Q925T6 (GRIP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate receptor-interacting protein 1
Short name=GRIP-1

Gene names

Name:

Grip1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1127 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons By similarity.
Subunit structure	Interacts with EFNB3, GRIA2, GRIA3, GRIPAP1/GRASP1, PPFIA1, PPFIA4, FRAS1, PTPRF, liprins-alpha and the C-terminal tail of PRLHR. Can form homomultimers or heteromultimers with GRIP2 By similarity. Interacts with EFNB1, EPHA7, EPHB2, KIF5A, KIF5B and KIF5C. Forms a ternary complex with GRIA2 and CSPG4. Interacts with SLC30A9 and PLCD4. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7
Subcellular location	Cytoplasmic vesicle. Endoplasmic reticulum. Cell junction › synapse › postsynaptic cell membrane By similarity. Note: Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in post-synaptic plasma membrane and post-synaptic densities By similarity. The palmitoylated form of isoform 2 is exclusively membrane-associated. Isoform 2: Membrane; Lipid-anchor.
Tissue specificity	Expressed in brain. Isoform 2 is the major isoform in brain. Expressed in oligodendrocyte lineage cells. Ref.1 Ref.5
Developmental stage	Detected in early development between postnatal days 3 (P3) and P8 and decreased from P14 in forebrain and cerebellum. Ref.1
Domain	PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 6 mediates interaction with the C-terminal of liprins-alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ-binding motif of FRAS1. PDZ 4 and PDZ 5 mediate interaction with PRLHR By similarity. PDZ 7 domain binds CSPG4. Ref.5
Post-translational modification	Palmitoylation of isoform 2.
Sequence similarities	Contains 7 PDZ (DHR) domains.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cytoplasmic vesicle Endoplasmic reticulum Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Lipoprotein Palmitate Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein localization Inferred from mutant phenotype. Source: MGI
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasmic membrane-bounded vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell membrane raft Inferred from direct assay. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction Ref.3. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Ephb2	P54763	2	EBI-537752,EBI-537711
Lrrfip1	Q3UZ39	2	EBI-537752,EBI-2270972

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q925T6-1)

Also known as: GRIP1a-L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q925T6-2)

Also known as: GRIP1b; GRIP1b-S;

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSIP → MPGWKKNIPICLQAEEQER
     348-400: VKIQRSDRQHPWDAWASNQCGVHTNHHHNTYHPDHCRVPALTFPKALPPNSPP → A
     911-925: Missing.

Note: Major isoform. Palmitoylated on Cys-11.

Isoform 3 (identifier: Q925T6-3)

Also known as: GRIP1a-S;

The sequence of this isoform differs from the canonical sequence as follows:
     19-45: Missing.
     348-400: VKIQRSDRQHPWDAWASNQCGVHTNHHHNTYHPDHCRVPALTFPKALPPNSPP → A
     911-925: Missing.

Note: May be due to exons 2, 10 and 11 skipping. No experimental confirmation available.

Isoform 4 (identifier: Q925T6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-415: Missing.
     416-451: LSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSL → MTAKRAERKEMKRPNSFHLPFRPSLRKGQKKNAAHV
     756-820: Missing.
     911-925: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1127

1127

Glutamate receptor-interacting protein 1

PRO_0000083850

Regions

Domain

53 – 136

84

PDZ 1

Domain

150 – 238

89

PDZ 2

Domain

252 – 336

85

PDZ 3

Domain

471 – 560

90

PDZ 4

Domain

572 – 657

86

PDZ 5

Domain

672 – 754

83

PDZ 6

Domain

1003 – 1085

83

PDZ 7

Amino acid modifications

Modified residue

43

1

Phosphoserine Ref.8

Modified residue

971

1

Phosphothreonine By similarity

Natural variations

Alternative sequence

1 – 415

415

Missing in isoform 4.

VSP_009745

Alternative sequence

1 – 45

45

MIAVS…RQSIP → MPGWKKNIPICLQAEEQER in isoform 2.

VSP_009744

Alternative sequence

19 – 45

27

Missing in isoform 3.

VSP_009746

Alternative sequence

348 – 400

53

VKIQR…PNSPP → A in isoform 2 and isoform 3.

VSP_009747

Alternative sequence

416 – 451

36

LSSLN…FKSSL → MTAKRAERKEMKRPNSFHLP FRPSLRKGQKKNAAHV in isoform 4.

