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Q92583 (CCL17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 17
Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine
Gene names
Name:CCL17
Synonyms:SCYA17, TARC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length94 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Ref.7

Subcellular location

Secreted.

Tissue specificity

Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Induction

By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Caution

Was originally (Ref.6) thought to be a ligand for CCR8.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.1
Chain24 – 9471C-C motif chemokine 17
PRO_0000005211

Amino acid modifications

Disulfide bond33 ↔ 57 Ref.8
Disulfide bond34 ↔ 73 Ref.8

Natural variations

Natural variant51K → N.
Corresponds to variant rs34693308 [ dbSNP | Ensembl ].
VAR_048708
Natural variant671V → M.
Corresponds to variant rs34379253 [ dbSNP | Ensembl ].
VAR_048709

Secondary structure

................ 94
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q92583 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 7959C56BA8FDAF08

FASTA9410,507
        10         20         30         40         50         60 
MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW YQTSEDCSRD 

        70         80         90 
AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector."
Imai T., Yoshida T., Baba M., Nishimura M., Kakizaki M., Yoshie O.
J. Biol. Chem. 271:21514-21521(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-32.
Tissue: Peripheral blood monocyte.
[2]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D.
Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor."
Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M., Menon S., Zlotnik A., Mantovani A., Santoni A., Napolitano M.
Eur. J. Immunol. 28:582-588(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: RECEPTOR INTERACTION.
[7]"The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8."
Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W., Umland S.P.
Eur. J. Immunol. 29:3210-3215(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Structures of thymus and activation-regulated chemokine (TARC)."
Asojo O.A., Boulegue C., Hoover D.M., Lu W., Lubkowski J.
Acta Crystallogr. D 59:1165-1173(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 24-94, DISULFIDE BONDS.
+Additional computationally mapped references.

Web resources

Wikipedia

CCL17 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D43767 mRNA. Translation: BAA07824.1.
EF064767 Genomic DNA. Translation: ABK41950.1.
AC004382 Genomic DNA. Translation: AAC24308.1.
CH471092 Genomic DNA. Translation: EAW82921.1.
BC069107 mRNA. Translation: AAH69107.1.
BC112066 mRNA. Translation: AAI12067.1.
BC112068 mRNA. Translation: AAI12069.1.
CCDSCCDS10780.1.
RefSeqNP_002978.1. NM_002987.2.
UniGeneHs.546294.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NR2X-ray2.18A/B24-94[»]
1NR4X-ray1.72A/B/C/D/E/F/G/H24-94[»]
ProteinModelPortalQ92583.
SMRQ92583. Positions 26-94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112264. 1 interaction.
DIPDIP-5842N.
MINTMINT-1525198.
STRING9606.ENSP00000219244.

PTM databases

PhosphoSiteQ92583.

Polymorphism databases

DMDM3024711.

Proteomic databases

PaxDbQ92583.
PRIDEQ92583.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000219244; ENSP00000219244; ENSG00000102970.
GeneID6361.
KEGGhsa:6361.
UCSCuc002elj.1. human.

Organism-specific databases

CTD6361.
GeneCardsGC16P057438.
HGNCHGNC:10615. CCL17.
HPACAB002583.
MIM601520. gene.
neXtProtNX_Q92583.
PharmGKBPA35548.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45053.
HOGENOMHOG000036685.
HOVERGENHBG098492.
InParanoidQ92583.
KOK05514.
OMACSDPKDT.
OrthoDBEOG7K0ZFZ.
PhylomeDBQ92583.
TreeFamTF334888.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ92583.
CleanExHS_CCL17.
GenevestigatorQ92583.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ92583.
GeneWikiCCL17.
GenomeRNAi6361.
NextBio24716.
PROQ92583.
SOURCESearch...

Entry information

Entry nameCCL17_HUMAN
AccessionPrimary (citable) accession number: Q92583
Secondary accession number(s): A0N0Q9, Q2M287
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM