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Protein

Gamma-1-syntrophin

Gene

Sntg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-1-syntrophin
Short name:
G1SYN
Alternative name(s):
Syntrophin-4
Short name:
SYN4
Gene namesi
Name:Sntg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918346. Sntg1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840141 – 517Gamma-1-syntrophinAdd BLAST517

Proteomic databases

PaxDbiQ925E1.
PRIDEiQ925E1.

PTM databases

iPTMnetiQ925E1.
PhosphoSitePlusiQ925E1.

Expressioni

Gene expression databases

CleanExiMM_SNTG1.

Interactioni

Subunit structurei

Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Interacts with DGKZ (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214473. 1 interactor.
STRINGi10090.ENSMUSP00000111151.

Structurei

3D structure databases

ProteinModelPortaliQ925E1.
SMRiQ925E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 140PDZPROSITE-ProRule annotationAdd BLAST84
Domaini283 – 390PHPROSITE-ProRule annotationAdd BLAST108

Domaini

The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Phylogenomic databases

eggNOGiKOG3549. Eukaryota.
ENOG410XQXQ. LUCA.
HOGENOMiHOG000230749.
HOVERGENiHBG060412.
InParanoidiQ925E1.
PhylomeDBiQ925E1.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiView protein in InterPro
IPR001478. PDZ.
IPR036034. PDZ_sf.
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
IPR015482. Syntrophin.
IPR015483. Syntrophin_gamma.
PANTHERiPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF2. PTHR10554:SF2. 1 hit.
PfamiView protein in Pfam
PF00595. PDZ. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiView protein in PROSITE
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q925E1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFRTTCEET KTGVCLLQDG NQEPFKVRLH LARDLLMLQE QDVLCVSGEP
60 70 80 90 100
FYSGERTVTI RRQTVGGFGL SIKGGAEHNI PVVISKISKE QRAELSGLLF
110 120 130 140 150
IGDAILQING INVRKCRHEE VVQVLRNAGE EVTLTVSFLK RAPAFLKLPV
160 170 180 190 200
NEDCACAPSD QSSGTSSPLC DSGLHLNYHP NNTDTLSCSS WPTSPGLRWE
210 220 230 240 250
KRWCDLRLIP LLHARFSQYV PGTDLSRQNE SQVVAVDGVC SGILQCLSAE
260 270 280 290 300
DCMDWLQAIA SNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQESLQD
310 320 330 340 350
RVYTPVFLAL RGSCLYRFLS PPVTTWDWTR AEKTFSVCEI MCKVLKDSDL
360 370 380 390 400
LDRRKHCFTM QSECGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT
410 420 430 440 450
YACVLESHLM GLTIDFSTGF ICFDAATKAV LWRYKFSQLK GSSDDGKSKI
460 470 480 490 500
KFLFQNPDTK QIEAKELEFS NLFAVLHCIH SFFAAKVACL DPLFLGNQAA
510
TTAAVSSAST SKAKHLA
Length:517
Mass (Da):57,982
Last modified:October 10, 2002 - v2
Checksum:i20133EFD3ED9EF6D
GO
Isoform 2 (identifier: Q925E1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.
     276-283: RNFPVNQQ → MIKHLPSY

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):27,579
Checksum:i7C30E4B8F5091C52
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0063611 – 275Missing in isoform 2. 1 PublicationAdd BLAST275
Alternative sequenceiVSP_006362276 – 283RNFPVNQQ → MIKHLPSY in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367759 mRNA. Translation: AAK53399.1.
AK016927 mRNA. Translation: BAB30501.1.
CCDSiCCDS35509.1. [Q925E1-1]
RefSeqiNP_001277322.1. NM_001290393.1.
UniGeneiMm.336395.
Mm.388998.

Genome annotation databases

GeneIDi71096.
KEGGimmu:71096.
UCSCiuc007agg.2. mouse. [Q925E1-2]
uc011whz.2. mouse. [Q925E1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNTG1_MOUSE
AccessioniPrimary (citable) accession number: Q925E1
Secondary accession number(s): Q9D3Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: November 22, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families