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Protein

Dedicator of cytokinesis protein 2

Gene

DOCK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: Ensembl
  • Rac guanyl-nucleotide exchange factor activity Source: UniProtKB
  • T cell receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-164944. Nef and signal transduction.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 2
Gene namesi
Name:DOCK2
Synonyms:KIAA0209
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:2988. DOCK2.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • endomembrane system Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 40 (IMD40)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of combined immunodeficiency characterized by lymphopenia, and defective T-cell, B-cell, and NK-cell responses. Patients suffer from severe invasive bacterial and viral infections in early childhood and may die without bone marrow transplantation.
See also OMIM:616433
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073859751R → S in IMD40. 1 Publication1
Natural variantiVAR_0738601104R → W in IMD40. 1 PublicationCorresponds to variant rs780318765dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1794.
MIMi616433. phenotype.
OpenTargetsiENSG00000134516.
PharmGKBiPA27454.

Polymorphism and mutation databases

BioMutaiDOCK2.
DMDMi32469765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001899861 – 1830Dedicator of cytokinesis protein 2Add BLAST1830

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei304N6-acetyllysineCombined sources1
Modified residuei588PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei738N6-acetyllysineCombined sources1
Modified residuei1685PhosphoserineCombined sources1
Modified residuei1706PhosphoserineCombined sources1
Modified residuei1731PhosphoserineCombined sources1
Modified residuei1784PhosphoserineCombined sources1
Modified residuei1825PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92608.
MaxQBiQ92608.
PaxDbiQ92608.
PeptideAtlasiQ92608.
PRIDEiQ92608.

PTM databases

iPTMnetiQ92608.
PhosphoSitePlusiQ92608.

Expressioni

Tissue specificityi

Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.1 Publication

Gene expression databases

BgeeiENSG00000134516.
CleanExiHS_DOCK2.
ExpressionAtlasiQ92608. baseline and differential.
GenevisibleiQ92608. HS.

Organism-specific databases

HPAiHPA036468.
HPA036469.

Interactioni

Subunit structurei

Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z.Curated4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-448771,EBI-739580
CCNDBP1O952733EBI-448771,EBI-748961
HNRNPKP619783EBI-448771,EBI-304185
HNRPKQ6IBN13EBI-448771,EBI-3440248
KHDRBS2Q5VWX15EBI-448771,EBI-742808
KRT40Q6A1625EBI-448771,EBI-10171697
KRTAP10-8P604105EBI-448771,EBI-10171774
KRTAP10-9P604113EBI-448771,EBI-10172052
KRTAP4-2Q9BYR53EBI-448771,EBI-10172511
KRTAP5-9P263715EBI-448771,EBI-3958099
KRTAP9-2Q9BYQ43EBI-448771,EBI-1044640
KRTAP9-4Q9BYQ23EBI-448771,EBI-10185730
MDFIQ997505EBI-448771,EBI-724076
MTUS2Q5JR593EBI-448771,EBI-742948
NOTCH2NLQ7Z3S95EBI-448771,EBI-945833
PLSCR1O151623EBI-448771,EBI-740019
RAC1P630003EBI-448771,EBI-413628
TRIM23P364063EBI-448771,EBI-740098

GO - Molecular functioni

  • T cell receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108129. 28 interactors.
DIPiDIP-31791N.
IntActiQ92608. 33 interactors.
MINTiMINT-2813049.
STRINGi9606.ENSP00000256935.

