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Q925S8

- YMEL1_RAT

UniProt

Q925S8 - YMEL1_RAT

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Protein
ATP-dependent zinc metalloprotease YME1L1
Gene
Yme1l1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity, and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1 By similarity.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi541 – 5411Zinc; catalytic By similarity
Active sitei542 – 5421 By similarity
Metal bindingi545 – 5451Zinc; catalytic By similarity
Metal bindingi619 – 6191Zinc; catalytic By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi321 – 3288ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metalloendopeptidase activity Source: InterPro
  4. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. misfolded or incompletely synthesized protein catabolic process Source: UniProtKB
  3. mitochondrion organization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPSiM41.026.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease YME1L1 (EC:3.4.24.-)
Alternative name(s):
ATP-dependent metalloprotease FtsH1
Meg-4
YME1-like protein 1
Gene namesi
Name:Yme1l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620764. Yme1l1.

Subcellular locationi

Mitochondrion inner membrane By similarity UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei238 – 25821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715ATP-dependent zinc metalloprotease YME1L1UniRule annotation
PRO_0000084669Add
BLAST

Proteomic databases

PRIDEiQ925S8.

Expressioni

Gene expression databases

GenevestigatoriQ925S8.

Interactioni

Protein-protein interaction databases

IntActiQ925S8. 1 interaction.
MINTiMINT-4611841.

Structurei

3D structure databases

ProteinModelPortaliQ925S8.
SMRiQ925S8. Positions 277-522.

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0465.
HOGENOMiHOG000217276.
HOVERGENiHBG057127.
InParanoidiQ925S8.
PhylomeDBiQ925S8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925S8-1 [UniParc]FASTAAdd to Basket

« Hide

MFSLSSTVQP QVTVPLSHLI NAFHSPKNIS VSVNTSASPK QHRDTVAEHE    50
APSSEPVLNL RDLGLSELKI GQIDKLVENL LPGFYKDKRV SSCWHTSHIS 100
AQSFFENKYG HLDMFSTLRS SSLYRQHPKT LQSICSDLQN FPVFIQSRGF 150
KTLKSRTRRL QSTSERLAEA QNIAPSFVKG FLLRDRGTDL ESLDKLMKTK 200
NIPEAHQDAF KTGFAEGFLK AQALTQKTND SLRRTRLILF VLLLFGIYGL 250
LKNPFLSVRF RTTTGLDSAV DPVQMKNVTF EHVKGVEEAK QELQEVVEFL 300
KNPQKFTVLG GKLPKGILLV GPPGTGKTLL ARAVAGEADV PFYYASGSEF 350
DEMFVGVGAS RIRNLFREAK ANAPCVIFID ELDSVGGKRI EFPMHPYSRQ 400
TIIQLLAEMD GFKPNEGVII IGATNFPEAL DNALIRPGRF DMQVTVPRPD 450
VKGRTEILKW YLNKIKFDKS VDPEIIARGT VGFSGAELEN LVNQAALKAA 500
VDGKEMVTMK ELEFSKDKIL MGPERRSVEI DNKNKTITAY HESGHAIIAY 550
YTKDAMPINK ATIMPRGPTL GHVSLLPEND RWNEIRAQLL AQMDVSMGGR 600
VAEELIFGTD HITTGASSDF DNATKIAKRM VTKFGMSEKL GVMTYSDTGK 650
LSPETQSAIE QEIRILLRES YERAKHILKT HAKEHKNLAE ALLTYETLDA 700
KEIQIVLEGK KLEVR 715
Length:715
Mass (Da):79,867
Last modified:December 1, 2001 - v1
Checksum:i900A98F4EB95AB92
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151784 mRNA. Translation: AAK57557.1.
UniGeneiRn.8153.

Genome annotation databases

UCSCiRGD:620764. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151784 mRNA. Translation: AAK57557.1 .
UniGenei Rn.8153.

3D structure databases

ProteinModelPortali Q925S8.
SMRi Q925S8. Positions 277-522.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q925S8. 1 interaction.
MINTi MINT-4611841.

Protein family/group databases

MEROPSi M41.026.

Proteomic databases

PRIDEi Q925S8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620764. rat.

Organism-specific databases

RGDi 620764. Yme1l1.

Phylogenomic databases

eggNOGi COG0465.
HOGENOMi HOG000217276.
HOVERGENi HBG057127.
InParanoidi Q925S8.
PhylomeDBi Q925S8.

Miscellaneous databases

PROi Q925S8.

Gene expression databases

Genevestigatori Q925S8.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_01458. FtsH.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR000642. Peptidase_M41.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01241. FtsH_fam. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Partial cDNA sequence of rat meg-4, ATP-dependent metalloprotease (FtsH) homolog."
    Miyata T., Inagi R., Yasuda Y., Kurokawa K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiYMEL1_RAT
AccessioniPrimary (citable) accession number: Q925S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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