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Protein

C-C motif chemokine 17

Gene

CCL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 17
Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine
Gene namesi
Name:CCL17
Synonyms:SCYA17, TARC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102970.10.
HGNCiHGNC:10615. CCL17.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6361.
OpenTargetsiENSG00000102970.
PharmGKBiPA35548.

Polymorphism and mutation databases

BioMutaiCCL17.
DMDMi3024711.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000521124 – 94C-C motif chemokine 17Add BLAST71

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 571 Publication
Disulfide bondi34 ↔ 731 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ92583.
PeptideAtlasiQ92583.
PRIDEiQ92583.

PTM databases

iPTMnetiQ92583.
PhosphoSitePlusiQ92583.

Expressioni

Tissue specificityi

Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Inductioni

By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

Gene expression databases

BgeeiENSG00000102970.
CleanExiHS_CCL17.
GenevisibleiQ92583. HS.

Organism-specific databases

HPAiCAB002583.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112264. 6 interactors.
DIPiDIP-5842N.
MINTiMINT-1525198.
STRINGi9606.ENSP00000219244.

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 29Combined sources3
Beta strandi32 – 36Combined sources5
Helixi44 – 46Combined sources3
Beta strandi47 – 52Combined sources6
Beta strandi57 – 59Combined sources3
Beta strandi62 – 66Combined sources5
Beta strandi71 – 74Combined sources4
Helixi79 – 90Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NR2X-ray2.18A/B24-94[»]
1NR4X-ray1.72A/B/C/D/E/F/G/H24-94[»]
ProteinModelPortaliQ92583.
SMRiQ92583.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92583.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0QF. Eukaryota.
ENOG41113EM. LUCA.
GeneTreeiENSGT00530000064258.
HOGENOMiHOG000036685.
HOVERGENiHBG098492.
InParanoidiQ92583.
KOiK21083.
OMAiCSDPKDT.
OrthoDBiEOG091G11AP.
PhylomeDBiQ92583.
TreeFamiTF334888.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR036048. Interleukin_8-like_sf.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW
60 70 80 90
YQTSEDCSRD AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS
Length:94
Mass (Da):10,507
Last modified:February 1, 1997 - v1
Checksum:i7959C56BA8FDAF08
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0487085K → N. Corresponds to variant dbSNP:rs34693308Ensembl.1
Natural variantiVAR_04870967V → M. Corresponds to variant dbSNP:rs34379253Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43767 mRNA. Translation: BAA07824.1.
EF064767 Genomic DNA. Translation: ABK41950.1.
AC004382 Genomic DNA. Translation: AAC24308.1.
CH471092 Genomic DNA. Translation: EAW82921.1.
BC069107 mRNA. Translation: AAH69107.1.
BC112066 mRNA. Translation: AAI12067.1.
BC112068 mRNA. Translation: AAI12069.1.
CCDSiCCDS10780.1.
RefSeqiNP_002978.1. NM_002987.2.
UniGeneiHs.546294.

Genome annotation databases

EnsembliENST00000219244; ENSP00000219244; ENSG00000102970.
ENST00000616880; ENSP00000480147; ENSG00000102970.
GeneIDi6361.
KEGGihsa:6361.
UCSCiuc002elj.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCL17_HUMAN
AccessioniPrimary (citable) accession number: Q92583
Secondary accession number(s): A0N0Q9, Q2M287
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: October 25, 2017
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a ligand for CCR8.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families