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Protein

Leukotriene C4 synthase

Gene

Ltc4s

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.1 Publication

Catalytic activityi

Leukotriene C4 = leukotriene A4 + glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30GlutathioneBy similarity1
Active sitei31Proton donorBy similarity1
Active sitei104Proton acceptorBy similarity1

GO - Molecular functioni

  • enzyme activator activity Source: InterPro
  • glutathione binding Source: RGD
  • glutathione peroxidase activity Source: GO_Central
  • glutathione transferase activity Source: GO_Central
  • leukotriene-C4 synthase activity Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to vitamin A Source: RGD
  • leukotriene biosynthetic process Source: RGD
  • response to axon injury Source: RGD
  • response to drug Source: RGD
  • response to inorganic substance Source: RGD
  • response to lipopolysaccharide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Leukotriene biosynthesis

Enzyme and pathway databases

BRENDAi4.4.1.20. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene C4 synthase (EC:4.4.1.20)
Short name:
LTC4 synthase
Alternative name(s):
Leukotriene-C(4) synthase
Gene namesi
Name:Ltc4s
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620677. Ltc4s.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicBy similarity6
Transmembranei7 – 27HelicalBy similarityAdd BLAST21
Topological domaini28 – 48LumenalBy similarityAdd BLAST21
Transmembranei49 – 69HelicalBy similarityAdd BLAST21
Topological domaini70 – 73CytoplasmicBy similarity4
Transmembranei74 – 94HelicalBy similarityAdd BLAST21
Topological domaini95 – 104LumenalBy similarity10
Transmembranei105 – 124HelicalBy similarityAdd BLAST20
Topological domaini125 – 150CytoplasmicBy similarityAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2172.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003780881 – 150Leukotriene C4 synthaseAdd BLAST150

Proteomic databases

PaxDbiQ925U2.
PRIDEiQ925U2.

Expressioni

Inductioni

Up-regulated by all-trans retinoic acid.1 Publication

Interactioni

Subunit structurei

Homotrimer. Interacts with ALOX5AP and ALOX5 (By similarity).By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004359.

Structurei

3D structure databases

ProteinModelPortaliQ925U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 55Glutathione bindingBy similarity5
Regioni58 – 59Glutathione bindingBy similarity2
Regioni93 – 97Glutathione bindingBy similarity5

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX5F. Eukaryota.
ENOG4111JV7. LUCA.
HOGENOMiHOG000116372.
InParanoidiQ925U2.
KOiK00807.
PhylomeDBiQ925U2.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR001446. 5_LipOase_AP.
IPR018295. FLAP/GST2/LTC4S_CS.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSiPR00488. 5LPOXGNASEAP.
PROSITEiPS01297. FLAP_GST2_LTC4S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEETALLAT VTLVGVLLQA YFSLQVISAR RTFHVSPPLT SGPPEFERVF
60 70 80 90 100
RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLFYLFAR LRYFQGYARS
110 120 130 140 150
AQHRLDPLYA SARALWLLVA MAALGLLVHF LPGTLRAALF RWLQVLLPMA
Length:150
Mass (Da):16,836
Last modified:June 1, 2002 - v2
Checksum:i7C458B43F4B15D4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048790 mRNA. Translation: BAB58882.2.
RefSeqiNP_446091.2. NM_053639.2.
UniGeneiRn.38594.

Genome annotation databases

GeneIDi114097.
KEGGirno:114097.
UCSCiRGD:620677. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048790 mRNA. Translation: BAB58882.2.
RefSeqiNP_446091.2. NM_053639.2.
UniGeneiRn.38594.

3D structure databases

ProteinModelPortaliQ925U2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004359.

Chemistry databases

ChEMBLiCHEMBL2172.

Proteomic databases

PaxDbiQ925U2.
PRIDEiQ925U2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114097.
KEGGirno:114097.
UCSCiRGD:620677. rat.

Organism-specific databases

CTDi4056.
RGDi620677. Ltc4s.

Phylogenomic databases

eggNOGiENOG410IX5F. Eukaryota.
ENOG4111JV7. LUCA.
HOGENOMiHOG000116372.
InParanoidiQ925U2.
KOiK00807.
PhylomeDBiQ925U2.

Enzyme and pathway databases

BRENDAi4.4.1.20. 5301.

Miscellaneous databases

PROiQ925U2.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR001446. 5_LipOase_AP.
IPR018295. FLAP/GST2/LTC4S_CS.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSiPR00488. 5LPOXGNASEAP.
PROSITEiPS01297. FLAP_GST2_LTC4S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLTC4S_RAT
AccessioniPrimary (citable) accession number: Q925U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 1, 2002
Last modified: October 5, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.