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Q925N4

- CLD16_MOUSE

UniProt

Q925N4 - CLD16_MOUSE

Protein

Claudin-16

Gene

Cldn16

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors By similarity.By similarity

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB
    2. ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-16
    Alternative name(s):
    Paracellin-1
    Gene namesi
    Name:Cldn16
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2148742. Cldn16.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Claudin-16PRO_0000144775Add
    BLAST

    Proteomic databases

    PRIDEiQ925N4.

    PTM databases

    PhosphoSiteiQ925N4.

    Expressioni

    Gene expression databases

    BgeeiQ925N4.
    CleanExiMM_CLDN16.
    GenevestigatoriQ925N4.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33CytoplasmicSequence Analysis
    Topological domaini25 – 7955ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini101 – 11515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini137 – 16933ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini191 – 23545CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG38970.
    GeneTreeiENSGT00730000111162.
    HOGENOMiHOG000111787.
    HOVERGENiHBG050987.
    InParanoidiQ925N4.
    KOiK06087.
    OMAiYAVDTRV.
    OrthoDBiEOG76HQ2T.
    PhylomeDBiQ925N4.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003927. Claudin16.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PTHR12002:SF56. PTHR12002:SF56. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01447. CLAUDIN16.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q925N4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDLLQYAAC FLAIFSTGFL IVATWTDCWM VNADDSLEVS TKCRGLWWEC    50
    VTNAFDGIRT CDEYDSIYAE HPLKLVVTRA LMITADILAG FGFITLLLGL 100
    DCVKFLPDDP QIKVRLCFVA GTTLLIAGTP GIIGSVWYAV DVYVERSSLV 150
    LHNIFLGIQY KFGWSCWLGM AGSLGCFLAG ALLTCCLYLF KDVGPERNYP 200
    YAMRKPYSTA GVSMAKSYKA PRTETAKMYA VDTRV 235
    Length:235
    Mass (Da):26,100
    Last modified:December 1, 2001 - v1
    Checksum:iC0601A64D87891FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF323748 mRNA. Translation: AAK49518.1.
    AK085268 mRNA. Translation: BAC39406.1.
    AK085333 mRNA. Translation: BAC39425.1.
    CCDSiCCDS28088.1.
    RefSeqiNP_444471.1. NM_053241.5.
    UniGeneiMm.275205.

    Genome annotation databases

    EnsembliENSMUST00000115302; ENSMUSP00000110957; ENSMUSG00000038148.
    ENSMUST00000161053; ENSMUSP00000124528; ENSMUSG00000038148.
    GeneIDi114141.
    KEGGimmu:114141.
    UCSCiuc007yva.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF323748 mRNA. Translation: AAK49518.1 .
    AK085268 mRNA. Translation: BAC39406.1 .
    AK085333 mRNA. Translation: BAC39425.1 .
    CCDSi CCDS28088.1.
    RefSeqi NP_444471.1. NM_053241.5.
    UniGenei Mm.275205.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q925N4.

    Proteomic databases

    PRIDEi Q925N4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000115302 ; ENSMUSP00000110957 ; ENSMUSG00000038148 .
    ENSMUST00000161053 ; ENSMUSP00000124528 ; ENSMUSG00000038148 .
    GeneIDi 114141.
    KEGGi mmu:114141.
    UCSCi uc007yva.2. mouse.

    Organism-specific databases

    CTDi 10686.
    MGIi MGI:2148742. Cldn16.

    Phylogenomic databases

    eggNOGi NOG38970.
    GeneTreei ENSGT00730000111162.
    HOGENOMi HOG000111787.
    HOVERGENi HBG050987.
    InParanoidi Q925N4.
    KOi K06087.
    OMAi YAVDTRV.
    OrthoDBi EOG76HQ2T.
    PhylomeDBi Q925N4.
    TreeFami TF331936.

    Miscellaneous databases

    NextBioi 368133.
    PROi Q925N4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q925N4.
    CleanExi MM_CLDN16.
    Genevestigatori Q925N4.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003927. Claudin16.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    PTHR12002:SF56. PTHR12002:SF56. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01447. CLAUDIN16.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary gene structure and expression studies of rodent paracellin-1."
      Weber S., Schlingmann K.P., Peters M., Nejsum L.N., Nielsen S., Engel H., Grzeschik K.H., Seyberth H.W., Grone H.J., Nusing R., Konrad M.
      J. Am. Soc. Nephrol. 12:2664-2672(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.

    Entry informationi

    Entry nameiCLD16_MOUSE
    AccessioniPrimary (citable) accession number: Q925N4
    Secondary accession number(s): Q542L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3