Q92599 (SEPT8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Septin-8

Gene names

Name:	SEPT8
Synonyms:	KIAA0202

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential. May play a role in platelet secretion. Ref.10
Subunit structure	Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity. Interacts with CDK14, SEPT4, SEPT5 and SEPT7 By similarity. Ref.1 Ref.2 Ref.9 Ref.10
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Note: In platelets, found in areas surrounding alpha-granules. Ref.10
Tissue specificity	Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. Ref.1 Ref.2 Ref.10 Ref.11
Sequence similarities	Belongs to the septin family.
Sequence caution	The sequence AAG09407.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH01329.1 differs from that shown. Reason: Erroneous initiation. The sequence AAO13878.1 differs from that shown. Reason: Erroneous initiation. The sequence AAO13879.1 differs from that shown. Reason: Erroneous initiation. The sequence AAO13880.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA13193.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA septin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92599-1)

Also known as: KIAA0202b; SEPT8_v2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92599-2)

Also known as: KIAA0202a; SEPT8_v1; KIAA0202c; SEPT8_v1*;

The sequence of this isoform differs from the canonical sequence as follows:
     430-483: Missing.

Note: KIAA0202a differs from KIAA0202c at the level of the 3'-UTR.

Isoform 3 (identifier: Q92599-3)

Also known as: KIAA0202d; SEPT8_v3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     430-483: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 483	482	Septin-8		PRO_0000173533
Regions
	Nucleotide binding	51 – 58	8	GTP By similarity
	Nucleotide binding	187 – 195	9	GTP By similarity
	Coiled coil	320 – 413	94	Potential
Sites
	Binding site	106	1	GTP; via amide nitrogen By similarity
	Binding site	241	1	GTP; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	256	1	GTP By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	10	1	Phosphoserine By similarity
	Modified residue	141	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 60	60	Missing in isoform 3.		VSP_009643
	Alternative sequence	430 – 483	54	Missing in isoform 2 and isoform 3.		VSP_009644

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (KIAA0202b) (SEPT8_v2) [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 35E1ACF95F5DBA6B	FASTA	483	55,756
	10 20 30 40 50 60 MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL 70 80 90 100 110 120 MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDESYRPI 130 140 150 160 170 180 VDYIDAQFEN YLQEELKIRR SLFDYHDTRI HVCLYFITPT GHSLKSLDLV TMKKLDSKVN 190 200 210 220 230 240 IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV 250 260 270 280 290 300 GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY 310 320 330 340 350 360 RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK 370 380 390 400 410 420 EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR RKAAVEALQS QALHATSQQP 430 440 450 460 470 480 LRKDKDKKNR SDIGAHQPGM SLSSSKVMMT KASVEPLNCS SWWPAIQCCS CLVRDATWRE GFL
	Isoform 2 (KIAA0202a) (SEPT8_v1) (KIAA0202c) (SEPT8_v1*) [UniParc]. Checksum: B6900F134CF67474	FASTA	429	49,814
	10 20 30 40 50 60 MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL 70 80 90 100 110 120 MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDESYRPI 130 140 150 160 170 180 VDYIDAQFEN YLQEELKIRR SLFDYHDTRI HVCLYFITPT GHSLKSLDLV TMKKLDSKVN 190 200 210 220 230 240 IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV 250 260 270 280 290 300 GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY 310 320 330 340 350 360 RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK 370 380 390 400 410 420 EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR RKAAVEALQS QALHATSQQP LRKDKDKKN
	Isoform 3 (KIAA0202d) (SEPT8_v3) [UniParc]. Checksum: 3C85574B0124B3BA	FASTA	369	43,519
	10 20 30 40 50 60 MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDESYRPI 70 80 90 100 110 120 VDYIDAQFEN YLQEELKIRR SLFDYHDTRI HVCLYFITPT GHSLKSLDLV TMKKLDSKVN 130 140 150 160 170 180 IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV 190 200 210 220 230 240 GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY 250 260 270 280 290 300 RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK 310 320 330 340 350 360 EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR RKAAVEALQS QALHATSQQP LRKDKDKKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human septin-septin interaction: CDCrel-1 partners with KIAA0202." Blaeser S., Jersch K., Hainmann I., Wunderle D., Zgaga-Griesz A., Busse A., Zieger B. FEBS Lett. 519:169-172(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH SEPT5, TISSUE SPECIFICITY.
[2]	"Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)." Blaeser S., Jersch K., Hainmann I., Zieger W., Wunderle D., Busse A., Zieger B. Gene 312:313-320(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), ALTERNATIVE SPLICING, INTERACTION WITH SEPT5, TISSUE SPECIFICITY.
[3]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Bone marrow.
[4]	"Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11." Wenderfer S.E., Slack J.P., McCluskey T.S., Monaco J.J. Genomics 63:354-373(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[5]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-483 (ISOFORMS 2/3). Tissue: Cervix.
[8]	"Mammalian septins nomenclature." Macara I.G., Baldarelli R., Field C.M., Glotzer M., Hayashi Y., Hsu S.-C., Kennedy M.B., Kinoshita M., Longtine M., Low C., Maltais L.J., McKenzie L., Mitchison T.J., Nishikawa T., Noda M., Petty E.M., Peifer M., Pringle J.R. , Robinson P.J., Roth D., Russell S.E.H., Stuhlmann H., Tanaka M., Tanaka T., Trimble W.S., Ware J., Zeleznik-Le N.J., Zieger B. Mol. Biol. Cell 13:4111-4113(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF INITIATOR METHIONINE.
[9]	"KIAA0202, a human septin family member, interacting with hPFTAIRE1." Yang T., Gao Y.K., Chen J.Y. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:520-525(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CDK14.
[10]	"The novel human platelet septin SEPT8 is an interaction partner of SEPT4." Blaeser S., Horn J., Wuermell P., Bauer H., Struempell S., Nurden P., Pagenstecher A., Busse A., Wunderle D., Hainmann I., Zieger B. Thromb. Haemost. 91:959-966(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SEPT4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]	"Expression profiling the human septin gene family." Hall P.A., Jung K., Hillan K.J., Russell S.E.H. J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D86957 mRNA. Translation: BAA13193.1. Different initiation. AF179995 mRNA. Translation: AAG09407.1. Different initiation. AF440761 mRNA. Translation: AAO13878.1. Different initiation. AF440762 mRNA. Translation: AAO13879.1. Different initiation. AF440763 mRNA. Translation: AAO13880.1. Different initiation. AC004775 Genomic DNA. No translation available. CH471062 Genomic DNA. Translation: EAW62315.1. CH471062 Genomic DNA. Translation: EAW62317.1. BC001329 mRNA. Translation: AAH01329.1. Different initiation.
IPI	IPI00022082. IPI00549434. IPI00787280.
RefSeq	NP_001092281.1. NM_001098811.1. NP_001092282.1. NM_001098812.1. NP_001092283.1. NM_001098813.1. NP_055961.1. NM_015146.1.
UniGene	Hs.522057.
3D structure databases
ProteinModelPortal	Q92599.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92599. 1 interaction.
STRING	9606.ENSP00000367991.
PTM databases
PhosphoSite	Q92599.
Polymorphism databases
DMDM	45645200.
Proteomic databases
PaxDb	Q92599.
PRIDE	Q92599.
Protocols and materials databases
DNASU	23176.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296873; ENSP00000296873; ENSG00000164402. ENST00000378699; ENSP00000367971; ENSG00000164402. ENST00000378719; ENSP00000367991; ENSG00000164402. ENST00000448933; ENSP00000399840; ENSG00000164402.
GeneID	23176.
KEGG	hsa:23176.
UCSC	uc003kxr.2. human.
Organism-specific databases
CTD	23176.
GeneCards	GC05M132086.
H-InvDB	HIX0032338.
HGNC	HGNC:16511. SEPT8.
HPA	HPA005665.
MIM	608418. gene.
neXtProt	NX_Q92599.
PharmGKB	PA134879270.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5019.
HOGENOM	HOG000233586.
HOVERGEN	HBG065093.
InParanoid	Q92599.
OMA	EASHHEA.
OrthoDB	EOG4320Z8.
Gene expression databases
ArrayExpress	Q92599.
Bgee	Q92599.
CleanEx	HS_SEPT8.
Genevestigator	Q92599.
GermOnline	ENSG00000164402. Homo sapiens.
Family and domain databases
InterPro	IPR000038. Cell_div_GTP-bd. IPR016491. Septin. [Graphical view]
PANTHER	PTHR18884. PTHR18884. 1 hit.
Pfam	PF00735. Septin. 1 hit. [Graphical view]
PIRSF	PIRSF006698. Septin. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	SEPT8. human.
GenomeRNAi	23176.
NextBio	44599.
SOURCE	Search...

Entry information

Entry name

SEPT8_HUMAN

Accession

Primary (citable) accession number: Q92599
Secondary accession number(s): A6NC65 , A6NKP6, Q8IX36, Q8IX37, Q9BVB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 111 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.