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Protein

Synaptotagmin-13

Gene

Syt13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transport vesicle docking to the plasma membrane.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name:
SytXIII
Gene namesi
Name:Syt13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621877. Syt13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66VesicularSequence analysis
Transmembranei7 – 2923HelicalSequence analysisAdd
BLAST
Topological domaini30 – 426397CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Synaptotagmin-13PRO_0000183977Add
BLAST

Proteomic databases

PaxDbiQ925B5.
PRIDEiQ925B5.

PTM databases

iPTMnetiQ925B5.

Expressioni

Tissue specificityi

Expressed in brain, spleen, kidney and testis.1 Publication

Interactioni

Subunit structurei

Interacts with NRXN1.By similarity

Protein-protein interaction databases

BioGridi249494. 1 interaction.
STRINGi10116.ENSRNOP00000011459.

Structurei

3D structure databases

ProteinModelPortaliQ925B5.
SMRiQ925B5. Positions 156-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 25985C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini289 – 394106C2 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.By similarity
The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3H. Eukaryota.
ENOG4110ZXG. LUCA.
HOGENOMiHOG000231448.
HOVERGENiHBG098553.
InParanoidiQ925B5.
KOiK19913.
OrthoDBiEOG71P2B0.
PhylomeDBiQ925B5.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view]
PANTHERiPTHR10024:SF250. PTHR10024:SF250. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q925B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDREPDPEK
60 70 80 90 100
ARPGVLQAAQ QFNVKKSTEP VQPRPLLKFP DIYGPRPAVT APEVINYADY
110 120 130 140 150
TLGTTEESAA PASPQAQSDS RLKRQVTEEL FILPQNGVVE DVCVMETWNP
160 170 180 190 200
EKAASWNQAP KLHFRLDYDQ KKAELFVTSL EAVTSDHEGG CDCYIQGSVA
210 220 230 240 250
VKTGSVEAQT ALKKRQLHTT WEEGLTLPLG EEELPTATLT LTLRTCDRFS
260 270 280 290 300
RHSVIGELRL GLNGASVPLG TAQWGELKTT AKEPSAGTGE VLLSISYLPA
310 320 330 340 350
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQAQKL KKKQTKRAKH
360 370 380 390 400
KINPVWNEMI MFELPDDLLQ ASSVELEVLG QGEEGPSCEL GRCSLGLHAS
410 420
GSERSHWEEM LKNPRRQIAM WHQLHL
Length:426
Mass (Da):46,881
Last modified:December 1, 2001 - v1
Checksum:i84048947BF2AB65B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2261T → A in AAG30575 (PubMed:11211934).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313453 mRNA. Translation: AAG30575.1.
AF375466 mRNA. Translation: AAK56961.1.
RefSeqiNP_110466.2. NM_030839.3.
UniGeneiRn.217068.

Genome annotation databases

GeneIDi80977.
KEGGirno:80977.
UCSCiRGD:621877. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313453 mRNA. Translation: AAG30575.1.
AF375466 mRNA. Translation: AAK56961.1.
RefSeqiNP_110466.2. NM_030839.3.
UniGeneiRn.217068.

3D structure databases

ProteinModelPortaliQ925B5.
SMRiQ925B5. Positions 156-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249494. 1 interaction.
STRINGi10116.ENSRNOP00000011459.

PTM databases

iPTMnetiQ925B5.

Proteomic databases

PaxDbiQ925B5.
PRIDEiQ925B5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80977.
KEGGirno:80977.
UCSCiRGD:621877. rat.

Organism-specific databases

CTDi57586.
RGDi621877. Syt13.

Phylogenomic databases

eggNOGiENOG410IT3H. Eukaryota.
ENOG4110ZXG. LUCA.
HOGENOMiHOG000231448.
HOVERGENiHBG098553.
InParanoidiQ925B5.
KOiK19913.
OrthoDBiEOG71P2B0.
PhylomeDBiQ925B5.
TreeFamiTF315600.

Miscellaneous databases

PROiQ925B5.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view]
PANTHERiPTHR10024:SF250. PTHR10024:SF250. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Synaptotagmin 13: structure and expression of a novel synaptotagmin."
    von Poser C., Suedhof T.C.
    Eur. J. Cell Biol. 80:41-47(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiSYT13_RAT
AccessioniPrimary (citable) accession number: Q925B5
Secondary accession number(s): Q9ERD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.