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Q925E1 (SNTG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-1-syntrophin
Short name=G1SYN
Alternative name(s):
Syntrophin-4
Short name=SYN4
Gene names
Name:Sntg1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation By similarity.

Subunit structure

Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Interacts with DGKZ By similarity.

Subcellular location

Cytoplasm › cytoskeleton By similarity. Nucleus By similarity. Note: Mainly cytoplasmic and weakly nuclear By similarity.

Domain

The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.

Sequence similarities

Belongs to the syntrophin family.

Contains 1 PDZ (DHR) domain.

Contains 1 PH domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Nucleus
   Coding sequence diversityAlternative splicing
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphospholipid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q925E1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q925E1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.
     276-283: RNFPVNQQ → MIKHLPSY
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Gamma-1-syntrophin
PRO_0000184014

Regions

Domain57 – 14084PDZ
Domain283 – 390108PH

Natural variations

Alternative sequence1 – 275275Missing in isoform 2.
VSP_006361
Alternative sequence276 – 2838RNFPVNQQ → MIKHLPSY in isoform 2.
VSP_006362

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 10, 2002. Version 2.
Checksum: 20133EFD3ED9EF6D

FASTA51757,982
        10         20         30         40         50         60 
MDFRTTCEET KTGVCLLQDG NQEPFKVRLH LARDLLMLQE QDVLCVSGEP FYSGERTVTI 

        70         80         90        100        110        120 
RRQTVGGFGL SIKGGAEHNI PVVISKISKE QRAELSGLLF IGDAILQING INVRKCRHEE 

       130        140        150        160        170        180 
VVQVLRNAGE EVTLTVSFLK RAPAFLKLPV NEDCACAPSD QSSGTSSPLC DSGLHLNYHP 

       190        200        210        220        230        240 
NNTDTLSCSS WPTSPGLRWE KRWCDLRLIP LLHARFSQYV PGTDLSRQNE SQVVAVDGVC 

       250        260        270        280        290        300 
SGILQCLSAE DCMDWLQAIA SNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQESLQD 

       310        320        330        340        350        360 
RVYTPVFLAL RGSCLYRFLS PPVTTWDWTR AEKTFSVCEI MCKVLKDSDL LDRRKHCFTM 

       370        380        390        400        410        420 
QSECGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT YACVLESHLM GLTIDFSTGF 

       430        440        450        460        470        480 
ICFDAATKAV LWRYKFSQLK GSSDDGKSKI KFLFQNPDTK QIEAKELEFS NLFAVLHCIH 

       490        500        510 
SFFAAKVACL DPLFLGNQAA TTAAVSSAST SKAKHLA

« Hide

Isoform 2 [UniParc].

Checksum: 7C30E4B8F5091C52
Show »

FASTA24227,579

References

« Hide 'large scale' references
[1]"Cloning and characterization of mouse gamma syntrophins."
Alessi A., Adams M.E., Froehner S.C.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF367759 mRNA. Translation: AAK53399.1.
AK016927 mRNA. Translation: BAB30501.1.
IPIIPI00309401.
IPI00875442.
UniGeneMm.388998.

3D structure databases

ProteinModelPortalQ925E1.
SMRQ925E1. Positions 56-140, 207-263.
ModBaseSearch...

PTM databases

PhosphoSiteQ925E1.

Proteomic databases

PRIDEQ925E1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000115484; ENSMUSP00000111147; ENSMUSG00000025909.
UCSCuc007agg.1. mouse.

Organism-specific databases

MGIMGI:1918346. Sntg1.

Phylogenomic databases

eggNOGNOG253217.
GeneTreeENSGT00550000074581.
HOGENOMHOG000230749.
HOVERGENHBG060412.
InParanoidQ925E1.

Gene expression databases

ArrayExpressQ925E1.
BgeeQ925E1.
CleanExMM_SNTG1.
GenevestigatorQ925E1.
GermOnlineENSMUSG00000025909. Mus musculus.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR001478. PDZ.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR015482. Syntrophin.
IPR015483. Syntrophin_gamma.
[Graphical view]
PANTHERPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF2. PTHR10554:SF2. 1 hit.
PfamPF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMSSF50156. PDZ. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSNTG1. mouse.
SOURCESearch...

Entry information

Entry nameSNTG1_MOUSE
AccessionPrimary (citable) accession number: Q925E1
Secondary accession number(s): Q9D3Z5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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