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Q925S4 (IL24_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-24

Short name=IL-24
Alternative name(s):
IL-4-induced secreted protein
Melanoma differentiation-associated gene 7 protein
Short name=MDA-7
Th2-specific cytokine FISP
Gene names
Name:Il24
Synonyms:Mda7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation By similarity.

Subcellular location

Secreted Potential.

Tissue specificity

Selectively expressed by Th2 cells. Ref.2

Induction

By IL-4. Ref.2

Post-translational modification

Ubiquitination at Lys-97 promotes proteasomal degradation By similarity.

Sequence similarities

Belongs to the IL-10 family.

Sequence caution

The sequence AAK52470.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
Isopeptide bond
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to interleukin-4

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from genetic interaction PubMed 18708357. Source: MGI

negative regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from direct assay PubMed 18708357. Source: MGI

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from genetic interaction PubMed 18708357. Source: MGI

positive regulation of apoptotic process

Inferred from direct assay PubMed 18708357. Source: MGI

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from direct assay PubMed 18708357. Source: MGI

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from electronic annotation. Source: Ensembl

serine phosphorylation of STAT3 protein

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentendoplasmic reticulum

Inferred from direct assay PubMed 18708357. Source: MGI

extracellular region

Inferred from direct assay Ref.2PubMed 18708357. Source: MGI

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine activity

Inferred from sequence alignment Ref.2. Source: MGI

protein binding

Inferred from physical interaction PubMed 18708357. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 181155Interleukin-24
PRO_0000042240

Amino acid modifications

Glycosylation741N-linked (GlcNAc...) Potential
Cross-link97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Experimental info

Sequence conflict311S → F in AAK52470. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q925S4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 05CA43872D53D555

FASTA18120,812
        10         20         30         40         50         60 
MSWGLQILPC LSLILLLWNQ VPGLEGQEFR SGSCQVTGVV LPELWEAFWT VKNTVQTQDD 

        70         80         90        100        110        120 
ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH SKIAKFKVLR SFSTLANNFI 

       130        140        150        160        170        180 
VIMSQLQPSK DNSMLPISES AHQRFLLFRR AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH 


L 

« Hide

References

[1]"Genomic structure, chromosomal localization and expression of melanoma differentiation associated gene-7 (mda-7): potential relationship with cellular senescence."
Madireddi M.T., Lin J., Su Z.-Z., Shay J.W., Huberman E., Fisher P.B.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/SvJ.
[2]"FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells."
Schaefer G., Venkataraman C., Schindler U.
J. Immunol. 166:5859-5863(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF235006 mRNA. Translation: AAK52590.1.
AF333251 mRNA. Translation: AAK52470.1. Different initiation.
RefSeqNP_444325.2. NM_053095.2.
UniGeneMm.196691.

3D structure databases

ProteinModelPortalQ925S4.
SMRQ925S4. Positions 32-177.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ925S4.

Proteomic databases

PRIDEQ925S4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000121040; ENSMUSP00000113064; ENSMUSG00000026420.
GeneID93672.
KEGGmmu:93672.

Organism-specific databases

CTD11009.
MGIMGI:2135548. Il24.

Phylogenomic databases

eggNOGNOG45557.
GeneTreeENSGT00410000025637.
HOGENOMHOG000113033.
HOVERGENHBG098494.
InParanoidQ925S4.
KOK05444.
OrthoDBEOG7060SK.
PhylomeDBQ925S4.
TreeFamTF333253.

Gene expression databases

BgeeQ925S4.
CleanExMM_IL24.
GenevestigatorQ925S4.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020444. IL-24.
[Graphical view]
PANTHERPTHR11585. PTHR11585. 1 hit.
PfamPF00726. IL10. 1 hit.
[Graphical view]
PRINTSPR01937. INTRLEUKIN24.
SMARTSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio351374.
PROQ925S4.
SOURCESearch...

Entry information

Entry nameIL24_MOUSE
AccessionPrimary (citable) accession number: Q925S4
Secondary accession number(s): Q925J3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot