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Q925H1

- TRPS1_MOUSE

UniProt

Q925H1 - TRPS1_MOUSE

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Protein
Zinc finger transcription factor Trps1
Gene
Trps1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24726C2H2-type 1; atypical
Add
BLAST
Zinc fingeri333 – 35826C2H2-type 2; atypical
Add
BLAST
Zinc fingeri614 – 63724C2H2-type 3; atypical
Add
BLAST
Zinc fingeri666 – 68924C2H2-type 4
Add
BLAST
Zinc fingeri692 – 71524C2H2-type 5
Add
BLAST
Zinc fingeri896 – 92025GATA-type
Add
BLAST
Zinc fingeri1215 – 123723C2H2-type 6
Add
BLAST
Zinc fingeri1243 – 126725C2H2-type 7
Add
BLAST

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. chondrocyte differentiation Source: MGI
  2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. negative regulation of transcription, DNA-templated Source: MGI
  4. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  5. regulation of chondrocyte differentiation Source: UniProtKB
  6. regulation of histone deacetylation Source: InterPro
  7. transcription, DNA-templated Source: UniProtKB-KW
  8. transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger transcription factor Trps1
Gene namesi
Name:Trps1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1927616. Trps1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12811281Zinc finger transcription factor Trps1
PRO_0000083509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1041 – 10411Phosphoserine By similarity
Modified residuei1085 – 10851Phosphoserine By similarity
Cross-linki1192 – 1192Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Cross-linki1201 – 1201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity

Post-translational modificationi

Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites By similarity.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ925H1.
PRIDEiQ925H1.

PTM databases

PhosphoSiteiQ925H1.

Expressioni

Tissue specificityi

In the embryo, expression is detected in both visceral and skeletal tissues. Found in the maxilla, mandible, snout, prospective phalanges and in the femoral head within the developing hip. Also expressed in the hair follicles.

Developmental stagei

Detected prior to E7.5, with peak levels at around E11.5. In the developing limbs and face, levels are highest at E13.5 and decline dramatically thereafter.1 Publication

Gene expression databases

CleanExiMM_TRPS1.
GenevestigatoriQ925H1.

Interactioni

Subunit structurei

Interacts with RNF4; regulates TRPS1 repressor activity. Interacts specifically with the activator form of GLI3 (GLI3A) but not with the repressor form (GLI3R).2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077089.

Structurei

3D structure databases

ProteinModelPortaliQ925H1.
SMRiQ925H1. Positions 423-468, 523-646, 686-726, 893-938.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni635 – 819185Mediates interaction with GLI3 By similarity
Add
BLAST
Regioni985 – 1184200Mediates interaction with RNF4
Add
BLAST
Regioni1163 – 1281119Transcriptional repressor domain By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
HOGENOMiHOG000146438.
HOVERGENiHBG067120.
InParanoidiQ925H1.
PhylomeDBiQ925H1.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR028440. Trps1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF6. PTHR10071:SF6. 1 hit.
PfamiPF00320. GATA. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00355. ZnF_C2H2. 9 hits.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 1 hit.
PS50114. GATA_ZN_FINGER_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925H1-1 [UniParc]FASTAAdd to Basket

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MVRKKHPPLR NVASEGEGQT LEPTATESKV SGKNKELSAD QMSENTDQSD     50
VAELNSKEEH STHGQEPSSS GKKDLQISGL SEKAGFNYES PSKGGSLVSF 100
PHDEVTDRNM LAFSSPAAGG VCEPLKSPQR AEADDPQDMA CTPSGDSLET 150
KEEHKMSPKA TEETGPVQSG QANCQGLSPV SVASKNPQVP SDGGVRLSKP 200
KGDLLVNDNP DPAPLSPELQ DFKCNICGYG YYGNDPTDLI KHFRKYHLGL 250
HNRTRQDAEL DSKILALHNM VQFSHSKDFQ KVNRSVLSGV LQDISSSRPA 300
LLNGTYDVQV TSGGTFIGIG RKTPDCQGNT KYFRCKFCNF TYMGNSSTEL 350
EQHFLQTHPN KIKVSLPSSE GVKPSEKNSN KSIPALRASD SGDVGKWQDK 400
MTVKAGDDTP VGYSVPIKPL DSSRQNGTEA TSYYWCKFCS FSCESSSSLK 450
LLEHYGKQHG AVQSGGLNPE LNDKLPRGSV INQNDLAKSV EGEPLTKPEK 500
GLSGAKKKDF PSKGAEDNMV TSYNCQFCDF RYSKSHGPDV IVVGPLLRHY 550
QQLHNIHKCT IKHCPFCPRG LCSPEKHLGE ITYPFACRKS NCSHCALLLL 600
HLSPGVAGSS RVKHQCHQCS FSTPDVDVLL FHYETVHESQ ASDVKQEANH 650
LLGSDGQQAV RDSKEHSCTK CDFITQVEEE ISRHYRRAHS CYKCRQCSFT 700
AADTQSLLEH FNTVHCQEQE ITTANGEEGG HAIPTIKEEP KIDLKVYSLL 750
NPDSKMGETV PESIVKREKL DDKEGLKDKI WTESSTDDLR GVAWRGADIL 800
RGSPSYTQAS LGLLTPVSSS QEQTKTLRDS PNVEAAHLAR PMYGLAVDTK 850
GFLQGAPAGS EKSASLTQQY PASGESKTKD ESQSLLRRRR GSGVFCANCL 900
TTKTSLWRKN ANGGYVCNAC GLYQKLHSTP RPLNIIKQNN GEQIIRRRTR 950
KRLNPEALQA EQLNKQQRGS GEEQVNGSPL ERRSEDHLSE SHPREIPLPS 1000
LSKYEAQGSL TKSHSAQQPV LVSQALDIHK RMQPLHIQIK SPQESTGDPG 1050
NSSSVSDGKG SSERGSPIEK YMRPAKHPNY SPPGSPIEKY QYPLFGVPFV 1100
HNDFQSEADW LRFWSKYKLS VPGNPHYLSH VPGLPNPCQN YVPYPTFNLP 1150
PHFSAVGSDN DIPLDLAIKH SRPGPTANGA SKEKTKAPPT VKNEDPLNVV 1200
KTEKVDRSTQ DELSTKCVHC GIVFLDEVMY ALHMSCHGDS GPFQCSICQH 1250
LCTDKYDFTT HIQRGLHRNN AQAEKNGKPK E 1281
Length:1,281
Mass (Da):141,035
Last modified:December 1, 2001 - v1
Checksum:iF0A71900C2357898
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF346836 mRNA. Translation: AAK39508.1.
CCDSiCCDS27460.1.
UniGeneiMm.30466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF346836 mRNA. Translation: AAK39508.1 .
CCDSi CCDS27460.1.
UniGenei Mm.30466.

3D structure databases

ProteinModelPortali Q925H1.
SMRi Q925H1. Positions 423-468, 523-646, 686-726, 893-938.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000077089.

PTM databases

PhosphoSitei Q925H1.

Proteomic databases

PaxDbi Q925H1.
PRIDEi Q925H1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1927616. Trps1.

Phylogenomic databases

eggNOGi COG5641.
HOGENOMi HOG000146438.
HOVERGENi HBG067120.
InParanoidi Q925H1.
PhylomeDBi Q925H1.

Miscellaneous databases

ChiTaRSi TRPS1. mouse.
PROi Q925H1.
SOURCEi Search...

Gene expression databases

CleanExi MM_TRPS1.
Genevestigatori Q925H1.

Family and domain databases

Gene3Di 3.30.50.10. 1 hit.
InterProi IPR028440. Trps1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
PANTHERi PTHR10071:SF6. PTHR10071:SF6. 1 hit.
Pfami PF00320. GATA. 1 hit.
[Graphical view ]
PRINTSi PR00619. GATAZNFINGER.
SMARTi SM00355. ZnF_C2H2. 9 hits.
SM00401. ZnF_GATA. 1 hit.
[Graphical view ]
PROSITEi PS00344. GATA_ZN_FINGER_1. 1 hit.
PS50114. GATA_ZN_FINGER_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1."
    Malik T.H., Shoichet S.A., Latham P., Kroll T.G., Peters L.L., Shivdasani R.A.
    EMBO J. 20:1715-1725(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    Tissue: Fetal intestine.
  2. "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor."
    Kaiser F.J., Moeroey T., Chang G.T., Horsthemke B., Luedecke H.J.
    J. Biol. Chem. 278:38780-38785(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF4.
  3. "Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3."
    Wuelling M., Kaiser F.J., Buelens L.A., Braunholz D., Shivdasani R.A., Depping R., Vortkamp A.
    Dev. Biol. 328:40-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GLI3.

Entry informationi

Entry nameiTRPS1_MOUSE
AccessioniPrimary (citable) accession number: Q925H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi