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Protein

Septin-8

Gene

SEPT8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion.By similarityCurated1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106GTP; via amide nitrogenBy similarity1
Binding sitei241GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei256GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 58GTPBy similarity8
Nucleotide bindingi187 – 195GTPBy similarity9

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-8
Gene namesi
Name:SEPT8
Synonyms:KIAA0202
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000164402.13
HGNCiHGNC:16511 SEPT8
MIMi608418 gene
neXtProtiNX_Q92599

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164402
PharmGKBiPA134879270

Polymorphism and mutation databases

BioMutaiSEPT8
DMDMi45645200

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001735332 – 483Septin-8Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92599
MaxQBiQ92599
PaxDbiQ92599
PeptideAtlasiQ92599
PRIDEiQ92599

PTM databases

iPTMnetiQ92599
PhosphoSitePlusiQ92599
SwissPalmiQ92599

Expressioni

Tissue specificityi

Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.4 Publications

Gene expression databases

BgeeiENSG00000164402
CleanExiHS_SEPT8
ExpressionAtlasiQ92599 baseline and differential
GenevisibleiQ92599 HS

Organism-specific databases

HPAiHPA036534

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with CDK14, SEPT4, SEPT5 and SEPT7 (By similarity).By similarity

Protein-protein interaction databases

BioGridi116788, 36 interactors
CORUMiQ92599
IntActiQ92599, 12 interactors
MINTiQ92599
STRINGi9606.ENSP00000367991

Structurei

3D structure databases

ProteinModelPortaliQ92599
SMRiQ92599
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 307Septin-type GPROSITE-ProRule annotationAdd BLAST267

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 58G1 motifPROSITE-ProRule annotation8
Regioni103 – 106G3 motifPROSITE-ProRule annotation4
Regioni186 – 189G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili320 – 413Sequence analysisAdd BLAST94

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ92599
KOiK16939
OMAiMDLVCMK
OrthoDBiEOG091G0IKM
PhylomeDBiQ92599
TreeFamiTF101080

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030646 SEPT8
IPR016491 Septin
PANTHERiPTHR18884:SF54 PTHR18884:SF54, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92599-1) [UniParc]FASTAAdd to basket
Also known as: KIAA0202b, SEPT8_v2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV
60 70 80 90 100
GETGIGKSTL MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT
110 120 130 140 150
IVDAVGFGDQ INKDESYRPI VDYIDAQFEN YLQEELKIRR SLFDYHDTRI
160 170 180 190 200
HVCLYFITPT GHSLKSLDLV TMKKLDSKVN IIPIIAKADT ISKSELHKFK
210 220 230 240 250
IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV GSTEEVKVGN
260 270 280 290 300
KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY
310 320 330 340 350
RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN
360 370 380 390 400
KVKETELELK EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR
410 420 430 440 450
RKAAVEALQS QALHATSQQP LRKDKDKKNR SDIGAHQPGM SLSSSKVMMT
460 470 480
KASVEPLNCS SWWPAIQCCS CLVRDATWRE GFL
Length:483
Mass (Da):55,756
Last modified:January 23, 2007 - v4
Checksum:i35E1ACF95F5DBA6B
GO
Isoform 2 (identifier: Q92599-2) [UniParc]FASTAAdd to basket
Also known as: KIAA0202a, SEPT8_v1, KIAA0202c, SEPT8_v1*

The sequence of this isoform differs from the canonical sequence as follows:
     430-483: Missing.

Note: KIAA0202a differs from KIAA0202c at the level of the 3'-UTR.
Show »
Length:429
Mass (Da):49,814
Checksum:iB6900F134CF67474
GO
Isoform 3 (identifier: Q92599-3) [UniParc]FASTAAdd to basket
Also known as: KIAA0202d, SEPT8_v3

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     430-483: Missing.

Show »
Length:369
Mass (Da):43,519
Checksum:i3C85574B0124B3BA
GO
Isoform 4 (identifier: Q92599-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-442: NRSDIGAHQPGMSL → KASGWSSIYSVTIP
     443-483: Missing.

Show »
Length:442
Mass (Da):51,178
Checksum:i4A3D69A996FE624C
GO

Sequence cautioni

The sequence AAG09407 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH01329 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO13878 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAO13879 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAO13880 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA13193 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116 – 117Missing in AK057797 (PubMed:14702039).Curated2
Sequence conflicti365E → V in AK057797 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0096431 – 60Missing in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_054085429 – 442NRSDI…PGMSL → KASGWSSIYSVTIP in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_009644430 – 483Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST54
Alternative sequenceiVSP_054086443 – 483Missing in isoform 4. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86957 mRNA Translation: BAA13193.1 Different initiation.
AF179995 mRNA Translation: AAG09407.1 Different initiation.
AF440761 mRNA Translation: AAO13878.1 Different initiation.
AF440762 mRNA Translation: AAO13879.1 Different initiation.
AF440763 mRNA Translation: AAO13880.1 Different initiation.
AK057797 mRNA No translation available.
AC004775 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62315.1
CH471062 Genomic DNA Translation: EAW62317.1
BC001329 mRNA Translation: AAH01329.1 Different initiation.
CCDSiCCDS43358.1 [Q92599-1]
CCDS43359.1 [Q92599-4]
CCDS43360.1 [Q92599-2]
CCDS47262.1 [Q92599-3]
RefSeqiNP_001092281.1, NM_001098811.1 [Q92599-1]
NP_001092282.1, NM_001098812.1 [Q92599-4]
NP_001092283.1, NM_001098813.1 [Q92599-3]
NP_001287727.1, NM_001300798.1
NP_001287728.1, NM_001300799.1
NP_055961.1, NM_015146.1 [Q92599-2]
UniGeneiHs.522057

Genome annotation databases

EnsembliENST00000296873; ENSP00000296873; ENSG00000164402 [Q92599-2]
ENST00000378699; ENSP00000367971; ENSG00000164402 [Q92599-3]
ENST00000378719; ENSP00000367991; ENSG00000164402 [Q92599-1]
ENST00000448933; ENSP00000399840; ENSG00000164402 [Q92599-3]
ENST00000458488; ENSP00000394766; ENSG00000164402 [Q92599-4]
GeneIDi23176
KEGGihsa:23176
UCSCiuc003kxr.2 human [Q92599-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSEPT8_HUMAN
AccessioniPrimary (citable) accession number: Q92599
Secondary accession number(s): A6NC65
, A6NKP6, F6W7K9, Q8IX36, Q8IX37, Q9BVB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 158 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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