Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycoprotein hormone alpha-2

Gene

Gpha2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormone alpha-2
Alternative name(s):
Putative secreted protein Zsig51
Thyrostimulin subunit alpha
Gene namesi
Name:Gpha2
Synonyms:Gpa2, Zsig51
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621748. Gpha2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 130108Glycoprotein hormone alpha-2PRO_0000011674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 90PROSITE-ProRule annotation
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi49 ↔ 104PROSITE-ProRule annotation
Disulfide bondi58 ↔ 120PROSITE-ProRule annotation
Disulfide bondi62 ↔ 122PROSITE-ProRule annotation
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ925Q4.

Expressioni

Gene expression databases

ExpressionAtlasiQ925Q4. baseline and differential.
GenevisibleiQ925Q4. RN.

Interactioni

Subunit structurei

Heterodimer with GPHB5.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028536.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYM3. Eukaryota.
ENOG4112671. LUCA.
GeneTreeiENSGT00390000009379.
HOGENOMiHOG000236306.
HOVERGENiHBG051795.
InParanoidiQ925Q4.
OMAiSRCCTIS.
OrthoDBiEOG722JBD.
PhylomeDBiQ925Q4.
TreeFamiTF332313.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q925Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMAPRVLLF CLLGLAVTEG HGLEAAVPIP GCHLHPFNVT VRSDRHGTCQ
60 70 80 90 100
GSHVAQACVG HCESSAFPSR YSVLVASGYR HNITSVSQCC TISSLKKVRV
110 120 130
WLHCVGNQRG ELEIFTARAC QCDMCRLSRY
Length:130
Mass (Da):14,199
Last modified:December 1, 2001 - v1
Checksum:i0BC46977131ED3DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260741 mRNA. Translation: AAK51640.1.
RefSeqiNP_598303.1. NM_133619.2.
XP_008758291.1. XM_008760069.1.
XP_008758292.1. XM_008760070.1.
UniGeneiRn.22078.

Genome annotation databases

EnsembliENSRNOT00000028536; ENSRNOP00000028536; ENSRNOG00000021020.
GeneIDi171158.
KEGGirno:171158.
UCSCiRGD:621748. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260741 mRNA. Translation: AAK51640.1.
RefSeqiNP_598303.1. NM_133619.2.
XP_008758291.1. XM_008760069.1.
XP_008758292.1. XM_008760070.1.
UniGeneiRn.22078.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028536.

Proteomic databases

PaxDbiQ925Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028536; ENSRNOP00000028536; ENSRNOG00000021020.
GeneIDi171158.
KEGGirno:171158.
UCSCiRGD:621748. rat.

Organism-specific databases

CTDi170589.
RGDi621748. Gpha2.

Phylogenomic databases

eggNOGiENOG410IYM3. Eukaryota.
ENOG4112671. LUCA.
GeneTreeiENSGT00390000009379.
HOGENOMiHOG000236306.
HOVERGENiHBG051795.
InParanoidiQ925Q4.
OMAiSRCCTIS.
OrthoDBiEOG722JBD.
PhylomeDBiQ925Q4.
TreeFamiTF332313.

Miscellaneous databases

PROiQ925Q4.

Gene expression databases

ExpressionAtlasiQ925Q4. baseline and differential.
GenevisibleiQ925Q4. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel cysteine knot protein expressed in pancreatic acinar cells."
    Dasovich M., Ching A., Lok S., Sheppard P., Webster P.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGPHA2_RAT
AccessioniPrimary (citable) accession number: Q925Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.