18F7	FASTA	2,054	233,115
	10 20 30 40 50 60 MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR SSKRESKTRL 70 80 90 100 110 120 EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 130 140 150 160 170 180 AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLVQHP 190 200 210 220 230 240 GPGIPRPGHR SRAPELVTKK FPVDLRLPPV VPLPPPTLRE LELQRRPTGD FGFSLRRTTM 250 260 270 280 290 300 LDRGPEGQAC RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG 310 320 330 340 350 360 DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDAKTEEQI AAEEAWNETE KVWLVHRDGF 370 380 390 400 410 420 SLASQLKSEE LNLPEGKVRV KLDHDGAILD VDEDDVEKAN APSCDRLEDL ASLVYLNESS 430 440 450 460 470 480 VLHTLRQRYG ASLLHTYAGP SLLVLGPRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT 490 500 510 520 530 540 AYRAMLMSRQ DQSIILLGSS GSGKTTSCQH LVQYLATIAG ISGNKVFSVE KWQALYTLLE 550 560 570 580 590 600 AFGNSPTIIN GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 610 620 630 640 650 660 LLACGDGTLR TELHLNHLAE NNVFGIVPLA KPEEKQKAAQ QFSKLQAAMK VLGISPDEQK 670 680 690 700 710 720 ACWFILAAIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY LLGCSLEELS SAIFKHQHKG 730 740 750 760 770 780 GTLQRSTSFR QGPEESGLGD GTGPKLSALE CLEGMAAGLY SELFTLLVSL VNRALKSSQH 790 800 810 820 830 840 SLCSMMIVDT PGFQNPEQGG SARGASFEEL CHNYTQDRLQ RLFHERTFVQ ELERYKEENI 850 860 870 880 890 900 ELAFDDLEPP TDDSVAAVDQ ASHQSLVRSL ARTDEARGLL WLLEEEALVP GASEDTLLER 910 920 930 940 950 960 LFSYYGPQEG DKKGQSPLLH SSKPHHFLLG HSHGTNWVEY NVTGWLNYTK QNPATQNAPR 970 980 990 1000 1010 1020 LLQDSQKKII SNLFLGRAGS ATVLSGSIAG LEGGSQLALR RATSMRKTFT TGMAAVKKKS 1030 1040 1050 1060 1070 1080 LCIQMKLQVD ALIDTIKKSK LHFVHCFLPV AEGWAGEPRS ASSRRVSSSS ELDLPSGDHC 1090 1100 1110 1120 1130 1140 EAGLLQLDVP LLRTQLRGSR LLDAMRMYRQ GYPDHMVFSE FRRRFDVLAP HLTKKHGRNY 1150 1160 1170 1180 1190 1200 IVVDERRAVE ELLECLDLEK SSCCMGLSRV FFRAGTLARL EEQRDEQTSR NLTLFQAACR 1210 1220 1230 1240 1250 1260 GYLARQHFKK RKIQDLAIRC VQKNIKKNKG VKDWPWWKLF TTVRPLIEVQ LSEEQIRNKD 1270 1280 1290 1300 1310 1320 EEIQQLRSKL EKAEKERNEL RLNSDRLESR ISELTSELTD ERNTGESASQ LLDAETAERL 1330 1340 1350 1360 1370 1380 RAEKEMKELQ TQYDALKKQM EVMEMEVMEA RLIRAAEING EVDDDDAGGE WRLKYERAVR 1390 1400 1410 1420 1430 1440 EVDFTKKRLQ QEFEDKLEVE QQNKRQLERR