Q925S4 (IL24_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-24
Short name=IL-24

Alternative name(s):
IL-4-induced secreted protein
Melanoma differentiation-associated gene 7 protein
Short name=MDA-7
Th2-specific cytokine FISP

Gene names

Name:	Il24
Synonyms:	Mda7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation By similarity.
Subcellular location	Secreted Potential.
Tissue specificity	Selectively expressed by Th2 cells. Ref.2
Induction	By IL-4. Ref.2
Sequence similarities	Belongs to the IL-10 family.
Sequence caution	The sequence AAK52470.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cellular response to interleukin-4 Inferred from electronic annotation. Source: Compara cellular response to lipopolysaccharide Inferred from electronic annotation. Source: Compara negative regulation of cell migration Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from direct assay PubMed 18708357. Source: MGI positive regulation of apoptotic process Inferred from direct assay PubMed 18708357. Source: MGI positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of tyrosine phosphorylation of Stat3 protein Inferred from electronic annotation. Source: Compara serine phosphorylation of STAT3 protein Inferred from electronic annotation. Source: Compara wound healing Inferred from electronic annotation. Source: Compara
Cellular_component	endoplasmic reticulum Inferred from direct assay PubMed 18708357. Source: MGI extracellular region Inferred from direct assay Ref.2PubMed 18708357. Source: MGI extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine activity Inferred from sequence alignment Ref.2. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 181	155	Interleukin-24		PRO_0000042240
Amino acid modifications
	Glycosylation	74	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	31	1	S → F in AAK52470. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q925S4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 05CA43872D53D555	FASTA	181	20,812
	10 20 30 40 50 60 MSWGLQILPC LSLILLLWNQ VPGLEGQEFR SGSCQVTGVV LPELWEAFWT VKNTVQTQDD 70 80 90 100 110 120 ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH SKIAKFKVLR SFSTLANNFI 130 140 150 160 170 180 VIMSQLQPSK DNSMLPISES AHQRFLLFRR AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH L

References

[1]	"Genomic structure, chromosomal localization and expression of melanoma differentiation associated gene-7 (mda-7): potential relationship with cellular senescence." Madireddi M.T., Lin J., Su Z.-Z., Shay J.W., Huberman E., Fisher P.B. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/SvJ.
[2]	"FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells." Schaefer G., Venkataraman C., Schindler U. J. Immunol. 166:5859-5863(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION. Strain: BALB/c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF235006 mRNA. Translation: AAK52590.1. AF333251 mRNA. Translation: AAK52470.1. Different initiation.
IPI	IPI00126941.
RefSeq	NP_444325.2. NM_053095.2.
UniGene	Mm.196691.
3D structure databases
ProteinModelPortal	Q925S4.
SMR	Q925S4. Positions 32-177.
ModBase	Search...
PTM databases
PhosphoSite	Q925S4.
Proteomic databases
PRIDE	Q925S4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000121040; ENSMUSP00000113064; ENSMUSG00000026420.
GeneID	93672.
KEGG	mmu:93672.
UCSC	uc007cmo.1. mouse.
Organism-specific databases
CTD	11009.
MGI	MGI:2135548. Il24.
Phylogenomic databases
eggNOG	NOG45557.
GeneTree	ENSGT00410000025637.
HOGENOM	HOG000113033.
HOVERGEN	HBG098494.
InParanoid	Q925S4.
KO	K05444.
OrthoDB	EOG4ZPDW8.
Gene expression databases
ArrayExpress	Q925S4.
Bgee	Q925S4.
CleanEx	MM_IL24.
Genevestigator	Q925S4.
GermOnline	ENSMUSG00000026420. Mus musculus.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR020443. Interleukin-10/19/20/24. IPR020423. Interleukin-10_CS. IPR020444. Interleukin-24. [Graphical view]
PANTHER	PTHR11585. PTHR11585. 1 hit.
Pfam	PF00726. IL10. 1 hit. [Graphical view]
PRINTS	PR01937. INTRLEUKIN24.
SMART	SM00188. IL10. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00520. INTERLEUKIN_10. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	351374.
SOURCE	Search...

Entry information

Entry name

IL24_MOUSE

Accession

Primary (citable) accession number: Q925S4
Secondary accession number(s): Q925J3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program