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Protein

RNA-binding protein 3

Gene

Rbm3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed (By similarity). Enhances phosphorylation of translation initiation factors and active polysome formation.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of translation Source: UniProtKB
  • regulation of translation Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 3
Alternative name(s):
RNA-binding motif protein 3
Gene namesi
Name:Rbm3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620145 Rbm3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003907751 – 155RNA-binding protein 3Add BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Omega-N-methylarginineBy similarity1
Modified residuei105Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei105Dimethylated arginine; alternateBy similarity1
Modified residuei105Omega-N-methylarginine; alternateBy similarity1
Modified residuei105Omega-N-methylated arginine; alternateBy similarity1
Modified residuei120Omega-N-methylarginineBy similarity1
Modified residuei130Omega-N-methylarginineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei145PhosphoserineBy similarity1
Modified residuei153PhosphotyrosineBy similarity1

Post-translational modificationi

Arg-105 is dimethylated, probably to asymmetric dimethylarginine.By similarity
Phosphorylated. Isoform 2 is methylated.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ925G0
PRIDEiQ925G0

Expressioni

Tissue specificityi

Widely expressed in the brain. Highly expressed in the cerebellum and olfactory bulb (at protein level). Expressed in neurons and glial cells.1 Publication

Interactioni

Subunit structurei

Interacts with RPL4. Associates with the 60S ribosomal subunits.1 Publication

Protein-protein interaction databases

IntActiQ925G0, 1 interactor
MINTiQ925G0
STRINGi10116.ENSRNOP00000007367

Structurei

3D structure databases

ProteinModelPortaliQ925G0
SMRiQ925G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 84RRMPROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
HOGENOMiHOG000276232
HOVERGENiHBG107480
InParanoidiQ925G0
KOiK13186
PhylomeDBiQ925G0

Family and domain databases

CDDicd12449 RRM_CIRBP_RBM3, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034278 RBM3/CIRBP_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q925G0-1) [UniParc]FASTAAdd to basket
Also known as: RBM3 Arg-

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSEEGKLFV GGLNFNTDEQ ALEDHFSSFG PISEVVVVKD RETQRSRGFG
60 70 80 90 100
FITFTNPEHA SDVMRAMNGE SLDGRQIRVD HAGKSARGTR GGAFGAHGRG
110 120 130 140 150
RSYSRGGGDQ GYGSGRYDSR PGGYGYGYGR SRDYSGSQGG YDRYSGGNYR

DNYDN
Length:155
Mass (Da):16,855
Last modified:January 19, 2010 - v2
Checksum:i9BD4118495D60411
GO
Isoform 2 (identifier: Q925G0-2) [UniParc]FASTAAdd to basket
Also known as: RBM3 Arg+

The sequence of this isoform differs from the canonical sequence as follows:
     136-136: G → GA

Show »
Length:156
Mass (Da):16,926
Checksum:iE9D15B3AD07FAD7B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63V → A in AAK39523 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038576136G → GA in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM093406 mRNA No translation available.
AF355190 mRNA Translation: AAK39523.1
RefSeqiNP_446148.1, NM_053696.1
UniGeneiRn.18057

Genome annotation databases

GeneIDi114488
KEGGirno:114488
UCSCiRGD:620145 rat [Q925G0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRBM3_RAT
AccessioniPrimary (citable) accession number: Q925G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: January 19, 2010
Last modified: May 23, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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