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Q925F4

- RNF37_MOUSE

UniProt

Q925F4 - RNF37_MOUSE

Protein

RING finger protein 37

Gene

Ubox5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri481 – 52646RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ubiquitin-protein transferase activity Source: MGI
    2. ubiquitin-ubiquitin ligase activity Source: MGI
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein polyubiquitination Source: MGI

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 37
    Alternative name(s):
    U-box domain-containing protein 5
    UbcM4-interacting protein 5
    Ubiquitin-conjugating enzyme 7-interacting protein 5
    Gene namesi
    Name:Ubox5
    Synonyms:Rnf37, Ubce7ip5, Uip5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2154658. Ubox5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. ubiquitin ligase complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 539539RING finger protein 37PRO_0000056077Add
    BLAST

    Proteomic databases

    PaxDbiQ925F4.
    PRIDEiQ925F4.

    PTM databases

    PhosphoSiteiQ925F4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ925F4.
    BgeeiQ925F4.
    CleanExiMM_UBOX5.
    GenevestigatoriQ925F4.

    Interactioni

    Subunit structurei

    Interacts with UBE2L3.

    Protein-protein interaction databases

    BioGridi228291. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ925F4.
    SMRiQ925F4. Positions 256-334, 480-536.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini258 – 33881U-boxAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 1 U-box domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri481 – 52646RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG72287.
    GeneTreeiENSGT00510000049555.
    HOGENOMiHOG000132931.
    HOVERGENiHBG054212.
    InParanoidiQ925F4.
    KOiK10600.
    OMAiKICITHV.
    PhylomeDBiQ925F4.
    TreeFamiTF329105.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    InterProiIPR003613. Ubox_domain.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF04564. U-box. 1 hit.
    PF14634. zf-RING_5. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00504. Ubox. 1 hit.
    [Graphical view]
    PROSITEiPS51698. U_BOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q925F4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVNLCLPQF RPRIHCNKVS ADGYEVENLI SEDLIKRSHG FRTEYFIRPP    50
    IYVTVSFPFN VEICRVNIDL TTGGYQNVSG LELYTSALSS RVSQDAQDCW 100
    TTGPVETSVP DKEAFTLVGK VLLKNQNHVV FSHRGFKARP PFSPMEVTLL 150
    SPAVVAQELW NKGALSLSHV AHLKIGITHV TGSGISCIKR LEVWGQPART 200
    CSQEVINSVL LIASESLPQD LDLHAPALPM ESDCDPGGQS ESQHSPCTLQ 250
    DMSEVESDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNLSEAAWG 300
    RVPSDPFTGL AFTPQSQPLP HPSLKARIDR FLLQHSISGC RLLGRAQTPS 350
    AMTPSVITLP SRKRKTEQAE HSSHYSLGMS ASSSATSPLF SPTTSEPTAK 400
    KMKATSELGL TDMDCSAGPV SHEQKLAQSL EIALTSTLGS MPSFTARLTK 450
    GQLQLGTRGS SACRRPASSS EHPRSVSGPE CASCKQAFSS YSTNEPVYQL 500
    PCGHLLCRPC LSEKQRSQPM MCTACRQPVT SQDVLRVHF 539
    Length:539
    Mass (Da):58,732
    Last modified:June 6, 2002 - v2
    Checksum:i93F7372A9F888814
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751Y → C in AAH25068. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF360997 mRNA. Translation: AAK51467.1.
    BC025068 mRNA. Translation: AAH25068.1.
    CCDSiCCDS16747.1.
    RefSeqiNP_001242922.1. NM_001255993.1.
    NP_001242923.1. NM_001255994.1.
    NP_542129.2. NM_080562.5.
    UniGeneiMm.486003.
    Mm.489731.
    Mm.489850.

    Genome annotation databases

    EnsembliENSMUST00000028761; ENSMUSP00000028761; ENSMUSG00000027300.
    GeneIDi140629.
    KEGGimmu:140629.
    UCSCiuc008mji.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF360997 mRNA. Translation: AAK51467.1 .
    BC025068 mRNA. Translation: AAH25068.1 .
    CCDSi CCDS16747.1.
    RefSeqi NP_001242922.1. NM_001255993.1.
    NP_001242923.1. NM_001255994.1.
    NP_542129.2. NM_080562.5.
    UniGenei Mm.486003.
    Mm.489731.
    Mm.489850.

    3D structure databases

    ProteinModelPortali Q925F4.
    SMRi Q925F4. Positions 256-334, 480-536.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 228291. 5 interactions.

    PTM databases

    PhosphoSitei Q925F4.

    Proteomic databases

    PaxDbi Q925F4.
    PRIDEi Q925F4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028761 ; ENSMUSP00000028761 ; ENSMUSG00000027300 .
    GeneIDi 140629.
    KEGGi mmu:140629.
    UCSCi uc008mji.3. mouse.

    Organism-specific databases

    CTDi 22888.
    MGIi MGI:2154658. Ubox5.

    Phylogenomic databases

    eggNOGi NOG72287.
    GeneTreei ENSGT00510000049555.
    HOGENOMi HOG000132931.
    HOVERGENi HBG054212.
    InParanoidi Q925F4.
    KOi K10600.
    OMAi KICITHV.
    PhylomeDBi Q925F4.
    TreeFami TF329105.

    Enzyme and pathway databases

    Reactomei REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    ChiTaRSi UBOX5. mouse.
    NextBioi 369909.
    PROi Q925F4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q925F4.
    Bgeei Q925F4.
    CleanExi MM_UBOX5.
    Genevestigatori Q925F4.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    InterProi IPR003613. Ubox_domain.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF04564. U-box. 1 hit.
    PF14634. zf-RING_5. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00504. Ubox. 1 hit.
    [Graphical view ]
    PROSITEi PS51698. U_BOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interaction of the RING finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes."
      Pringa E., Martinez-Noel G., Muller U., Harbers K.
      J. Biol. Chem. 276:19617-19623(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiRNF37_MOUSE
    AccessioniPrimary (citable) accession number: Q925F4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3