VSP_009748

Alternative sequence

756 – 820

65

Missing in isoform 4.

VSP_009749

Alternative sequence

911 – 925

15

Missing in isoform 2, isoform 3 and isoform 4.

VSP_009750

Experimental info

Sequence conflict

1011

1

G → C in BAC26668. Ref.2

Sequence conflict

1044

1

L → M in BAC31662. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1127

Helix Strand Turn

Details...

Beta strand

467 – 474

8

Beta strand

493 – 495

3

Helix

510 – 513

4

Beta strand

523 – 526

4

Beta strand

530 – 534

5

Helix

536 – 546

11

Turn

547 – 551

5

Beta strand

552 – 559

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (GRIP1a-L) [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 556DFCCE2CE6248A	FASTA	1,127	122,058
	10 20 30 40 50 60 MIAVSFKCRC QILRRLTKDE SPYTKSASQT KPPDGALAVR RQSIPEEFKG STVVELMKKE 70 80 90 100 110 120 GTTLGLTVSG GIDKDGKPRV SNLRQGGIAA RSDQLDVGDY IKAVNGINLA KFRHDEIISL 130 140 150 160 170 180 LKNVGERVVL EVEYELPPVS VQGSSVMFRT VEVTLHKEGN TFGFVIRGGA HDDRNKSRPV 190 200 210 220 230 240 VITCVRPGGP ADREGTIKPG DRLLSVDGIR LLGTTHAEAM SILKQCGQEA TLLIEYDVSV 250 260 270 280 290 300 MDSVATASGP LLVEVAKTPG ASLGVALTTS VCCNKQVIVI DKIKSASIAD RCGALHVGDH 310 320 330 340 350 360 ILSIDGTSME YCTLAEATQF LANTTDQVKL EILPHHQTRL ALKGPDHVKI QRSDRQHPWD 370 380 390 400 410 420 AWASNQCGVH TNHHHNTYHP DHCRVPALTF PKALPPNSPP AMVPSSSPTS MSAYSLSSLN 430 440 450 460 470 480 MGTLPRSLYS TSPRGTMMRR RLKKKDFKSS LSLASSTVGL AGQVVHTETT EVVLTADPVT 490 500 510 520 530 540 GFGIQLQGSV FATETLSSPP LISYIEADSP AERCGVLQIG DRVMAINGIP TEDSTFEEAN 550 560 570 580 590 600 QLLRDSSITS KVTLEIEFDV AESVIPSSGT FHVKLPKKHS VELGITISSP SSRKPGDPLV 610 620 630 640 650 660 ISDIKKGSVA HRTGTLELGD KLLAIDNIRL DNCSMEDAVQ ILQQCEDLVK LKIRKDEDNS 670 680 690 700 710 720 DEQESSGAII YTVELKRYGG PLGITISGTE EPFDPIIISS LTKGGLAERT GAIHIGDRIL 730 740 750 760 770 780 AINSSSLKGK PLSEAIHLLQ MAGETVTLKI KKQTDAQSAS SPKKFPIPGH SGDLGDGEED 790 800 810 820 830 840 PSPIQKPGKL SDAYPSTVPS VDSAVDSWDG SGIDASYGSQ GSTFQTSGYN YNTYDWRSPK 850 860 870 880 890 900 QRTSLSPVPK PRSQTYPDVG LSNEDWDRST ASGFVGASDS ADAEQEENFW SQALEDLETC 910 920 930 940 950 960 GQSGILRELE EKADRRVSLR NMTLLATIMS GSTMSLNHEA PMARSQLGRQ ASFQERSSSR 970 980 990 1000 1010 1020 PHYSQTTRSN TLPSDVGRKS VTLRKMKQEI KEIMSPTPVE LHKVTLYKDS GMEDFGFSVA 1030 1040 1050 1060 1070 1080 DGLLEKGVYV KNIRPAGPGD VGGLKPYDRL LQVNHVRTRD FDCCLVVPLI AESGNKLDLV 1090 1100 1110 1120 ISRNPLASQK SIEQPALPSD WSEQNSAFFQ QPSHGGNLET REPTNTL
	Isoform 2 (GRIP1b) (GRIP1b-S) [UniParc]. Checksum: 91DF2CDD7367028A	FASTA	1,034	111,487
	10 20 30 40 50 60 MPGWKKNIPI CLQAEEQERE EFKGSTVVEL MKKEGTTLGL TVSGGIDKDG KPRVSNLRQG 70 80 90 100 110 120 GIAARSDQLD VGDYIKAVNG INLAKFRHDE IISLLKNVGE RVVLEVEYEL PPVSVQGSSV 130 140 150 160 170 180 MFRTVEVTLH KEGNTFGFVI RGGAHDDRNK SRPVVITCVR PGGPADREGT IKPGDRLLSV 190 200 210 220 230 240 DGIRLLGTTH AEAMSILKQC GQEATLLIEY DVSVMDSVAT ASGPLLVEVA KTPGASLGVA 250 260 270 280 290 300 LTTSVCCNKQ VIVIDKIKSA SIADRCGALH VGDHILSIDG TSMEYCTLAE ATQFLANTTD 310 320 330 340 350 360 QVKLEILPHH QTRLALKGPD HAAMVPSSSP