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Protein

Interleukin-24

Gene

Il24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.By similarity

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. cellular response to interleukin-4 Source: Ensembl
  2. cellular response to lipopolysaccharide Source: Ensembl
  3. immune response Source: GO_Central
  4. inflammatory response Source: GO_Central
  5. negative regulation of apoptotic process Source: MGI
  6. negative regulation of cell migration Source: Ensembl
  7. negative regulation of cell proliferation Source: MGI
  8. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  9. positive regulation of apoptotic process Source: MGI
  10. positive regulation of cell proliferation Source: Ensembl
  11. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  12. positive regulation of JAK-STAT cascade Source: GO_Central
  13. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  14. serine phosphorylation of STAT3 protein Source: Ensembl
  15. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-24
Short name:
IL-24
Alternative name(s):
IL-4-induced secreted protein
Melanoma differentiation-associated gene 7 protein
Short name:
MDA-7
Th2-specific cytokine FISP
Gene namesi
Name:Il24
Synonyms:Mda7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2135548. Il24.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. extracellular region Source: MGI
  3. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 181155Interleukin-24PRO_0000042240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Cross-linki97 – 97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitination at Lys-97 promotes proteasomal degradation.By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiQ925S4.

PTM databases

PhosphoSiteiQ925S4.

Expressioni

Tissue specificityi

Selectively expressed by Th2 cells.1 Publication

Inductioni

By IL-4.1 Publication

Gene expression databases

BgeeiQ925S4.
CleanExiMM_IL24.
GenevestigatoriQ925S4.

Structurei

3D structure databases

ProteinModelPortaliQ925S4.
SMRiQ925S4. Positions 32-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45557.
HOGENOMiHOG000113033.
HOVERGENiHBG098494.
InParanoidiQ925S4.
KOiK05444.
OrthoDBiEOG7060SK.
PhylomeDBiQ925S4.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020444. IL-24.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01937. INTRLEUKIN24.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q925S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWGLQILPC LSLILLLWNQ VPGLEGQEFR SGSCQVTGVV LPELWEAFWT
60 70 80 90 100
VKNTVQTQDD ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH
110 120 130 140 150
SKIAKFKVLR SFSTLANNFI VIMSQLQPSK DNSMLPISES AHQRFLLFRR
160 170 180
AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH L
Length:181
Mass (Da):20,812
Last modified:December 1, 2001 - v1
Checksum:i05CA43872D53D555
GO

Sequence cautioni

The sequence AAK52470.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311S → F in AAK52470 (PubMed:11342597).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235006 mRNA. Translation: AAK52590.1.
AF333251 mRNA. Translation: AAK52470.1. Different initiation.
RefSeqiNP_444325.2. NM_053095.2.
UniGeneiMm.196691.

Genome annotation databases

GeneIDi93672.
KEGGimmu:93672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235006 mRNA. Translation: AAK52590.1.
AF333251 mRNA. Translation: AAK52470.1. Different initiation.
RefSeqiNP_444325.2. NM_053095.2.
UniGeneiMm.196691.

3D structure databases

ProteinModelPortaliQ925S4.
SMRiQ925S4. Positions 32-177.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ925S4.

Proteomic databases

PRIDEiQ925S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi93672.
KEGGimmu:93672.

Organism-specific databases

CTDi11009.
MGIiMGI:2135548. Il24.

Phylogenomic databases

eggNOGiNOG45557.
HOGENOMiHOG000113033.
HOVERGENiHBG098494.
InParanoidiQ925S4.
KOiK05444.
OrthoDBiEOG7060SK.
PhylomeDBiQ925S4.
TreeFamiTF333253.

Miscellaneous databases

NextBioi351374.
PROiQ925S4.
SOURCEiSearch...

Gene expression databases

BgeeiQ925S4.
CleanExiMM_IL24.
GenevestigatoriQ925S4.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020444. IL-24.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01937. INTRLEUKIN24.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic structure, chromosomal localization and expression of melanoma differentiation associated gene-7 (mda-7): potential relationship with cellular senescence."
    Madireddi M.T., Lin J., Su Z.-Z., Shay J.W., Huberman E., Fisher P.B.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
  2. "FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells."
    Schaefer G., Venkataraman C., Schindler U.
    J. Immunol. 166:5859-5863(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: BALB/c.

Entry informationi

Entry nameiIL24_MOUSE
AccessioniPrimary (citable) accession number: Q925S4
Secondary accession number(s): Q925J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.