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Protein

Glycoprotein hormone alpha-2

Gene

Gpha2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.By similarity

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormone alpha-2
Alternative name(s):
Putative secreted protein Zsig51
Thyrostimulin subunit alpha
Gene namesi
Name:Gpha2
Synonyms:Gpa2, Zsig51
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621748. Gpha2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001167423 – 130Glycoprotein hormone alpha-2Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 90PROSITE-ProRule annotation
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi49 ↔ 104PROSITE-ProRule annotation
Disulfide bondi58 ↔ 120PROSITE-ProRule annotation
Disulfide bondi62 ↔ 122PROSITE-ProRule annotation
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ925Q4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021020.
ExpressionAtlasiQ925Q4. baseline and differential.
GenevisibleiQ925Q4. RN.

Interactioni

Subunit structurei

Heterodimer with GPHB5; this heterodimer interacts with thyroid-stimulating hormone receptor (TSHR), and hence stimulates cAMP production.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028536.

Structurei

3D structure databases

SMRiQ925Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYM3. Eukaryota.
ENOG4112671. LUCA.
GeneTreeiENSGT00390000009379.
HOGENOMiHOG000236306.
HOVERGENiHBG051795.
InParanoidiQ925Q4.
OMAiSRCCTIS.
OrthoDBiEOG091G0UTF.
PhylomeDBiQ925Q4.
TreeFamiTF332313.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q925Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMAPRVLLF CLLGLAVTEG HGLEAAVPIP GCHLHPFNVT VRSDRHGTCQ
60 70 80 90 100
GSHVAQACVG HCESSAFPSR YSVLVASGYR HNITSVSQCC TISSLKKVRV
110 120 130
WLHCVGNQRG ELEIFTARAC QCDMCRLSRY
Length:130
Mass (Da):14,199
Last modified:December 1, 2001 - v1
Checksum:i0BC46977131ED3DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260741 mRNA. Translation: AAK51640.1.
RefSeqiNP_598303.1. NM_133619.2.
XP_008758291.1. XM_008760069.2.
XP_008758292.1. XM_008760070.2.
UniGeneiRn.22078.

Genome annotation databases

EnsembliENSRNOT00000028536; ENSRNOP00000028536; ENSRNOG00000021020.
GeneIDi171158.
KEGGirno:171158.
UCSCiRGD:621748. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260741 mRNA. Translation: AAK51640.1.
RefSeqiNP_598303.1. NM_133619.2.
XP_008758291.1. XM_008760069.2.
XP_008758292.1. XM_008760070.2.
UniGeneiRn.22078.

3D structure databases

SMRiQ925Q4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028536.

Proteomic databases

PaxDbiQ925Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028536; ENSRNOP00000028536; ENSRNOG00000021020.
GeneIDi171158.
KEGGirno:171158.
UCSCiRGD:621748. rat.

Organism-specific databases

CTDi170589.
RGDi621748. Gpha2.

Phylogenomic databases

eggNOGiENOG410IYM3. Eukaryota.
ENOG4112671. LUCA.
GeneTreeiENSGT00390000009379.
HOGENOMiHOG000236306.
HOVERGENiHBG051795.
InParanoidiQ925Q4.
OMAiSRCCTIS.
OrthoDBiEOG091G0UTF.
PhylomeDBiQ925Q4.
TreeFamiTF332313.

Enzyme and pathway databases

ReactomeiR-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiPR:Q925Q4.

Gene expression databases

BgeeiENSRNOG00000021020.
ExpressionAtlasiQ925Q4. baseline and differential.
GenevisibleiQ925Q4. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPHA2_RAT
AccessioniPrimary (citable) accession number: Q925Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: April 12, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.