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Q92608

- DOCK2_HUMAN

UniProt

Q92608 - DOCK2_HUMAN

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Protein
Dedicator of cytokinesis protein 2
Gene
DOCK2, KIAA0209
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.1 Publication

GO - Molecular functioni

  1. Rac GTPase activator activity Source: Ensembl
  2. Rac guanyl-nucleotide exchange factor activity Source: UniProtKB
  3. T cell receptor binding Source: UniProtKB
  4. protein binding Source: IntAct

GO - Biological processi

  1. actin cytoskeleton organization Source: UniProtKB
  2. alpha-beta T cell proliferation Source: Ensembl
  3. chemotaxis Source: Ensembl
  4. establishment of T cell polarity Source: Ensembl
  5. immunological synapse formation Source: Ensembl
  6. macropinocytosis Source: UniProtKB
  7. membrane raft polarization Source: Ensembl
  8. myeloid dendritic cell activation involved in immune response Source: UniProtKB
  9. negative thymic T cell selection Source: Ensembl
  10. positive regulation of phagocytosis Source: UniProtKB
  11. positive thymic T cell selection Source: Ensembl
  12. regulation of Rac GTPase activity Source: GOC
  13. regulation of defense response to virus by virus Source: Reactome
  14. small GTPase mediated signal transduction Source: InterPro
  15. viral process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_11068. Nef and signal transduction.
REACT_24970. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 2
Gene namesi
Name:DOCK2
Synonyms:KIAA0209
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:2988. DOCK2.

Subcellular locationi

Endomembrane system; Peripheral membrane protein. Cytoplasmcytoskeleton
Note: Colocalizes with F-actin.1 Publication

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
  3. endomembrane system Source: UniProtKB-SubCell
  4. extracellular vesicular exosome Source: UniProt
  5. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18301830Dedicator of cytokinesis protein 2
PRO_0000189986Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei304 – 3041N6-acetyllysine1 Publication
Modified residuei588 – 5881Phosphoserine1 Publication
Modified residuei593 – 5931Phosphoserine1 Publication
Modified residuei738 – 7381N6-acetyllysine1 Publication
Modified residuei1685 – 16851Phosphoserine3 Publications
Modified residuei1731 – 17311Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ92608.
PaxDbiQ92608.
PeptideAtlasiQ92608.
PRIDEiQ92608.

PTM databases

PhosphoSiteiQ92608.

Expressioni

Tissue specificityi

Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.1 Publication

Gene expression databases

ArrayExpressiQ92608.
BgeeiQ92608.
CleanExiHS_DOCK2.
GenevestigatoriQ92608.

Organism-specific databases

HPAiHPA036468.
HPA036469.

Interactioni

Subunit structurei

Homodimer Inferred. Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RAC1P630003EBI-448771,EBI-413628

Protein-protein interaction databases

BioGridi108129. 9 interactions.
DIPiDIP-31791N.
IntActiQ92608. 3 interactions.
MINTiMINT-2813049.
STRINGi9606.ENSP00000256935.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 176
Beta strandi34 – 418
Beta strandi44 – 496
Beta strandi52 – 609
Helixi61 – 633
Beta strandi64 – 674
Helixi84 – 10724
Helixi111 – 13323
Helixi138 – 15821
Helixi1197 – 121418
Helixi1217 – 123317
Helixi1237 – 124812
Turni1265 – 12673
Helixi1273 – 129119
Helixi1294 – 131017
Helixi1315 – 133420
Beta strandi1342 – 13498
Turni1354 – 13585
Beta strandi1359 – 13646
Helixi1371 – 138111
Beta strandi1385 – 13873
Helixi1396 – 14005
Beta strandi1405 – 141410
Helixi1419 – 14213
Beta strandi1422 – 14243
Helixi1428 – 14369
Beta strandi1437 – 144913
Helixi1458 – 14614
Beta strandi1462 – 149231
Helixi1494 – 151825
Beta strandi1520 – 15223
Helixi1525 – 153511
Beta strandi1538 – 15403
Helixi1544 – 15507
Helixi1553 – 15586
Helixi1560 – 15623
Helixi1563 – 158927
Helixi1593 – 15953
Helixi1596 – 161722