LGDLQADSEE SQRALQQLKK KCQRLTAELQ 1450 1460 1470 1480 1490 1500 DTKLHLEGQQ VRNHELEKKQ RRFDSELSQA HEEAQREKLQ REKLQREKDM LLAEAFSLKQ 1510 1520 1530 1540 1550 1560 QLEEKDMDIA GFTQKVVSLE AELQDISSQE SKDEASLAKV KKQLRDLEAK VKDQEEELDE 1570 1580 1590 1600 1610 1620 QAGTIQMLEQ AKLRLEMEME RMRQTHSKEM ESRDEEVEEA RQSCQKKLKQ MEVQLEEEYE 1630 1640 1650 1660 1670 1680 DKQKVLREKR ELEGKLATLS DQVNRRDFES EKRLRKDLKR TKALLADAQL MLDHLKNSAP 1690 1700 1710 1720 1730 1740 SKREIAQLKN QLEESEFTCA AAVKARKAME VEIEDLHLQI DDIAKAKTAL EEQLSRLQRE 1750 1760 1770 1780 1790 1800 KNEIQNRLEE DQEDMNELMK KHKAAVAQAS RDLAQINDLQ AQLEEANKEK QELQEKLQAL 1810 1820 1830 1840 1850 1860 QSQVEFLEQS MVDKSLVSRQ EAKIRELETR LEFERTQVKR LESLASRLKE NMEKLTEERD 1870 1880 1890 1900 1910 1920 QRIAAENREK EQNKRLQRQL RDTKEEMGEL ARKEAEASRK KHELEMDLES LEAANQSLQA 1930 1940 1950 1960 1970 1980 DLKLAFKRIG DLQAAIEDEM ESDENEDLIN SLQDMVTKYQ KRKNKLEGDS DVDSELEDRV 1990 2000 2010 2020 2030 2040 DGVKSWLSKN KGPSKAASDD GSLKSSSPTS YWKSLAPDRS DDEHDPLDNT SRPRYSHSYL 2050 SDSDTEAKLT ETNA
	Isoform 2 (Beta) [UniParc]. Checksum: A0764A2A6D54D6EC	FASTA	1,723	196,438
	10 20 30 40 50 60 MRAKTEEQIA AEEAWNETEK VWLVHRDGFS LASQLKSEEL NLPEGKVRVK LDHDGAILDV 70 80 90 100 110 120 DEDDVEKANA PSCDRLEDLA SLVYLNESSV LHTLRQRYGA SLLHTYAGPS LLVLGPRGAP 130 140 150 160 170 180 AVYSEKVMHM FKGCRREDMA PHIYAVAQTA YRAMLMSRQD QSIILLGSSG SGKTTSCQHL 190 200 210 220 230 240 VQYLATIAGI SGNKVFSVEK WQALYTLLEA FGNSPTIING NATRFSQILS LDFDQAGQVA 250 260 270 280 290 300 SASIQTMLLE KLRVARRPAS EATFNVFYYL LACGDGTLRT ELHLNHLAEN NVFGIVPLAK 310 320 330 340 350 360 PEEKQKAAQQ FSKLQAAMKV LGISPDEQKA CWFILAAIYH LGAAGATKEA AEAGRKQFAR 370 380 390 400 410 420 HEWAQKAAYL LGCSLEELSS AIFKHQHKGG TLQRSTSFRQ GPEESGLGDG TGPKLSALEC 430 440 450 460 470 480 LEGMAAGLYS ELFTLLVSLV NRALKSSQHS LCSMMIVDTP GFQNPEQGGS ARGASFEELC 490 500 510 520 530 540 HNYTQDRLQR LFHERTFVQE LERYKEENIE LAFDDLEPPT DDSVAAVDQA SHQSLVRSLA 550 560 570 580 590 600 RTDEARGLLW LLEEEALVPG ASEDTLLERL FSYYGPQEGD KKGQSPLLHS SKPHHFLLGH 610 620 630 640 650 660 SHGTNWVEYN VTGWLNYTKQ NPATQNAPRL LQDSQKKIIS NLFLGRAGSA TVLSGSIAGL 670 680 690 700 710 720 EGGSQLALRR ATSMRKTFTT GMAAVKKKSL CIQMKLQVDA LIDTIKKSKL HFVHCFLPVA 730 740 750 760 770 780 EGWAGEPRSA SSRRVSSSSE LDLPSGDHCE AGLLQLDVPL LRTQLRGSRL LDAMRMYRQG 790 800 810 820 830 840 YPDHMVFSEF RRRFDVLAPH LTKKHGRNYI VVDERRAVEE LLECLDLEKS SCCMGLSRVF 850 860 870 880 890 900 FRAGTLARLE EQRDEQTSRN LTLFQAACRG YLARQHFKKR KIQDLAIRCV QKNIKKNKGV 910 920 930 940 950 960 KDWPWWKLFT TVRPLIEVQL SEEQIRNKDE EIQQLRSKLE KAEKERNELR LNSDRLESRI 970 980 990 1000 1010 1020 SELTSELTDE RNTGESASQL LDAETAERLR AEKEMKELQT QYDALKKQME VMEMEVMEAR 1030 1040 1050 1060 1070 1080 LIRAAEINGE VDDDDAGGEW RLKYERAVRE VDFTKKRLQQ EFEDKLEVEQ QNKRQLERRL 1090 1100 1110 1120 1130 1140 GDLQADSEES QRALQQLKKK CQRLTAELQD TKLHLEGQQV RNHELEKKQR RFDSELSQAH 1150 1160 1170 1180 1190 1200 EEAQREKLQR EKLQREKDML LAEAFSLKQQ LEEKDMDIAG FTQKVVSLEA ELQDISSQES 1210 1220 1230 1240 1250 1260 KDEASLAKVK KQLRDLEAKV KDQEEELDEQ AGTIQMLEQA KLRLEMEMER MRQTHSKEME 1270 1280 1290 1300 1310 1320 SRDEEVEEAR QSCQKKLKQM EVQLEEEYED KQKVLREKRE LEGKLATLSD QVNRRDFESE 1330 1340 1350 1360 1370 1380 KRLRKDLKRT KALLADAQLM LDHLKNSAPS KREIAQLKNQ LEESEFTCAA AVKARKAMEV 1390 1400 1410 1420 1430 1440 EIEDLHLQID DIAKAKTALE EQLSRLQREK NEIQNRLEED QEDMNELMKK HKAAVAQASR 1450 1460 1470 1480 1490 1500 DLAQINDLQA QLEEANKEKQ ELQEKLQALQ SQVEFLEQSM VDKSLVSRQE AKIRELETRL 1510 1520 1530 1540 1550 1560 EFERTQVKRL ESLASRLKEN MEKLTEERDQ RIAAENREKE QNKRLQRQLR DTKEEMGELA 1570 1580 1590 1600 1610 1620 RKEAEASRKK HELEMDLESL EAANQSLQAD LKLAFKRIGD LQAAIEDEME SDENEDLINS 1630 1640 1650 1660 1670 1680 LQDMVTKYQK RKNKLEGDSD VDSELEDRVD GVKSWLSKNK GPSKAASDDG SLKSSSPTSY 1690 1700 1710 1720 WKSLAPDRSD DEHDPLDNTS RPRYSHSYLS DSDTEAKLTE TNA
	Isoform 3 [UniParc]. Checksum: 89350E07C2CF8B03	FASTA	2,002	226,690
	10 20 30 40 50 60 MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR SSKRESKTRL 70 80 90 100 110 120 EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 130 140 150 160 170 180 AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLVQHP 190 200 210 220 230 240 GPGIPRPGHR SRAPELVTKK FPVDLRLPPV VPLPPPTLRE LELQRRPTGD FGFSLRRTTM 250 260 270 280 290 300 LDRGPEGQAC RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG 310 320 330 340 350 360 DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDAKTEEQI AAEEAWNETE KVWLVHRDGF 370 380 390 400 410 420 SLASQLKSEE LNLPEGKVRV KLDHDGAILD VDEDDVEKAN APSCDRLEDL ASLVYLNESS 430 440 450 460 470 480 VLHTLRQRYG ASLLHTYAGP SLLVLGPRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT 490 500 510 520 530 540 AYRAMLMSRQ DQSIILLGSS GSGKTTSCQH LVQYLATIAG ISGNKVFSVE KWQALYTLLE 550 560 570 580 590 600 AFGNSPTIIN GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 610 620 630 640 650 660 LLACGDGTLR TELHLNHLAE NNVFGIVPLA KPEEKQKAAQ QFSKLQAAMK VLGISPDEQK 670 680 690 700 710 720 ACWFILAAIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY LLGCSLEELS SAIFKHQHKG 730 740 750 760 770 780 GTLQRSTSFR QGPEESGLGD GTGPKLSALE CLEGMAAGLY SELFTLLVSL VNRALKSSQH 790 800 810 820 830 840 SLCSMMIVDT PGFQNPEQGG SARGASFEEL CHNYTQDRLQ RLFHERTFVQ ELERYKEENI 850 860 870 880 890 900 ELAFDDLEPP TDDSVAAVDQ ASHQSLVRSL ARTDEARGLL WLLEEEALVP GASEDTLLER 910 920 930 940 950 960 LFSYYGPQEG DKKGQSPLLH SSKPHHFLLG HSHGTNWVEY NVTGWLNYTK QNPATQNAPR 970 980 990 1000 1010 1020 LLQDSQKKII SNLFLGRAGS ATVLSGSIAG LEGGSQLALR RATSMRKTFT TGMAAVKKKS 1030 1040 1050 1060 1070 1080 LCIQMKLQVD ALIDTIKKSK LHFVHCFLPV AEGWAGEPRS ASSRRVSSSS ELDLPSGDHC 1090 1100 1110 1120 1130 1140 EAGLLQLDVP LLRTQLRGSR LLDAMRMYRQ GYPDHMVFSE FRRRFDVLAP HLTKKHGRNY 1150 1160 1170 1180 1190 1200 IVVDERRAVE ELLECLDLEK SSCCMGLSRV FFRAGTLARL EEQRDEQTSR NLTLFQAACR 1210 1220 1230 1240 1250 1260 GYLARQHFKK RKIQDLAIRC VQKNIKKNKG VKDWPWWKLF TTVRPLIEVQ LSEEQIRNKD 1270 1280 1290 1300 1310 1320 EEIQQLRSKL EKAEKERNEL RLNSDRLESR ISELTSELTD ERNTGESASQ LLDAETAERL 1330 1340 1350 1360 1370 1380 RAEKEMKELQ TQYDALKKQM EVMEMEVMEA RLIRAAEING EVDDDDAGGE WRLKYERAVR 1390 1400 1410 1420 1430 1440 EVDFTKKRLQ QEFEDKLEVE QQNKRQLERR LGDLQADSEE SQRALQQLKK KCQRLTAELQ 1450 1460 1470 1480 1490 1500 DTKLHLEGQQ VRNHELEKKQ RRFDSELSQA HEEAQREKLQ REKLQREKDM LLAEAFSLKQ 1510 1520 1530 1540 1550 1560 QLEEKDMDIA GFTQKVVSLE AELQDISSQE SKDEASLAKV KKQLRDLEAK VKDQEEELDE 1570 1580 1590 1600 1610 1620 QAGTIQMLEQ LKQMEVQLEE EYEDKQKVLR EKRELEGKLA TLSDQVNRRD FESEKRLRKD 1630 1640 1650 1660 1670 1680 LKRTKALLAD AQLMLDHLKN SAPSKREIAQ LKNQLEESEF TCAAAVKARK AMEVEIEDLH 1690 1700 1710 1720 1730 1740 LQIDDIAKAK TALEEQLSRL QREKNEIQNR LEEDQEDMNE LMKKHKAAVA QASRDLAQIN 1750 1760 1770 1780 1790 1800 DLQAQLEEAN KEKQELQEKL QALQSQVEFL EQSMVDKSLV SRQEAKIREL ETRLEFERTQ 1810 1820 1830 1840 1850 1860 VKRLESLASR LKENMEKLTE ERDQRIAAEN REKEQNKRLQ RQLRDTKEEM GELARKEAEA 1870 1880 1890 1900 1910 1920 SRKKHELEMD LESLEAANQS LQADLKLAFK RIGDLQAAIE DEMESDENED LINSEGDSDV 1930 1940 1950 1960 1970 1980 DSELEDRVDG VKSWLSKNKG PSKAASDDGS LKSSSPTSYW KSLAPDRSDD EHDPLDNTSR 1990 2000 PRYSHSYLSD SDTEAKLTET NA
