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Q92599 (SEPT8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Septin-8
Gene names
Name:SEPT8
Synonyms:KIAA0202
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential. May play a role in platelet secretion. Ref.11

Subunit structure

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity. Interacts with CDK14, SEPT4, SEPT5 and SEPT7 By similarity. Ref.1 Ref.2 Ref.10 Ref.11

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Note: In platelets, found in areas surrounding alpha-granules. Ref.11

Tissue specificity

Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. Ref.1 Ref.2 Ref.11 Ref.12

Sequence similarities

Belongs to the septin family.

Sequence caution

The sequence AAG09407.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAH01329.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAO13878.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAO13879.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAO13880.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAA13193.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   LigandGTP-binding
Nucleotide-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: InterPro

   Cellular_componentseptin complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92599-1)

Also known as: KIAA0202b; SEPT8_v2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92599-2)

Also known as: KIAA0202a; SEPT8_v1; KIAA0202c; SEPT8_v1*;

The sequence of this isoform differs from the canonical sequence as follows:
     430-483: Missing.
Note: KIAA0202a differs from KIAA0202c at the level of the 3'-UTR.
Isoform 3 (identifier: Q92599-3)

Also known as: KIAA0202d; SEPT8_v3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     430-483: Missing.
Isoform 4 (identifier: Q92599-4)

The sequence of this isoform differs from the canonical sequence as follows:
     429-442: NRSDIGAHQPGMSL → KASGWSSIYSVTIP
     443-483: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.14
Chain2 – 483482Septin-8
PRO_0000173533

Regions

Nucleotide binding51 – 588GTP By similarity
Nucleotide binding187 – 1959GTP By similarity
Coiled coil320 – 41394 Potential

Sites

Binding site1061GTP; via amide nitrogen By similarity
Binding site2411GTP; via amide nitrogen and carbonyl oxygen By similarity
Binding site2561GTP By similarity

Amino acid modifications

Modified residue21N-acetylalanine Ref.14
Modified residue101Phosphoserine By similarity

Natural variations

Alternative sequence1 – 6060Missing in isoform 3.
VSP_009643
Alternative sequence429 – 44214NRSDI…PGMSL → KASGWSSIYSVTIP in isoform 4.
VSP_054085
Alternative sequence430 – 48354Missing in isoform 2 and isoform 3.
VSP_009644
Alternative sequence443 – 48341Missing in isoform 4.
VSP_054086

Experimental info

Sequence conflict116 – 1172Missing in AK057797. Ref.5
Sequence conflict3651E → V in AK057797. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (KIAA0202b) (SEPT8_v2) [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 35E1ACF95F5DBA6B

FASTA48355,756
        10         20         30         40         50         60 
MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL 

        70         80         90        100        110        120 
MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDESYRPI 

       130        140        150        160        170        180 
VDYIDAQFEN YLQEELKIRR SLFDYHDTRI HVCLYFITPT GHSLKSLDLV TMKKLDSKVN 

       190        200        210        220        230        240 
IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV 

       250        260        270        280        290        300 
GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY 

       310        320        330        340        350        360 
RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK 

       370        380        390        400        410        420 
EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR RKAAVEALQS QALHATSQQP 

       430        440        450        460        470        480 
LRKDKDKKNR SDIGAHQPGM SLSSSKVMMT KASVEPLNCS SWWPAIQCCS CLVRDATWRE 


GFL 

« Hide

Isoform 2 (KIAA0202a) (SEPT8_v1) (KIAA0202c) (SEPT8_v1*) [UniParc].

Checksum: B6900F134CF67474
Show »

FASTA42949,814
Isoform 3 (KIAA0202d) (SEPT8_v3) [UniParc].

Checksum: 3C85574B0124B3BA
Show »

FASTA36943,519
Isoform 4 [UniParc].

Checksum: 4A3D69A996FE624C
Show »

FASTA44251,178

References

« Hide 'large scale' references
[1]"Human septin-septin interaction: CDCrel-1 partners with KIAA0202."
Blaeser S., Jersch K., Hainmann I., Wunderle D., Zgaga-Griesz A., Busse A., Zieger B.
FEBS Lett. 519:169-172(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH SEPT5, TISSUE SPECIFICITY.
[2]"Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)."
Blaeser S., Jersch K., Hainmann I., Zieger W., Wunderle D., Busse A., Zieger B.
Gene 312:313-320(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), ALTERNATIVE SPLICING, INTERACTION WITH SEPT5, TISSUE SPECIFICITY.
[3]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Bone marrow.
[4]"Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11."
Wenderfer S.E., Slack J.P., McCluskey T.S., Monaco J.J.
Genomics 63:354-373(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[6]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-483 (ISOFORMS 2/3).
Tissue: Cervix.
[9]"Mammalian septins nomenclature."
Macara I.G., Baldarelli R., Field C.M., Glotzer M., Hayashi Y., Hsu S.-C., Kennedy M.B., Kinoshita M., Longtine M., Low C., Maltais L.J., McKenzie L., Mitchison T.J., Nishikawa T., Noda M., Petty E.M., Peifer M., Pringle J.R. expand/collapse author list , Robinson P.J., Roth D., Russell S.E.H., Stuhlmann H., Tanaka M., Tanaka T., Trimble W.S., Ware J., Zeleznik-Le N.J., Zieger B.
Mol. Biol. Cell 13:4111-4113(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF INITIATOR METHIONINE.
[10]"KIAA0202, a human septin family member, interacting with hPFTAIRE1."
Yang T., Gao Y.K., Chen J.Y.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:520-525(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CDK14.
[11]"The novel human platelet septin SEPT8 is an interaction partner of SEPT4."
Blaeser S., Horn J., Wuermell P., Bauer H., Struempell S., Nurden P., Pagenstecher A., Busse A., Wunderle D., Hainmann I., Zieger B.
Thromb. Haemost. 91:959-966(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SEPT4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[12]"Expression profiling the human septin gene family."
Hall P.A., Jung K., Hillan K.J., Russell S.E.H.
J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86957 mRNA. Translation: BAA13193.1. Different initiation.
AF179995 mRNA. Translation: AAG09407.1. Different initiation.
AF440761 mRNA. Translation: AAO13878.1. Different initiation.
AF440762 mRNA. Translation: AAO13879.1. Different initiation.
AF440763 mRNA. Translation: AAO13880.1. Different initiation.
AK057797 mRNA. No translation available.
AC004775 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62315.1.
CH471062 Genomic DNA. Translation: EAW62317.1.
BC001329 mRNA. Translation: AAH01329.1. Different initiation.
RefSeqNP_001092281.1. NM_001098811.1.
NP_001092282.1. NM_001098812.1.
NP_001092283.1. NM_001098813.1.
NP_055961.1. NM_015146.1.
UniGeneHs.522057.

3D structure databases

ProteinModelPortalQ92599.
SMRQ92599. Positions 21-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116788. 12 interactions.
IntActQ92599. 7 interactions.
MINTMINT-6941937.
STRING9606.ENSP00000367991.

PTM databases

PhosphoSiteQ92599.

Polymorphism databases

DMDM45645200.

Proteomic databases

PaxDbQ92599.
PRIDEQ92599.

Protocols and materials databases

DNASU23176.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296873; ENSP00000296873; ENSG00000164402. [Q92599-2]
ENST00000378699; ENSP00000367971; ENSG00000164402. [Q92599-3]
ENST00000378719; ENSP00000367991; ENSG00000164402. [Q92599-1]
ENST00000448933; ENSP00000399840; ENSG00000164402. [Q92599-3]
ENST00000458488; ENSP00000394766; ENSG00000164402.
GeneID23176.
KEGGhsa:23176.
UCSCuc003kxr.2. human. [Q92599-1]

Organism-specific databases

CTD23176.
GeneCardsGC05M132086.
H-InvDBHIX0032338.
HGNCHGNC:16511. SEPT8.
HPAHPA005665.
MIM608418. gene.
neXtProtNX_Q92599.
PharmGKBPA134879270.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5019.
HOGENOMHOG000233586.
HOVERGENHBG065093.
InParanoidQ92599.
KOK16939.
OMAASHHEAC.
OrthoDBEOG7J9VQK.
PhylomeDBQ92599.
TreeFamTF101080.

Gene expression databases

ArrayExpressQ92599.
BgeeQ92599.
CleanExHS_SEPT8.
GenevestigatorQ92599.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERPTHR18884. PTHR18884. 1 hit.
PfamPF00735. Septin. 1 hit.
[Graphical view]
PIRSFPIRSF006698. Septin. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSEPT8. human.
GeneWikiSEPT8.
GenomeRNAi23176.
NextBio44599.
PROQ92599.
SOURCESearch...

Entry information

Entry nameSEPT8_HUMAN
AccessionPrimary (citable) accession number: Q92599
Secondary accession number(s): A6NC65 expand/collapse secondary AC list , A6NKP6, F6W7K9, Q8IX36, Q8IX37, Q9BVB3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM