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Protein

C-C motif chemokine 17

Gene

CCL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.1 Publication

GO - Molecular functioni

  1. chemokine activity Source: ProtInc
  2. receptor binding Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. chemotaxis Source: ProtInc
  4. G-protein coupled receptor signaling pathway Source: ProtInc
  5. immune response Source: InterPro
  6. inflammatory response Source: UniProtKB-KW
  7. multicellular organismal development Source: ProtInc
  8. negative regulation of myoblast differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 17
Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine
Gene namesi
Name:CCL17
Synonyms:SCYA17, TARC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:10615. CCL17.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 9471C-C motif chemokine 17PRO_0000005211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 571 Publication
Disulfide bondi34 ↔ 731 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ92583.
PRIDEiQ92583.

PTM databases

PhosphoSiteiQ92583.

Expressioni

Tissue specificityi

Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Inductioni

By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

Gene expression databases

BgeeiQ92583.
CleanExiHS_CCL17.
GenevestigatoriQ92583.

Organism-specific databases

HPAiCAB002583.

Interactioni

Protein-protein interaction databases

BioGridi112264. 1 interaction.
DIPiDIP-5842N.
MINTiMINT-1525198.
STRINGi9606.ENSP00000219244.

Structurei

Secondary structure

1
94
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 293Combined sources
Beta strandi32 – 365Combined sources
Helixi44 – 463Combined sources
Beta strandi47 – 526Combined sources
Beta strandi57 – 593Combined sources
Beta strandi62 – 665Combined sources
Beta strandi71 – 744Combined sources
Helixi79 – 9012Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NR2X-ray2.18A/B24-94[»]
1NR4X-ray1.72A/B/C/D/E/F/G/H24-94[»]
ProteinModelPortaliQ92583.
SMRiQ92583. Positions 26-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92583.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45053.
GeneTreeiENSGT00530000064258.
HOGENOMiHOG000036685.
HOVERGENiHBG098492.
InParanoidiQ92583.
KOiK05514.
OMAiCSDPKDT.
OrthoDBiEOG7K0ZFZ.
PhylomeDBiQ92583.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW
60 70 80 90
YQTSEDCSRD AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS
Length:94
Mass (Da):10,507
Last modified:February 1, 1997 - v1
Checksum:i7959C56BA8FDAF08
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51K → N.
Corresponds to variant rs34693308 [ dbSNP | Ensembl ].
VAR_048708
Natural varianti67 – 671V → M.
Corresponds to variant rs34379253 [ dbSNP | Ensembl ].
VAR_048709

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43767 mRNA. Translation: BAA07824.1.
EF064767 Genomic DNA. Translation: ABK41950.1.
AC004382 Genomic DNA. Translation: AAC24308.1.
CH471092 Genomic DNA. Translation: EAW82921.1.
BC069107 mRNA. Translation: AAH69107.1.
BC112066 mRNA. Translation: AAI12067.1.
BC112068 mRNA. Translation: AAI12069.1.
CCDSiCCDS10780.1.
RefSeqiNP_002978.1. NM_002987.2.
UniGeneiHs.546294.

Genome annotation databases

EnsembliENST00000219244; ENSP00000219244; ENSG00000102970.
ENST00000616880; ENSP00000480147; ENSG00000102970.
GeneIDi6361.
KEGGihsa:6361.
UCSCiuc002elj.1. human.

Polymorphism databases

DMDMi3024711.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43767 mRNA. Translation: BAA07824.1.
EF064767 Genomic DNA. Translation: ABK41950.1.
AC004382 Genomic DNA. Translation: AAC24308.1.
CH471092 Genomic DNA. Translation: EAW82921.1.
BC069107 mRNA. Translation: AAH69107.1.
BC112066 mRNA. Translation: AAI12067.1.
BC112068 mRNA. Translation: AAI12069.1.
CCDSiCCDS10780.1.
RefSeqiNP_002978.1. NM_002987.2.
UniGeneiHs.546294.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NR2X-ray2.18A/B24-94[»]
1NR4X-ray1.72A/B/C/D/E/F/G/H24-94[»]
ProteinModelPortaliQ92583.
SMRiQ92583. Positions 26-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112264. 1 interaction.
DIPiDIP-5842N.
MINTiMINT-1525198.
STRINGi9606.ENSP00000219244.

PTM databases

PhosphoSiteiQ92583.

Polymorphism databases

DMDMi3024711.

Proteomic databases

PaxDbiQ92583.
PRIDEiQ92583.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219244; ENSP00000219244; ENSG00000102970.
ENST00000616880; ENSP00000480147; ENSG00000102970.
GeneIDi6361.
KEGGihsa:6361.
UCSCiuc002elj.1. human.

Organism-specific databases

CTDi6361.
GeneCardsiGC16P057438.
HGNCiHGNC:10615. CCL17.
HPAiCAB002583.
MIMi601520. gene.
neXtProtiNX_Q92583.
PharmGKBiPA35548.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45053.
GeneTreeiENSGT00530000064258.
HOGENOMiHOG000036685.
HOVERGENiHBG098492.
InParanoidiQ92583.
KOiK05514.
OMAiCSDPKDT.
OrthoDBiEOG7K0ZFZ.
PhylomeDBiQ92583.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Miscellaneous databases

EvolutionaryTraceiQ92583.
GeneWikiiCCL17.
GenomeRNAii6361.
NextBioi24716.
PROiQ92583.
SOURCEiSearch...

Gene expression databases

BgeeiQ92583.
CleanExiHS_CCL17.
GenevestigatoriQ92583.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector."
    Imai T., Yoshida T., Baba M., Nishimura M., Kakizaki M., Yoshie O.
    J. Biol. Chem. 271:21514-21521(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-32.
    Tissue: Peripheral blood monocyte.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor."
    Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M., Menon S., Zlotnik A., Mantovani A., Santoni A., Napolitano M.
    Eur. J. Immunol. 28:582-588(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECEPTOR INTERACTION.
  7. "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8."
    Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W., Umland S.P.
    Eur. J. Immunol. 29:3210-3215(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Structures of thymus and activation-regulated chemokine (TARC)."
    Asojo O.A., Boulegue C., Hoover D.M., Lu W., Lubkowski J.
    Acta Crystallogr. D 59:1165-1173(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 24-94, DISULFIDE BONDS.

Entry informationi

Entry nameiCCL17_HUMAN
AccessioniPrimary (citable) accession number: Q92583
Secondary accession number(s): A0N0Q9, Q2M287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 4, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a ligand for CCR8.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.