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Protein

PEX5-related protein

Gene

Pex5l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.1 Publication

GO - Molecular functioni

  • intracellular cyclic nucleotide activated cation channel activity Source: UniProtKB
  • Rab GTPase binding Source: RGD

GO - Biological processi

  • cation transmembrane transport Source: GOC
  • positive regulation of corticotropin secretion Source: RGD
  • regulated exocytosis Source: RGD
  • regulation of cAMP-mediated signaling Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PEX5-related protein
Alternative name(s):
PEX5-like protein
Peroxin-5-related protein
TPR-containing Rab8b-interacting protein
Tetratricopeptide repeat-containing Rab8b-interacting protein
Short name:
Pex5Rp
Short name:
TRIP8b
Gene namesi
Name:Pex5l
Synonyms:Pex2, Pex5r, Trip8b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708407. Pex5l.

Subcellular locationi

GO - Cellular componenti

  • cell tip Source: RGD
  • membrane Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602PEX5-related proteinPRO_0000106319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei181 – 1811PhosphoserineBy similarity
Modified residuei229 – 2291PhosphoserineCombined sources
Modified residuei233 – 2331PhosphoserineCombined sources
Modified residuei237 – 2371PhosphoserineCombined sources
Modified residuei421 – 4211PhosphoserineBy similarity
Modified residuei423 – 4231PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ925N3.
PRIDEiQ925N3.

PTM databases

iPTMnetiQ925N3.
PhosphoSiteiQ925N3.

Expressioni

Tissue specificityi

Brain specific.1 Publication

Interactioni

Subunit structurei

Forms an obligate 4:4 complex with HCN2 (By similarity). Interacts with RAB8B.By similarity2 Publications

GO - Molecular functioni

  • Rab GTPase binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015200.

Structurei

3D structure databases

ProteinModelPortaliQ925N3.
SMRiQ925N3. Positions 287-601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati302 – 33534TPR 1Add
BLAST
Repeati336 – 36934TPR 2Add
BLAST
Repeati371 – 40333TPR 3Add
BLAST
Repeati450 – 48334TPR 4Add
BLAST
Repeati485 – 51733TPR 5Add
BLAST
Repeati519 – 55133TPR 6Add
BLAST

Sequence similaritiesi

Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiQ925N3.
KOiK13342.
PhylomeDBiQ925N3.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024112. PEX5-rel.
IPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PTHR10130:SF1. PTHR10130:SF1. 1 hit.
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQGHMQGKG SRAADKAVAM VMKEIPREES AEEKPLLTMT SQLVNEQQES
60 70 80 90 100
RPLLSPSIDD FLCETKSEAI AKPVTSNTAV LTTGLDLLDL SEPVSQTQTK
110 120 130 140 150
AKKSESSSKS SSLKKKADGS DLISADAEQR AQALRGPETS SLDLDIQTQL
160 170 180 190 200
EKWDDVKFHG DRTSKGHLMA ERKSCSSRAG SKELLWSSEH RSQPELSTGK
210 220 230 240 250
SALNSESASE LELVAPAQAR LTKEHRWGSA LLSRNHSLEE EFERAKAAVE
260 270 280 290 300
SDTEFWDKMQ AEWEEMARRN WISENQEAQN QVTVSASEKG YYFHTENPFK
310 320 330 340 350
DWPGAFEEGL KRLKEGDLPV TILFMEAAIL QDPGNAEAWQ FLGITQAENE
360 370 380 390 400
NEQAAIVALQ RCLELQPNNL KALMALAVSY TNTSHQQDAC EALKNWIKQN
410 420 430 440 450
PKYKYLVKNK KGSPGLTRRM SKSPVDSSVL EGVKDLYLEA AHQNGDMIDP
460 470 480 490 500
DLQTGLGVLF HLSGEFNRAI DAFNAALTVR PEDYSLWNRL GATLANGDRS
510 520 530 540 550
EEAVEAYTRA LEIQPGFIRS RYNLGISCIN LGAYREAVSN FLTALSLQRK
560 570 580 590 600
SRNQQQVPHP AISGNIWAAL RIALSLMDQP ELFQAANLGD LDVLLRAFNL

DP
Length:602
Mass (Da):66,872
Last modified:December 1, 2001 - v1
Checksum:i5B8841F2AE1D558F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324454 mRNA. Translation: AAK38580.1.
RefSeqiNP_775175.1. NM_173152.1.
UniGeneiRn.207886.

Genome annotation databases

GeneIDi286937.
KEGGirno:286937.
UCSCiRGD:708407. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324454 mRNA. Translation: AAK38580.1.
RefSeqiNP_775175.1. NM_173152.1.
UniGeneiRn.207886.

3D structure databases

ProteinModelPortaliQ925N3.
SMRiQ925N3. Positions 287-601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015200.

PTM databases

iPTMnetiQ925N3.
PhosphoSiteiQ925N3.

Proteomic databases

PaxDbiQ925N3.
PRIDEiQ925N3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286937.
KEGGirno:286937.
UCSCiRGD:708407. rat.

Organism-specific databases

CTDi51555.
RGDi708407. Pex5l.

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiQ925N3.
KOiK13342.
PhylomeDBiQ925N3.

Miscellaneous databases

NextBioi625124.
PROiQ925N3.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024112. PEX5-rel.
IPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PTHR10130:SF1. PTHR10130:SF1. 1 hit.
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rab8b and its interacting partner TRIP8b are involved in regulated secretion in AtT20 cells."
    Chen S., Liang M.C., Chia J.N., Ngsee J.K., Ting A.E.
    J. Biol. Chem. 276:13209-13216(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH RAB8B.
    Tissue: Brain.
  2. "Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation."
    Zolles G., Wenzel D., Bildl W., Schulte U., Hofmann A., Muller C.S., Thumfart J.O., Vlachos A., Deller T., Pfeifer A., Fleischmann B.K., Roeper J., Fakler B., Klocker N.
    Neuron 62:814-825(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; SER-233; SER-237 AND SER-423, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX5R_RAT
AccessioniPrimary (citable) accession number: Q925N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.