	Isoform 4 [UniParc]. Checksum: 70DDB5F30E54B9C3	FASTA	2,039	231,240
	10 20 30 40 50 60 MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR SSKRESKTRL 70 80 90 100 110 120 EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 130 140 150 160 170 180 AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLVQHP 190 200 210 220 230 240 GPGIPRPGHR SRAPELVTKK FPVDLRLPPV VPLPPPTLRE LELQRRPTGD FGFSLRRTTM 250 260 270 280 290 300 LDRGPEGQAC RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG 310 320 330 340 350 360 DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDAKTEEQI AAEEAWNETE KVWLVHRDGF 370 380 390 400 410 420 SLASQLKSEE LNLPEGKVRV KLDHDGAILD VDEDDVEKAN APSCDRLEDL ASLVYLNESS 430 440 450 460 470 480 VLHTLRQRYG ASLLHTYAGP SLLVLGPRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT 490 500 510 520 530 540 AYRAMLMSRQ DQSIILLGSS GSGKTTSCQH LVQYLATIAG ISGNKVFSVE KWQALYTLLE 550 560 570 580 590 600 AFGNSPTIIN GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 610 620 630 640 650 660 LLACGDGTLR TELHLNHLAE NNVFGIVPLA KPEEKQKAAQ QFSKLQAAMK VLGISPDEQK 670 680 690 700 710 720 ACWFILAAIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY LLGCSLEELS SAIFKHQHKG 730 740 750 760 770 780 GTLQRSTSFR QGPEESGLGD GTGPKLSALE CLEGMAAGLY SELFTLLVSL VNRALKSSQH 790 800 810 820 830 840 SLCSMMIVDT PGFQNPEQGG SARGASFEEL CHNYTQDRLQ RLFHERTFVQ ELERYKEENI 850 860 870 880 890 900 ELAFDDLEPP TDDSVAAVDQ ASHQSLVRSL ARTDEARGLL WLLEEEALVP GASEDTLLER 910 920 930 940 950 960 LFSYYGPQEG DKKGQSPLLH SSKPHHFLLG HSHGTNWVEY NVTGWLNYTK QNPATQNAPR 970 980 990 1000 1010 1020 LLQDSQKKII SNLFLGRAGS ATVLSGSIAG LEGGSQLALR RATSMRKTFT TGMAAVKKKS 1030 1040 1050 1060 1070 1080 LCIQMKLQVD ALIDTIKKSK LHFVHCFLPV AEGWAGEPRS ASSRRVSSSS ELDLPSGDHC 1090 1100 1110 1120 1130 1140 EAGLLQLDVP LLRTQLRGSR LLDAMRMYRQ GYPDHMVFSE FRRRFDVLAP HLTKKHGRNY 1150 1160 1170 1180 1190 1200 IVVDERRAVE ELLECLDLEK SSCCMGLSRV FFRAGTLARL EEQRDEQTSR NLTLFQAACR 1210 1220 1230 1240 1250 1260 GYLARQHFKK RKIQDLAIRC VQKNIKKNKG VKDWPWWKLF