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Q925S8 (YMEL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent zinc metalloprotease YME1L1

EC=3.4.24.-
Alternative name(s):
ATP-dependent metalloprotease FtsH1
Meg-4
YME1-like protein 1
Gene names
Name:Yme1l1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length715 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity, and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1 By similarity. HAMAP-Rule MF_01458

Cofactor

Binds 1 zinc ion per subunit Potential.

Subcellular location

Mitochondrion inner membrane By similarity HAMAP-Rule MF_01458.

Sequence similarities

In the N-terminal section; belongs to the AAA ATPase family.

In the C-terminal section; belongs to the peptidase M41 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 715715ATP-dependent zinc metalloprotease YME1L1 HAMAP-Rule MF_01458
PRO_0000084669

Regions

Transmembrane238 – 25821Helical; Potential
Nucleotide binding321 – 3288ATP Potential

Sites

Active site5421 By similarity
Metal binding5411Zinc; catalytic By similarity
Metal binding5451Zinc; catalytic By similarity
Metal binding6191Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q925S8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 900A98F4EB95AB92

FASTA71579,867
        10         20         30         40         50         60 
MFSLSSTVQP QVTVPLSHLI NAFHSPKNIS VSVNTSASPK QHRDTVAEHE APSSEPVLNL 

        70         80         90        100        110        120 
RDLGLSELKI GQIDKLVENL LPGFYKDKRV SSCWHTSHIS AQSFFENKYG HLDMFSTLRS 

       130        140        150        160        170        180 
SSLYRQHPKT LQSICSDLQN FPVFIQSRGF KTLKSRTRRL QSTSERLAEA QNIAPSFVKG 

       190        200        210        220        230        240 
FLLRDRGTDL ESLDKLMKTK NIPEAHQDAF KTGFAEGFLK AQALTQKTND SLRRTRLILF 

       250        260        270        280        290        300 
VLLLFGIYGL LKNPFLSVRF RTTTGLDSAV DPVQMKNVTF EHVKGVEEAK QELQEVVEFL 

       310        320        330        340        350        360 
KNPQKFTVLG GKLPKGILLV GPPGTGKTLL ARAVAGEADV PFYYASGSEF DEMFVGVGAS 

       370        380        390        400        410        420 
RIRNLFREAK ANAPCVIFID ELDSVGGKRI EFPMHPYSRQ TIIQLLAEMD GFKPNEGVII 

       430        440        450        460        470        480 
IGATNFPEAL DNALIRPGRF DMQVTVPRPD VKGRTEILKW YLNKIKFDKS VDPEIIARGT 

       490        500        510        520        530        540 
VGFSGAELEN LVNQAALKAA VDGKEMVTMK ELEFSKDKIL MGPERRSVEI DNKNKTITAY 

       550        560        570        580        590        600 
HESGHAIIAY YTKDAMPINK ATIMPRGPTL GHVSLLPEND RWNEIRAQLL AQMDVSMGGR 

       610        620        630        640        650        660 
VAEELIFGTD HITTGASSDF DNATKIAKRM VTKFGMSEKL GVMTYSDTGK LSPETQSAIE 

       670        680        690        700        710 
QEIRILLRES YERAKHILKT HAKEHKNLAE ALLTYETLDA KEIQIVLEGK KLEVR 

« Hide

References

[1]"Partial cDNA sequence of rat meg-4, ATP-dependent metalloprotease (FtsH) homolog."
Miyata T., Inagi R., Yasuda Y., Kurokawa K.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF151784 mRNA. Translation: AAK57557.1.
UniGeneRn.8153.

3D structure databases

ProteinModelPortalQ925S8.
SMRQ925S8. Positions 277-522.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ925S8. 1 interaction.
MINTMINT-4611841.

Protein family/group databases

MEROPSM41.026.

Proteomic databases

PRIDEQ925S8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:620764. rat.

Organism-specific databases

RGD620764. Yme1l1.

Phylogenomic databases

eggNOGCOG0465.
HOGENOMHOG000217276.
HOVERGENHBG057127.
InParanoidQ925S8.
PhylomeDBQ925S8.

Gene expression databases

GenevestigatorQ925S8.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_01458. FtsH.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR000642. Peptidase_M41.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01241. FtsH_fam. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ925S8.

Entry information

Entry nameYMEL1_RAT
AccessionPrimary (citable) accession number: Q925S8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries