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Protein

RING finger protein 37

Gene

Ubox5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri481 – 526RING-typePROSITE-ProRule annotationAdd BLAST46

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: MGI
  • ubiquitin protein ligase binding Source: UniProtKB
  • ubiquitin-ubiquitin ligase activity Source: MGI

GO - Biological processi

  • protein polyubiquitination Source: MGI

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 37Curated (EC:2.3.2.271 Publication)
Alternative name(s):
RING-type E3 ubiquitin transferase RNF37Curated
U-box domain-containing protein 5Imported
UbcM4-interacting protein 51 Publication
Gene namesi
Name:Ubox5
Synonyms:Rnf37Curated, Uip51 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2154658. Ubox5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi292C → A: No effect on E3 ubiquitin-protein ligase activity. 1 Publication1
Mutagenesisi306P → A: Loss of E3 ubiquitin-protein ligase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560771 – 539RING finger protein 37Add BLAST539

Proteomic databases

MaxQBiQ925F4.
PaxDbiQ925F4.
PRIDEiQ925F4.

PTM databases

PhosphoSitePlusiQ925F4.

Expressioni

Tissue specificityi

Expressed in testis and placenta.1 Publication

Developmental stagei

Expressed in embryos at 14.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000027300.
CleanExiMM_UBOX5.
ExpressionAtlasiQ925F4. baseline and differential.
GenevisibleiQ925F4. MM.

Interactioni

Subunit structurei

Interacts with UBE2L3. Interacts with VCP.2 Publications

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi228291. 5 interactors.
STRINGi10090.ENSMUSP00000028761.

Structurei

3D structure databases

ProteinModelPortaliQ925F4.
SMRiQ925F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini258 – 338U-boxAdd BLAST81

Domaini

The U-box domain mediates interaction with E2 ubiquitin ligases and is required for the ubiquitin-protein ligase activity.By similarity1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri481 – 526RING-typePROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2042. Eukaryota.
COG5113. LUCA.
GeneTreeiENSGT00510000049555.
HOGENOMiHOG000132931.
HOVERGENiHBG054212.
InParanoidiQ925F4.
KOiK10600.
OMAiYQLPCGH.
OrthoDBiEOG091G0L8V.
PhylomeDBiQ925F4.
TreeFamiTF329105.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like_sf.
IPR003613. Ubox_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF04564. U-box. 1 hit.
PF14634. zf-RING_5. 1 hit.
SMARTiView protein in SMART
SM00504. Ubox. 1 hit.
PROSITEiView protein in PROSITE
PS51698. U_BOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q925F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVNLCLPQF RPRIHCNKVS ADGYEVENLI SEDLIKRSHG FRTEYFIRPP
60 70 80 90 100
IYVTVSFPFN VEICRVNIDL TTGGYQNVSG LELYTSALSS RVSQDAQDCW
110 120 130 140 150
TTGPVETSVP DKEAFTLVGK VLLKNQNHVV FSHRGFKARP PFSPMEVTLL
160 170 180 190 200
SPAVVAQELW NKGALSLSHV AHLKIGITHV TGSGISCIKR LEVWGQPART
210 220 230 240 250
CSQEVINSVL LIASESLPQD LDLHAPALPM ESDCDPGGQS ESQHSPCTLQ
260 270 280 290 300
DMSEVESDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNLSEAAWG
310 320 330 340 350
RVPSDPFTGL AFTPQSQPLP HPSLKARIDR FLLQHSISGC RLLGRAQTPS
360 370 380 390 400
AMTPSVITLP SRKRKTEQAE HSSHYSLGMS ASSSATSPLF SPTTSEPTAK
410 420 430 440 450
KMKATSELGL TDMDCSAGPV SHEQKLAQSL EIALTSTLGS MPSFTARLTK
460 470 480 490 500
GQLQLGTRGS SACRRPASSS EHPRSVSGPE CASCKQAFSS YSTNEPVYQL
510 520 530
PCGHLLCRPC LSEKQRSQPM MCTACRQPVT SQDVLRVHF
Length:539
Mass (Da):58,732
Last modified:June 6, 2002 - v2
Checksum:i93F7372A9F888814
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75Y → C in AAH25068 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF360997 mRNA. Translation: AAK51467.1.
BC025068 mRNA. Translation: AAH25068.1.
CCDSiCCDS16747.1.
RefSeqiNP_001242922.1. NM_001255993.1.
NP_001242923.1. NM_001255994.1.
NP_542129.2. NM_080562.5.
UniGeneiMm.486003.
Mm.489731.
Mm.489850.

Genome annotation databases

EnsembliENSMUST00000028761; ENSMUSP00000028761; ENSMUSG00000027300.
GeneIDi140629.
KEGGimmu:140629.
UCSCiuc008mji.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiRNF37_MOUSE
AccessioniPrimary (citable) accession number: Q925F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: November 22, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways