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Q925U2

- LTC4S_RAT

UniProt

Q925U2 - LTC4S_RAT

Protein

Leukotriene C4 synthase

Gene

Ltc4s

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.1 Publication

    Catalytic activityi

    Leukotriene C4 = leukotriene A4 + glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei30 – 301GlutathioneBy similarity
    Active sitei31 – 311Proton donorBy similarity
    Active sitei104 – 1041Proton acceptorBy similarity

    GO - Molecular functioni

    1. enzyme activator activity Source: InterPro
    2. glutathione binding Source: RGD
    3. glutathione peroxidase activity Source: RefGenome
    4. glutathione transferase activity Source: RefGenome
    5. leukotriene-C4 synthase activity Source: RGD
    6. protein heterodimerization activity Source: RGD

    GO - Biological processi

    1. cellular response to lipopolysaccharide Source: RGD
    2. cellular response to vitamin A Source: RGD
    3. leukotriene biosynthetic process Source: RGD
    4. oxidation-reduction process Source: GOC
    5. response to axon injury Source: RGD
    6. response to drug Source: RGD
    7. response to inorganic substance Source: RGD
    8. response to lipopolysaccharide Source: RGD

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Leukotriene biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukotriene C4 synthase (EC:4.4.1.20)
    Short name:
    LTC4 synthase
    Alternative name(s):
    Leukotriene-C(4) synthase
    Gene namesi
    Name:Ltc4s
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620677. Ltc4s.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular membrane-bounded organelle Source: RGD
    5. nuclear envelope Source: RefGenome
    6. nuclear outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150150Leukotriene C4 synthasePRO_0000378088Add
    BLAST

    Proteomic databases

    PRIDEiQ925U2.

    Expressioni

    Inductioni

    Up-regulated by all-trans retinoic acid.1 Publication

    Gene expression databases

    GenevestigatoriQ925U2.

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with ALOX5AP and ALOX5 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004359.

    Structurei

    3D structure databases

    ProteinModelPortaliQ925U2.
    SMRiQ925U2. Positions 2-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicBy similarity
    Topological domaini28 – 4821LumenalBy similarityAdd
    BLAST
    Topological domaini70 – 734CytoplasmicBy similarity
    Topological domaini95 – 10410LumenalBy similarity
    Topological domaini125 – 15026CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalBy similarityAdd
    BLAST
    Transmembranei49 – 6921HelicalBy similarityAdd
    BLAST
    Transmembranei74 – 9421HelicalBy similarityAdd
    BLAST
    Transmembranei105 – 12420HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 555Glutathione bindingBy similarity
    Regioni58 – 592Glutathione bindingBy similarity
    Regioni93 – 975Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the MAPEG family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146874.
    HOGENOMiHOG000116372.
    InParanoidiQ925U2.
    KOiK00807.
    PhylomeDBiQ925U2.

    Family and domain databases

    Gene3Di1.20.120.550. 1 hit.
    InterProiIPR001446. 5_LipOase_AP.
    IPR018295. FLAP/GST2/LTC4S_CS.
    IPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view]
    PfamiPF01124. MAPEG. 1 hit.
    [Graphical view]
    PRINTSiPR00488. 5LPOXGNASEAP.
    PROSITEiPS01297. FLAP_GST2_LTC4S. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q925U2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEETALLAT VTLVGVLLQA YFSLQVISAR RTFHVSPPLT SGPPEFERVF    50
    RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLFYLFAR LRYFQGYARS 100
    AQHRLDPLYA SARALWLLVA MAALGLLVHF LPGTLRAALF RWLQVLLPMA 150
    Length:150
    Mass (Da):16,836
    Last modified:June 1, 2002 - v2
    Checksum:i7C458B43F4B15D4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB048790 mRNA. Translation: BAB58882.2.
    RefSeqiNP_446091.2. NM_053639.2.
    UniGeneiRn.38594.

    Genome annotation databases

    GeneIDi114097.
    KEGGirno:114097.
    UCSCiRGD:620677. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB048790 mRNA. Translation: BAB58882.2 .
    RefSeqi NP_446091.2. NM_053639.2.
    UniGenei Rn.38594.

    3D structure databases

    ProteinModelPortali Q925U2.
    SMRi Q925U2. Positions 2-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004359.

    Chemistry

    ChEMBLi CHEMBL2172.

    Proteomic databases

    PRIDEi Q925U2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 114097.
    KEGGi rno:114097.
    UCSCi RGD:620677. rat.

    Organism-specific databases

    CTDi 4056.
    RGDi 620677. Ltc4s.

    Phylogenomic databases

    eggNOGi NOG146874.
    HOGENOMi HOG000116372.
    InParanoidi Q925U2.
    KOi K00807.
    PhylomeDBi Q925U2.

    Miscellaneous databases

    NextBioi 618245.
    PROi Q925U2.

    Gene expression databases

    Genevestigatori Q925U2.

    Family and domain databases

    Gene3Di 1.20.120.550. 1 hit.
    InterProi IPR001446. 5_LipOase_AP.
    IPR018295. FLAP/GST2/LTC4S_CS.
    IPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view ]
    Pfami PF01124. MAPEG. 1 hit.
    [Graphical view ]
    PRINTSi PR00488. 5LPOXGNASEAP.
    PROSITEi PS01297. FLAP_GST2_LTC4S. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and expression of rat leukotriene C(4) synthase: elevated expression in rat basophilic leukemia-1 cells after treatment with retinoic acid."
      Abe M., Shibata K., Saruwatar S., Soeda S., Shimeno H., Katsuragi T.
      Prostaglandins Leukot. Essent. Fatty Acids 67:319-326(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiLTC4S_RAT
    AccessioniPrimary (citable) accession number: Q925U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3