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RQRNMR-A8-70[»]
2YINX-ray2.70A/B1192-1622[»]
3A98X-ray2.10A/C1-177[»]
3B13X-ray3.01A/C1196-1622[»]
ProteinModelPortaliQ92608.
SMRiQ92608. Positions 1-167, 423-609, 1196-1622.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 6962SH3
Add
BLAST
Domaini423 – 607185DHR-1
Add
BLAST
Domaini1211 – 1622412DHR-2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni939 – 1476538Interaction with CRKL
Add
BLAST

Domaini

The DHR-2 domain may mediate the GEF activity By similarity.

Sequence similaritiesi

Belongs to the DOCK family.
Contains 1 DHR-1 domain.
Contains 1 DHR-2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG289808.
HOGENOMiHOG000006631.
HOVERGENiHBG051389.
InParanoidiQ92608.
KOiK12367.
OMAiGDWMAMS.
OrthoDBiEOG7QNVK8.
PhylomeDBiQ92608.
TreeFamiTF300423.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR026799. DOCK_2.
IPR010703. DOCK_C.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PTHR23317:SF73. PTHR23317:SF73. 1 hit.
PfamiPF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92608-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPWRKADKE RHGVAIYNFQ GSGAPQLSLQ IGDVVRIQET CGDWYRGYLI     50
KHKMLQGIFP KSFIHIKEVT VEKRRNTENI IPAEIPLAQE VTTTLWEWGS 100
IWKQLYVASK KERFLQVQSM MYDLMEWRSQ LLSGTLPKDE LKELKQKVTS 150
KIDYGNKILE LDLIVRDEDG NILDPDNTSV ISLFHAHEEA TDKITERIKE 200
EMSKDQPDYA MYSRISSSPT HSLYVFVRNF VCRIGEDAEL FMSLYDPNKQ 250
TVISENYLVR WGSRGFPKEI EMLNNLKVVF TDLGNKDLNR DKIYLICQIV 300
RVGKMDLKDT GAKKCTQGLR RPFGVAVMDI TDIIKGKAES DEEKQHFIPF 350
HPVTAENDFL HSLLGKVIAS KGDSGGQGLW VTMKMLVGDI IQIRKDYPHL 400
VDRTTVVARK LGFPEIIMPG DVRNDIYITL LQGDFDKYNK TTQRNVEVIM 450
CVCAEDGKTL PNAICVGAGD KPMNEYRSVV YYQVKQPRWM ETVKVAVPIE 500
DMQRIHLRFM FRHRSSLESK DKGEKNFAMS YVKLMKEDGT TLHDGFHDLV 550
VLKGDSKKME DASAYLTLPS YRHHVENKGA TLSRSSSSVG GLSVSSRDVF 600
SISTLVCSTK LTQNVGLLGL LKWRMKPQLL QENLEKLKIV DGEEVVKFLQ 650
DTLDALFNIM MEHSQSDEYD ILVFDALIYI IGLIADRKFQ HFNTVLEAYI 700
QQHFSATLAY KKLMTVLKTY LDTSSRGEQC EPILRTLKAL EYVFKFIVRS 750
RTLFSQLYEG KEQMEFEESM RRLFESINNL MKSQYKTTIL LQVAALKYIP 800
SVLHDVEMVF DAKLLSQLLY EFYTCIPPVK LQKQKVQSMN EIVQSNLFKK 850
QECRDILLPV ITKELKELLE QKDDMQHQVL ERKYCVELLN SILEVLSYQD 900
AAFTYHHIQE IMVQLLRTVN RTVITMGRDH ILISHFVACM TAILNQMGDQ 950
HYSFYIETFQ TSSELVDFLM ETFIMFKDLI GKNVYPGDWM AMSMVQNRVF 1000
LRAINKFAET MNQKFLEHTN FEFQLWNNYF HLAVAFITQD SLQLEQFSHA 1050
KYNKILNKYG DMRRLIGFSI RDMWYKLGQN KICFIPGMVG PILEMTLIPE 1100
AELRKATIPI FFDMMLCEYQ RSGDFKKFEN EIILKLDHEV EGGRGDEQYM 1150
QLLESILMEC AAEHPTIAKS VENFVNLVKG LLEKLLDYRG VMTDESKDNR 1200
MSCTVNLLNF YKDNNREEMY IRYLYKLRDL HLDCDNYTEA AYTLLLHTWL 1250
LKWSDEQCAS QVMQTGQQHP QTHRQLKETL YETIIGYFDK GKMWEEAISL 1300
CKELAEQYEM EIFDYELLSQ NLIQQAKFYE SIMKILRPKP DYFAVGYYGQ 1350
GFPSFLRNKV FIYRGKEYER REDFQMQLMT QFPNAEKMNT TSAPGDDVKN 1400
APGQYIQCFT VQPVLDEHPR FKNKPVPDQI INFYKSNYVQ RFHYSRPVRR 1450
GTVDPENEFA SMWIERTSFV TAYKLPGILR WFEVVHMSQT TISPLENAIE 1500
TMSTANEKIL MMINQYQSDE TLPINPLSML LNGIVDPAVM GGFAKYEKAF 1550
FTEEYVRDHP EDQDKLTHLK DLIAWQIPFL GAGIKIHEKR VSDNLRPFHD 1600
RMEECFKNLK MKVEKEYGVR EMPDFDDRRV GRPRSMLRSY RQMSIISLAS 1650
MNSDCSTPSK PTSESFDLEL ASPKTPRVEQ EEPISPGSTL PEVKLRRSKK 1700
RTKRSSVVFA DEKAAAESDL KRLSRKHEFM SDTNLSEHAA IPLKASVLSQ 1750
MSFASQSMPT IPALALSVAG IPGLDEANTS PRLSQTFLQL SDGDKKTLTR 1800
KKVNQFFKTM LASKSAEEGK QIPDSLSTDL 1830
Length:1,830
Mass (Da):211,948
Last modified:July 3, 2003 - v2
Checksum:i18568D3322DAA92A
GO
Isoform 2 (identifier: Q92608-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-449: Missing.
     462-494: Missing.
     630-766: Missing.
     934-955: SHFVACMTAILNQMGDQHYSFY → GACCNCGFPSSTPHSLIQWLWG
     956-1830: Missing.

