Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q925E7 (2ABD_MOUSE)

Last modified February 9, 2010. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Alternative name(s):
    PP2A subunit B isoform delta
    PP2A subunit B isoform B55-delta
    PP2A subunit B isoform PR55-delta
    PP2A subunit B isoform R2-delta
Gene names
Name: Ppp2r2d
Synonyms: D7Ertd753e, Kiaa1541
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment By similarity.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the phosphatase 2A regulatory subunit B family.

Contains 7 WD repeats.

Hide | Top

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
WD repeat
Gene Ontology (GO)
   Biological processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

protein phosphatase type 2A complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionprotein phosphatase type 2A regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
PRO_0000071434

Regions

Repeat32 – 7140WD 1
Repeat97 – 13842WD 2
Repeat181 – 21939WD 3
Repeat230 – 27041WD 4
Repeat289 – 32739WD 5
Repeat344 – 38542WD 6
Repeat420 – 45233WD 7
Compositional bias3 – 86Poly-Gly

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q925E7-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: C4B474AA28397576

FASTA45351,957
        10         20         30         40         50         60 
MAGAGGGGCP AGGNDFQWCF SQVKGAVDED VAEADIISTV EFNYSGDLLA TGDKGGRVVI 

        70         80         90        100        110        120 
FQREQENKGR AHSRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAHFLLST 

       130        140        150        160        170        180 
NDKTIKLWKI SERDKRAEGY NLKDEDGRLR DPFRITALRV PILKPMDLMV EASPRRIFAN 

       190        200        210        220        230        240 
AHTYHINSIS VNSDHETYLS ADDLRINLWH LEITDRSFNI VDIKPANMEE LTEVITAAEF 

       250        260        270        280        290        300 
HPHQCNVFVY SSSKGTIRLC DMRSSALCDR HAKFFEEPED PSSRSFFSEI ISSISDVKFS 

       310        320        330        340        350        360 
HSGRYMMTRD YLSVKVWDLN MEGRPVETHQ VHEYLRSKLC SLYENDCIFD KFECCWNGSD 

       370        380        390        400        410        420 
SAIMTGSYNN FFRMFDRNTR RDVTLEASRE NSKPRASLKP RKVCTGGKRK KDEISVDSLD 

       430        440        450 
FNKKILHTAW HPMESIIAVA ATNNLYIFQD KIN

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Analysis of mDRA (Mouse Down-regulated in Adenoma) interaction in yeast two-hybrid system."
Chang H., Lee S., Park K.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed: 14621295] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Natural killer cell.
[3]Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF366393 mRNA. Translation: AAK53703.1.
AK129386 mRNA. Translation: BAC98196.2. Different initiation.
BC066022 mRNA. Translation: AAH66022.1.
IPIIPI00473753.
RefSeqNP_080667.1.
UniGeneMm.258739

3D structure databases

SMRQ925E7. Positions 32-380, 34-442, 84-449.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ925E7.

Proteomic databases

PRIDEQ925E7.

Genome annotation databases

EnsemblENSMUST00000041097; ENSMUSP00000040321; ENSMUSG00000041769; Mus musculus. [Genome view]
GeneID52432.
KEGGmmu:52432.
UCSCuc009kfe.1. mouse.

Organism-specific databases

CTD52432.
MGIMGI:1289252. Ppp2r2d.
RougeSearch...

Phylogenomic databases

eggNOGroNOG04944.
HOGENOMHBG443924.
HOVERGENQ925E7.
InParanoidQ925E7.
OMASTVEFNC.
OrthoDBEOG9Q87GQ.
PhylomeDBQ925E7.

Gene expression databases

ArrayExpressQ925E7.
BgeeQ925E7.
GenevestigatorQ925E7.
GermOnlineENSMUSG00000041769. Mus musculus.

Family and domain databases

InterProIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019781. WD40_repeat_sg.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PANTHERPTHR11871. Pp2A_PR55. 1 hit.
PfamPF00400. WD40. 1 hit.
[Graphical view]
PIRSFPIRSF037309. PP2A_PR55. 1 hit.
PRINTSPR00600. PP2APR55.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
PROSITEPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. False negative.
PS50082. WD_REPEATS_2. False negative.
PS50294. WD_REPEATS_REGION. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio308948.
SOURCESearch...

Hide | Top

Entry information

Entry name2ABD_MOUSE
AccessionPrimary (citable) accession number: Q925E7
Secondary accession number(s): Q6ZPN5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 1, 2001
Last modified: February 9, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents