Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q925H1

- TRPS1_MOUSE

UniProt

Q925H1 - TRPS1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger transcription factor Trps1

Gene

Trps1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24726C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35826C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri614 – 63724C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri666 – 68924C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri692 – 71524C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri896 – 92025GATA-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1215 – 123723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1243 – 126725C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. chondrocyte differentiation Source: MGI
  2. negative regulation of transcription, DNA-templated Source: MGI
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  5. regulation of chondrocyte differentiation Source: UniProtKB
  6. regulation of histone deacetylation Source: InterPro
  7. transcription, DNA-templated Source: UniProtKB-KW
  8. transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger transcription factor Trps1
Gene namesi
Name:Trps1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1927616. Trps1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12811281Zinc finger transcription factor Trps1PRO_0000083509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1041 – 10411PhosphoserineBy similarity
Modified residuei1085 – 10851PhosphoserineBy similarity
Cross-linki1192 – 1192Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki1201 – 1201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ925H1.
PaxDbiQ925H1.
PRIDEiQ925H1.

PTM databases

PhosphoSiteiQ925H1.

Expressioni

Tissue specificityi

In the embryo, expression is detected in both visceral and skeletal tissues. Found in the maxilla, mandible, snout, prospective phalanges and in the femoral head within the developing hip. Also expressed in the hair follicles.

Developmental stagei

Detected prior to E7.5, with peak levels at around E11.5. In the developing limbs and face, levels are highest at E13.5 and decline dramatically thereafter.1 Publication

Gene expression databases

CleanExiMM_TRPS1.
GenevestigatoriQ925H1.

Interactioni

Subunit structurei

Interacts with RNF4; regulates TRPS1 repressor activity. Interacts specifically with the activator form of GLI3 (GLI3A) but not with the repressor form (GLI3R).2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077089.

Structurei

3D structure databases

ProteinModelPortaliQ925H1.
SMRiQ925H1. Positions 423-468, 614-643, 687-718, 893-938.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni635 – 819185Mediates interaction with GLI3By similarityAdd
BLAST
Regioni985 – 1184200Mediates interaction with RNF4Add
BLAST
Regioni1163 – 1281119Transcriptional repressor domainBy similarityAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24726C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35826C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri614 – 63724C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri666 – 68924C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri692 – 71524C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri896 – 92025GATA-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1215 – 123723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1243 – 126725C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
HOGENOMiHOG000146438.
HOVERGENiHBG067120.
InParanoidiQ925H1.
PhylomeDBiQ925H1.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR028440. Trps1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF6. PTHR10071:SF6. 1 hit.
PfamiPF00320. GATA. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00355. ZnF_C2H2. 9 hits.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 1 hit.
PS50114. GATA_ZN_FINGER_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925H1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRKKHPPLR NVASEGEGQT LEPTATESKV SGKNKELSAD QMSENTDQSD
60 70 80 90 100
VAELNSKEEH STHGQEPSSS GKKDLQISGL SEKAGFNYES PSKGGSLVSF
110 120 130 140 150
PHDEVTDRNM LAFSSPAAGG VCEPLKSPQR AEADDPQDMA CTPSGDSLET
160 170 180 190 200
KEEHKMSPKA TEETGPVQSG QANCQGLSPV SVASKNPQVP SDGGVRLSKP
210 220 230 240 250
KGDLLVNDNP DPAPLSPELQ DFKCNICGYG YYGNDPTDLI KHFRKYHLGL
260 270 280 290 300
HNRTRQDAEL DSKILALHNM VQFSHSKDFQ KVNRSVLSGV LQDISSSRPA
310 320 330 340 350
LLNGTYDVQV TSGGTFIGIG RKTPDCQGNT KYFRCKFCNF TYMGNSSTEL
360 370 380 390 400
EQHFLQTHPN KIKVSLPSSE GVKPSEKNSN KSIPALRASD SGDVGKWQDK
410 420 430 440 450
MTVKAGDDTP VGYSVPIKPL DSSRQNGTEA TSYYWCKFCS FSCESSSSLK
460 470 480 490 500
LLEHYGKQHG AVQSGGLNPE LNDKLPRGSV INQNDLAKSV EGEPLTKPEK
510 520 530 540 550
GLSGAKKKDF PSKGAEDNMV TSYNCQFCDF RYSKSHGPDV IVVGPLLRHY
560 570 580 590 600
QQLHNIHKCT IKHCPFCPRG LCSPEKHLGE ITYPFACRKS NCSHCALLLL
610 620 630 640 650
HLSPGVAGSS RVKHQCHQCS FSTPDVDVLL FHYETVHESQ ASDVKQEANH
660 670 680 690 700
LLGSDGQQAV RDSKEHSCTK CDFITQVEEE ISRHYRRAHS CYKCRQCSFT
710 720 730 740 750
AADTQSLLEH FNTVHCQEQE ITTANGEEGG HAIPTIKEEP KIDLKVYSLL
760 770 780 790 800
NPDSKMGETV PESIVKREKL DDKEGLKDKI WTESSTDDLR GVAWRGADIL
810 820 830 840 850
RGSPSYTQAS LGLLTPVSSS QEQTKTLRDS PNVEAAHLAR PMYGLAVDTK
860 870 880 890 900
GFLQGAPAGS EKSASLTQQY PASGESKTKD ESQSLLRRRR GSGVFCANCL
910 920 930 940 950
TTKTSLWRKN ANGGYVCNAC GLYQKLHSTP RPLNIIKQNN GEQIIRRRTR
960 970 980 990 1000
KRLNPEALQA EQLNKQQRGS GEEQVNGSPL ERRSEDHLSE SHPREIPLPS
1010 1020 1030 1040 1050
LSKYEAQGSL TKSHSAQQPV LVSQALDIHK RMQPLHIQIK SPQESTGDPG
1060 1070 1080 1090 1100
NSSSVSDGKG SSERGSPIEK YMRPAKHPNY SPPGSPIEKY QYPLFGVPFV
1110 1120 1130 1140 1150
HNDFQSEADW LRFWSKYKLS VPGNPHYLSH VPGLPNPCQN YVPYPTFNLP
1160 1170 1180 1190 1200
PHFSAVGSDN DIPLDLAIKH SRPGPTANGA SKEKTKAPPT VKNEDPLNVV
1210 1220 1230 1240 1250
KTEKVDRSTQ DELSTKCVHC GIVFLDEVMY ALHMSCHGDS GPFQCSICQH
1260 1270 1280
LCTDKYDFTT HIQRGLHRNN AQAEKNGKPK E
Length:1,281
Mass (Da):141,035
Last modified:December 1, 2001 - v1
Checksum:iF0A71900C2357898
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346836 mRNA. Translation: AAK39508.1.
CCDSiCCDS27460.1.
UniGeneiMm.30466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346836 mRNA. Translation: AAK39508.1 .
CCDSi CCDS27460.1.
UniGenei Mm.30466.

3D structure databases

ProteinModelPortali Q925H1.
SMRi Q925H1. Positions 423-468, 614-643, 687-718, 893-938.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000077089.

PTM databases

PhosphoSitei Q925H1.

Proteomic databases

MaxQBi Q925H1.
PaxDbi Q925H1.
PRIDEi Q925H1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1927616. Trps1.

Phylogenomic databases

eggNOGi COG5641.
HOGENOMi HOG000146438.
HOVERGENi HBG067120.
InParanoidi Q925H1.
PhylomeDBi Q925H1.

Miscellaneous databases

ChiTaRSi Trps1. mouse.
PROi Q925H1.
SOURCEi Search...

Gene expression databases

CleanExi MM_TRPS1.
Genevestigatori Q925H1.

Family and domain databases

Gene3Di 3.30.50.10. 1 hit.
InterProi IPR028440. Trps1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
PANTHERi PTHR10071:SF6. PTHR10071:SF6. 1 hit.
Pfami PF00320. GATA. 1 hit.
[Graphical view ]
PRINTSi PR00619. GATAZNFINGER.
SMARTi SM00355. ZnF_C2H2. 9 hits.
SM00401. ZnF_GATA. 1 hit.
[Graphical view ]
PROSITEi PS00344. GATA_ZN_FINGER_1. 1 hit.
PS50114. GATA_ZN_FINGER_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1."
    Malik T.H., Shoichet S.A., Latham P., Kroll T.G., Peters L.L., Shivdasani R.A.
    EMBO J. 20:1715-1725(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    Tissue: Fetal intestine.
  2. "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor."
    Kaiser F.J., Moeroey T., Chang G.T., Horsthemke B., Luedecke H.J.
    J. Biol. Chem. 278:38780-38785(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF4.
  3. "Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3."
    Wuelling M., Kaiser F.J., Buelens L.A., Braunholz D., Shivdasani R.A., Depping R., Vortkamp A.
    Dev. Biol. 328:40-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GLI3.

Entry informationi

Entry nameiTRPS1_MOUSE
AccessioniPrimary (citable) accession number: Q925H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3