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Protein

C-type lectin domain family 2 member D5

Gene

Ocil

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Lectin-type cell surface receptor.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 2 member D5
Alternative name(s):
Osteoclast inhibitory lectin
Gene namesi
Name:Ocil
Synonyms:Clec2d5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620070. Ocil.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676CytoplasmicSequence analysisAdd
BLAST
Transmembranei77 – 9721Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini98 – 233136ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233C-type lectin domain family 2 member D5PRO_0000315294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ925N7.

Structurei

3D structure databases

ProteinModelPortaliQ925N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 228110C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000060206.
HOVERGENiHBG107716.
InParanoidiQ925N7.
PhylomeDBiQ925N7.
TreeFamiTF351467.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSAHLQDP PPLLSRTLTQ NEGQTSLRQS SSCGPSAASA SESLSGSTES
60 70 80 90 100
RIPHSKMLQG KLPRNIPLEY PAGLYCCYVV IIVLSVAVVA LSVALSVKKT
110 120 130 140 150
AQISTINTYA ACPRNWIGVG NKCFYFNEIP SNWTLSQTLC KEQGAELARF
160 170 180 190 200
DTEEELNFLR RYKGSSGYWF GLHRESSAHP WKWTDNTEYN NSVSIGGDEK
210 220 230
HGFLSDNGFS SGRGYIVRKS ICRKPNSYTS QCL
Length:233
Mass (Da):25,686
Last modified:December 1, 2001 - v1
Checksum:i56C7B6D08171CDEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321552 mRNA. Translation: AAK50880.1.
EF100688 mRNA. Translation: ABO15828.1.
RefSeqiNP_569086.1. NM_130402.2.
XP_008761531.1. XM_008763309.1.
UniGeneiRn.22573.

Genome annotation databases

GeneIDi113937.
KEGGirno:113937.
UCSCiRGD:620070. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321552 mRNA. Translation: AAK50880.1.
EF100688 mRNA. Translation: ABO15828.1.
RefSeqiNP_569086.1. NM_130402.2.
XP_008761531.1. XM_008763309.1.
UniGeneiRn.22573.

3D structure databases

ProteinModelPortaliQ925N7.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ925N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi113937.
KEGGirno:113937.
UCSCiRGD:620070. rat.

Organism-specific databases

CTDi29121.
RGDi620070. Ocil.

Phylogenomic databases

HOGENOMiHOG000060206.
HOVERGENiHBG107716.
InParanoidiQ925N7.
PhylomeDBiQ925N7.
TreeFamiTF351467.

Miscellaneous databases

PROiQ925N7.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel osteoblast-derived C-type lectin that inhibits osteoclast formation."
    Zhou H., Kartsogiannis V., Hu Y.S., Elliott J., Quinn J.M.W., McKinstry W.J., Gillespie M.T., Ng K.W.
    J. Biol. Chem. 276:14916-14923(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Ocil/Clr-b missing-self axis."
    Voigt S., Mesci A., Ettinger J., Fine J.H., Chen P., Chou W., Carlyle J.R.
    Immunity 26:617-627(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCL2D5_RAT
AccessioniPrimary (citable) accession number: Q925N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.