Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q92611 (EDEM1_HUMAN)

Last modified June 16, 2009. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    ER degradation-enhancing alpha-mannosidase-like 1
Gene names
Name: EDEM1
Synonyms: EDEM, KIAA0212
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Ref.3

Subunit structure

Interacts with DERL2 and DERL3. Ref.4

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyl hydrolase 47 family.

Hide | Top

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BZW1Q9BUY01EBI-1056336,EBI-1046727

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 657657ER degradation-enhancing alpha-mannosidase-like 1
PRO_0000210321

Regions

Topological domain1 – 44Cytoplasmic Potential
Transmembrane5 – 2521Signal-anchor for type II membrane protein Potential
Topological domain26 – 657632Lumenal Potential

Amino acid modifications

Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation2991N-linked (GlcNAc...) Potential
Glycosylation3421N-linked (GlcNAc...) Potential
Glycosylation6241N-linked (GlcNAc...) Potential

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q92611-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: E0097901B3BF02FB

FASTA65773,768
        10         20         30         40         50         60 
MQWRALVLGL VLLRLGLHGV LWLVFGLGPS MGFYQRFPLS FGFQRLRSPD GPASPTSGPV 

        70         80         90        100        110        120 
GRPGGVSGPS WLQPPGTGAA QSPRKAPRRP GPGMCGPANW GYVLGGRGRG PDEYEKRYSG 

       130        140        150        160        170        180 
AFPPQLRAQM RDLARGMFVF GYDNYMAHAF PQDELNPIHC RGRGPDRGDP SNLNINDVLG 

       190        200        210        220        230        240 
NYSLTLVDAL DTLAIMGNSS EFQKAVKLVI NTVSFDKDST VQVFEATIRV LGSLLSAHRI 

       250        260        270        280        290        300 
ITDSKQPFGD MTIKDYDNEL LYMAHDLAVR LLPAFENTKT GIPYPRVNLK TGVPPDTNNE 

       310        320        330        340        350        360 
TCTAGAGSLL VEFGILSRLL GDSTFEWVAR RAVKALWNLR SNDTGLLGNV VNIQTGHWVG 

       370        380        390        400        410        420 
KQSGLGAGLD SFYEYLLKSY ILFGEKEDLE MFNAAYQSIQ NYLRRGREAC NEGEGDPPLY 

       430        440        450        460        470        480 
VNVNMFSGQL MNTWIDSLQA FFPGLQVLIG DVEDAICLHA FYYAIWKRYG ALPERYNWQL 

       490        500        510        520        530        540 
QAPDVLFYPL RPELVESTYL LYQATKNPFY LHVGMDILQS LEKYTKVKCG YATLHHVIDK 

       550        560        570        580        590        600 
STEDRMESFF LSETCKYLYL LFDEDNPVHK SGTRYMFTTE GHIVSVDEHL RELPWKEFFS 

       610        620        630        640        650 
EEGGQDQGGK SVHRPKPHEL KVINSSSNCN RVPDERRYSL PLKSIYMRQI DQMVGLI

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[3]"Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle."
Molinari M., Calanca V., Galli C., Lucca P., Paganetti P.
Science 299:1397-1400(2003) [PubMed: 12610306] [Abstract]
Cited for: FUNCTION.
[4]"Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation."
Oda Y., Okada T., Yoshida H., Kaufman R.J., Nagata K., Mori K.
J. Cell Biol. 172:383-393(2006) [PubMed: 16449189] [Abstract]
Cited for: INTERACTION WITH DERL2 AND DERL3.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

D86967 mRNA. Translation: BAA13203.2. Different initiation.
BC019088 mRNA. Translation: AAH19088.1.
IPIIPI00005683.
RefSeqNP_055489.1.
UniGeneHs.224616

3D structure databases

HSSPHSSP built from PDB template 1FO3 based on UniProtKB Q9UKM7.
ModBaseSearch...

Protein-protein interaction databases

IntActQ92611. 1 interaction.

Protein family/group databases

CAZyGH47. Glycoside Hydrolase Family 47.

Proteomic databases

PRIDEQ92611.

Genome annotation databases

EnsemblENSG00000134109. Homo sapiens. [Contig view]
GeneID9695.
KEGGhsa:9695.

Organism-specific databases

GeneCardsGC03P005203.
H-InvDBHIX0003017.
HGNCHGNC:18967. EDEM1.
MIM607673. gene.
PharmGKBPA128394554.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ92611.
HOVERGENQ92611.
OMAQ92611. DLARGMF.

Gene expression databases

ArrayExpressQ92611.
BgeeQ92611.
CleanExHS_EDEM1.
GermOnlineENSG00000134109. Homo sapiens.

Family and domain databases

InterProIPR001382. Glyco_hydro_47.
[Graphical view]
Gene3DG3DSA:1.50.10.50. Glyco_hydro_47. 1 hit.
PANTHERPTHR11742. Glyco_hydro_47. 1 hit.
PfamPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSPR00747. GLYHDRLASE47.
ProtoNetSearch...

Other Resources

NextBio36427.
SOURCESearch...

Hide | Top

Entry information

Entry nameEDEM1_HUMAN
AccessionPrimary (citable) accession number: Q92611
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 1, 1997
Last modified: June 16, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents