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Protein

Gamma-2-syntrophin

Gene

Sntg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-2-syntrophin
Short name:
G2SYN
Alternative name(s):
Syntrophin-5
Short name:
SYN5
Gene namesi
Name:Sntg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1919541 Sntg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840161 – 539Gamma-2-syntrophinAdd BLAST539

Proteomic databases

MaxQBiQ925E0
PaxDbiQ925E0
PRIDEiQ925E0

PTM databases

iPTMnetiQ925E0
PhosphoSitePlusiQ925E0

Expressioni

Gene expression databases

BgeeiENSMUSG00000020672
CleanExiMM_SNTG2
ExpressionAtlasiQ925E0 baseline and differential
GenevisibleiQ925E0 MM

Interactioni

Subunit structurei

Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ925E0, 1 interactor
MINTiQ925E0
STRINGi10090.ENSMUSP00000021004

Structurei

3D structure databases

ProteinModelPortaliQ925E0
SMRiQ925E0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 156PDZPROSITE-ProRule annotationAdd BLAST84
Domaini296 – 421PHPROSITE-ProRule annotationAdd BLAST126

Domaini

The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Phylogenomic databases

eggNOGiKOG3549 Eukaryota
ENOG410XQXQ LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000230749
HOVERGENiHBG060412
InParanoidiQ925E0
OMAiSFQRAIF
OrthoDBiEOG091G04YZ
PhylomeDBiQ925E0
TreeFamiTF317932

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001849 PH_domain
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q925E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEGSQSLA APRGRPSHLL VPARTKTALA LLYDEGLENA YDVRLKLTKE
60 70 80 90 100
VLTIQKQDVV CIGGAPPGAN HRTVTLRRQP VGGLGLSIKG GAEHGVPVVI
110 120 130 140 150
SKIFKDQAAD QTEMLFIGDA VLQVNGINVE NATHEEVVHL LRNAGDDVTI
160 170 180 190 200
TVEYLREAPS FLKLPLGSPG PSSDHSSRAS SPLFDSGLHL NGHCSHTAPS
210 220 230 240 250
SPSSPIANEP KYEKRWLDTL SVPLSMARIS RYKAGTEKLR SSALEVLALD
260 270 280 290 300
GASTGVLQFS TAQDCADWLR SISTNISDLT LQHMKMANKC CSPCDQVVHM
310 320 330 340 350
GWVNERLQGA DNSQNFRPKF LALRGSSFYI FGAPPVSTLD WGRAERAYNL
360 370 380 390 400
CEVLFKVHKF WLSDNYWLQA NLYLGLQDFD CEDPRSYCFS VLANHGKSHI
410 420 430 440 450
FSVELGSELA VWEKAFQRAT FMEVQRTGSK TYLCSWQGET LCFTVDFALG
460 470 480 490 500
FTCFDGKTKN VLWRFKFSQL KGSSDDGKTR VKLLFQNLDT KQIETKELEF
510 520 530
QDLTAVLHCI HSFIAAKVAS LDPVFMDSQS MARRYLCSS
Length:539
Mass (Da):59,598
Last modified:December 1, 2001 - v1
Checksum:i4DB2A0916336D379
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367760 mRNA Translation: AAK53400.1
BC138956 mRNA Translation: AAI38957.1
CCDSiCCDS25858.1
RefSeqiNP_766539.2, NM_172951.3
UniGeneiMm.279765

Genome annotation databases

EnsembliENSMUST00000021004; ENSMUSP00000021004; ENSMUSG00000020672
GeneIDi268534
KEGGimmu:268534
UCSCiuc007ngr.2 mouse

Entry informationi

Entry nameiSNTG2_MOUSE
AccessioniPrimary (citable) accession number: Q925E0
Secondary accession number(s): B2RSQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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