Structurei

Secondary structure

11830
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 17Combined sources6
Beta strandi34 – 41Combined sources8
Beta strandi44 – 49Combined sources6
Beta strandi52 – 60Combined sources9
Helixi61 – 63Combined sources3
Beta strandi64 – 67Combined sources4
Helixi84 – 107Combined sources24
Helixi111 – 133Combined sources23
Helixi138 – 158Combined sources21
Helixi1197 – 1214Combined sources18
Helixi1217 – 1233Combined sources17
Helixi1237 – 1248Combined sources12
Turni1265 – 1267Combined sources3
Helixi1273 – 1291Combined sources19
Helixi1294 – 1310Combined sources17
Helixi1315 – 1334Combined sources20
Beta strandi1342 – 1349Combined sources8
Turni1354 – 1358Combined sources5
Beta strandi1359 – 1364Combined sources6
Helixi1371 – 1381Combined sources11
Beta strandi1385 – 1387Combined sources3
Helixi1396 – 1400Combined sources5
Beta strandi1405 – 1414Combined sources10
Helixi1419 – 1421Combined sources3
Beta strandi1422 – 1424Combined sources3
Helixi1428 – 1436Combined sources9
Beta strandi1437 – 1449Combined sources13
Helixi1458 – 1461Combined sources4
Beta strandi1462 – 1492Combined sources31
Helixi1494 – 1518Combined sources25
Beta strandi1520 – 1522Combined sources3
Helixi1525 – 1535Combined sources11
Beta strandi1538 – 1540Combined sources3
Helixi1544 – 1550Combined sources7
Helixi1553 – 1558Combined sources6
Helixi1560 – 1562Combined sources3
Helixi1563 – 1589Combined sources27
Helixi1593 – 1595Combined sources3
Helixi1596 – 1617Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RQRNMR-A8-70[»]
2YINX-ray2.70A/B1192-1622[»]
3A98X-ray2.10A/C1-177[»]
3B13X-ray3.01A/C1196-1622[»]
ProteinModelPortaliQ92608.
SMRiQ92608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 69SH3PROSITE-ProRule annotationAdd BLAST62
Domaini423 – 607DHR-1PROSITE-ProRule annotationAdd BLAST185
Domaini1211 – 1622DHR-2PROSITE-ProRule annotationAdd BLAST412

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni939 – 1476Interaction with CRKL1 PublicationAdd BLAST538

Domaini

The DHR-2 domain may mediate the GEF activity.By similarity

Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation
Contains 1 DHR-1 domain.PROSITE-ProRule annotation
Contains 1 DHR-2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG1998. Eukaryota.
ENOG410XQH7. LUCA.
GeneTreeiENSGT00610000085806.
HOGENOMiHOG000006631.
HOVERGENiHBG051389.
InParanoidiQ92608.
KOiK12367.
OMAiMEHSQSD.
OrthoDBiEOG091G007D.
PhylomeDBiQ92608.
TreeFamiTF300423.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR026799. DOCK_2.
IPR010703. DOCK_C.
IPR032376. DOCK_N.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PTHR23317:SF73. PTHR23317:SF73. 1 hit.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF16172. DOCK_N. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92608-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPWRKADKE RHGVAIYNFQ GSGAPQLSLQ IGDVVRIQET CGDWYRGYLI
60 70 80 90 100
KHKMLQGIFP KSFIHIKEVT VEKRRNTENI IPAEIPLAQE VTTTLWEWGS
110 120 130 140 150
IWKQLYVASK KERFLQVQSM MYDLMEWRSQ LLSGTLPKDE LKELKQKVTS
160 170 180 190 200
KIDYGNKILE LDLIVRDEDG NILDPDNTSV ISLFHAHEEA TDKITERIKE
210 220 230 240 250
EMSKDQPDYA MYSRISSSPT HSLYVFVRNF VCRIGEDAEL FMSLYDPNKQ
260 270 280 290 300
TVISENYLVR WGSRGFPKEI EMLNNLKVVF TDLGNKDLNR DKIYLICQIV
310 320 330 340 350
RVGKMDLKDT GAKKCTQGLR RPFGVAVMDI TDIIKGKAES DEEKQHFIPF
360 370 380 390 400
HPVTAENDFL HSLLGKVIAS KGDSGGQGLW VTMKMLVGDI IQIRKDYPHL
410 420 430 440 450
VDRTTVVARK LGFPEIIMPG DVRNDIYITL LQGDFDKYNK TTQRNVEVIM
460 470 480 490 500
CVCAEDGKTL PNAICVGAGD KPMNEYRSVV YYQVKQPRWM ETVKVAVPIE
510 520 530 540 550
DMQRIHLRFM FRHRSSLESK DKGEKNFAMS YVKLMKEDGT TLHDGFHDLV
560 570 580 590 600
VLKGDSKKME DASAYLTLPS YRHHVENKGA TLSRSSSSVG GLSVSSRDVF
610 620 630 640 650
SISTLVCSTK LTQNVGLLGL LKWRMKPQLL QENLEKLKIV DGEEVVKFLQ
660 670 680 690 700
DTLDALFNIM MEHSQSDEYD ILVFDALIYI IGLIADRKFQ HFNTVLEAYI
710 720 730 740 750
QQHFSATLAY KKLMTVLKTY LDTSSRGEQC EPILRTLKAL EYVFKFIVRS
760 770 780 790 800
RTLFSQLYEG KEQMEFEESM RRLFESINNL MKSQYKTTIL LQVAALKYIP
810 820 830 840 850
SVLHDVEMVF DAKLLSQLLY EFYTCIPPVK LQKQKVQSMN EIVQSNLFKK
860 870 880 890 900
QECRDILLPV ITKELKELLE QKDDMQHQVL ERKYCVELLN SILEVLSYQD
910 920 930 940 950
AAFTYHHIQE IMVQLLRTVN RTVITMGRDH ILISHFVACM TAILNQMGDQ
960 970 980 990 1000
HYSFYIETFQ TSSELVDFLM ETFIMFKDLI GKNVYPGDWM AMSMVQNRVF
1010 1020 1030 1040 1050
LRAINKFAET MNQKFLEHTN FEFQLWNNYF HLAVAFITQD SLQLEQFSHA
1060 1070 1080 1090 1100
KYNKILNKYG DMRRLIGFSI RDMWYKLGQN KICFIPGMVG PILEMTLIPE
1110 1120 1130 1140 1150
AELRKATIPI FFDMMLCEYQ RSGDFKKFEN EIILKLDHEV EGGRGDEQYM
1160 1170 1180 1190 1200
QLLESILMEC AAEHPTIAKS VENFVNLVKG LLEKLLDYRG VMTDESKDNR
1210 1220 1230 1240 1250
MSCTVNLLNF YKDNNREEMY IRYLYKLRDL HLDCDNYTEA AYTLLLHTWL
1260 1270 1280 1290 1300
LKWSDEQCAS QVMQTGQQHP QTHRQLKETL YETIIGYFDK GKMWEEAISL
1310 1320 1330 1340 1350
CKELAEQYEM EIFDYELLSQ NLIQQAKFYE SIMKILRPKP DYFAVGYYGQ
1360 1370 1380 1390 1400
GFPSFLRNKV FIYRGKEYER REDFQMQLMT QFPNAEKMNT TSAPGDDVKN
1410 1420 1430 1440 1450
APGQYIQCFT VQPVLDEHPR FKNKPVPDQI INFYKSNYVQ RFHYSRPVRR
1460 1470 1480 1490 1500
GTVDPENEFA SMWIERTSFV TAYKLPGILR WFEVVHMSQT TISPLENAIE
1510 1520 1530 1540 1550
TMSTANEKIL MMINQYQSDE TLPINPLSML LNGIVDPAVM GGFAKYEKAF
1560 1570 1580 1590 1600
FTEEYVRDHP EDQDKLTHLK DLIAWQIPFL GAGIKIHEKR VSDNLRPFHD
1610 1620 1630 1640 1650
RMEECFKNLK MKVEKEYGVR EMPDFDDRRV GRPRSMLRSY RQMSIISLAS
1660 1670 1680 1690 1700
MNSDCSTPSK PTSESFDLEL ASPKTPRVEQ EEPISPGSTL PEVKLRRSKK
1710 1720 1730 1740 1750
RTKRSSVVFA DEKAAAESDL KRLSRKHEFM SDTNLSEHAA IPLKASVLSQ
1760 1770 1780 1790 1800
MSFASQSMPT IPALALSVAG IPGLDEANTS PRLSQTFLQL SDGDKKTLTR
1810 1820 1830
KKVNQFFKTM LASKSAEEGK QIPDSLSTDL
Length:1,830
Mass (Da):211,948
Last modified:July 3, 2003 - v2
Checksum:i18568D3322DAA92A
GO
Isoform 2 (identifier: Q92608-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-449: Missing.
     462-494: Missing.
     630-766: Missing.
     934-955: SHFVACMTAILNQMGDQHYSFY → GACCNCGFPSSTPHSLIQWLWG
     956-1830: Missing.

