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Q925F4

- RNF37_MOUSE

UniProt

Q925F4 - RNF37_MOUSE

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Protein

RING finger protein 37

Gene

Ubox5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri481 – 52646RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: MGI
  2. ubiquitin-ubiquitin ligase activity Source: MGI
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein polyubiquitination Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 37Curated (EC:6.3.2.-1 Publication)
Alternative name(s):
U-box domain-containing protein 5Imported
UbcM4-interacting protein 51 Publication
Gene namesi
Name:Ubox5
Synonyms:Rnf37Curated, Uip51 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2154658. Ubox5.

Subcellular locationi

Nucleus 1 Publication
Note: Enriched in nuclear bodies.By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi292 – 2921C → A: No effect on E3 ubiquitin-protein ligase activity. 1 Publication
Mutagenesisi306 – 3061P → A: Loss of E3 ubiquitin-protein ligase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539RING finger protein 37PRO_0000056077Add
BLAST

Proteomic databases

PaxDbiQ925F4.
PRIDEiQ925F4.

PTM databases

PhosphoSiteiQ925F4.

Expressioni

Tissue specificityi

Expressed in testis and placenta.1 Publication

Developmental stagei

Expressed in embryos at 14.5 dpc.1 Publication

Gene expression databases

BgeeiQ925F4.
CleanExiMM_UBOX5.
ExpressionAtlasiQ925F4. baseline and differential.
GenevestigatoriQ925F4.

Interactioni

Subunit structurei

Interacts with UBE2L3. Interacts with VCP.2 Publications

Protein-protein interaction databases

BioGridi228291. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ925F4.
SMRiQ925F4. Positions 480-536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini258 – 33881U-boxAdd
BLAST

Domaini

The U-box domain mediates interaction with E2 ubiquitin ligases and is required for the ubiquitin-protein ligase activity.By similarity1 Publication

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 U-box domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri481 – 52646RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG72287.
GeneTreeiENSGT00510000049555.
HOGENOMiHOG000132931.
HOVERGENiHBG054212.
InParanoidiQ925F4.
KOiK10600.
OMAiKICITHV.
PhylomeDBiQ925F4.
TreeFamiTF329105.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR003613. Ubox_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04564. U-box. 1 hit.
PF14634. zf-RING_5. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00504. Ubox. 1 hit.
[Graphical view]
PROSITEiPS51698. U_BOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925F4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVNLCLPQF RPRIHCNKVS ADGYEVENLI SEDLIKRSHG FRTEYFIRPP
60 70 80 90 100
IYVTVSFPFN VEICRVNIDL TTGGYQNVSG LELYTSALSS RVSQDAQDCW
110 120 130 140 150
TTGPVETSVP DKEAFTLVGK VLLKNQNHVV FSHRGFKARP PFSPMEVTLL
160 170 180 190 200
SPAVVAQELW NKGALSLSHV AHLKIGITHV TGSGISCIKR LEVWGQPART
210 220 230 240 250
CSQEVINSVL LIASESLPQD LDLHAPALPM ESDCDPGGQS ESQHSPCTLQ
260 270 280 290 300
DMSEVESDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNLSEAAWG
310 320 330 340 350
RVPSDPFTGL AFTPQSQPLP HPSLKARIDR FLLQHSISGC RLLGRAQTPS
360 370 380 390 400
AMTPSVITLP SRKRKTEQAE HSSHYSLGMS ASSSATSPLF SPTTSEPTAK
410 420 430 440 450
KMKATSELGL TDMDCSAGPV SHEQKLAQSL EIALTSTLGS MPSFTARLTK
460 470 480 490 500
GQLQLGTRGS SACRRPASSS EHPRSVSGPE CASCKQAFSS YSTNEPVYQL
510 520 530
PCGHLLCRPC LSEKQRSQPM MCTACRQPVT SQDVLRVHF
Length:539
Mass (Da):58,732
Last modified:June 6, 2002 - v2
Checksum:i93F7372A9F888814
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751Y → C in AAH25068. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF360997 mRNA. Translation: AAK51467.1.
BC025068 mRNA. Translation: AAH25068.1.
CCDSiCCDS16747.1.
RefSeqiNP_001242922.1. NM_001255993.1.
NP_001242923.1. NM_001255994.1.
NP_542129.2. NM_080562.5.
UniGeneiMm.486003.
Mm.489731.
Mm.489850.

Genome annotation databases

EnsembliENSMUST00000028761; ENSMUSP00000028761; ENSMUSG00000027300.
GeneIDi140629.
KEGGimmu:140629.
UCSCiuc008mji.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF360997 mRNA. Translation: AAK51467.1 .
BC025068 mRNA. Translation: AAH25068.1 .
CCDSi CCDS16747.1.
RefSeqi NP_001242922.1. NM_001255993.1.
NP_001242923.1. NM_001255994.1.
NP_542129.2. NM_080562.5.
UniGenei Mm.486003.
Mm.489731.
Mm.489850.

3D structure databases

ProteinModelPortali Q925F4.
SMRi Q925F4. Positions 480-536.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228291. 5 interactions.

PTM databases

PhosphoSitei Q925F4.

Proteomic databases

PaxDbi Q925F4.
PRIDEi Q925F4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028761 ; ENSMUSP00000028761 ; ENSMUSG00000027300 .
GeneIDi 140629.
KEGGi mmu:140629.
UCSCi uc008mji.3. mouse.

Organism-specific databases

CTDi 22888.
MGIi MGI:2154658. Ubox5.

Phylogenomic databases

eggNOGi NOG72287.
GeneTreei ENSGT00510000049555.
HOGENOMi HOG000132931.
HOVERGENi HBG054212.
InParanoidi Q925F4.
KOi K10600.
OMAi KICITHV.
PhylomeDBi Q925F4.
TreeFami TF329105.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSi UBOX5. mouse.
NextBioi 369909.
PROi Q925F4.
SOURCEi Search...

Gene expression databases

Bgeei Q925F4.
CleanExi MM_UBOX5.
ExpressionAtlasi Q925F4. baseline and differential.
Genevestigatori Q925F4.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
InterProi IPR003613. Ubox_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF04564. U-box. 1 hit.
PF14634. zf-RING_5. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00504. Ubox. 1 hit.
[Graphical view ]
PROSITEi PS51698. U_BOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of the RING finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes."
    Pringa E., Martinez-Noel G., Muller U., Harbers K.
    J. Biol. Chem. 276:19617-19623(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH UBE2L3, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "U box proteins as a new family of ubiquitin-protein ligases."
    Hatakeyama S., Yada M., Matsumoto M., Ishida N., Nakayama K.I.
    J. Biol. Chem. 276:33111-33120(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY, SUBCELLULAR LOCATION, DOMAIN, MUTAGENESIS OF CYS-292 AND PRO-306.
  4. "Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones."
    Hatakeyama S., Matsumoto M., Yada M., Nakayama K.I.
    Genes Cells 9:533-548(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VCP.

Entry informationi

Entry nameiRNF37_MOUSE
AccessioniPrimary (citable) accession number: Q925F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3