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Protein

Testis-specific serine/threonine-protein kinase 6

Gene

Tssk6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPPROSITE-ProRule annotationBy similarity1
Active sitei135Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • multicellular organism development Source: UniProtKB-KW
  • protein phosphorylation Source: UniProtKB
  • sperm chromatin condensation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine/threonine-protein kinase 6 (EC:2.7.11.1)
Short name:
TSK-6
Short name:
TSSK-6
Short name:
Testis-specific kinase 6
Alternative name(s):
Serine/threonine-protein kinase SSTK
Small serine/threonine kinase
Gene namesi
Name:Tssk6Imported
Synonyms:SstkImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2148775. Tssk6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Mice are sterile due to profound impairment in motility and morphology of spermatozoa.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277471 – 273Testis-specific serine/threonine-protein kinase 6Add BLAST273

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ925K9.
PRIDEiQ925K9.

PTM databases

PhosphoSitePlusiQ925K9.

Expressioni

Tissue specificityi

Expressed in the testis, localized to the heads of elongating spermatids.1 Publication

Gene expression databases

BgeeiENSMUSG00000047654.
CleanExiMM_TSSK6.
GenevisibleiQ925K9. MM.

Interactioni

Subunit structurei

Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062783.

Structurei

3D structure databases

ProteinModelPortaliQ925K9.
SMRiQ925K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 267Protein kinasePROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00770000120521.
HOGENOMiHOG000233016.
HOVERGENiHBG101110.
InParanoidiQ925K9.
KOiK08811.
OMAiLEVSERC.
OrthoDBiEOG091G0EZI.
PhylomeDBiQ925K9.
TreeFamiTF105333.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDKLLSEL GYKLGRTIGE GSYSKVKVAT SKKYKGTVAI KVVDRRRAPP
60 70 80 90 100
DFVNKFLPRE LSILRGVRHP HIVHVFEFIE VCNGKLYIVM EAAATDLLQA
110 120 130 140 150
VQRNGRIPGS QARELFSQIA GAVRYLHDHH LVHRDLKCEN VLLSPDERRV
160 170 180 190 200
KITDFGFGRQ AHGYPDLSTT YCGSAAYASP EVLLGIPYDP KKYDVWSLGV
210 220 230 240 250
VLYVMVTGCM PFDDSDIAGL PRRQKRGVLY PDGLELSERC KSLIAELLQF
260 270
SPSARPSAGQ VARNGWLRAG DSG
Length:273
Mass (Da):30,287
Last modified:December 1, 2001 - v1
Checksum:iA04A76290EA7E4B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61L → M in BAC36437 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329484 mRNA. Translation: AAK48828.1.
BC049542 mRNA. No translation available.
AK076653 mRNA. Translation: BAC36437.2.
CCDSiCCDS22354.1.
RefSeqiNP_114393.1. NM_032004.2.
UniGeneiMm.432504.

Genome annotation databases

EnsembliENSMUST00000050373; ENSMUSP00000062783; ENSMUSG00000047654.
GeneIDi83984.
KEGGimmu:83984.
UCSCiuc009lye.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329484 mRNA. Translation: AAK48828.1.
BC049542 mRNA. No translation available.
AK076653 mRNA. Translation: BAC36437.2.
CCDSiCCDS22354.1.
RefSeqiNP_114393.1. NM_032004.2.
UniGeneiMm.432504.

3D structure databases

ProteinModelPortaliQ925K9.
SMRiQ925K9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062783.

PTM databases

PhosphoSitePlusiQ925K9.

Proteomic databases

PaxDbiQ925K9.
PRIDEiQ925K9.

Protocols and materials databases

DNASUi83984.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050373; ENSMUSP00000062783; ENSMUSG00000047654.
GeneIDi83984.
KEGGimmu:83984.
UCSCiuc009lye.1. mouse.

Organism-specific databases

CTDi83983.
MGIiMGI:2148775. Tssk6.

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00770000120521.
HOGENOMiHOG000233016.
HOVERGENiHBG101110.
InParanoidiQ925K9.
KOiK08811.
OMAiLEVSERC.
OrthoDBiEOG091G0EZI.
PhylomeDBiQ925K9.
TreeFamiTF105333.

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.

Miscellaneous databases

PROiQ925K9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047654.
CleanExiMM_TSSK6.
GenevisibleiQ925K9. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSSK6_MOUSE
AccessioniPrimary (citable) accession number: Q925K9
Secondary accession number(s): Q5RL09, Q8C625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.