TTVRPLIEVQ LSEEQIRNKD 1270 1280 1290 1300 1310 1320 EEIQQLRSKL EKAEKERNEL RLNSDRLESR ISELTSELTD ERNTGESASQ LLDAETAERL 1330 1340 1350 1360 1370 1380 RAEKEMKELQ TQYDALKKQM EVMEMEVMEA RLIRAAEING EVDDDDAGGE WRLKYERAVR 1390 1400 1410 1420 1430 1440 EVDFTKKRLQ QEFEDKLEVE QQNKRQLERR LGDLQADSEE SQRALQQLKK KCQRLTAELQ 1450 1460 1470 1480 1490 1500 DTKLHLEGQQ VRNHELEKKQ RRFDSELSQA HEEAQREKLQ REKLQREKDM LLAEAFSLKQ 1510 1520 1530 1540 1550 1560 QLEEKDMDIA GFTQKVVSLE AELQDISSQE SKDEASLAKV KKQLRDLEAK VKDQEEELDE 1570 1580 1590 1600 1610 1620 QAGTIQMLEQ AKLRLEMEME RMRQTHSKEM ESRDEEVEEA RQSCQKKLKQ MEVQLEEEYE 1630 1640 1650 1660 1670 1680 DKQKVLREKR ELEGKLATLS DQVNRRDFES EKRLRKDLKR TKALLADAQL MLDHLKNSAP 1690 1700 1710 1720 1730 1740 SKREIAQLKN QLEESEFTCA AAVKARKAME VEIEDLHLQI DDIAKAKTAL EEQLSRLQRE 1750 1760 1770 1780 1790 1800 KNEIQNRLEE DQEDMNELMK KHKAAVAQAS RDLAQINDLQ AQLEEANKEK QELQEKLQAL 1810 1820 1830 1840 1850 1860 QSQVEFLEQS MVDKSLVSRQ EAKIRELETR LEFERTQVKR LESLASRLKE NMEKLTEERD 1870 1880 1890 1900 1910 1920 QRIAAENREK EQNKRLQRQL RDTKEEMGEL ARKEAEASRK KHELEMDLES LEAANQSLQA 1930 1940 1950 1960 1970 1980 DLKLAFKRIG DLQAAIEDEM ESDENEDLIN SEGDSDVDSE LEDRVDGVKS WLSKNKGPSK 1990 2000 2010 2020 2030 AASDDGSLKS SSPTSYWKSL APDRSDDEHD PLDNTSRPRY SHSYLSDSDT EAKLTETNA
	Isoform 5 [UniParc]. Checksum: DDE7EF34D1A7E515	FASTA	1,581	180,495
	10 20 30 40 50 60 MHMFKGCRRE DMAPHIYAVA QTAYRAMLMS RQDQSIILLG SSGSGKTTSC QHLVQYLATI 70 80 90 100 110 120 AGISGNKVFS VEKWQALYTL LEAFGNSPTI INGNATRFSQ ILSLDFDQAG QVASASIQTM 130 140 150 160 170 180 LLEKLRVARR PASEATFNVF YYLLACGDGT LRTELHLNHL AENNVFGIVP LAKPEEKQKA 190 200 210 220 230 240 AQQFSKLQAA MKVLGISPDE QKACWFILAA IYHLGAAGAT KEAAEAGRKQ FARHEWAQKA 250 260 270 280 290 300 AYLLGCSLEE LSSAIFKHQH KGGTLQRSTS FRQGPEESGL GDGTGPKLSA LECLEGMAAG 310 320 330 340 350 360 LYSELFTLLV SLVNRALKSS QHSLCSMMIV DTPGFQNPEQ GGSARGASFE ELCHNYTQDR 370 380 390 400 410 420 LQRLFHERTF VQELERYKEE NIELAFDDLE PPTDDSVAAV DQASHQSLVR SLARTDEARG 430 440 450 460 470 480 LLWLLEEEAL VPGASEDTLL ERLFSYYGPQ EGDKKGQSPL LHSSKPHHFL LGHSHGTNWV 490 500 510 520 530 540 EYNVTGWLNY TKQNPATQNA PRLLQDSQKK IISNLFLGRA GSATVLSGSI AGLEGGSQLA 550 560 570 580 590 600 LRRATSMRKT FTTGMAAVKK KSLCIQMKLQ VDALIDTIKK SKLHFVHCFL PVAEGWAGEP 610 620 630 640 