Q92604 (LGAT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1
EC=2.3.1.-

Gene names

Name:	LPGAT1
Synonyms:	FAM34A, KIAA0205

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Lysophoshatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor. Ref.1
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon. Ref.1
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Sequence caution	The sequence BAA13196.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Acyl-CoA:lysophosphatidylglycerol acyltransferase 1		PRO_0000208204
Regions
	Transmembrane	22 – 42	21	Helical; Potential
	Transmembrane	342 – 362	21	Helical; Potential
	Motif	101 – 106	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	Q92604 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 93498544EA651541	FASTA	370	43,089
	10 20 30 40 50 60 MAITLEEAPW LGWLLVKALM RFAFMVVNNL VAIPSYICYV IILQPLRVLD SKRFWYIEGI 70 80 90 100 110 120 MYKWLLGMVA SWGWYAGYTV MEWGEDIKAV SKDEAVMLVN HQATGDVCTL MMCLQDKGLV 130 140 150 160 170 180 VAQMMWLMDH IFKYTNFGIV SLVHGDFFIR QGRSYRDQQL LLLKKHLENN YRSRDRKWIV 190 200 210 220 230 240 LFPEGGFLRK RRETSQAFAK KNNLPFLTNV TLPRSGATKI ILNALVAQQK NGSPAGGDAK 250 260 270 280 290 300 ELDSKSKGLQ WIIDTTIAYP KAEPIDIQTW ILGYRKPTVT HVHYRIFPIK DVPLETDDLT 310 320 330 340 350 360 TWLYQRFVEK EDLLSHFYET GAFPPSKGHK EAVSREMTLS NLWIFLIQSF AFLSGYMWYN 370 IIQYFYHCLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase." Yang Y., Cao J., Shi Y. J. Biol. Chem. 279:55866-55874(2004) [PubMed: 15485873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Liver.
[2]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D86960 mRNA. Translation: BAA13196.2. Different initiation. BC034621 mRNA. Translation: AAH34621.1.
IPI	IPI00022447.
RefSeq	NP_055688.1. NM_014873.2.
UniGene	Hs.725980.
3D structure databases
ProteinModelPortal	Q92604.
ModBase	Search...
Protein-protein interaction databases
STRING	Q92604.
PTM databases
PhosphoSite	Q92604.
Polymorphism databases
DMDM	6136501.
Proteomic databases
PRIDE	Q92604.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366996; ENSP00000355963; ENSG00000123684. ENST00000366997; ENSP00000355964; ENSG00000123684.
GeneID	9926.
KEGG	hsa:9926.
UCSC	uc001hiu.1. human.
Organism-specific databases
CTD	9926.
GeneCards	GC01M211916.
H-InvDB	HIX0022966.
HGNC	HGNC:28985. LPGAT1.
HPA	HPA008304.
MIM	610473. gene.
neXtProt	NX_Q92604.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16142.
GeneTree	ENSGT00390000012157.
HOGENOM	HBG713799.
HOVERGEN	HBG051533.
InParanoid	Q92604.
OMA	WYAGYTV.
OrthoDB	EOG43XV3N.
PhylomeDB	Q92604.
Gene expression databases
ArrayExpress	Q92604.
Bgee	Q92604.
CleanEx	HS_LPGAT1.
Genevestigator	Q92604.
GermOnline	ENSG00000123684. Homo sapiens.
Family and domain databases
InterPro	IPR002123. Acyltransferase. [Graphical view]
KO	K13514.
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	37450.
SOURCE	Search...

Entry information

Entry name

LGAT1_HUMAN

Accession

Primary (citable) accession number: Q92604

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.