TSMSAYSLSS LNMGTLPRSL YSTSPRGTMM 370 380 390 400 410 420 RRRLKKKDFK SSLSLASSTV GLAGQVVHTE TTEVVLTADP VTGFGIQLQG SVFATETLSS 430 440 450 460 470 480 PPLISYIEAD SPAERCGVLQ IGDRVMAING IPTEDSTFEE ANQLLRDSSI TSKVTLEIEF 490 500 510 520 530 540 DVAESVIPSS GTFHVKLPKK HSVELGITIS SPSSRKPGDP LVISDIKKGS VAHRTGTLEL 550 560 570 580 590 600 GDKLLAIDNI RLDNCSMEDA VQILQQCEDL VKLKIRKDED NSDEQESSGA IIYTVELKRY 610 620 630 640 650 660 GGPLGITISG TEEPFDPIII SSLTKGGLAE RTGAIHIGDR ILAINSSSLK GKPLSEAIHL 670 680 690 700 710 720 LQMAGETVTL KIKKQTDAQS ASSPKKFPIP GHSGDLGDGE EDPSPIQKPG KLSDAYPSTV 730 740 750 760 770 780 PSVDSAVDSW DGSGIDASYG SQGSTFQTSG YNYNTYDWRS PKQRTSLSPV PKPRSQTYPD 790 800 810 820 830 840 VGLSNEDWDR STASGFVGAS DSADAEQEEN FWSQALEDLE TCGQSGILRE LEATIMSGST 850 860 870 880 890 900 MSLNHEAPMA RSQLGRQASF QERSSSRPHY SQTTRSNTLP SDVGRKSVTL RKMKQEIKEI 910 920 930 940 950 960 MSPTPVELHK VTLYKDSGME DFGFSVADGL LEKGVYVKNI RPAGPGDVGG LKPYDRLLQV 970 980 990 1000 1010 1020 NHVRTRDFDC CLVVPLIAES GNKLDLVISR NPLASQKSIE QPALPSDWSE QNSAFFQQPS 1030 HGGNLETREP TNTL
	Isoform 3 (GRIP1a-S) [UniParc]. Checksum: 82F04408111C9AF2	FASTA	1,033	111,383
	10 20 30 40 50 60 MIAVSFKCRC QILRRLTKEE FKGSTVVELM KKEGTTLGLT VSGGIDKDGK PRVSNLRQGG 70 80 90 100 110 120 IAARSDQLDV GDYIKAVNGI NLAKFRHDEI ISLLKNVGER VVLEVEYELP PVSVQGSSVM 130 140 150 160 170 180 FRTVEVTLHK EGNTFGFVIR GGAHDDRNKS RPVVITCVRP GGPADREGTI KPGDRLLSVD 190 200 210 220 230 240 GIRLLGTTHA EAMSILKQCG QEATLLIEYD VSVMDSVATA SGPLLVEVAK TPGASLGVAL 250 260 270 280 290 300 TTSVCCNKQV IVIDKIKSAS IADRCGALHV GDHILSIDGT SMEYCTLAEA TQFLANTTDQ 310 320 330 340 350 360 VKLEILPHHQ TRLALKGPDH AAMVPSSSPT SMSAYSLSSL NMGTLPRSLY STSPRGTMMR 370 380 390 400 410 420 RRLKKKDFKS SLSLASSTVG LAGQVVHTET TEVVLTADPV TGFGIQLQGS VFATETLSSP 430 440 450 460 470 480 PLISYIEADS PAERCGVLQI GDRVMAINGI PTEDSTFEEA NQLLRDSSIT SKVTLEIEFD 490 500 510 520 530 540 VAESVIPSSG TFHVKLPKKH SVELGITISS PSSRKPGDPL VISDIKKGSV AHRTGTLELG 550 560 570 580 590 600 DKLLAIDNIR LDNCSMEDAV QILQQCEDLV KLKIRKDEDN SDEQESSGAI IYTVELKRYG 610 620 630 640 650 660 GPLGITISGT EEPFDPIIIS SLTKGGLAER TGAIHIGDRI LAINSSSLKG KPLSEAIHLL 670 680 690 700 710 720 QMAGETVTLK IKKQTDAQSA SSPKKFPIPG HSGDLGDGEE DPSPIQKPGK LSDAYPSTVP 730 740 750 760 770 780 SVDSAVDSWD GSGIDASYGS QGSTFQTSGY NYNTYDWRSP KQRTSLSPVP KPRSQTYPDV 790 800 810 820 830 840 GLSNEDWDRS TASGFVGASD SADAEQEENF WSQALEDLET CGQSGILREL EATIMSGSTM 850 860 870 880 890 900 SLNHEAPMAR SQLGRQASFQ ERSSSRPHYS QTTRSNTLPS DVGRKSVTLR KMKQEIKEIM 910 920 930 940 950 960 SPTPVELHKV TLYKDSGMED FGFSVADGLL EKGVYVKNIR PAGPGDVGGL KPYDRLLQVN 970 980 990 1000 1010 1020 HVRTRDFDCC LVVPLIAESG NKLDLVISRN PLASQKSIEQ PALPSDWSEQ NSAFFQQPSH 1030 GGNLETREPT NTL
	Isoform 4 [UniParc]. Checksum: 172ACDBA40467E43	FASTA	632	68,966
	10 20 30 40 50 60 MTAKRAERKE MKRPNSFHLP FRPSLRKGQK KNAAHVSLAS STVGLAGQVV HTETTEVVLT 70 80 90 100 110 120 ADPVTGFGIQ LQGSVFATET LSSPPLISYI EADSPAERCG VLQIGDRVMA INGIPTEDST 130 140 150 160 170 180 FEEANQLLRD SSITSKVTLE IEFDVAESVI PSSGTFHVKL PKKHSVELGI TISSPSSRKP 190 200 210 220 230 240 GDPLVISDIK KGSVAHRTGT LELGDKLLAI DNIRLDNCSM EDAVQILQQC EDLVKLKIRK 250 260 270 280 290 300 DEDNSDEQES SGAIIYTVEL KRYGGPLGIT ISGTEEPFDP IIISSLTKGG LAERTGAIHI 310 320 330 340 350 360 GDRILAINSS SLKGKPLSEA IHLLQMAGET VTLKIKKQTD GSTFQTSGYN YNTYDWRSPK 370 380 390 400 410 420 QRTSLSPVPK PRSQTYPDVG LSNEDWDRST ASGFVGASDS ADAEQEENFW SQALEDLETC 430 440 450 460 470 480 GQSGILRELE ATIMSGSTMS LNHEAPMARS QLGRQASFQE RSSSRPHYSQ TTRSNTLPSD 490 500 510 520 530 540 VGRKSVTLRK MKQEIKEIMS PTPVELHKVT LYKDSGMEDF GFSVADGLLE KGVYVKNIRP 550 560 570 580 590 600 AGPGDVGGLK PYDRLLQVNH VRTRDFDCCL VVPLIAESGN KLDLVISRNP LASQKSIEQP 610 620 630 ALPSDWSEQN SAFFQQPSHG GNLETREPTN TL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential palmitoylation of two mouse glutamate receptor interacting protein 1 forms with different N-terminal sequences." Yamazaki M., Fukaya M., Abe M., Ikeno K., Kakizaki T., Watanabe M., Sakimura K. Neurosci. Lett. 304:81-84(2001) [PubMed: 11335060] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, PALMITOYLATION OF ISOFORM 2. Tissue: Brain.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Strain: C57BL/6J. Tissue: Testis.
[3]	"PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands." Torres R., Firestein B.L., Dong H., Staudinger J., Olson E.N., Huganir R.L., Bredt D.S., Gale N.W., Yancopoulos G.D. Neuron 21:1453-1463(1998) [PubMed: 9883737] [Abstract] Cited for: INTERACTION WITH EFNB1; EPHA7 AND EPHB2.
[4]	"Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites." Setou M., Seog D.-H., Tanaka Y., Kanai Y., Takei Y., Kawagishi M., Hirokawa N. Nature 417:83-87(2002) [PubMed: 11986669] [Abstract] Cited for: INTERACTION WITH KIF5A; KIF5B AND KIF5C.
[5]	"The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling." Stegmueller J., Werner H., Nave K.-A., Trotter J. J. Biol. Chem. 278:3590-3598(2003) [PubMed: 12458226] [Abstract] Cited for: INTERACTION WITH CSPG4 AND GRIA2, DOMAIN, TISSUE SPECIFICITY.
[6]	"Phospholipase Cdelta4 associates with glutamate receptor interacting protein 1 in testis." Irino Y., Ichinohe M., Nakamura Y., Nakahara M., Fukami K. J. Biochem. 138:451-456(2005) [PubMed: 16272139] [Abstract] Cited for: INTERACTION WITH PLCD4.
[7]	"GAC63, a GRIP1-dependent nuclear receptor coactivator." Chen Y.-H., Kim J.H., Stallcup M.R. Mol. Cell. Biol. 25:5965-5972(2005) [PubMed: 15988012] [Abstract] Cited for: INTERACTION WITH SLC30A9.
[8]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 19367708] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, MASS SPECTROMETRY. Tissue: Melanoma.
[9]	"Solution structure of the PDZ domain from mouse glutamate receptor interacting protein 1A-L (GRIP1) homolog." RIKEN structural genomics initiative (RSGI) Submitted (MAY-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 461-570.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB051560 mRNA. Translation: BAB46929.1.
AB051561 mRNA. Translation: BAB46930.1.
AB051562 mRNA. Translation: BAB46931.1.
AK029905 mRNA. Translation: BAC26668.1.
AK043821 mRNA. Translation: BAC31662.2.