650 660 RSASSRRVSS SSELDLPSGD HCEAGLLQLD VPLLRTQLRG SRLLDAMRMY RQGYPDHMVF 670 680 690 700 710 720 SEFRRRFDVL APHLTKKHGR NYIVVDERRA VEELLECLDL EKSSCCMGLS RVFFRAGTLA 730 740 750 760 770 780 RLEEQRDEQT SRNLTLFQAA CRGYLARQHF KKRKIQDLAI RCVQKNIKKN KGVKDWPWWK 790 800 810 820 830 840 LFTTVRPLIE VQLSEEQIRN KDEEIQQLRS KLEKAEKERN ELRLNSDRLE SRISELTSEL 850 860 870 880 890 900 TDERNTGESA SQLLDAETAE RLRAEKEMKE LQTQYDALKK QMEVMEMEVM EARLIRAAEI 910 920 930 940 950 960 NGEVDDDDAG GEWRLKYERA VREVDFTKKR LQQEFEDKLE VEQQNKRQLE RRLGDLQADS 970 980 990 1000 1010 1020 EESQRALQQL KKKCQRLTAE LQDTKLHLEG QQVRNHELEK KQRRFDSELS QAHEEAQREK 1030 1040 1050 1060 1070 1080 LQREKLQREK DMLLAEAFSL KQQLEEKDMD IAGFTQKVVS LEAELQDISS QESKDEASLA 1090 1100 1110 1120 1130 1140 KVKKQLRDLE AKVKDQEEEL DEQAGTIQML EQAKLRLEME MERMRQTHSK EMESRDEEVE 1150 1160 1170 1180 1190 1200 EARQSCQKKL KQMEVQLEEE YEDKQKVLRE KRELEGKLAT LSDQVNRRDF ESEKRLRKDL 1210 1220 1230 1240 1250 1260 KRTKALLADA QLMLDHLKNS APSKREIAQL KNQLEESEFT CAAAVKARKA MEVEIEDLHL 1270 1280 1290 1300 1310 1320 QIDDIAKAKT ALEEQLSRLQ REKNEIQNRL EEDQEDMNEL MKKHKAAVAQ ASRDLAQIND 1330 1340 1350 1360 1370 1380 LQAQLEEANK EKQELQEKLQ ALQSQVEFLE QSMVDKSLVS RQEAKIRELE TRLEFERTQV 1390 1400 1410 1420 1430 1440 KRLESLASRL KENMEKLTEE RDQRIAAENR EKEQNKRLQR QLRDTKEEMG ELARKEAEAS 1450 1460 1470 1480 1490 1500 RKKHELEMDL ESLEAANQSL QADLKLAFKR IGDLQAAIED EMESDENEDL INSEGDSDVD 1510 1520 1530 1540 1550 1560 SELEDRVDGV KSWLSKNKGP SKAASDDGSL KSSSPTSYWK SLAPDRSDDE HDPLDNTSRP 1570 1580 RYSHSYLSDS DTEAKLTETN A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alternative splice variants encoding unstable protein domains exist in the human brain." Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K. J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [MRNA] OF 9-2054 (ISOFORM 1). Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-958. Tissue: Brain.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Amygdala.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT VAL-958. Tissue: Testis.
[5]	"A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival." Ji H., Zhai Q., Zhu J., Yan M., Sun L., Liu X., Zheng Z. Biochem. Biophys. Res. Commun. 270:267-271(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH JAK3.
