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Q925H1

- TRPS1_MOUSE

UniProt

Q925H1 - TRPS1_MOUSE

Protein

Zinc finger transcription factor Trps1

Gene

Trps1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri222 – 24726C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 35826C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri614 – 63724C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri666 – 68924C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri692 – 71524C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri896 – 92025GATA-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1215 – 123723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1243 – 126725C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. chondrocyte differentiation Source: MGI
    2. negative regulation of transcription, DNA-templated Source: MGI
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    5. regulation of chondrocyte differentiation Source: UniProtKB
    6. regulation of histone deacetylation Source: InterPro
    7. transcription, DNA-templated Source: UniProtKB-KW
    8. transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger transcription factor Trps1
    Gene namesi
    Name:Trps1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1927616. Trps1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12811281Zinc finger transcription factor Trps1PRO_0000083509Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1041 – 10411PhosphoserineBy similarity
    Modified residuei1085 – 10851PhosphoserineBy similarity
    Cross-linki1192 – 1192Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Cross-linki1201 – 1201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

    Post-translational modificationi

    Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites By similarity.By similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ925H1.
    PRIDEiQ925H1.

    PTM databases

    PhosphoSiteiQ925H1.

    Expressioni

    Tissue specificityi

    In the embryo, expression is detected in both visceral and skeletal tissues. Found in the maxilla, mandible, snout, prospective phalanges and in the femoral head within the developing hip. Also expressed in the hair follicles.

    Developmental stagei

    Detected prior to E7.5, with peak levels at around E11.5. In the developing limbs and face, levels are highest at E13.5 and decline dramatically thereafter.1 Publication

    Gene expression databases

    CleanExiMM_TRPS1.
    GenevestigatoriQ925H1.

    Interactioni

    Subunit structurei

    Interacts with RNF4; regulates TRPS1 repressor activity. Interacts specifically with the activator form of GLI3 (GLI3A) but not with the repressor form (GLI3R).2 Publications

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000077089.

    Structurei

    3D structure databases

    ProteinModelPortaliQ925H1.
    SMRiQ925H1. Positions 423-468, 523-646, 686-726, 893-938.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni635 – 819185Mediates interaction with GLI3By similarityAdd
    BLAST
    Regioni985 – 1184200Mediates interaction with RNF4Add
    BLAST
    Regioni1163 – 1281119Transcriptional repressor domainBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri222 – 24726C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 35826C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri614 – 63724C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri666 – 68924C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri692 – 71524C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri896 – 92025GATA-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1215 – 123723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1243 – 126725C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5641.
    HOGENOMiHOG000146438.
    HOVERGENiHBG067120.
    InParanoidiQ925H1.
    PhylomeDBiQ925H1.

