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Protein

BMP/retinoic acid-inducible neural-specific protein 1

Gene

Brinp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
BMP/retinoic acid-inducible neural-specific protein 1
Alternative name(s):
Deleted in bladder cancer protein 1 homolog
Gene namesi
Name:Brinp1
Synonyms:Brinp, Dbc1, Dbccr1, Fam5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708519. Brinp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 760744BMP/retinoic acid-inducible neural-specific protein 1PRO_0000045768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence analysis
Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence analysis
Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence analysis
Glycosylationi599 – 5991N-linked (GlcNAc...)Sequence analysis
Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence analysis
Glycosylationi676 – 6761N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ925T8.
PRIDEiQ925T8.

PTM databases

PhosphoSiteiQ925T8.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007578.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 251184MACPFAdd
BLAST

Sequence similaritiesi

Belongs to the BRINP family.Curated
Contains 1 MACPF domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF4X. Eukaryota.
ENOG410XQ74. LUCA.
HOGENOMiHOG000049122.
HOVERGENiHBG081412.
InParanoidiQ925T8.
PhylomeDBiQ925T8.

Family and domain databases

InterProiIPR020864. MACPF.
[Graphical view]
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q925T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWRFVELLY FLFVWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH
60 70 80 90 100
SRSYLSFVER HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE
110 120 130 140 150
FQRSIRLLGR RPTTQQFIDT IIKKYGTHLL ISATLGGEEA LTMYMDKSRL
160 170 180 190 200
DRKSGNATQS VEALHQLASS YFVDRDGTMR RLHEIQISTG AIKVTETRTG
210 220 230 240 250
LLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE KFVQSALSYI
260 270 280 290 300
MCNGEGEYVC QNSQCRCQCA EEFPQCNCPI TDIQIMEFTL ANMAKAWTEA
310 320 330 340 350
YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQS RYKLLQSATE
360 370 380 390 400
AQRQKIQRTA RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN
410 420 430 440 450
GFWGTFLESQ RSCVCHGSTT LCQRPIPCII GGNNSCAMCS LANISLCGSC
460 470 480 490 500
NKGYKLYRGR CEPQNVDSER SEQFISFETD LDFQDLELKY LLQKMDSRLY
510 520 530 540 550
VHTTFISNEI RLDTFFDLRW RKRMSLTLKS NKNRMDFIHM VIGMSMRICQ
560 570 580 590 600
MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW
610 620 630 640 650
TLLLGNRWKT FFETVHIYLR SRTRLPTLRN ETGQGPVDLS DPSKRQFYIK
660 670 680 690 700
ISDVQVFGYS LRFNADLLRS AVQQVNQSYT QGGQFYSSSS VMLLMLDIRD
710 720 730 740 750
RINRLAPPVA PGKPQLDLFS CMLKHRLKLT NSEIIRVNHA LDLYNTEILK
760
QSDQMTAKLC
Length:760
Mass (Da):88,654
Last modified:December 1, 2001 - v1
Checksum:i22A30E493BC265D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051356 mRNA. Translation: BAB55642.1.
RefSeqiNP_536730.1. NM_080482.2.
UniGeneiRn.211646.

Genome annotation databases

GeneIDi140610.
KEGGirno:140610.
UCSCiRGD:708519. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051356 mRNA. Translation: BAB55642.1.
RefSeqiNP_536730.1. NM_080482.2.
UniGeneiRn.211646.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007578.

PTM databases

PhosphoSiteiQ925T8.

Proteomic databases

PaxDbiQ925T8.
PRIDEiQ925T8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140610.
KEGGirno:140610.
UCSCiRGD:708519. rat.

Organism-specific databases

CTDi1620.
RGDi708519. Brinp1.

Phylogenomic databases

eggNOGiENOG410IF4X. Eukaryota.
ENOG410XQ74. LUCA.
HOGENOMiHOG000049122.
HOVERGENiHBG081412.
InParanoidiQ925T8.
PhylomeDBiQ925T8.

Miscellaneous databases

PROiQ925T8.

Family and domain databases

InterProiIPR020864. MACPF.
[Graphical view]
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRNP1_RAT
AccessioniPrimary (citable) accession number: Q925T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.