Q92583 (CCL17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 17

Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine

Gene names

Name:	CCL17
Synonyms:	SCYA17, TARC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Ref.7
Subcellular location	Secreted.
Tissue specificity	Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.
Induction	By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.
Caution	Was originally (Ref.6) thought to be a ligand for CCR8.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc cell-cell signaling Traceable author statement Ref.1. Source: ProtInc chemotaxis Traceable author statement PubMed 9743322. Source: ProtInc immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Traceable author statement Ref.1. Source: ProtInc
Cellular_component	extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chemokine activity Traceable author statement PubMed 9743322. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Ref.1

Chain

24 – 94

71

C-C motif chemokine 17

PRO_0000005211

Amino acid modifications

Disulfide bond

33 ↔ 57

Ref.8

Disulfide bond

34 ↔ 73

Ref.8

Natural variations

Natural variant

5

1

K → N.
Corresponds to variant rs34693308 [ dbSNP | Ensembl ].

VAR_048708

Natural variant

67

1

V → M.
Corresponds to variant rs34379253 [ dbSNP | Ensembl ].

VAR_048709

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

94

Helix Strand Turn

Details...

Beta strand

27 – 29

3

Beta strand

32 – 36

5

Helix

44 – 46

3

Beta strand

47 – 52

6

Beta strand

57 – 59

3

Beta strand

62 – 66

5

Beta strand

71 – 74

4

Helix

79 – 90

12

Sequences

	Sequence		Length	Mass (Da)
	Q92583 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 7959C56BA8FDAF08	FASTA	94	10,507
	10 20 30 40 50 60 MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW YQTSEDCSRD 70 80 90 AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector." Imai T., Yoshida T., Baba M., Nishimura M., Kakizaki M., Yoshie O. J. Biol. Chem. 271:21514-21521(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-32. Tissue: Peripheral blood monocyte.
[2]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D. Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor." Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M., Menon S., Zlotnik A., Mantovani A., Santoni A., Napolitano M. Eur. J. Immunol. 28:582-588(1998) [PubMed] [Europe PMC] [Abstract] Cited for: RECEPTOR INTERACTION.
[7]	"The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8." Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W., Umland S.P. Eur. J. Immunol. 29:3210-3215(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[8]	"Structures of thymus and activation-regulated chemokine (TARC)." Asojo O.A., Boulegue C., Hoover D.M., Lu W., Lubkowski J. Acta Crystallogr. D 59:1165-1173(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 24-94, DISULFIDE BONDS.
+	Additional computationally mapped references.

Web resources

Wikipedia

CCL17 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D43767 mRNA. Translation: BAA07824.1.
EF064767 Genomic DNA. Translation: ABK41950.1.
AC004382 Genomic DNA. Translation: AAC24308.1.
CH471092 Genomic DNA. Translation: EAW82921.1.
BC069107 mRNA. Translation: AAH69107.1.
BC112066 mRNA. Translation: AAI12067.1.
BC112068 mRNA. Translation: AAI12069.1.

IPI

IPI00022062.

RefSeq

NP_002978.1. NM_002987.2.

UniGene

Hs.546294.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1NR2	X-ray	2.18	A/B	24-94	[»]
1NR4	X-ray	1.72	A/B/C/D/E/F/G/H	24-94	[»]

ProteinModelPortal

Q92583.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5842N.

STRING

9606.ENSP00000219244.

PTM databases

PhosphoSite

Q92583.

Polymorphism databases

DMDM

3024711.

Proteomic databases

PaxDb

Q92583.

PRIDE

Q92583.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000219244; ENSP00000219244; ENSG00000102970.

GeneID

6361.

KEGG

hsa:6361.

UCSC

uc002elj.1. human.

Organism-specific databases

CTD

6361.

GeneCards

GC16P057438.

HGNC

HGNC:10615. CCL17.

HPA

CAB002583.

MIM

601520. gene.

neXtProt

NX_Q92583.

PharmGKB

PA35548.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG45053.

HOGENOM

HOG000036685.

HOVERGEN

HBG098492.

InParanoid

Q92583.

KO

K05514.

OMA

AIPIRKL.

OrthoDB

EOG451DSD.

PhylomeDB

Q92583.

Enzyme and pathway databases

Pathway_Interaction_DB

il4_2pathway. IL4-mediated signaling events.

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

Bgee

Q92583.

CleanEx

HS_CCL17.

Genevestigator

Q92583.

GermOnline

ENSG00000102970. Homo sapiens.

Family and domain databases

InterPro

IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]

Pfam

PF00048. IL8. 1 hit.
[Graphical view]

SMART

SM00199. SCY. 1 hit.
[Graphical view]

SUPFAM

SSF54117. Chemokine_IL8. 1 hit.

PROSITE

PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q92583.

GenomeRNAi

6361.

NextBio

24716.

SOURCE

Search...

Entry information

Entry name

CCL17_HUMAN

Accession

Primary (citable) accession number: Q92583
Secondary accession number(s): A0N0Q9, Q2M287

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 119 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.