IPI

IPI00127232.
IPI00269503.
IPI00399863.
IPI00409947.

RefSeq

NP_083012.1. NM_028736.1.
NP_570961.1. NM_130891.1.
NP_597699.1. NM_133442.1.

UniGene

Mm.196692.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V5Q	NMR	-	A	461-569	[»]

ProteinModelPortal

Q925T6.

SMR

Q925T6. Positions 48-343, 463-753, 995-1085.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q925T6. 6 interactions.

MINT

MINT-1787557.

STRING

Q925T6.

PTM databases

PhosphoSite

Q925T6.

Proteomic databases

PRIDE

Q925T6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000077871; ENSMUSP00000077033; ENSMUSG00000034813.
ENSMUST00000105261; ENSMUSP00000100896; ENSMUSG00000034813.
ENSMUST00000138410; ENSMUSP00000123234; ENSMUSG00000034813.
ENSMUST00000144825; ENSMUSP00000121670; ENSMUSG00000034813.

GeneID

74053.

KEGG

mmu:74053.

UCSC

uc007heg.1. mouse.
uc007hek.1. mouse.
uc007hel.1. mouse.
uc007hep.1. mouse.

Organism-specific databases

CTD

23426.

MGI

MGI:1921303. Grip1.

Phylogenomic databases

GeneTree

ENSGT00390000013494.

HOGENOM

HBG506549.

HOVERGEN

HBG051841.

InParanoid

Q925T6.

OMA

ASSPKKF.

Gene expression databases

ArrayExpress

Q925T6.

Bgee

Q925T6.

CleanEx

MM_GRIP1.

Genevestigator

Q925T6.

GermOnline

ENSMUSG00000034813. Mus musculus.

Family and domain databases

InterPro

IPR001478. PDZ/DHR/GLGF.
[Graphical view]

Pfam

PF00595. PDZ. 7 hits.
[Graphical view]

SMART

SM00228. PDZ. 7 hits.
[Graphical view]

SUPFAM

SSF50156. PDZ. 7 hits.

PROSITE

PS50106. PDZ. 7 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

339644.

SOURCE

Search...

Entry information

Entry name

GRIP1_MOUSE

Accession

Primary (citable) accession number: Q925T6
Secondary accession number(s): Q8BLQ3 , Q8C0T3, Q925T5, Q925T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	December 1, 2001
Last modified:	November 16, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program