[6]	"Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)." Mori K., Furusawa T., Okubo T., Inoue T., Ikawa S., Yanai N., Mori K.J., Obinata M. J. Biochem. 133:405-413(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
[7]	"The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site." Isogawa Y., Kon T., Inoue T., Ohkura R., Yamakawa H., Ohara O., Sutoh K. Biochemistry 44:6190-6196(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, HOMODIMERIZATION, INTERACTION WITH ACTIN, MUTAGENESIS OF 114-ARG-GLY-115 AND 117-VAL-LEU-118.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1970 AND SER-1974, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow." Tan I., Yong J., Dong J.M., Lim L., Leung T. Cell 135:123-136(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH LURAP1 AND CDC42BPA/CDC42BPB.
[10]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2020, MASS SPECTROMETRY. Tissue: Platelet.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1070; SER-1998; SER-2002; SER-2020; SER-2041; SER-2043 AND THR-2045, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1970 AND SER-1974, MASS SPECTROMETRY. Tissue: Liver.
[14]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041 AND SER-2043, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[15]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-140; SER-2041 AND SER-2043, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-1970; SER-2007; SER-2041 AND SER-2043, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB177858 mRNA. Translation: BAD66836.1. AB177860 mRNA. Translation: BAD66838.1. Different initiation. D86970 mRNA. Translation: BAA13206.2. Different initiation. CR933614 mRNA. Translation: CAI45931.1. BC039612 mRNA. Translation: AAH39612.1.
IPI	IPI00334410. IPI00760846. IPI00760925. IPI00828082. IPI01014006.
RefSeq	NP_510880.2. NM_078471.3. NP_976063.1. NM_203318.1.
UniGene	Hs.462590.
3D structure databases
ProteinModelPortal	Q92614.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92614. 17 interactions.
STRING	9606.ENSP00000346291.
PTM databases
PhosphoSite	Q92614.
Polymorphism databases
DMDM	33301318.
Proteomic databases
PaxDb	Q92614.
PRIDE	Q92614.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000527372; ENSP00000437073; ENSG00000196535. ENST00000531253; ENSP00000434228; ENSG00000196535. ENST00000533112; ENSP00000435932; ENSG00000196535.
GeneID	399687.
KEGG	hsa:399687.
UCSC	uc002hds.2. human. uc002hdt.1. human. uc002hdu.1. human. uc010csa.1. human. uc010wbd.1. human.
Organism-specific databases
CTD	399687.
GeneCards	GC17M027400.
HGNC	HGNC:31104. MYO18A.
HPA	HPA019646. HPA021121.
MIM	609517. gene. 610067. gene.
neXtProt	NX_Q92614.
PharmGKB	PA134978348.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5022.
HOGENOM	HOG000113701.
HOVERGEN	HBG052543.
InParanoid	Q92614.
KO	K10362.
OMA	LRTELHF.
OrthoDB	EOG46T30M.
Enzyme and pathway databases
Reactome	REACT_116125. Disease.
Gene expression databases
ArrayExpress	Q92614.
Bgee	Q92614.
CleanEx	HS_MYO18A.
Genevestigator	Q92614.
GermOnline	ENSG00000196535. Homo sapiens.
Family and domain databases
Gene3D	4.10.270.10. 1 hit.
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR027401. Myosin-like_IQ_dom. IPR001609. Myosin_head_motor_dom. IPR002928. Myosin_tail. IPR027417. P-loop_NTPase. IPR001478. PDZ. IPR020587. RecA_monomer-monomer_interface. [Graphical view]
Pfam	PF00063. Myosin_head. 2 hits. PF01576. Myosin_tail_1. 1 hit. PF00595. PDZ. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00015. IQ. 1 hit. SM00242. MYSc. 1 hit. SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit. SSF52540. SSF52540. 1 hit.
PROSITE	PS50096. IQ. 1 hit. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MYO18A. human.
GenomeRNAi	399687.
NextBio	105494.
SOURCE	Search...

Entry information

Entry name

MY18A_HUMAN

Accession

Primary (citable) accession number: Q92614
Secondary accession number(s): Q5H9U3 , Q5W9F9, Q5W9G1, Q8IXP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	July 25, 2003
Last modified:	May 29, 2013
This is version 134 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.