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Protein

Hepatoma-derived growth factor-related protein 2

Gene

Hdgfl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cellular growth control, through the regulation of cyclin D1 expression.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 2
Short name:
HRP-2
Alternative name(s):
Hepatoma-derived growth factor 3
Short name:
HDGF-3
Gene namesi
Name:Hdgfl2
Synonyms:Hdgf3, Hdgfrp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi621013 Hdgfl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176451 – 669Hepatoma-derived growth factor-related protein 2Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1
Modified residuei229PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei233PhosphoserineBy similarity1
Modified residuei239PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei366PhosphoserineCombined sources1
Modified residuei367PhosphoserineBy similarity1
Modified residuei391PhosphoserineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei393PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1
Modified residuei450PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Cross-linki550Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei609PhosphothreonineCombined sources1
Modified residuei628PhosphoserineBy similarity1
Modified residuei629PhosphoserineBy similarity1
Modified residuei635PhosphoserineBy similarity1
Modified residuei640PhosphoserineBy similarity1
Modified residuei659PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei669PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ925G1
PRIDEiQ925G1

PTM databases

iPTMnetiQ925G1

Expressioni

Gene expression databases

BgeeiENSRNOG00000049142
ExpressionAtlasiQ925G1 baseline and differential
GenevisibleiQ925G1 RN

Interactioni

Subunit structurei

Interacts with HDGF (By similarity). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3 (By similarity). Interacts with IWS1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064555

Structurei

3D structure databases

ProteinModelPortaliQ925G1
SMRiQ925G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 64PWWPPROSITE-ProRule annotationAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi223 – 226Poly-Lys4
Compositional biasi229 – 271Ser-richAdd BLAST43
Compositional biasi322 – 363Arg-richAdd BLAST42
Compositional biasi663 – 668Poly-Asp6

Sequence similaritiesi

Belongs to the HDGF family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1904 Eukaryota
ENOG4111PJT LUCA
GeneTreeiENSGT00530000063013
HOVERGENiHBG099722
InParanoidiQ925G1
OMAiANKEVME
OrthoDBiEOG091G045X
PhylomeDBiQ925G1

Family and domain databases

CDDicd05834 HDGF_related, 1 hit
Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035496 HDGF-rel_PWWP
IPR036218 HIVI-bd_sf
IPR021567 LEDGF_IBD
IPR000313 PWWP_dom
IPR035441 TFIIS/LEDGF_dom_sf
PfamiView protein in Pfam
PF11467 LEDGF, 1 hit
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
SUPFAMiSSF140576 SSF140576, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q925G1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET
60 70 80 90 100
AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPLPVSS
110 120 130 140 150
SDSEAPEADL GGGSDADKEK EARRVMTVTA VTTTATSGRT ESDSDSDKNS
160 170 180 190 200
DHSGLKRKTP VLKMSVSKRA RKASSDLDQA SVSPSEEDSE SPSESEKTSD
210 220 230 240 250
QDFTPEKKTI ARAPRRAPLG GRKKKKVPSA SDSDSRADSD GAKEEPVVTA
260 270 280 290 300
QPSPSSSSSS SSSSASDSDV SIKKPPRGRK PAEKPPPKPR GRRSKPERPP
310 320 330 340 350
STSSSDSDSD SGEVDRISEW KRRDEERRRE LEARRRREQE EELRRLREQE
360 370 380 390 400
REEKERRKER AERGGSSGEE LEDEEPVKKR SRKARGRGTP SSSDSEPEGE
410 420 430 440 450
LGKEGKKLAK KSQLQGSESA RKPGQKEKRG RPDEKPRARP VKVERTRKRS
460 470 480 490 500
EGLSLDRKGE KKKEPSVEER LQKLHSEIKF ALKVDNPDVR RCLSALEELG
510 520 530 540 550
TLQVTSQILQ KNTDVVATLK KIRRYKANKD VMAKAAEVYT RLKSRVLGPK
560 570 580 590 600
VEALQKVNKA GAEKERADGE KVEEQPGEQA PRELAEDEPS TDRSAPVNGE
610 620 630 640 650
AASQKGENTE DGAQEDGQDL EDGPRGGSSE ELHDSPQDSS DPARPGNEHQ
660
DHERMQLASE SADDDDEDS
Length:669
Mass (Da):74,018
Last modified:February 5, 2008 - v2
Checksum:i64EEA3192CDEE2A0
GO
Isoform 2 (identifier: Q925G1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     635-635: Missing.

Show »
Length:668
Mass (Da):73,931
Checksum:i046C79A334642BA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257S → A in AAK50635 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031120635Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355102 mRNA Translation: AAK50635.1
BC071178 mRNA Translation: AAH71178.1
BC087695 mRNA Translation: AAH87695.1
RefSeqiNP_598232.1, NM_133548.1
XP_006244353.1, XM_006244291.3 [Q925G1-2]
UniGeneiRn.29462

Genome annotation databases

EnsembliENSRNOT00000073011; ENSRNOP00000064555; ENSRNOG00000049142 [Q925G1-1]
GeneIDi171073
KEGGirno:171073

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHDGR2_RAT
AccessioniPrimary (citable) accession number: Q925G1
Secondary accession number(s): Q5PPH2, Q68G63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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