Note: Splicing donor and acceptor sites between exon 6 and exon 7 are not canonical. No experimental confirmation available.

Show »
Length:336
Mass (Da):38,461
Checksum:iC5D6CAAB1C3A3490
GO

Sequence cautioni

The sequence BAA13200.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1558 – 15581D → A.
Corresponds to variant rs13179480 [ dbSNP | Ensembl ].
VAR_053064
Natural varianti1746 – 17461S → T.
Corresponds to variant rs2270898 [ dbSNP | Ensembl ].
VAR_015822
Natural varianti1779 – 17791T → S.
Corresponds to variant rs2270898 [ dbSNP | Ensembl ].
VAR_022137

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 449449Missing in isoform 2.
VSP_007696Add
BLAST
Alternative sequencei462 – 49433Missing in isoform 2.
VSP_007697Add
BLAST
Alternative sequencei630 – 766137Missing in isoform 2.
VSP_007698Add
BLAST
Alternative sequencei934 – 95522SHFVA…HYSFY → GACCNCGFPSSTPHSLIQWL WG in isoform 2.
VSP_007699Add
BLAST
Alternative sequencei956 – 1830875Missing in isoform 2.
VSP_007700Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86964 mRNA. Translation: BAA13200.1. Different initiation.
BC016996 mRNA. Translation: AAH16996.1.
BC104900 mRNA. Translation: AAI04901.1.
BC113457 mRNA. Translation: AAI13458.1.
CCDSiCCDS4371.1. [Q92608-1]
RefSeqiNP_004937.1. NM_004946.2. [Q92608-1]
UniGeneiHs.586174.

Genome annotation databases

EnsembliENST00000256935; ENSP00000256935; ENSG00000134516. [Q92608-1]
GeneIDi1794.
KEGGihsa:1794.
UCSCiuc003maf.3. human. [Q92608-1]

Polymorphism databases

DMDMi32469765.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86964 mRNA. Translation: BAA13200.1 . Different initiation.
BC016996 mRNA. Translation: AAH16996.1 .
BC104900 mRNA. Translation: AAI04901.1 .
BC113457 mRNA. Translation: AAI13458.1 .
CCDSi CCDS4371.1. [Q92608-1 ]
RefSeqi NP_004937.1. NM_004946.2. [Q92608-1 ]
UniGenei Hs.586174.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RQR NMR - A 8-70 [» ]
2YIN X-ray 2.70 A/B 1192-1622 [» ]
3A98 X-ray 2.10 A/C 1-177 [» ]
3B13 X-ray 3.01 A/C 1196-1622 [» ]
ProteinModelPortali Q92608.
SMRi Q92608. Positions 1-167, 423-609, 1196-1622.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108129. 9 interactions.
DIPi DIP-31791N.
IntActi Q92608. 3 interactions.
MINTi MINT-2813049.
STRINGi 9606.ENSP00000256935.

PTM databases

PhosphoSitei Q92608.

Polymorphism databases

DMDMi 32469765.

Proteomic databases

MaxQBi Q92608.
PaxDbi Q92608.
PeptideAtlasi Q92608.
PRIDEi Q92608.

Protocols and materials databases

DNASUi 1794.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256935 ; ENSP00000256935 ; ENSG00000134516 . [Q92608-1 ]
GeneIDi 1794.
KEGGi hsa:1794.
UCSCi uc003maf.3. human. [Q92608-1 ]

Organism-specific databases

CTDi 1794.
GeneCardsi GC05P169064.
HGNCi HGNC:2988. DOCK2.
HPAi HPA036468.
HPA036469.
MIMi 603122. gene.
neXtProti NX_Q92608.
PharmGKBi PA27454.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289808.
HOGENOMi HOG000006631.
HOVERGENi HBG051389.
InParanoidi Q92608.
KOi K12367.
OMAi GDWMAMS.
OrthoDBi EOG7QNVK8.
PhylomeDBi Q92608.
TreeFami TF300423.

Enzyme and pathway databases

Reactomei REACT_11068. Nef and signal transduction.
REACT_24970. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSi DOCK2. human.
GeneWikii Dock2.
GenomeRNAii 1794.
NextBioi 7309.
PROi Q92608.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92608.
Bgeei Q92608.
CleanExi HS_DOCK2.
Genevestigatori Q92608.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR026799. DOCK_2.
IPR010703. DOCK_C.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR23317. PTHR23317. 1 hit.
PTHR23317:SF73. PTHR23317:SF73. 1 hit.
Pfami PF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
SSF50044. SSF50044. 1 hit.
PROSITEi PS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon and Liver.
  3. "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins."
    Nishihara H., Kobayashi S., Hashimoto Y., Ohba F., Mochizuki N., Kurata T., Nagashima K., Matsuda M.
    Biochim. Biophys. Acta 1452:179-187(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, RAC1 ACTIVATION, INTERACTION WITH RAC1 AND RAC2.
  4. "DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines."
    Nishihara H., Maeda M., Oda A., Tsuda M., Sawa H., Nagashima K., Tanaka S.
    Blood 100:3968-3974(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CRKL AND VAV.
  5. "DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription."
    Nishihara H., Maeda M., Tsuda M., Makino Y., Sawa H., Nagashima K., Tanaka S.
    Biochem. Biophys. Res. Commun. 296:716-720(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD3Z.
  6. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."
    Cote J.-F., Vuori K.
    J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1685, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1685, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588; SER-593; SER-1685 AND SER-1731, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-304 AND LYS-738, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The solution structure of human DOCK2 SH3 domain - ELMO1 peptide chimera complex."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2010) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 8-70.
  14. "Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors."
    Kulkarni K., Yang J., Zhang Z., Barford D.
    J. Biol. Chem. 286:25341-25351(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1192-1622 IN COMPLEX WITH RAC1, INTERACTION WITH RAC1, SUBUNIT, FUNCTION.

Entry informationi

Entry nameiDOCK2_HUMAN
AccessioniPrimary (citable) accession number: Q92608
Secondary accession number(s): Q2M3I0, Q96AK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: September 3, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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