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Q925F4

- RNF37_MOUSE

UniProt

Q925F4 - RNF37_MOUSE

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Protein

RING finger protein 37

Gene
Ubox5, Rnf37, Ubce7ip5, Uip5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri481 – 52646RING-typeAdd
BLAST

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: MGI
  2. ubiquitin-ubiquitin ligase activity Source: MGI
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein polyubiquitination Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 37
Alternative name(s):
U-box domain-containing protein 5
UbcM4-interacting protein 5
Ubiquitin-conjugating enzyme 7-interacting protein 5
Gene namesi
Name:Ubox5
Synonyms:Rnf37, Ubce7ip5, Uip5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2154658. Ubox5.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. ubiquitin ligase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539RING finger protein 37PRO_0000056077Add
BLAST

Proteomic databases

PaxDbiQ925F4.
PRIDEiQ925F4.

PTM databases

PhosphoSiteiQ925F4.

Expressioni

Gene expression databases

ArrayExpressiQ925F4.
BgeeiQ925F4.
CleanExiMM_UBOX5.
GenevestigatoriQ925F4.

Interactioni

Subunit structurei

Interacts with UBE2L3.

Protein-protein interaction databases

BioGridi228291. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ925F4.
SMRiQ925F4. Positions 256-334, 480-536.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini258 – 33881U-boxAdd
BLAST

Sequence similaritiesi

Contains 1 U-box domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri481 – 52646RING-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG72287.
GeneTreeiENSGT00510000049555.
HOGENOMiHOG000132931.
HOVERGENiHBG054212.
InParanoidiQ925F4.
KOiK10600.
OMAiKICITHV.
PhylomeDBiQ925F4.
TreeFamiTF329105.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR003613. Ubox_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04564. U-box. 1 hit.
PF14634. zf-RING_5. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00504. Ubox. 1 hit.
[Graphical view]
PROSITEiPS51698. U_BOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925F4-1 [UniParc]FASTAAdd to Basket

« Hide

MVVNLCLPQF RPRIHCNKVS ADGYEVENLI SEDLIKRSHG FRTEYFIRPP    50
IYVTVSFPFN VEICRVNIDL TTGGYQNVSG LELYTSALSS RVSQDAQDCW 100
TTGPVETSVP DKEAFTLVGK VLLKNQNHVV FSHRGFKARP PFSPMEVTLL 150
SPAVVAQELW NKGALSLSHV AHLKIGITHV TGSGISCIKR LEVWGQPART 200
CSQEVINSVL LIASESLPQD LDLHAPALPM ESDCDPGGQS ESQHSPCTLQ 250
DMSEVESDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNLSEAAWG 300
RVPSDPFTGL AFTPQSQPLP HPSLKARIDR FLLQHSISGC RLLGRAQTPS 350
AMTPSVITLP SRKRKTEQAE HSSHYSLGMS ASSSATSPLF SPTTSEPTAK 400
KMKATSELGL TDMDCSAGPV SHEQKLAQSL EIALTSTLGS MPSFTARLTK 450
GQLQLGTRGS SACRRPASSS EHPRSVSGPE CASCKQAFSS YSTNEPVYQL 500
PCGHLLCRPC LSEKQRSQPM MCTACRQPVT SQDVLRVHF 539
Length:539
Mass (Da):58,732
Last modified:June 6, 2002 - v2
Checksum:i93F7372A9F888814
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751Y → C in AAH25068. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF360997 mRNA. Translation: AAK51467.1.
BC025068 mRNA. Translation: AAH25068.1.
CCDSiCCDS16747.1.
RefSeqiNP_001242922.1. NM_001255993.1.
NP_001242923.1. NM_001255994.1.
NP_542129.2. NM_080562.5.
UniGeneiMm.486003.
Mm.489731.
Mm.489850.

Genome annotation databases

EnsembliENSMUST00000028761; ENSMUSP00000028761; ENSMUSG00000027300.
GeneIDi140629.
KEGGimmu:140629.
UCSCiuc008mji.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF360997 mRNA. Translation: AAK51467.1 .
BC025068 mRNA. Translation: AAH25068.1 .
CCDSi CCDS16747.1.
RefSeqi NP_001242922.1. NM_001255993.1.
NP_001242923.1. NM_001255994.1.
NP_542129.2. NM_080562.5.
UniGenei Mm.486003.
Mm.489731.
Mm.489850.

3D structure databases

ProteinModelPortali Q925F4.
SMRi Q925F4. Positions 256-334, 480-536.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228291. 5 interactions.

PTM databases

PhosphoSitei Q925F4.

Proteomic databases

PaxDbi Q925F4.
PRIDEi Q925F4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028761 ; ENSMUSP00000028761 ; ENSMUSG00000027300 .
GeneIDi 140629.
KEGGi mmu:140629.
UCSCi uc008mji.3. mouse.

Organism-specific databases

CTDi 22888.
MGIi MGI:2154658. Ubox5.

Phylogenomic databases

eggNOGi NOG72287.
GeneTreei ENSGT00510000049555.
HOGENOMi HOG000132931.
HOVERGENi HBG054212.
InParanoidi Q925F4.
KOi K10600.
OMAi KICITHV.
PhylomeDBi Q925F4.
TreeFami TF329105.

Enzyme and pathway databases

Reactomei REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSi UBOX5. mouse.
NextBioi 369909.
PROi Q925F4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q925F4.
Bgeei Q925F4.
CleanExi MM_UBOX5.
Genevestigatori Q925F4.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
InterProi IPR003613. Ubox_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF04564. U-box. 1 hit.
PF14634. zf-RING_5. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00504. Ubox. 1 hit.
[Graphical view ]
PROSITEi PS51698. U_BOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of the RING finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes."
    Pringa E., Martinez-Noel G., Muller U., Harbers K.
    J. Biol. Chem. 276:19617-19623(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiRNF37_MOUSE
AccessioniPrimary (citable) accession number: Q925F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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