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Q925S8

- YMEL1_RAT

UniProt

Q925S8 - YMEL1_RAT

Protein

ATP-dependent zinc metalloprotease YME1L1

Gene

Yme1l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity, and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1 By similarity.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi541 – 5411Zinc; catalyticBy similarity
    Active sitei542 – 5421By similarity
    Metal bindingi545 – 5451Zinc; catalyticBy similarity
    Metal bindingi619 – 6191Zinc; catalyticBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi321 – 3288ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. metalloendopeptidase activity Source: InterPro
    4. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. misfolded or incompletely synthesized protein catabolic process Source: UniProtKB
    3. mitochondrion organization Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Protein family/group databases

    MEROPSiM41.026.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent zinc metalloprotease YME1L1 (EC:3.4.24.-)
    Alternative name(s):
    ATP-dependent metalloprotease FtsH1
    Meg-4
    YME1-like protein 1
    Gene namesi
    Name:Yme1l1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620764. Yme1l1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 715715ATP-dependent zinc metalloprotease YME1L1PRO_0000084669Add
    BLAST

    Proteomic databases

    PRIDEiQ925S8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ925S8.

    Interactioni

    Protein-protein interaction databases

    IntActiQ925S8. 1 interaction.
    MINTiMINT-4611841.

    Structurei

    3D structure databases

    ProteinModelPortaliQ925S8.
    SMRiQ925S8. Positions 277-522.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    In the N-terminal section; belongs to the AAA ATPase family.Curated
    In the C-terminal section; belongs to the peptidase M41 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0465.
    HOGENOMiHOG000217276.
    HOVERGENiHBG057127.
    InParanoidiQ925S8.
    PhylomeDBiQ925S8.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_01458. FtsH.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR005936. FtsH.
    IPR027417. P-loop_NTPase.
    IPR000642. Peptidase_M41.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF01434. Peptidase_M41. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q925S8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSLSSTVQP QVTVPLSHLI NAFHSPKNIS VSVNTSASPK QHRDTVAEHE    50
    APSSEPVLNL RDLGLSELKI GQIDKLVENL LPGFYKDKRV SSCWHTSHIS 100
    AQSFFENKYG HLDMFSTLRS SSLYRQHPKT LQSICSDLQN FPVFIQSRGF 150
    KTLKSRTRRL QSTSERLAEA QNIAPSFVKG FLLRDRGTDL ESLDKLMKTK 200
    NIPEAHQDAF KTGFAEGFLK AQALTQKTND SLRRTRLILF VLLLFGIYGL 250
    LKNPFLSVRF RTTTGLDSAV DPVQMKNVTF EHVKGVEEAK QELQEVVEFL 300
    KNPQKFTVLG GKLPKGILLV GPPGTGKTLL ARAVAGEADV PFYYASGSEF 350
    DEMFVGVGAS RIRNLFREAK ANAPCVIFID ELDSVGGKRI EFPMHPYSRQ 400
    TIIQLLAEMD GFKPNEGVII IGATNFPEAL DNALIRPGRF DMQVTVPRPD 450
    VKGRTEILKW YLNKIKFDKS VDPEIIARGT VGFSGAELEN LVNQAALKAA 500
    VDGKEMVTMK ELEFSKDKIL MGPERRSVEI DNKNKTITAY HESGHAIIAY 550
    YTKDAMPINK ATIMPRGPTL GHVSLLPEND RWNEIRAQLL AQMDVSMGGR 600
    VAEELIFGTD HITTGASSDF DNATKIAKRM VTKFGMSEKL GVMTYSDTGK 650
    LSPETQSAIE QEIRILLRES YERAKHILKT HAKEHKNLAE ALLTYETLDA 700
    KEIQIVLEGK KLEVR 715
    Length:715
    Mass (Da):79,867
    Last modified:December 1, 2001 - v1
    Checksum:i900A98F4EB95AB92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151784 mRNA. Translation: AAK57557.1.
    UniGeneiRn.8153.

    Genome annotation databases

    UCSCiRGD:620764. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151784 mRNA. Translation: AAK57557.1 .
    UniGenei Rn.8153.

    3D structure databases

    ProteinModelPortali Q925S8.
    SMRi Q925S8. Positions 277-522.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q925S8. 1 interaction.
    MINTi MINT-4611841.

    Protein family/group databases

    MEROPSi M41.026.

    Proteomic databases

    PRIDEi Q925S8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620764. rat.

    Organism-specific databases

    RGDi 620764. Yme1l1.

    Phylogenomic databases

    eggNOGi COG0465.
    HOGENOMi HOG000217276.
    HOVERGENi HBG057127.
    InParanoidi Q925S8.
    PhylomeDBi Q925S8.

    Miscellaneous databases

    PROi Q925S8.

    Gene expression databases

    Genevestigatori Q925S8.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_01458. FtsH.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR005936. FtsH.
    IPR027417. P-loop_NTPase.
    IPR000642. Peptidase_M41.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF01434. Peptidase_M41. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01241. FtsH_fam. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Partial cDNA sequence of rat meg-4, ATP-dependent metalloprotease (FtsH) homolog."
      Miyata T., Inagi R., Yasuda Y., Kurokawa K.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiYMEL1_RAT
    AccessioniPrimary (citable) accession number: Q925S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3