Note: Splicing donor and acceptor sites between exon 6 and exon 7 are not canonical. No experimental confirmation available.
Show »
Length:336
Mass (Da):38,461
Checksum:iC5D6CAAB1C3A3490
GO

Sequence cautioni

The sequence BAA13200 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073859751R → S in IMD40. 1 Publication1
Natural variantiVAR_0738601104R → W in IMD40. 1 PublicationCorresponds to variant rs780318765dbSNPEnsembl.1
Natural variantiVAR_0530641558D → A.Corresponds to variant rs13179480dbSNPEnsembl.1
Natural variantiVAR_0158221746S → T.Corresponds to variant rs2270898dbSNPEnsembl.1
Natural variantiVAR_0221371779T → S.Corresponds to variant rs2270898dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0076961 – 449Missing in isoform 2. 1 PublicationAdd BLAST449
Alternative sequenceiVSP_007697462 – 494Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_007698630 – 766Missing in isoform 2. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_007699934 – 955SHFVA…HYSFY → GACCNCGFPSSTPHSLIQWL WG in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_007700956 – 1830Missing in isoform 2. 1 PublicationAdd BLAST875

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86964 mRNA. Translation: BAA13200.1. Different initiation.
BC016996 mRNA. Translation: AAH16996.1.
BC104900 mRNA. Translation: AAI04901.1.
BC113457 mRNA. Translation: AAI13458.1.
CCDSiCCDS4371.1. [Q92608-1]
RefSeqiNP_004937.1. NM_004946.2. [Q92608-1]
UniGeneiHs.586174.

Genome annotation databases

EnsembliENST00000256935; ENSP00000256935; ENSG00000134516. [Q92608-1]
GeneIDi1794.
KEGGihsa:1794.
UCSCiuc003maf.3. human. [Q92608-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86964 mRNA. Translation: BAA13200.1. Different initiation.
BC016996 mRNA. Translation: AAH16996.1.
BC104900 mRNA. Translation: AAI04901.1.
BC113457 mRNA. Translation: AAI13458.1.
CCDSiCCDS4371.1. [Q92608-1]
RefSeqiNP_004937.1. NM_004946.2. [Q92608-1]
UniGeneiHs.586174.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RQRNMR-A8-70[»]
2YINX-ray2.70A/B1192-1622[»]
3A98X-ray2.10A/C1-177[»]
3B13X-ray3.01A/C1196-1622[»]
ProteinModelPortaliQ92608.
SMRiQ92608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108129. 28 interactors.
DIPiDIP-31791N.
IntActiQ92608. 33 interactors.
MINTiMINT-2813049.
STRINGi9606.ENSP00000256935.

PTM databases

iPTMnetiQ92608.
PhosphoSitePlusiQ92608.

Polymorphism and mutation databases

BioMutaiDOCK2.
DMDMi32469765.

Proteomic databases

EPDiQ92608.
MaxQBiQ92608.
PaxDbiQ92608.
PeptideAtlasiQ92608.
PRIDEiQ92608.

Protocols and materials databases

DNASUi1794.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256935; ENSP00000256935; ENSG00000134516. [Q92608-1]
GeneIDi1794.
KEGGihsa:1794.
UCSCiuc003maf.3. human. [Q92608-1]

Organism-specific databases

CTDi1794.
DisGeNETi1794.
GeneCardsiDOCK2.
HGNCiHGNC:2988. DOCK2.
HPAiHPA036468.
HPA036469.
MIMi603122. gene.
616433. phenotype.
neXtProtiNX_Q92608.
OpenTargetsiENSG00000134516.
PharmGKBiPA27454.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1998. Eukaryota.
ENOG410XQH7. LUCA.
GeneTreeiENSGT00610000085806.
HOGENOMiHOG000006631.
HOVERGENiHBG051389.
InParanoidiQ92608.
KOiK12367.
OMAiMEHSQSD.
OrthoDBiEOG091G007D.
PhylomeDBiQ92608.
TreeFamiTF300423.

Enzyme and pathway databases

ReactomeiR-HSA-164944. Nef and signal transduction.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSiDOCK2. human.
GeneWikiiDock2.
GenomeRNAii1794.
PROiQ92608.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134516.
CleanExiHS_DOCK2.
ExpressionAtlasiQ92608. baseline and differential.
GenevisibleiQ92608. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR026799. DOCK_2.
IPR010703. DOCK_C.
IPR032376. DOCK_N.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PTHR23317:SF73. PTHR23317:SF73. 1 hit.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF16172. DOCK_N. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOCK2_HUMAN
AccessioniPrimary (citable) accession number: Q92608
Secondary accession number(s): Q2M3I0, Q96AK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: November 30, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.