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Protein

Gamma-2-syntrophin

Gene

Sntg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-2-syntrophin
Short name:
G2SYN
Alternative name(s):
Syntrophin-5
Short name:
SYN5
Gene namesi
Name:Sntg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919541. Sntg2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840161 – 539Gamma-2-syntrophinAdd BLAST539

Proteomic databases

PaxDbiQ925E0.
PRIDEiQ925E0.

PTM databases

iPTMnetiQ925E0.
PhosphoSitePlusiQ925E0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020672.
CleanExiMM_SNTG2.
ExpressionAtlasiQ925E0. baseline and differential.
GenevisibleiQ925E0. MM.

Interactioni

Subunit structurei

Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ925E0. 1 interactor.
STRINGi10090.ENSMUSP00000021004.

Structurei

3D structure databases

ProteinModelPortaliQ925E0.
SMRiQ925E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 156PDZPROSITE-ProRule annotationAdd BLAST84
Domaini296 – 421PHPROSITE-ProRule annotationAdd BLAST126

Domaini

The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3549. Eukaryota.
ENOG410XQXQ. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000230749.
HOVERGENiHBG060412.
InParanoidiQ925E0.
OMAiSFQRAIF.
OrthoDBiEOG091G04YZ.
PhylomeDBiQ925E0.
TreeFamiTF317932.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEGSQSLA APRGRPSHLL VPARTKTALA LLYDEGLENA YDVRLKLTKE
60 70 80 90 100
VLTIQKQDVV CIGGAPPGAN HRTVTLRRQP VGGLGLSIKG GAEHGVPVVI
110 120 130 140 150
SKIFKDQAAD QTEMLFIGDA VLQVNGINVE NATHEEVVHL LRNAGDDVTI
160 170 180 190 200
TVEYLREAPS FLKLPLGSPG PSSDHSSRAS SPLFDSGLHL NGHCSHTAPS
210 220 230 240 250
SPSSPIANEP KYEKRWLDTL SVPLSMARIS RYKAGTEKLR SSALEVLALD
260 270 280 290 300
GASTGVLQFS TAQDCADWLR SISTNISDLT LQHMKMANKC CSPCDQVVHM
310 320 330 340 350
GWVNERLQGA DNSQNFRPKF LALRGSSFYI FGAPPVSTLD WGRAERAYNL
360 370 380 390 400
CEVLFKVHKF WLSDNYWLQA NLYLGLQDFD CEDPRSYCFS VLANHGKSHI
410 420 430 440 450
FSVELGSELA VWEKAFQRAT FMEVQRTGSK TYLCSWQGET LCFTVDFALG
460 470 480 490 500
FTCFDGKTKN VLWRFKFSQL KGSSDDGKTR VKLLFQNLDT KQIETKELEF
510 520 530
QDLTAVLHCI HSFIAAKVAS LDPVFMDSQS MARRYLCSS
Length:539
Mass (Da):59,598
Last modified:December 1, 2001 - v1
Checksum:i4DB2A0916336D379
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367760 mRNA. Translation: AAK53400.1.
BC138956 mRNA. Translation: AAI38957.1.
CCDSiCCDS25858.1.
RefSeqiNP_766539.2. NM_172951.3.
UniGeneiMm.279765.

Genome annotation databases

EnsembliENSMUST00000021004; ENSMUSP00000021004; ENSMUSG00000020672.
GeneIDi268534.
KEGGimmu:268534.
UCSCiuc007ngr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367760 mRNA. Translation: AAK53400.1.
BC138956 mRNA. Translation: AAI38957.1.
CCDSiCCDS25858.1.
RefSeqiNP_766539.2. NM_172951.3.
UniGeneiMm.279765.

3D structure databases

ProteinModelPortaliQ925E0.
SMRiQ925E0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ925E0. 1 interactor.
STRINGi10090.ENSMUSP00000021004.

PTM databases

iPTMnetiQ925E0.
PhosphoSitePlusiQ925E0.

Proteomic databases

PaxDbiQ925E0.
PRIDEiQ925E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021004; ENSMUSP00000021004; ENSMUSG00000020672.
GeneIDi268534.
KEGGimmu:268534.
UCSCiuc007ngr.2. mouse.

Organism-specific databases

CTDi54221.
MGIiMGI:1919541. Sntg2.

Phylogenomic databases

eggNOGiKOG3549. Eukaryota.
ENOG410XQXQ. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000230749.
HOVERGENiHBG060412.
InParanoidiQ925E0.
OMAiSFQRAIF.
OrthoDBiEOG091G04YZ.
PhylomeDBiQ925E0.
TreeFamiTF317932.

Miscellaneous databases

PROiQ925E0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020672.
CleanExiMM_SNTG2.
ExpressionAtlasiQ925E0. baseline and differential.
GenevisibleiQ925E0. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNTG2_MOUSE
AccessioniPrimary (citable) accession number: Q925E0
Secondary accession number(s): B2RSQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.