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Protein

Hepatoma-derived growth factor-related protein 2

Gene

Hdgfrp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cellular growth control, through the regulation of cyclin D1 expression.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 2
Short name:
HRP-2
Alternative name(s):
Hepatoma-derived growth factor 3
Short name:
HDGF-3
Gene namesi
Name:Hdgfrp2
Synonyms:Hdgf3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi621013. Hdgfrp2.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Hepatoma-derived growth factor-related protein 2PRO_0000317645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei366 – 3661PhosphoserineCombined sources
Modified residuei367 – 3671PhosphoserineBy similarity
Modified residuei450 – 4501PhosphoserineCombined sources
Modified residuei454 – 4541PhosphoserineCombined sources
Modified residuei609 – 6091PhosphothreonineCombined sources
Modified residuei628 – 6281PhosphoserineBy similarity
Modified residuei629 – 6291PhosphoserineBy similarity
Modified residuei635 – 6351PhosphoserineBy similarity
Modified residuei640 – 6401PhosphoserineBy similarity
Modified residuei659 – 6591PhosphoserineCombined sources
Modified residuei661 – 6611PhosphoserineCombined sources
Modified residuei669 – 6691PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ925G1.
PRIDEiQ925G1.

PTM databases

iPTMnetiQ925G1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000049142.
ExpressionAtlasiQ925G1. baseline and differential.
GenevisibleiQ925G1. RN.

Interactioni

Subunit structurei

Interacts with HDGF (By similarity). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3 (By similarity). Interacts with IWS1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064555.

Structurei

3D structure databases

ProteinModelPortaliQ925G1.
SMRiQ925G1. Positions 5-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6458PWWPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi223 – 2264Poly-Lys
Compositional biasi229 – 27143Ser-richAdd
BLAST
Compositional biasi322 – 36342Arg-richAdd
BLAST
Compositional biasi663 – 6686Poly-Asp

Sequence similaritiesi

Belongs to the HDGF family.Curated
Contains 1 PWWP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1904. Eukaryota.
ENOG4111PJT. LUCA.
GeneTreeiENSGT00530000063013.
HOVERGENiHBG099722.
InParanoidiQ925G1.
OMAiANKEVME.
OrthoDBiEOG091G045X.
PhylomeDBiQ925G1.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q925G1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET
60 70 80 90 100
AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPLPVSS
110 120 130 140 150
SDSEAPEADL GGGSDADKEK EARRVMTVTA VTTTATSGRT ESDSDSDKNS
160 170 180 190 200
DHSGLKRKTP VLKMSVSKRA RKASSDLDQA SVSPSEEDSE SPSESEKTSD
210 220 230 240 250
QDFTPEKKTI ARAPRRAPLG GRKKKKVPSA SDSDSRADSD GAKEEPVVTA
260 270 280 290 300
QPSPSSSSSS SSSSASDSDV SIKKPPRGRK PAEKPPPKPR GRRSKPERPP
310 320 330 340 350
STSSSDSDSD SGEVDRISEW KRRDEERRRE LEARRRREQE EELRRLREQE
360 370 380 390 400
REEKERRKER AERGGSSGEE LEDEEPVKKR SRKARGRGTP SSSDSEPEGE
410 420 430 440 450
LGKEGKKLAK KSQLQGSESA RKPGQKEKRG RPDEKPRARP VKVERTRKRS
460 470 480 490 500
EGLSLDRKGE KKKEPSVEER LQKLHSEIKF ALKVDNPDVR RCLSALEELG
510 520 530 540 550
TLQVTSQILQ KNTDVVATLK KIRRYKANKD VMAKAAEVYT RLKSRVLGPK
560 570 580 590 600
VEALQKVNKA GAEKERADGE KVEEQPGEQA PRELAEDEPS TDRSAPVNGE
610 620 630 640 650
AASQKGENTE DGAQEDGQDL EDGPRGGSSE ELHDSPQDSS DPARPGNEHQ
660
DHERMQLASE SADDDDEDS
Length:669
Mass (Da):74,018
Last modified:February 5, 2008 - v2
Checksum:i64EEA3192CDEE2A0
GO
Isoform 2 (identifier: Q925G1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     635-635: Missing.

Show »
Length:668
Mass (Da):73,931
Checksum:i046C79A334642BA9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571S → A in AAK50635 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei635 – 6351Missing in isoform 2. 1 PublicationVSP_031120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355102 mRNA. Translation: AAK50635.1.
BC071178 mRNA. Translation: AAH71178.1.
BC087695 mRNA. Translation: AAH87695.1.
RefSeqiNP_598232.1. NM_133548.1.
XP_006244353.1. XM_006244291.2. [Q925G1-2]
UniGeneiRn.29462.

Genome annotation databases

EnsembliENSRNOT00000073011; ENSRNOP00000064555; ENSRNOG00000049142. [Q925G1-1]
GeneIDi171073.
KEGGirno:171073.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355102 mRNA. Translation: AAK50635.1.
BC071178 mRNA. Translation: AAH71178.1.
BC087695 mRNA. Translation: AAH87695.1.
RefSeqiNP_598232.1. NM_133548.1.
XP_006244353.1. XM_006244291.2. [Q925G1-2]
UniGeneiRn.29462.

3D structure databases

ProteinModelPortaliQ925G1.
SMRiQ925G1. Positions 5-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064555.

PTM databases

iPTMnetiQ925G1.

Proteomic databases

PaxDbiQ925G1.
PRIDEiQ925G1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073011; ENSRNOP00000064555; ENSRNOG00000049142. [Q925G1-1]
GeneIDi171073.
KEGGirno:171073.

Organism-specific databases

CTDi84717.
RGDi621013. Hdgfrp2.

Phylogenomic databases

eggNOGiKOG1904. Eukaryota.
ENOG4111PJT. LUCA.
GeneTreeiENSGT00530000063013.
HOVERGENiHBG099722.
InParanoidiQ925G1.
OMAiANKEVME.
OrthoDBiEOG091G045X.
PhylomeDBiQ925G1.

Miscellaneous databases

PROiQ925G1.

Gene expression databases

BgeeiENSRNOG00000049142.
ExpressionAtlasiQ925G1. baseline and differential.
GenevisibleiQ925G1. RN.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHDGR2_RAT
AccessioniPrimary (citable) accession number: Q925G1
Secondary accession number(s): Q5PPH2, Q68G63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.