Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q925U2

- LTC4S_RAT

UniProt

Q925U2 - LTC4S_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leukotriene C4 synthase

Gene

Ltc4s

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.1 Publication

Catalytic activityi

Leukotriene C4 = leukotriene A4 + glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301GlutathioneBy similarity
Active sitei31 – 311Proton donorBy similarity
Active sitei104 – 1041Proton acceptorBy similarity

GO - Molecular functioni

  1. enzyme activator activity Source: InterPro
  2. glutathione binding Source: RGD
  3. glutathione peroxidase activity Source: RefGenome
  4. glutathione transferase activity Source: RefGenome
  5. leukotriene-C4 synthase activity Source: RGD
  6. protein heterodimerization activity Source: RGD

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: RGD
  2. cellular response to vitamin A Source: RGD
  3. leukotriene biosynthetic process Source: RGD
  4. oxidation-reduction process Source: GOC
  5. response to axon injury Source: RGD
  6. response to drug Source: RGD
  7. response to inorganic substance Source: RGD
  8. response to lipopolysaccharide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Leukotriene biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene C4 synthase (EC:4.4.1.20)
Short name:
LTC4 synthase
Alternative name(s):
Leukotriene-C(4) synthase
Gene namesi
Name:Ltc4s
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620677. Ltc4s.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: RGD
  4. nuclear envelope Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Leukotriene C4 synthasePRO_0000378088Add
BLAST

Proteomic databases

PRIDEiQ925U2.

Expressioni

Inductioni

Up-regulated by all-trans retinoic acid.1 Publication

Gene expression databases

GenevestigatoriQ925U2.

Interactioni

Subunit structurei

Homotrimer. Interacts with ALOX5AP and ALOX5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004359.

Structurei

3D structure databases

ProteinModelPortaliQ925U2.
SMRiQ925U2. Positions 2-111.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicBy similarity
Topological domaini28 – 4821LumenalBy similarityAdd
BLAST
Topological domaini70 – 734CytoplasmicBy similarity
Topological domaini95 – 10410LumenalBy similarity
Topological domaini125 – 15026CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalBy similarityAdd
BLAST
Transmembranei49 – 6921HelicalBy similarityAdd
BLAST
Transmembranei74 – 9421HelicalBy similarityAdd
BLAST
Transmembranei105 – 12420HelicalBy similarityAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 555Glutathione bindingBy similarity
Regioni58 – 592Glutathione bindingBy similarity
Regioni93 – 975Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146874.
HOGENOMiHOG000116372.
InParanoidiQ925U2.
KOiK00807.
PhylomeDBiQ925U2.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR001446. 5_LipOase_AP.
IPR018295. FLAP/GST2/LTC4S_CS.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSiPR00488. 5LPOXGNASEAP.
PROSITEiPS01297. FLAP_GST2_LTC4S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925U2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEETALLAT VTLVGVLLQA YFSLQVISAR RTFHVSPPLT SGPPEFERVF
60 70 80 90 100
RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLFYLFAR LRYFQGYARS
110 120 130 140 150
AQHRLDPLYA SARALWLLVA MAALGLLVHF LPGTLRAALF RWLQVLLPMA
Length:150
Mass (Da):16,836
Last modified:June 1, 2002 - v2
Checksum:i7C458B43F4B15D4C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB048790 mRNA. Translation: BAB58882.2.
RefSeqiNP_446091.2. NM_053639.2.
UniGeneiRn.38594.

Genome annotation databases

GeneIDi114097.
KEGGirno:114097.
UCSCiRGD:620677. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB048790 mRNA. Translation: BAB58882.2 .
RefSeqi NP_446091.2. NM_053639.2.
UniGenei Rn.38594.

3D structure databases

ProteinModelPortali Q925U2.
SMRi Q925U2. Positions 2-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000004359.

Chemistry

ChEMBLi CHEMBL2172.

Proteomic databases

PRIDEi Q925U2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 114097.
KEGGi rno:114097.
UCSCi RGD:620677. rat.

Organism-specific databases

CTDi 4056.
RGDi 620677. Ltc4s.

Phylogenomic databases

eggNOGi NOG146874.
HOGENOMi HOG000116372.
InParanoidi Q925U2.
KOi K00807.
PhylomeDBi Q925U2.

Miscellaneous databases

NextBioi 618245.
PROi Q925U2.

Gene expression databases

Genevestigatori Q925U2.

Family and domain databases

Gene3Di 1.20.120.550. 1 hit.
InterProi IPR001446. 5_LipOase_AP.
IPR018295. FLAP/GST2/LTC4S_CS.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view ]
Pfami PF01124. MAPEG. 1 hit.
[Graphical view ]
PRINTSi PR00488. 5LPOXGNASEAP.
PROSITEi PS01297. FLAP_GST2_LTC4S. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and expression of rat leukotriene C(4) synthase: elevated expression in rat basophilic leukemia-1 cells after treatment with retinoic acid."
    Abe M., Shibata K., Saruwatar S., Soeda S., Shimeno H., Katsuragi T.
    Prostaglandins Leukot. Essent. Fatty Acids 67:319-326(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.

Entry informationi

Entry nameiLTC4S_RAT
AccessioniPrimary (citable) accession number: Q925U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3