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Protein

Immunoglobulin superfamily member 1

Gene

Igsf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription (By similarity).By similarity

GO - Molecular functioni

  • coreceptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 1
Short name:
IgSF1
Alternative name(s):
Inhibin-binding protein
Short name:
InhBP
Gene namesi
Name:Igsf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi631402. Igsf1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 504486ExtracellularSequence analysisAdd
BLAST
Transmembranei505 – 52521HelicalSequence analysisAdd
BLAST
Topological domaini526 – 5349CytoplasmicSequence analysis
Transmembranei535 – 55521HelicalSequence analysisAdd
BLAST
Topological domaini556 – 1320765ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 13201302Immunoglobulin superfamily member 1PRO_0000318514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi49 ↔ 97PROSITE-ProRule annotation
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi334 ↔ 383PROSITE-ProRule annotation
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence analysis
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi423 ↔ 466PROSITE-ProRule annotation
Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence analysis
Glycosylationi731 – 7311N-linked (GlcNAc...)Sequence analysis
Glycosylationi782 – 7821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi783 ↔ 833PROSITE-ProRule annotation
Glycosylationi830 – 8301N-linked (GlcNAc...)Sequence analysis
Glycosylationi874 – 8741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi879 ↔ 926PROSITE-ProRule annotation
Glycosylationi923 – 9231N-linked (GlcNAc...)Sequence analysis
Glycosylationi970 – 9701N-linked (GlcNAc...)Sequence analysis
Glycosylationi1011 – 10111N-linked (GlcNAc...)Sequence analysis
Glycosylationi1066 – 10661N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1071 ↔ 1118PROSITE-ProRule annotation
Glycosylationi1131 – 11311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1167 ↔ 1210PROSITE-ProRule annotation
Glycosylationi1207 – 12071N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ925N6.
PRIDEiQ925N6.

PTM databases

PhosphoSiteiQ925N6.
UniCarbKBiQ925N6.

Expressioni

Tissue specificityi

Expressed in pituitary gland, testis and liver. Isoform 2 is expressed pituitary gland and testis.2 Publications

Gene expression databases

GenevisibleiQ925N6. RN.

Interactioni

Subunit structurei

Interacts with INHA; the interaction is not confirmed by standard receptor binding assays. Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A. Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B (By similarity). Interacts with HECTD1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010325.

Structurei

3D structure databases

ProteinModelPortaliQ925N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 11385Ig-like C2-type 1Add
BLAST
Domaini115 – 21298Ig-like C2-type 2Add
BLAST
Domaini224 – 30885Ig-like C2-type 3Add
BLAST
Domaini312 – 39988Ig-like C2-type 4Add
BLAST
Domaini401 – 48282Ig-like C2-type 5Add
BLAST
Domaini572 – 66594Ig-like C2-type 6Add
BLAST
Domaini662 – 75695Ig-like C2-type 7Add
BLAST
Domaini761 – 85393Ig-like C2-type 8Add
BLAST
Domaini857 – 94286Ig-like C2-type 9Add
BLAST
Domaini949 – 104496Ig-like C2-type 10Add
BLAST
Domaini1049 – 113486Ig-like C2-type 11Add
BLAST
Domaini1145 – 122682Ig-like C2-type 12Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIFF. Eukaryota.
ENOG410YSQG. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000113017.
HOVERGENiHBG098292.
InParanoidiQ925N6.
OMAiPWENITL.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ925N6.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 11 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q925N6-1) [UniParc]FASTAAdd to basket

Also known as: InhBP-L, long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLRTFTLLL LCIWLNRGMT SMAAVESQPE LWIESNYPQA PWENITLWCK
60 70 80 90 100
SPSRVSSKFL LLKDNTQMTW IHPPYKTFQV SFFIGALTES NTGLYRCCYW
110 120 130 140 150
NEKGWSKPSK ILELEAPGQL PKPIFWIQAE TPPFPGCNVN ILCHGWLQDL
160 170 180 190 200
VFMLFKEGYT EPIDYQVPTG TMAIFSIDNL APENEGIYIC RTHIQMLPTL
210 220 230 240 250
WSEPSNPLKL VVAGLYPKPT LTAHPGPILA PGESLSLRCQ GPIYGMTFAL
260 270 280 290 300
MRLEDLKKPY YYKKPIKNEA YFYFQALKTQ DTGHYLCFYY DGSYRGSLLS
310 320 330 340 350
DILKIWVTDT FPKTWLLVQP SPVIQMGQNV SLRCGGLMDG VGLALHKKGE
360 370 380 390 400
EKPLQFLDAT SNTGNNSFFL KNVTYRDAGI YSCHYYLTWK TSIKMATYNT
410 420 430 440 450
VELIVVAWPS SVFKVGKTIT LQCRVSHPVL EFSLEWEETT TFQKFSVDGD
460 470 480 490 500
FIITNIEGQG TGTYSCSYRI ESHANIWSHR SEPLKLVGPA VTGFLPWNSI
510 520 530 540 550
LNEAIRVSLT VQFLSLLLLV LWLQWKCRRL RLREAWLLGT AQGVAMLVIL
560 570 580 590 600
IALLCCGLCN GALTEEIEII MPTPKPELWA ETNFPQAPWK NVTLWCRSPS
610 620 630 640 650
GSTKEFVLLK DGTGWIATRP ASEQVRAAFP LGALTQSHTG SYHCHSWEEM
660 670 680 690 700
AVSEPSEALE LVGTDILPKP VISASLPIRG QELQIRCKGW LEGLGFALYK
710 720 730 740 750
MGEQEPVQQL GAVGREAFFT IQRMEDKEEG NYSCRTHTEK QPFKWSEPSA
760 770 780 790 800
PLELVIKELY PKPFFKTWAS PVVTPGSRVT FNCSTSREHM SFILYKDGNE
810 820 830 840 850
IASSDPVWGN PGTSTAHFLI ISVGIGDGGN YSCRYYDFSI WSEPSDPVEL
860 870 880 890 900
IVTEFYPKPT LLAQPGPVVL PGKNVTLRCQ GIFQGMRFAL LQEGAHAPLQ
910 920 930 940 950
FQSASGTSVD FLLHTVGAED FGNYSCVYYE TTMSNRGSYL STPLMIWVTD
960 970 980 990 1000
TFPRPWLSAE PSSVVTMGQN VTLWCQGPVH GVGYILHKEG EATSMQLWDS
1010 1020 1030 1040 1050
TSNEGAFPII NISGASIGRY SCCYHPDWMS PIKIQPSNTL ELIVTGLLPK
1060 1070 1080 1090 1100
PSLLVQPGPM VVPGENMTFQ CQGELPDSTF VLLKEGTQQP IEQQRPSGYR
1110 1120 1130 1140 1150
ADFWMPVVRD QDSGVYSCVY YLDSAPLVAS NHSNSLEIWV TDKPPKPSLS
1160 1170 1180 1190 1200
AWPSTVFKLG KDITLQCRGP LPGVEFVLEH DGEEAPQQFS EDGDFVIGNM
1210 1220 1230 1240 1250
EGKGIGNYSC SYRLQAYPDI WSEPSDSLEL VGAAGPVAQE CTVGNIVRST
1260 1270 1280 1290 1300
LIVVVVVALG IVLAIEWKKW PRLRTRGSET DGRDQTIVLE ECNQDGEPGT
1310 1320
ATNSPSSALQ GVSVEQTVPI
Length:1,320
Mass (Da):147,293
Last modified:December 1, 2001 - v1
Checksum:iF5F5B2AA77BA3C2A
GO
Isoform 2 (identifier: Q925N6-2) [UniParc]FASTAAdd to basket

Also known as: InhBP-S, short

The sequence of this isoform differs from the canonical sequence as follows:
     215-233: LYPKPTLTAHPGPILAPGE → GCAHGCWHLTIVIPGIMAG
     234-1320: Missing.

Show »
Length:233
Mass (Da):26,502
Checksum:i8D2EC6BCA4C71743
GO
Isoform 3 (identifier: Q925N6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: Missing.
     215-233: LYPKPTLTAHPGPILAPGE → GCAHGCWHLTIVIPGIMAG
     234-1320: Missing.

Show »
Length:232
Mass (Da):26,431
Checksum:i68893979D19A73F9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei24 – 241Missing in isoform 3. 1 PublicationVSP_031204
Alternative sequencei215 – 23319LYPKP…LAPGE → GCAHGCWHLTIVIPGIMAG in isoform 2 and isoform 3. 2 PublicationsVSP_031205Add
BLAST
Alternative sequencei234 – 13201087Missing in isoform 2 and isoform 3. 2 PublicationsVSP_031206Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322216 mRNA. Translation: AAK40083.1.
AF322217 mRNA. Translation: AAK40084.1.
BC060309 mRNA. Translation: AAH60309.1.
BC127478 mRNA. Translation: AAI27479.1.
RefSeqiNP_786939.1. NM_175763.2. [Q925N6-1]
UniGeneiRn.23738.

Genome annotation databases

EnsembliENSRNOT00000010325; ENSRNOP00000010325; ENSRNOG00000007600. [Q925N6-1]
GeneIDi302822.
KEGGirno:302822.
UCSCiRGD:631402. rat. [Q925N6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322216 mRNA. Translation: AAK40083.1.
AF322217 mRNA. Translation: AAK40084.1.
BC060309 mRNA. Translation: AAH60309.1.
BC127478 mRNA. Translation: AAI27479.1.
RefSeqiNP_786939.1. NM_175763.2. [Q925N6-1]
UniGeneiRn.23738.

3D structure databases

ProteinModelPortaliQ925N6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010325.

PTM databases

PhosphoSiteiQ925N6.
UniCarbKBiQ925N6.

Proteomic databases

PaxDbiQ925N6.
PRIDEiQ925N6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010325; ENSRNOP00000010325; ENSRNOG00000007600. [Q925N6-1]
GeneIDi302822.
KEGGirno:302822.
UCSCiRGD:631402. rat. [Q925N6-1]

Organism-specific databases

CTDi3547.
RGDi631402. Igsf1.

Phylogenomic databases

eggNOGiENOG410IIFF. Eukaryota.
ENOG410YSQG. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000113017.
HOVERGENiHBG098292.
InParanoidiQ925N6.
OMAiPWENITL.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ925N6.
TreeFamiTF336644.

Miscellaneous databases

NextBioi650212.
PROiQ925N6.

Gene expression databases

GenevisibleiQ925N6. RN.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 11 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Inhibin binding protein in rats: alternative transcripts and regulation in the pituitary across the estrous cycle."
    Bernard D.J., Woodruff T.K.
    Mol. Endocrinol. 15:654-667(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Pituitary.
  3. "Structure and expression of a membrane component of the inhibin receptor system."
    Chong H., Pangas S.A., Bernard D.J., Wang E., Gitch J., Chen W., Draper L.B., Cox E.T., Woodruff T.K.
    Endocrinology 141:2600-2607(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiIGSF1_RAT
AccessioniPrimary (citable) accession number: Q925N6
Secondary accession number(s): A0JPK8, Q925N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.