Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q925E1

- SNTG1_MOUSE

UniProt

Q925E1 - SNTG1_MOUSE

Protein

Gamma-1-syntrophin

Gene

Sntg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (10 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation By similarity.By similarity

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-1-syntrophin
    Short name:
    G1SYN
    Alternative name(s):
    Syntrophin-4
    Short name:
    SYN4
    Gene namesi
    Name:Sntg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1918346. Sntg1.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Nucleus By similarity
    Note: Mainly cytoplasmic and weakly nuclear.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Gamma-1-syntrophinPRO_0000184014Add
    BLAST

    Proteomic databases

    PRIDEiQ925E1.

    PTM databases

    PhosphoSiteiQ925E1.

    Expressioni

    Gene expression databases

    BgeeiQ925E1.
    CleanExiMM_SNTG1.
    GenevestigatoriQ925E1.

    Interactioni

    Subunit structurei

    Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Interacts with DGKZ By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ925E1.
    SMRiQ925E1. Positions 56-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 14084PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini283 – 390108PHPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.By similarity

    Sequence similaritiesi

    Belongs to the syntrophin family.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG253217.
    GeneTreeiENSGT00550000074581.
    HOGENOMiHOG000230749.
    HOVERGENiHBG060412.
    InParanoidiQ925E1.
    PhylomeDBiQ925E1.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015482. Syntrophin.
    IPR015483. Syntrophin_gamma.
    [Graphical view]
    PANTHERiPTHR10554. PTHR10554. 1 hit.
    PTHR10554:SF2. PTHR10554:SF2. 1 hit.
    PfamiPF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q925E1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDFRTTCEET KTGVCLLQDG NQEPFKVRLH LARDLLMLQE QDVLCVSGEP    50
    FYSGERTVTI RRQTVGGFGL SIKGGAEHNI PVVISKISKE QRAELSGLLF 100
    IGDAILQING INVRKCRHEE VVQVLRNAGE EVTLTVSFLK RAPAFLKLPV 150
    NEDCACAPSD QSSGTSSPLC DSGLHLNYHP NNTDTLSCSS WPTSPGLRWE 200
    KRWCDLRLIP LLHARFSQYV PGTDLSRQNE SQVVAVDGVC SGILQCLSAE 250
    DCMDWLQAIA SNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQESLQD 300
    RVYTPVFLAL RGSCLYRFLS PPVTTWDWTR AEKTFSVCEI MCKVLKDSDL 350
    LDRRKHCFTM QSECGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT 400
    YACVLESHLM GLTIDFSTGF ICFDAATKAV LWRYKFSQLK GSSDDGKSKI 450
    KFLFQNPDTK QIEAKELEFS NLFAVLHCIH SFFAAKVACL DPLFLGNQAA 500
    TTAAVSSAST SKAKHLA 517
    Length:517
    Mass (Da):57,982
    Last modified:October 10, 2002 - v2
    Checksum:i20133EFD3ED9EF6D
    GO
    Isoform 2 (identifier: Q925E1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-275: Missing.
         276-283: RNFPVNQQ → MIKHLPSY

    Note: No experimental confirmation available.

    Show »
    Length:242
    Mass (Da):27,579
    Checksum:i7C30E4B8F5091C52
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 275275Missing in isoform 2. 1 PublicationVSP_006361Add
    BLAST
    Alternative sequencei276 – 2838RNFPVNQQ → MIKHLPSY in isoform 2. 1 PublicationVSP_006362

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF367759 mRNA. Translation: AAK53399.1.
    AK016927 mRNA. Translation: BAB30501.1.
    CCDSiCCDS35509.1. [Q925E1-1]
    RefSeqiNP_001277322.1. NM_001290393.1.
    UniGeneiMm.336395.
    Mm.388998.

    Genome annotation databases

    EnsembliENSMUST00000115484; ENSMUSP00000111147; ENSMUSG00000025909. [Q925E1-2]
    GeneIDi71096.
    UCSCiuc007agg.1. mouse. [Q925E1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF367759 mRNA. Translation: AAK53399.1 .
    AK016927 mRNA. Translation: BAB30501.1 .
    CCDSi CCDS35509.1. [Q925E1-1 ]
    RefSeqi NP_001277322.1. NM_001290393.1.
    UniGenei Mm.336395.
    Mm.388998.

    3D structure databases

    ProteinModelPortali Q925E1.
    SMRi Q925E1. Positions 56-140.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q925E1.

    Proteomic databases

    PRIDEi Q925E1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000115484 ; ENSMUSP00000111147 ; ENSMUSG00000025909 . [Q925E1-2 ]
    GeneIDi 71096.
    UCSCi uc007agg.1. mouse. [Q925E1-2 ]

    Organism-specific databases

    MGIi MGI:1918346. Sntg1.

    Phylogenomic databases

    eggNOGi NOG253217.
    GeneTreei ENSGT00550000074581.
    HOGENOMi HOG000230749.
    HOVERGENi HBG060412.
    InParanoidi Q925E1.
    PhylomeDBi Q925E1.

    Miscellaneous databases

    ChiTaRSi SNTG1. mouse.
    PROi Q925E1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q925E1.
    CleanExi MM_SNTG1.
    Genevestigatori Q925E1.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015482. Syntrophin.
    IPR015483. Syntrophin_gamma.
    [Graphical view ]
    PANTHERi PTHR10554. PTHR10554. 1 hit.
    PTHR10554:SF2. PTHR10554:SF2. 1 hit.
    Pfami PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of mouse gamma syntrophins."
      Alessi A., Adams M.E., Froehner S.C.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Testis.

    Entry informationi

    Entry nameiSNTG1_MOUSE
    AccessioniPrimary (citable) accession number: Q925E1
    Secondary accession number(s): Q9D3Z5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3