Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA-binding protein 3

Gene

Rbm3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed (By similarity). Enhances phosphorylation of translation initiation factors and active polysome formation.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of translation Source: UniProtKB
  • regulation of translation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 3
Alternative name(s):
RNA-binding motif protein 3
Gene namesi
Name:Rbm3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620145. Rbm3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • dendrite Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155RNA-binding protein 3PRO_0000390775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051Dimethylated arginine; alternateBy similarity
Modified residuei105 – 1051Omega-N-methylated arginine; alternateBy similarity
Modified residuei135 – 1351PhosphoserineBy similarity
Modified residuei145 – 1451PhosphoserineBy similarity
Modified residuei153 – 1531PhosphotyrosineBy similarity

Post-translational modificationi

Arg-105 is dimethylated, probably to asymmetric dimethylarginine.By similarity
Phosphorylated. Isoform 2 is methylated.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ925G0.
PRIDEiQ925G0.

Expressioni

Tissue specificityi

Widely expressed in the brain. Highly expressed in the cerebellum and olfactory bulb (at protein level). Expressed in neurons and glial cells.1 Publication

Interactioni

Subunit structurei

Interacts with RPL4. Associates with the 60S ribosomal subunits.1 Publication

Protein-protein interaction databases

IntActiQ925G0. 1 interaction.
MINTiMINT-4611770.
STRINGi10116.ENSRNOP00000007367.

Structurei

3D structure databases

ProteinModelPortaliQ925G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 8479RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
HOGENOMiHOG000276232.
HOVERGENiHBG107480.
InParanoidiQ925G0.
KOiK13186.
PhylomeDBiQ925G0.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q925G0-1) [UniParc]FASTAAdd to basket
Also known as: RBM3 Arg-

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSEEGKLFV GGLNFNTDEQ ALEDHFSSFG PISEVVVVKD RETQRSRGFG
60 70 80 90 100
FITFTNPEHA SDVMRAMNGE SLDGRQIRVD HAGKSARGTR GGAFGAHGRG
110 120 130 140 150
RSYSRGGGDQ GYGSGRYDSR PGGYGYGYGR SRDYSGSQGG YDRYSGGNYR

DNYDN
Length:155
Mass (Da):16,855
Last modified:January 19, 2010 - v2
Checksum:i9BD4118495D60411
GO
Isoform 2 (identifier: Q925G0-2) [UniParc]FASTAAdd to basket
Also known as: RBM3 Arg+

The sequence of this isoform differs from the canonical sequence as follows:
     136-136: G → GA

Show »
Length:156
Mass (Da):16,926
Checksum:iE9D15B3AD07FAD7B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631V → A in AAK39523 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei136 – 1361G → GA in isoform 2. CuratedVSP_038576

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM093406 mRNA. No translation available.
AF355190 mRNA. Translation: AAK39523.1.
RefSeqiNP_446148.1. NM_053696.1.
UniGeneiRn.18057.

Genome annotation databases

GeneIDi114488.
KEGGirno:114488.
UCSCiRGD:620145. rat. [Q925G0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM093406 mRNA. No translation available.
AF355190 mRNA. Translation: AAK39523.1.
RefSeqiNP_446148.1. NM_053696.1.
UniGeneiRn.18057.

3D structure databases

ProteinModelPortaliQ925G0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ925G0. 1 interaction.
MINTiMINT-4611770.
STRINGi10116.ENSRNOP00000007367.

Proteomic databases

PaxDbiQ925G0.
PRIDEiQ925G0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114488.
KEGGirno:114488.
UCSCiRGD:620145. rat. [Q925G0-1]

Organism-specific databases

CTDi5935.
RGDi620145. Rbm3.

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
HOGENOMiHOG000276232.
HOVERGENiHBG107480.
InParanoidiQ925G0.
KOiK13186.
PhylomeDBiQ925G0.

Miscellaneous databases

PROiQ925G0.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM3_RAT
AccessioniPrimary (citable) accession number: Q925G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: January 19, 2010
Last modified: June 8, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.