    Family and domain databases

    Gene3Di3.30.50.10. 1 hit.
    InterProiIPR028440. Trps1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PANTHERiPTHR10071:SF6. PTHR10071:SF6. 1 hit.
    PfamiPF00320. GATA. 1 hit.
    [Graphical view]
    PRINTSiPR00619. GATAZNFINGER.
    SMARTiSM00355. ZnF_C2H2. 9 hits.
    SM00401. ZnF_GATA. 1 hit.
    [Graphical view]
    PROSITEiPS00344. GATA_ZN_FINGER_1. 1 hit.
    PS50114. GATA_ZN_FINGER_2. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q925H1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRKKHPPLR NVASEGEGQT LEPTATESKV SGKNKELSAD QMSENTDQSD     50
    VAELNSKEEH STHGQEPSSS GKKDLQISGL SEKAGFNYES PSKGGSLVSF 100
    PHDEVTDRNM LAFSSPAAGG VCEPLKSPQR AEADDPQDMA CTPSGDSLET 150
    KEEHKMSPKA TEETGPVQSG QANCQGLSPV SVASKNPQVP SDGGVRLSKP 200
    KGDLLVNDNP DPAPLSPELQ DFKCNICGYG YYGNDPTDLI KHFRKYHLGL 250
    HNRTRQDAEL DSKILALHNM VQFSHSKDFQ KVNRSVLSGV LQDISSSRPA 300
    LLNGTYDVQV TSGGTFIGIG RKTPDCQGNT KYFRCKFCNF TYMGNSSTEL 350
    EQHFLQTHPN KIKVSLPSSE GVKPSEKNSN KSIPALRASD SGDVGKWQDK 400
    MTVKAGDDTP VGYSVPIKPL DSSRQNGTEA TSYYWCKFCS FSCESSSSLK 450
    LLEHYGKQHG AVQSGGLNPE LNDKLPRGSV INQNDLAKSV EGEPLTKPEK 500
    GLSGAKKKDF PSKGAEDNMV TSYNCQFCDF RYSKSHGPDV IVVGPLLRHY 550
    QQLHNIHKCT IKHCPFCPRG LCSPEKHLGE ITYPFACRKS NCSHCALLLL 600
    HLSPGVAGSS RVKHQCHQCS FSTPDVDVLL FHYETVHESQ ASDVKQEANH 650
    LLGSDGQQAV RDSKEHSCTK CDFITQVEEE ISRHYRRAHS CYKCRQCSFT 700
    AADTQSLLEH FNTVHCQEQE ITTANGEEGG HAIPTIKEEP KIDLKVYSLL 750
    NPDSKMGETV PESIVKREKL DDKEGLKDKI WTESSTDDLR GVAWRGADIL 800
    RGSPSYTQAS LGLLTPVSSS QEQTKTLRDS PNVEAAHLAR PMYGLAVDTK 850
    GFLQGAPAGS EKSASLTQQY PASGESKTKD ESQSLLRRRR GSGVFCANCL 900
    TTKTSLWRKN ANGGYVCNAC GLYQKLHSTP RPLNIIKQNN GEQIIRRRTR 950
    KRLNPEALQA EQLNKQQRGS GEEQVNGSPL ERRSEDHLSE SHPREIPLPS 1000
    LSKYEAQGSL TKSHSAQQPV LVSQALDIHK RMQPLHIQIK SPQESTGDPG 1050
    NSSSVSDGKG SSERGSPIEK YMRPAKHPNY SPPGSPIEKY QYPLFGVPFV 1100
    HNDFQSEADW LRFWSKYKLS VPGNPHYLSH VPGLPNPCQN YVPYPTFNLP 1150
    PHFSAVGSDN DIPLDLAIKH SRPGPTANGA SKEKTKAPPT VKNEDPLNVV 1200
    KTEKVDRSTQ DELSTKCVHC GIVFLDEVMY ALHMSCHGDS GPFQCSICQH 1250
    LCTDKYDFTT HIQRGLHRNN AQAEKNGKPK E 1281
    Length:1,281
    Mass (Da):141,035
    Last modified:December 1, 2001 - v1
    Checksum:iF0A71900C2357898
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF346836 mRNA. Translation: AAK39508.1.
    CCDSiCCDS27460.1.
    UniGeneiMm.30466.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF346836 mRNA. Translation: AAK39508.1 .
    CCDSi CCDS27460.1.
    UniGenei Mm.30466.

    3D structure databases

    ProteinModelPortali Q925H1.
    SMRi Q925H1. Positions 423-468, 523-646, 686-726, 893-938.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000077089.

    PTM databases

    PhosphoSitei Q925H1.

    Proteomic databases

    PaxDbi Q925H1.
    PRIDEi Q925H1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1927616. Trps1.

    Phylogenomic databases

    eggNOGi COG5641.
    HOGENOMi HOG000146438.
    HOVERGENi HBG067120.
    InParanoidi Q925H1.
    PhylomeDBi Q925H1.

    Miscellaneous databases

    ChiTaRSi TRPS1. mouse.
    PROi Q925H1.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_TRPS1.
    Genevestigatori Q925H1.

    Family and domain databases

    Gene3Di 3.30.50.10. 1 hit.
    InterProi IPR028440. Trps1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    PANTHERi PTHR10071:SF6. PTHR10071:SF6. 1 hit.
    Pfami PF00320. GATA. 1 hit.
    [Graphical view ]
    PRINTSi PR00619. GATAZNFINGER.
    SMARTi SM00355. ZnF_C2H2. 9 hits.
    SM00401. ZnF_GATA. 1 hit.
    [Graphical view ]
    PROSITEi PS00344. GATA_ZN_FINGER_1. 1 hit.
    PS50114. GATA_ZN_FINGER_2. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1."
      Malik T.H., Shoichet S.A., Latham P., Kroll T.G., Peters L.L., Shivdasani R.A.
      EMBO J. 20:1715-1725(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
      Tissue: Fetal intestine.
    2. "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor."
      Kaiser F.J., Moeroey T., Chang G.T., Horsthemke B., Luedecke H.J.
      J. Biol. Chem. 278:38780-38785(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RNF4.
    3. "Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3."
      Wuelling M., Kaiser F.J., Buelens L.A., Braunholz D., Shivdasani R.A., Depping R., Vortkamp A.
      Dev. Biol. 328:40-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GLI3.

    Entry informationi

    Entry nameiTRPS1_MOUSE
    AccessioniPrimary (citable) accession number: Q925H1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3