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Protein
Submitted name:

Mitogen-activated protein kinase kinase 6

Gene

Map2k6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: RGD
  • apoptotic process Source: RGD
  • cardiac muscle contraction Source: RGD
  • cellular response to sorbitol Source: RGD
  • MAPK cascade Source: RGD
  • ovulation cycle process Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of nitric-oxide synthase biosynthetic process Source: RGD
  • positive regulation of prostaglandin secretion Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • protein phosphorylation Source: RGD
  • regulation of mitotic cell cycle Source: GO_Central
  • response to drug Source: RGD
  • response to ischemia Source: RGD
  • stress-activated protein kinase signaling cascade Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-168638. NOD1/2 Signaling Pathway.
R-RNO-2559580. Oxidative Stress Induced Senescence.
R-RNO-446652. Interleukin-1 family signaling.
R-RNO-450302. activated TAK1 mediates p38 MAPK activation.
R-RNO-6811555. PI5P Regulates TP53 Acetylation.

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase 6Imported
Submitted name:
Mitogen-activated protein kinase kinase 6, isoform CRA_aImported
Gene namesi
Name:Map2k6Imported
Synonyms:Mkk6Imported
ORF Names:rCG_34806Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620666. Map2k6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000004437.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006217.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 314Protein kinaseInterPro annotationAdd BLAST262

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
GeneTreeiENSGT00760000119199.
HOGENOMiHOG000234206.
HOVERGENiHBG108518.
KOiK04433.
OMAiWGTPFEQ.
OrthoDBiEOG091G0A9H.
TreeFamiTF350701.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q925D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSKGKKRN PGLKIPREAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA
60 70 80 90 100
DDLEPIVELG RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL
110 120 130 140 150
DVSMRTVDCP FTVTFYGALF REGDVWICME LMDTSLDKFY KQVIDKGQTI
160 170 180 190 200
PEDILGKIAV SIVKALEHLH SKLSVIHRDV KPSNVLINTL GQVKMCDFGI
210 220 230 240 250
SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI WSLGITMIEL
260 270 280 290 300
AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSADFVDF TSQCLKKNSK
310 320 330
ERPTYPELMQ HPFFTVHEAK AADVASFVKL ILGD
Length:334
Mass (Da):37,444
Last modified:December 1, 2001 - v1
Checksum:iC6A4843F82F63D87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030670 Genomic DNA. No translation available.
AABR07030671 Genomic DNA. No translation available.
AABR07030672 Genomic DNA. No translation available.
AABR07030673 Genomic DNA. No translation available.
BC087004 mRNA. Translation: AAH87004.1.
AF369384 mRNA. Translation: AAK53428.1.
CH473948 Genomic DNA. Translation: EDM06489.1.
RefSeqiNP_446155.1. NM_053703.3.
UniGeneiRn.17256.

Genome annotation databases

EnsembliENSRNOT00000006217; ENSRNOP00000006217; ENSRNOG00000004437.
GeneIDi114495.
KEGGirno:114495.

Similar proteinsi

Entry informationi

Entry nameiQ925D6_RAT
AccessioniPrimary (citable) accession number: Q925D6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported