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Q925S4

- IL24_MOUSE

UniProt

Q925S4 - IL24_MOUSE

Protein

Interleukin-24

Gene

Il24

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.By similarity

    GO - Molecular functioni

    1. cytokine activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. cellular response to interleukin-4 Source: Ensembl
    2. cellular response to lipopolysaccharide Source: Ensembl
    3. negative regulation of apoptotic process Source: MGI
    4. negative regulation of cell migration Source: Ensembl
    5. negative regulation of cell proliferation Source: MGI
    6. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
    7. positive regulation of apoptotic process Source: MGI
    8. positive regulation of cell proliferation Source: Ensembl
    9. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
    10. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
    11. serine phosphorylation of STAT3 protein Source: Ensembl
    12. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-24
    Short name:
    IL-24
    Alternative name(s):
    IL-4-induced secreted protein
    Melanoma differentiation-associated gene 7 protein
    Short name:
    MDA-7
    Th2-specific cytokine FISP
    Gene namesi
    Name:Il24
    Synonyms:Mda7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2135548. Il24.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. extracellular region Source: MGI
    3. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 181155Interleukin-24PRO_0000042240Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Cross-linki97 – 97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Post-translational modificationi

    Ubiquitination at Lys-97 promotes proteasomal degradation.By similarity

    Keywords - PTMi

    Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PRIDEiQ925S4.

    PTM databases

    PhosphoSiteiQ925S4.

    Expressioni

    Tissue specificityi

    Selectively expressed by Th2 cells.1 Publication

    Inductioni

    By IL-4.1 Publication

    Gene expression databases

    BgeeiQ925S4.
    CleanExiMM_IL24.
    GenevestigatoriQ925S4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ925S4.
    SMRiQ925S4. Positions 32-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45557.
    GeneTreeiENSGT00410000025637.
    HOGENOMiHOG000113033.
    HOVERGENiHBG098494.
    InParanoidiQ925S4.
    KOiK05444.
    OrthoDBiEOG7060SK.
    PhylomeDBiQ925S4.
    TreeFamiTF333253.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    IPR020444. IL-24.
    [Graphical view]
    PANTHERiPTHR11585. PTHR11585. 1 hit.
    PfamiPF00726. IL10. 1 hit.
    [Graphical view]
    PRINTSiPR01937. INTRLEUKIN24.
    SMARTiSM00188. IL10. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q925S4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWGLQILPC LSLILLLWNQ VPGLEGQEFR SGSCQVTGVV LPELWEAFWT    50
    VKNTVQTQDD ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH 100
    SKIAKFKVLR SFSTLANNFI VIMSQLQPSK DNSMLPISES AHQRFLLFRR 150
    AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH L 181
    Length:181
    Mass (Da):20,812
    Last modified:December 1, 2001 - v1
    Checksum:i05CA43872D53D555
    GO

    Sequence cautioni

    The sequence AAK52470.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311S → F in AAK52470. (PubMed:11342597)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF235006 mRNA. Translation: AAK52590.1.
    AF333251 mRNA. Translation: AAK52470.1. Different initiation.
    RefSeqiNP_444325.2. NM_053095.2.
    UniGeneiMm.196691.

    Genome annotation databases

    EnsembliENSMUST00000121040; ENSMUSP00000113064; ENSMUSG00000026420.
    GeneIDi93672.
    KEGGimmu:93672.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF235006 mRNA. Translation: AAK52590.1 .
    AF333251 mRNA. Translation: AAK52470.1 . Different initiation.
    RefSeqi NP_444325.2. NM_053095.2.
    UniGenei Mm.196691.

    3D structure databases

    ProteinModelPortali Q925S4.
    SMRi Q925S4. Positions 32-177.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q925S4.

    Proteomic databases

    PRIDEi Q925S4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000121040 ; ENSMUSP00000113064 ; ENSMUSG00000026420 .
    GeneIDi 93672.
    KEGGi mmu:93672.

    Organism-specific databases

    CTDi 11009.
    MGIi MGI:2135548. Il24.

    Phylogenomic databases

    eggNOGi NOG45557.
    GeneTreei ENSGT00410000025637.
    HOGENOMi HOG000113033.
    HOVERGENi HBG098494.
    InParanoidi Q925S4.
    KOi K05444.
    OrthoDBi EOG7060SK.
    PhylomeDBi Q925S4.
    TreeFami TF333253.

    Miscellaneous databases

    NextBioi 351374.
    PROi Q925S4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q925S4.
    CleanExi MM_IL24.
    Genevestigatori Q925S4.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    IPR020444. IL-24.
    [Graphical view ]
    PANTHERi PTHR11585. PTHR11585. 1 hit.
    Pfami PF00726. IL10. 1 hit.
    [Graphical view ]
    PRINTSi PR01937. INTRLEUKIN24.
    SMARTi SM00188. IL10. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure, chromosomal localization and expression of melanoma differentiation associated gene-7 (mda-7): potential relationship with cellular senescence."
      Madireddi M.T., Lin J., Su Z.-Z., Shay J.W., Huberman E., Fisher P.B.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
    2. "FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells."
      Schaefer G., Venkataraman C., Schindler U.
      J. Immunol. 166:5859-5863(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Strain: BALB/c.

    Entry informationi

    Entry nameiIL24_MOUSE
    AccessioniPrimary (citable) accession number: Q925S4
    Secondary accession number(s): Q925J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3