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Protein

Synaptotagmin-13

Gene

Syt13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transport vesicle docking to the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name:
SytXIII
Gene namesi
Name:Syt13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621877. Syt13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6VesicularSequence analysis6
Transmembranei7 – 29HelicalSequence analysisAdd BLAST23
Topological domaini30 – 426CytoplasmicSequence analysisAdd BLAST397

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839771 – 426Synaptotagmin-13Add BLAST426

Proteomic databases

PaxDbiQ925B5.
PRIDEiQ925B5.

PTM databases

iPTMnetiQ925B5.
PhosphoSitePlusiQ925B5.

Expressioni

Tissue specificityi

Expressed in brain, spleen, kidney and testis.1 Publication

Interactioni

Subunit structurei

Interacts with NRXN1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249494. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ925B5.
SMRiQ925B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 259C2 1Add BLAST85
Domaini289 – 394C2 2Add BLAST106

Domaini

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.By similarity
The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3H. Eukaryota.
ENOG4110ZXG. LUCA.
HOGENOMiHOG000231448.
HOVERGENiHBG098553.
InParanoidiQ925B5.
KOiK19913.
PhylomeDBiQ925B5.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR028692. SYT13.
PANTHERiPTHR10024:SF250. PTHR10024:SF250. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 2 hits.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q925B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDREPDPEK
60 70 80 90 100
ARPGVLQAAQ QFNVKKSTEP VQPRPLLKFP DIYGPRPAVT APEVINYADY
110 120 130 140 150
TLGTTEESAA PASPQAQSDS RLKRQVTEEL FILPQNGVVE DVCVMETWNP
160 170 180 190 200
EKAASWNQAP KLHFRLDYDQ KKAELFVTSL EAVTSDHEGG CDCYIQGSVA
210 220 230 240 250
VKTGSVEAQT ALKKRQLHTT WEEGLTLPLG EEELPTATLT LTLRTCDRFS
260 270 280 290 300
RHSVIGELRL GLNGASVPLG TAQWGELKTT AKEPSAGTGE VLLSISYLPA
310 320 330 340 350
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQAQKL KKKQTKRAKH
360 370 380 390 400
KINPVWNEMI MFELPDDLLQ ASSVELEVLG QGEEGPSCEL GRCSLGLHAS
410 420
GSERSHWEEM LKNPRRQIAM WHQLHL
Length:426
Mass (Da):46,881
Last modified:December 1, 2001 - v1
Checksum:i84048947BF2AB65B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226T → A in AAG30575 (PubMed:11211934).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313453 mRNA. Translation: AAG30575.1.
AF375466 mRNA. Translation: AAK56961.1.
RefSeqiNP_110466.2. NM_030839.3.
UniGeneiRn.217068.

Genome annotation databases

GeneIDi80977.
KEGGirno:80977.
UCSCiRGD:621877. rat.

Similar proteinsi

Entry informationi

Entry nameiSYT13_RAT
AccessioniPrimary (citable) accession number: Q925B5
Secondary accession number(s): Q9ERD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families