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Q925E1

- SNTG1_MOUSE

UniProt

Q925E1 - SNTG1_MOUSE

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Protein

Gamma-1-syntrophin

Gene
Sntg1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation By similarity.

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-1-syntrophin
Short name:
G1SYN
Alternative name(s):
Syntrophin-4
Short name:
SYN4
Gene namesi
Name:Sntg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1918346. Sntg1.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Nucleus By similarity
Note: Mainly cytoplasmic and weakly nuclear By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Gamma-1-syntrophinPRO_0000184014Add
BLAST

Proteomic databases

PRIDEiQ925E1.

PTM databases

PhosphoSiteiQ925E1.

Expressioni

Gene expression databases

BgeeiQ925E1.
CleanExiMM_SNTG1.
GenevestigatoriQ925E1.

Interactioni

Subunit structurei

Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Interacts with DGKZ By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ925E1.
SMRiQ925E1. Positions 56-140.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 14084PDZAdd
BLAST
Domaini283 – 390108PHAdd
BLAST

Domaini

The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.

Sequence similaritiesi

Belongs to the syntrophin family.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.

Phylogenomic databases

eggNOGiNOG253217.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000230749.
HOVERGENiHBG060412.
InParanoidiQ925E1.
PhylomeDBiQ925E1.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015482. Syntrophin.
IPR015483. Syntrophin_gamma.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF2. PTHR10554:SF2. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q925E1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDFRTTCEET KTGVCLLQDG NQEPFKVRLH LARDLLMLQE QDVLCVSGEP    50
FYSGERTVTI RRQTVGGFGL SIKGGAEHNI PVVISKISKE QRAELSGLLF 100
IGDAILQING INVRKCRHEE VVQVLRNAGE EVTLTVSFLK RAPAFLKLPV 150
NEDCACAPSD QSSGTSSPLC DSGLHLNYHP NNTDTLSCSS WPTSPGLRWE 200
KRWCDLRLIP LLHARFSQYV PGTDLSRQNE SQVVAVDGVC SGILQCLSAE 250
DCMDWLQAIA SNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQESLQD 300
RVYTPVFLAL RGSCLYRFLS PPVTTWDWTR AEKTFSVCEI MCKVLKDSDL 350
LDRRKHCFTM QSECGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT 400
YACVLESHLM GLTIDFSTGF ICFDAATKAV LWRYKFSQLK GSSDDGKSKI 450
KFLFQNPDTK QIEAKELEFS NLFAVLHCIH SFFAAKVACL DPLFLGNQAA 500
TTAAVSSAST SKAKHLA 517
Length:517
Mass (Da):57,982
Last modified:October 10, 2002 - v2
Checksum:i20133EFD3ED9EF6D
GO
Isoform 2 (identifier: Q925E1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.
     276-283: RNFPVNQQ → MIKHLPSY

Note: No experimental confirmation available.

Show »
Length:242
Mass (Da):27,579
Checksum:i7C30E4B8F5091C52
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 275275Missing in isoform 2. VSP_006361Add
BLAST
Alternative sequencei276 – 2838RNFPVNQQ → MIKHLPSY in isoform 2. VSP_006362

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF367759 mRNA. Translation: AAK53399.1.
AK016927 mRNA. Translation: BAB30501.1.
CCDSiCCDS35509.1. [Q925E1-1]
RefSeqiNP_001277322.1. NM_001290393.1.
UniGeneiMm.336395.
Mm.388998.

Genome annotation databases

EnsembliENSMUST00000115484; ENSMUSP00000111147; ENSMUSG00000025909. [Q925E1-2]
GeneIDi71096.
UCSCiuc007agg.1. mouse. [Q925E1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF367759 mRNA. Translation: AAK53399.1 .
AK016927 mRNA. Translation: BAB30501.1 .
CCDSi CCDS35509.1. [Q925E1-1 ]
RefSeqi NP_001277322.1. NM_001290393.1.
UniGenei Mm.336395.
Mm.388998.

3D structure databases

ProteinModelPortali Q925E1.
SMRi Q925E1. Positions 56-140.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q925E1.

Proteomic databases

PRIDEi Q925E1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115484 ; ENSMUSP00000111147 ; ENSMUSG00000025909 . [Q925E1-2 ]
GeneIDi 71096.
UCSCi uc007agg.1. mouse. [Q925E1-2 ]

Organism-specific databases

MGIi MGI:1918346. Sntg1.

Phylogenomic databases

eggNOGi NOG253217.
GeneTreei ENSGT00550000074581.
HOGENOMi HOG000230749.
HOVERGENi HBG060412.
InParanoidi Q925E1.
PhylomeDBi Q925E1.

Miscellaneous databases

ChiTaRSi SNTG1. mouse.
PROi Q925E1.
SOURCEi Search...

Gene expression databases

Bgeei Q925E1.
CleanExi MM_SNTG1.
Genevestigatori Q925E1.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015482. Syntrophin.
IPR015483. Syntrophin_gamma.
[Graphical view ]
PANTHERi PTHR10554. PTHR10554. 1 hit.
PTHR10554:SF2. PTHR10554:SF2. 1 hit.
Pfami PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of mouse gamma syntrophins."
    Alessi A., Adams M.E., Froehner S.C.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiSNTG1_MOUSE
AccessioniPrimary (citable) accession number: Q925E1
Secondary accession number(s): Q9D3Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi