Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Claudin-16

Gene

Cldn16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity).By similarity

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  2. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-16
Alternative name(s):
Paracellin-1
Gene namesi
Name:Cldn16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2148742. Cldn16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicSequence Analysis
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Topological domaini25 – 7955ExtracellularSequence AnalysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST
Topological domaini101 – 11515CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Topological domaini137 – 16933ExtracellularSequence AnalysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Topological domaini191 – 23545CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Claudin-16PRO_0000144775Add
BLAST

Proteomic databases

PRIDEiQ925N4.

PTM databases

PhosphoSiteiQ925N4.

Expressioni

Gene expression databases

BgeeiQ925N4.
CleanExiMM_CLDN16.
ExpressionAtlasiQ925N4. baseline and differential.
GenevestigatoriQ925N4.

Structurei

3D structure databases

ProteinModelPortaliQ925N4.
SMRiQ925N4. Positions 37-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG38970.
GeneTreeiENSGT00730000111162.
HOGENOMiHOG000111787.
HOVERGENiHBG050987.
InParanoidiQ925N4.
KOiK06087.
OMAiYAVDTRV.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ925N4.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003927. Claudin16.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF56. PTHR12002:SF56. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01447. CLAUDIN16.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925N4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDLLQYAAC FLAIFSTGFL IVATWTDCWM VNADDSLEVS TKCRGLWWEC
60 70 80 90 100
VTNAFDGIRT CDEYDSIYAE HPLKLVVTRA LMITADILAG FGFITLLLGL
110 120 130 140 150
DCVKFLPDDP QIKVRLCFVA GTTLLIAGTP GIIGSVWYAV DVYVERSSLV
160 170 180 190 200
LHNIFLGIQY KFGWSCWLGM AGSLGCFLAG ALLTCCLYLF KDVGPERNYP
210 220 230
YAMRKPYSTA GVSMAKSYKA PRTETAKMYA VDTRV
Length:235
Mass (Da):26,100
Last modified:December 1, 2001 - v1
Checksum:iC0601A64D87891FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323748 mRNA. Translation: AAK49518.1.
AK085268 mRNA. Translation: BAC39406.1.
AK085333 mRNA. Translation: BAC39425.1.
CCDSiCCDS28088.1.
RefSeqiNP_444471.1. NM_053241.5.
UniGeneiMm.275205.

Genome annotation databases

EnsembliENSMUST00000115302; ENSMUSP00000110957; ENSMUSG00000038148.
ENSMUST00000161053; ENSMUSP00000124528; ENSMUSG00000038148.
GeneIDi114141.
KEGGimmu:114141.
UCSCiuc007yva.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323748 mRNA. Translation: AAK49518.1.
AK085268 mRNA. Translation: BAC39406.1.
AK085333 mRNA. Translation: BAC39425.1.
CCDSiCCDS28088.1.
RefSeqiNP_444471.1. NM_053241.5.
UniGeneiMm.275205.

3D structure databases

ProteinModelPortaliQ925N4.
SMRiQ925N4. Positions 37-180.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ925N4.

Proteomic databases

PRIDEiQ925N4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115302; ENSMUSP00000110957; ENSMUSG00000038148.
ENSMUST00000161053; ENSMUSP00000124528; ENSMUSG00000038148.
GeneIDi114141.
KEGGimmu:114141.
UCSCiuc007yva.2. mouse.

Organism-specific databases

CTDi10686.
MGIiMGI:2148742. Cldn16.

Phylogenomic databases

eggNOGiNOG38970.
GeneTreeiENSGT00730000111162.
HOGENOMiHOG000111787.
HOVERGENiHBG050987.
InParanoidiQ925N4.
KOiK06087.
OMAiYAVDTRV.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ925N4.
TreeFamiTF331936.

Miscellaneous databases

NextBioi368133.
PROiQ925N4.
SOURCEiSearch...

Gene expression databases

BgeeiQ925N4.
CleanExiMM_CLDN16.
ExpressionAtlasiQ925N4. baseline and differential.
GenevestigatoriQ925N4.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003927. Claudin16.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF56. PTHR12002:SF56. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01447. CLAUDIN16.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary gene structure and expression studies of rodent paracellin-1."
    Weber S., Schlingmann K.P., Peters M., Nejsum L.N., Nielsen S., Engel H., Grzeschik K.H., Seyberth H.W., Grone H.J., Nusing R., Konrad M.
    J. Am. Soc. Nephrol. 12:2664-2672(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.

Entry informationi

Entry nameiCLD16_MOUSE
AccessioniPrimary (citable) accession number: Q925N4
Secondary accession number(s): Q542L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.