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Protein

Taste receptor type 1 member 2

Gene

Tas1r2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 2
Alternative name(s):
G-protein coupled receptor 71
Sweet taste receptor T1R2
Gene namesi
Name:Tas1r2
Synonyms:Gpr71, T1r2, Tr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1933546. Tas1r2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 570551ExtracellularSequence analysisAdd
BLAST
Transmembranei571 – 59121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini592 – 60615CytoplasmicSequence analysisAdd
BLAST
Transmembranei607 – 62721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini628 – 64215ExtracellularSequence analysisAdd
BLAST
Transmembranei643 – 66321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini664 – 68219CytoplasmicSequence analysisAdd
BLAST
Transmembranei683 – 70321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini704 – 73128ExtracellularSequence analysisAdd
BLAST
Transmembranei732 – 75221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini753 – 76412CytoplasmicSequence analysisAdd
BLAST
Transmembranei765 – 78521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini786 – 7894ExtracellularSequence analysis
Transmembranei790 – 81021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini811 – 84333CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 843824Taste receptor type 1 member 2PRO_0000012958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence analysis
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence analysis
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence analysis
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ925I4.
PRIDEiQ925I4.

PTM databases

PhosphoSiteiQ925I4.

Expressioni

Tissue specificityi

Expressed mainly in circumvallate and foliate taste papillae.1 Publication

Gene expression databases

BgeeiQ925I4.
CleanExiMM_TAS1R2.
ExpressionAtlasiQ925I4. baseline and differential.
GenevisibleiQ925I4. MM.

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030510.

Structurei

3D structure databases

ProteinModelPortaliQ925I4.
SMRiQ925I4. Positions 28-487, 562-826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ925I4.
KOiK04625.
OMAiVAYMVVP.
OrthoDBiEOG7H791N.
PhylomeDBiQ925I4.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q925I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPQARTLHL LFLLLHALPK PVMLVGNSDF HLAGDYLLGG LFTLHANVKS
60 70 80 90 100
VSHLSYLQVP KCNEYNMKVL GYNLMQAMRF AVEEINNCSS LLPGVLLGYE
110 120 130 140 150
MVDVCYLSNN IQPGLYFLSQ IDDFLPILKD YSQYRPQVVA VIGPDNSESA
160 170 180 190 200
ITVSNILSYF LVPQVTYSAI TDKLRDKRRF PAMLRTVPSA THHIEAMVQL
210 220 230 240 250
MVHFQWNWIV VLVSDDDYGR ENSHLLSQRL TNTGDICIAF QEVLPVPEPN
260 270 280 290 300
QAVRPEEQDQ LDNILDKLRR TSARVVVIFS PELSLHNFFR EVLRWNFTGF
310 320 330 340 350
VWIASESWAI DPVLHNLTEL RHTGTFLGVT IQRVSIPGFS QFRVRHDKPE
360 370 380 390 400
YPMPNETSLR TTCNQDCDAC MNITESFNNV LMLSGERVVY SVYSAVYAVA
410 420 430 440 450
HTLHRLLHCN QVRCTKQIVY PWQLLREIWH VNFTLLGNQL FFDEQGDMPM
460 470 480 490 500
LLDIIQWQWG LSQNPFQSIA SYSPTETRLT YISNVSWYTP NNTVPISMCS
510 520 530 540 550
KSCQPGQMKK PIGLHPCCFE CVDCPPGTYL NRSVDEFNCL SCPGSMWSYK
560 570 580 590 600
NNIACFKRRL AFLEWHEVPT IVVTILAALG FISTLAILLI FWRHFQTPMV
610 620 630 640 650
RSAGGPMCFL MLVPLLLAFG MVPVYVGPPT VFSCFCRQAF FTVCFSVCLS
660 670 680 690 700
CITVRSFQIV CVFKMARRLP SAYGFWMRYH GPYVFVAFIT AVKVALVAGN
710 720 730 740 750
MLATTINPIG RTDPDDPNII ILSCHPNYRN GLLFNTSMDL LLSVLGFSFA
760 770 780 790 800
YVGKELPTNY NEAKFITLSM TFSFTSSISL CTFMSVHDGV LVTIMDLLVT
810 820 830 840
VLNFLAIGLG YFGPKCYMIL FYPERNTSAY FNSMIQGYTM RKS
Length:843
Mass (Da):95,736
Last modified:December 1, 2001 - v1
Checksum:i0543834EA4E7AC2E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751R → Q in AAK51604 (PubMed:11509186).Curated
Sequence conflicti527 – 5271G → D in AAK51604 (PubMed:11509186).Curated
Sequence conflicti695 – 6951A → V (PubMed:12892531).Curated
Sequence conflicti701 – 7011M → T (PubMed:12892531).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti350 – 3501E → G in strain: DBA/2J. 1 Publication
Natural varianti352 – 3521P → R in strain: DBA/2J. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337041 mRNA. Translation: AAK39438.1.
AY032623 mRNA. Translation: AAK51604.1.
AL831790 Genomic DNA. Translation: CAM21312.1.
CCDSiCCDS18849.1.
RefSeqiNP_114079.1. NM_031873.1.
UniGeneiMm.190612.

Genome annotation databases

EnsembliENSMUST00000030510; ENSMUSP00000030510; ENSMUSG00000028738.
GeneIDi83770.
KEGGimmu:83770.
UCSCiuc008vmr.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337041 mRNA. Translation: AAK39438.1.
AY032623 mRNA. Translation: AAK51604.1.
AL831790 Genomic DNA. Translation: CAM21312.1.
CCDSiCCDS18849.1.
RefSeqiNP_114079.1. NM_031873.1.
UniGeneiMm.190612.

3D structure databases

ProteinModelPortaliQ925I4.
SMRiQ925I4. Positions 28-487, 562-826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030510.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ925I4.

Proteomic databases

PaxDbiQ925I4.
PRIDEiQ925I4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030510; ENSMUSP00000030510; ENSMUSG00000028738.
GeneIDi83770.
KEGGimmu:83770.
UCSCiuc008vmr.1. mouse.

Organism-specific databases

CTDi80834.
MGIiMGI:1933546. Tas1r2.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ925I4.
KOiK04625.
OMAiVAYMVVP.
OrthoDBiEOG7H791N.
PhylomeDBiQ925I4.
TreeFamiTF331269.

Enzyme and pathway databases

ReactomeiR-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

ChiTaRSiTas1r2. mouse.
NextBioi350768.
PROiQ925I4.
SOURCEiSearch...

Gene expression databases

BgeeiQ925I4.
CleanExiMM_TAS1R2.
ExpressionAtlasiQ925I4. baseline and differential.
GenevisibleiQ925I4. MM.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A candidate taste receptor gene near a sweet taste locus."
    Montmayeur J.-P., Liberles S.D., Matsunami H., Buck L.B.
    Nat. Neurosci. 4:492-498(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS GLY-350 AND ARG-352.
    Strain: C57BL/6J and DBA/2J.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose."
    Ariyasu T., Matsumoto S., Kyono F., Hanaya T., Arai S., Ikeda M., Kurimoto M.
    In Vitro Cell. Dev. Biol. Anim. 39:80-88(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiTS1R2_MOUSE
AccessioniPrimary (citable) accession number: Q925I4
Secondary accession number(s): B1AXX0, Q923J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.