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Protein

Transmembrane protein 176B

Gene

Tmem176b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the development of cerebellar granule cells (By similarity). May play a role in the process of maturation of dendritic cells.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 176B
Alternative name(s):
Protein LR8
Tolerance-related and induced transcript protein
Gene namesi
Name:Tmem176b
Synonyms:Lr8, Torid
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi708403. Tmem176b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei61 – 8121HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Transmembrane protein 176BPRO_0000279878Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491PhosphoserineCombined sources
Modified residuei253 – 2531PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ925D4.
PRIDEiQ925D4.

Expressioni

Tissue specificityi

Expressed in spleen by a variety of myeloid cells including macrophages and dendritic cells (at protein level). Ubiquitously expressed with higher expression in lymphoid tissues.1 Publication

Inductioni

Up-regulated in tolerated allografts. Down-regulated in activated macrophages.1 Publication

Gene expression databases

GenevisibleiQ925D4. RN.

Interactioni

Protein-protein interaction databases

BioGridi251237. 1 interaction.
STRINGi10116.ENSRNOP00000011327.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM176 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXII. Eukaryota.
ENOG410ZDNZ. LUCA.
GeneTreeiENSGT00530000064074.
HOGENOMiHOG000290691.
HOVERGENiHBG094020.
InParanoidiQ925D4.
OMAiRASGCAF.
OrthoDBiEOG7H4DVP.
PhylomeDBiQ925D4.
TreeFamiTF335389.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR009281. TMEM176A/TMEM176B.
[Graphical view]
PANTHERiPTHR15756. PTHR15756. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQATVTVDG VKVTSTRPQS AQISIHIHHK SALEQLLGAM GSLKKFLSYP
60 70 80 90 100
QARIHYGQLS LGVTQILLGL VSCVLGVCLY FGPWTELCAS GCAFWSGSVA
110 120 130 140 150
ILAGVGIVIH EMGQGKLSGH ISRLLLLACS ATAAAATVMG VKSLIWQTSA
160 170 180 190 200
SYYFEISSTC DSLQPSIVDR FRSVRFTDDS DWRTERCREY LRMMMNLFLA
210 220 230 240 250
FCILFTVICI LKIVVSVASL GLSLRSMCGR NSQVLNDEET EKKLLGGDSA
260
PASPTKEKIP VTP
Length:263
Mass (Da):28,485
Last modified:December 1, 2001 - v1
Checksum:i49F231E020A2DE31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370882 mRNA. Translation: AAK51554.1.
BC059116 mRNA. Translation: AAH59116.1.
RefSeqiNP_001257518.1. NM_001270589.1.
NP_001257519.1. NM_001270590.1.
NP_001257520.1. NM_001270591.1.
NP_001257521.1. NM_001270592.1.
NP_001257522.1. NM_001270593.1.
NP_001257523.1. NM_001270594.1.
NP_599217.1. NM_134390.3.
XP_006236517.1. XM_006236455.2.
UniGeneiRn.26876.

Genome annotation databases

EnsembliENSRNOT00000011327; ENSRNOP00000011327; ENSRNOG00000008465.
ENSRNOT00000078473; ENSRNOP00000074935; ENSRNOG00000008465.
GeneIDi171411.
KEGGirno:171411.
UCSCiRGD:708403. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370882 mRNA. Translation: AAK51554.1.
BC059116 mRNA. Translation: AAH59116.1.
RefSeqiNP_001257518.1. NM_001270589.1.
NP_001257519.1. NM_001270590.1.
NP_001257520.1. NM_001270591.1.
NP_001257521.1. NM_001270592.1.
NP_001257522.1. NM_001270593.1.
NP_001257523.1. NM_001270594.1.
NP_599217.1. NM_134390.3.
XP_006236517.1. XM_006236455.2.
UniGeneiRn.26876.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251237. 1 interaction.
STRINGi10116.ENSRNOP00000011327.

Proteomic databases

PaxDbiQ925D4.
PRIDEiQ925D4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011327; ENSRNOP00000011327; ENSRNOG00000008465.
ENSRNOT00000078473; ENSRNOP00000074935; ENSRNOG00000008465.
GeneIDi171411.
KEGGirno:171411.
UCSCiRGD:708403. rat.

Organism-specific databases

CTDi28959.
RGDi708403. Tmem176b.

Phylogenomic databases

eggNOGiENOG410IXII. Eukaryota.
ENOG410ZDNZ. LUCA.
GeneTreeiENSGT00530000064074.
HOGENOMiHOG000290691.
HOVERGENiHBG094020.
InParanoidiQ925D4.
OMAiRASGCAF.
OrthoDBiEOG7H4DVP.
PhylomeDBiQ925D4.
TreeFamiTF335389.

Miscellaneous databases

NextBioi622292.
PROiQ925D4.

Gene expression databases

GenevisibleiQ925D4. RN.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR009281. TMEM176A/TMEM176B.
[Graphical view]
PANTHERiPTHR15756. PTHR15756. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts."
    Louvet C., Chiffoleau E., Heslan M., Tesson L., Heslan J.-M., Brion R., Beriou G., Guillonneau C., Khalife J., Anegon I., Cuturi M.-C.
    Am. J. Transplant. 5:2143-2153(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: Lewis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249 AND SER-253, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiT176B_RAT
AccessioniPrimary (citable) accession number: Q925D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: February 17, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression of Tmem176b alters maturation of bone marrow-derived dendritic cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.