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Protein

Taste receptor type 1 member 2

Gene

Tas1r2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 2
Alternative name(s):
G-protein coupled receptor 71
Sweet taste receptor T1R2
Gene namesi
Name:Tas1r2
Synonyms:Gpr71, T1r2, Tr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1933546 Tas1r2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 570ExtracellularSequence analysisAdd BLAST551
Transmembranei571 – 591Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini592 – 606CytoplasmicSequence analysisAdd BLAST15
Transmembranei607 – 627Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini628 – 642ExtracellularSequence analysisAdd BLAST15
Transmembranei643 – 663Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini664 – 682CytoplasmicSequence analysisAdd BLAST19
Transmembranei683 – 703Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini704 – 731ExtracellularSequence analysisAdd BLAST28
Transmembranei732 – 752Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini753 – 764CytoplasmicSequence analysisAdd BLAST12
Transmembranei765 – 785Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini786 – 789ExtracellularSequence analysis4
Transmembranei790 – 810Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini811 – 843CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001295820 – 843Taste receptor type 1 member 2Add BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ925I4
PRIDEiQ925I4

PTM databases

PhosphoSitePlusiQ925I4

Expressioni

Tissue specificityi

Expressed mainly in circumvallate and foliate taste papillae.1 Publication

Gene expression databases

BgeeiENSMUSG00000028738
CleanExiMM_TAS1R2
ExpressionAtlasiQ925I4 baseline and differential
GenevisibleiQ925I4 MM

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.

Protein-protein interaction databases

IntActiQ925I4, 1 interactor
STRINGi10090.ENSMUSP00000030510

Structurei

3D structure databases

ProteinModelPortaliQ925I4
SMRiQ925I4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOGENOMiHOG000038047
HOVERGENiHBG108601
InParanoidiQ925I4
KOiK04625
OMAiFITLSMT
OrthoDBiEOG091G035J
PhylomeDBiQ925I4
TreeFamiTF331269

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q925I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPQARTLHL LFLLLHALPK PVMLVGNSDF HLAGDYLLGG LFTLHANVKS
60 70 80 90 100
VSHLSYLQVP KCNEYNMKVL GYNLMQAMRF AVEEINNCSS LLPGVLLGYE
110 120 130 140 150
MVDVCYLSNN IQPGLYFLSQ IDDFLPILKD YSQYRPQVVA VIGPDNSESA
160 170 180 190 200
ITVSNILSYF LVPQVTYSAI TDKLRDKRRF PAMLRTVPSA THHIEAMVQL
210 220 230 240 250
MVHFQWNWIV VLVSDDDYGR ENSHLLSQRL TNTGDICIAF QEVLPVPEPN
260 270 280 290 300
QAVRPEEQDQ LDNILDKLRR TSARVVVIFS PELSLHNFFR EVLRWNFTGF
310 320 330 340 350
VWIASESWAI DPVLHNLTEL RHTGTFLGVT IQRVSIPGFS QFRVRHDKPE
360 370 380 390 400
YPMPNETSLR TTCNQDCDAC MNITESFNNV LMLSGERVVY SVYSAVYAVA
410 420 430 440 450
HTLHRLLHCN QVRCTKQIVY PWQLLREIWH VNFTLLGNQL FFDEQGDMPM
460 470 480 490 500
LLDIIQWQWG LSQNPFQSIA SYSPTETRLT YISNVSWYTP NNTVPISMCS
510 520 530 540 550
KSCQPGQMKK PIGLHPCCFE CVDCPPGTYL NRSVDEFNCL SCPGSMWSYK
560 570 580 590 600
NNIACFKRRL AFLEWHEVPT IVVTILAALG FISTLAILLI FWRHFQTPMV
610 620 630 640 650
RSAGGPMCFL MLVPLLLAFG MVPVYVGPPT VFSCFCRQAF FTVCFSVCLS
660 670 680 690 700
CITVRSFQIV CVFKMARRLP SAYGFWMRYH GPYVFVAFIT AVKVALVAGN
710 720 730 740 750
MLATTINPIG RTDPDDPNII ILSCHPNYRN GLLFNTSMDL LLSVLGFSFA
760 770 780 790 800
YVGKELPTNY NEAKFITLSM TFSFTSSISL CTFMSVHDGV LVTIMDLLVT
810 820 830 840
VLNFLAIGLG YFGPKCYMIL FYPERNTSAY FNSMIQGYTM RKS
Length:843
Mass (Da):95,736
Last modified:December 1, 2001 - v1
Checksum:i0543834EA4E7AC2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175R → Q in AAK51604 (PubMed:11509186).Curated1
Sequence conflicti527G → D in AAK51604 (PubMed:11509186).Curated1
Sequence conflicti695A → V (PubMed:12892531).Curated1
Sequence conflicti701M → T (PubMed:12892531).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti350E → G in strain: DBA/2J. 1 Publication1
Natural varianti352P → R in strain: DBA/2J. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337041 mRNA Translation: AAK39438.1
AY032623 mRNA Translation: AAK51604.1
AL831790 Genomic DNA No translation available.
CCDSiCCDS18849.1
RefSeqiNP_114079.1, NM_031873.1
UniGeneiMm.190612

Genome annotation databases

EnsembliENSMUST00000030510; ENSMUSP00000030510; ENSMUSG00000028738
GeneIDi83770
KEGGimmu:83770
UCSCiuc008vmr.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTS1R2_MOUSE
AccessioniPrimary (citable) accession number: Q925I4
Secondary accession number(s): B1AXX0, Q923J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health