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Protein

Testis-specific serine/threonine-protein kinase 6

Gene

Tssk6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPPROSITE-ProRule annotationBy similarity1
Active sitei135Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • multicellular organism development Source: UniProtKB-KW
  • protein phosphorylation Source: UniProtKB
  • sperm chromatin condensation Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Spermatogenesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine/threonine-protein kinase 6 (EC:2.7.11.1)
Short name:
TSK-6
Short name:
TSSK-6
Short name:
Testis-specific kinase 6
Alternative name(s):
Serine/threonine-protein kinase SSTK
Small serine/threonine kinase
Gene namesi
Name:Tssk6Imported
Synonyms:SstkImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2148775 Tssk6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Mice are sterile due to profound impairment in motility and morphology of spermatozoa.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277471 – 273Testis-specific serine/threonine-protein kinase 6Add BLAST273

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ925K9
PRIDEiQ925K9

PTM databases

PhosphoSitePlusiQ925K9

Expressioni

Tissue specificityi

Expressed in the testis, localized to the heads of elongating spermatids.1 Publication

Gene expression databases

BgeeiENSMUSG00000047654
CleanExiMM_TSSK6
GenevisibleiQ925K9 MM

Interactioni

Subunit structurei

Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062783

Structurei

3D structure databases

ProteinModelPortaliQ925K9
SMRiQ925K9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 267Protein kinasePROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00770000120521
HOGENOMiHOG000233016
HOVERGENiHBG101110
InParanoidiQ925K9
KOiK08811
OMAiCWPALRT
OrthoDBiEOG091G0EZI
PhylomeDBiQ925K9
TreeFamiTF105333

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q925K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDKLLSEL GYKLGRTIGE GSYSKVKVAT SKKYKGTVAI KVVDRRRAPP
60 70 80 90 100
DFVNKFLPRE LSILRGVRHP HIVHVFEFIE VCNGKLYIVM EAAATDLLQA
110 120 130 140 150
VQRNGRIPGS QARELFSQIA GAVRYLHDHH LVHRDLKCEN VLLSPDERRV
160 170 180 190 200
KITDFGFGRQ AHGYPDLSTT YCGSAAYASP EVLLGIPYDP KKYDVWSLGV
210 220 230 240 250
VLYVMVTGCM PFDDSDIAGL PRRQKRGVLY PDGLELSERC KSLIAELLQF
260 270
SPSARPSAGQ VARNGWLRAG DSG
Length:273
Mass (Da):30,287
Last modified:December 1, 2001 - v1
Checksum:iA04A76290EA7E4B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61L → M in BAC36437 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329484 mRNA Translation: AAK48828.1
BC049542 mRNA No translation available.
AK076653 mRNA Translation: BAC36437.2
CCDSiCCDS22354.1
RefSeqiNP_114393.1, NM_032004.2
UniGeneiMm.432504

Genome annotation databases

EnsembliENSMUST00000050373; ENSMUSP00000062783; ENSMUSG00000047654
GeneIDi83984
KEGGimmu:83984
UCSCiuc009lye.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTSSK6_MOUSE
AccessioniPrimary (citable) accession number: Q925K9
Secondary accession number(s): Q5RL09, Q8C625
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health