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Q92583

- CCL17_HUMAN

UniProt

Q92583 - CCL17_HUMAN

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Protein
C-C motif chemokine 17
Gene
CCL17, SCYA17, TARC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.1 Publication

GO - Molecular functioni

  1. chemokine activity Source: ProtInc
  2. receptor binding Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. cell-cell signaling Source: ProtInc
  4. chemotaxis Source: ProtInc
  5. immune response Source: InterPro
  6. inflammatory response Source: UniProtKB-KW
  7. multicellular organismal development Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 17
Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine
Gene namesi
Name:CCL17
Synonyms:SCYA17, TARC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:10615. CCL17.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 Publication
Add
BLAST
Chaini24 – 9471C-C motif chemokine 17
PRO_0000005211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 571 Publication
Disulfide bondi34 ↔ 731 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ92583.
PRIDEiQ92583.

PTM databases

PhosphoSiteiQ92583.

Expressioni

Tissue specificityi

Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Inductioni

By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

Gene expression databases

BgeeiQ92583.
CleanExiHS_CCL17.
GenevestigatoriQ92583.

Organism-specific databases

HPAiCAB002583.

Interactioni

Protein-protein interaction databases

BioGridi112264. 1 interaction.
DIPiDIP-5842N.
MINTiMINT-1525198.
STRINGi9606.ENSP00000219244.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 293
Beta strandi32 – 365
Helixi44 – 463
Beta strandi47 – 526
Beta strandi57 – 593
Beta strandi62 – 665
Beta strandi71 – 744
Helixi79 – 9012

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NR2X-ray2.18A/B24-94[»]
1NR4X-ray1.72A/B/C/D/E/F/G/H24-94[»]
ProteinModelPortaliQ92583.
SMRiQ92583. Positions 26-94.

Miscellaneous databases

EvolutionaryTraceiQ92583.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45053.
HOGENOMiHOG000036685.
HOVERGENiHBG098492.
InParanoidiQ92583.
KOiK05514.
OMAiCSDPKDT.
OrthoDBiEOG7K0ZFZ.
PhylomeDBiQ92583.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92583-1 [UniParc]FASTAAdd to Basket

« Hide

MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW   50
YQTSEDCSRD AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS 94
Length:94
Mass (Da):10,507
Last modified:February 1, 1997 - v1
Checksum:i7959C56BA8FDAF08
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51K → N.
Corresponds to variant rs34693308 [ dbSNP | Ensembl ].
VAR_048708
Natural varianti67 – 671V → M.
Corresponds to variant rs34379253 [ dbSNP | Ensembl ].
VAR_048709

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43767 mRNA. Translation: BAA07824.1.
EF064767 Genomic DNA. Translation: ABK41950.1.
AC004382 Genomic DNA. Translation: AAC24308.1.
CH471092 Genomic DNA. Translation: EAW82921.1.
BC069107 mRNA. Translation: AAH69107.1.
BC112066 mRNA. Translation: AAI12067.1.
BC112068 mRNA. Translation: AAI12069.1.
CCDSiCCDS10780.1.
RefSeqiNP_002978.1. NM_002987.2.
UniGeneiHs.546294.

Genome annotation databases

EnsembliENST00000219244; ENSP00000219244; ENSG00000102970.
GeneIDi6361.
KEGGihsa:6361.
UCSCiuc002elj.1. human.

Polymorphism databases

DMDMi3024711.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL17 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43767 mRNA. Translation: BAA07824.1 .
EF064767 Genomic DNA. Translation: ABK41950.1 .
AC004382 Genomic DNA. Translation: AAC24308.1 .
CH471092 Genomic DNA. Translation: EAW82921.1 .
BC069107 mRNA. Translation: AAH69107.1 .
BC112066 mRNA. Translation: AAI12067.1 .
BC112068 mRNA. Translation: AAI12069.1 .
CCDSi CCDS10780.1.
RefSeqi NP_002978.1. NM_002987.2.
UniGenei Hs.546294.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NR2 X-ray 2.18 A/B 24-94 [» ]
1NR4 X-ray 1.72 A/B/C/D/E/F/G/H 24-94 [» ]
ProteinModelPortali Q92583.
SMRi Q92583. Positions 26-94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112264. 1 interaction.
DIPi DIP-5842N.
MINTi MINT-1525198.
STRINGi 9606.ENSP00000219244.

PTM databases

PhosphoSitei Q92583.

Polymorphism databases

DMDMi 3024711.

Proteomic databases

PaxDbi Q92583.
PRIDEi Q92583.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000219244 ; ENSP00000219244 ; ENSG00000102970 .
GeneIDi 6361.
KEGGi hsa:6361.
UCSCi uc002elj.1. human.

Organism-specific databases

CTDi 6361.
GeneCardsi GC16P057438.
HGNCi HGNC:10615. CCL17.
HPAi CAB002583.
MIMi 601520. gene.
neXtProti NX_Q92583.
PharmGKBi PA35548.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45053.
HOGENOMi HOG000036685.
HOVERGENi HBG098492.
InParanoidi Q92583.
KOi K05514.
OMAi CSDPKDT.
OrthoDBi EOG7K0ZFZ.
PhylomeDBi Q92583.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.

Miscellaneous databases

EvolutionaryTracei Q92583.
GeneWikii CCL17.
GenomeRNAii 6361.
NextBioi 24716.
PROi Q92583.
SOURCEi Search...

Gene expression databases

Bgeei Q92583.
CleanExi HS_CCL17.
Genevestigatori Q92583.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector."
    Imai T., Yoshida T., Baba M., Nishimura M., Kakizaki M., Yoshie O.
    J. Biol. Chem. 271:21514-21521(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-32.
    Tissue: Peripheral blood monocyte.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor."
    Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M., Menon S., Zlotnik A., Mantovani A., Santoni A., Napolitano M.
    Eur. J. Immunol. 28:582-588(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECEPTOR INTERACTION.
  7. "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8."
    Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W., Umland S.P.
    Eur. J. Immunol. 29:3210-3215(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Structures of thymus and activation-regulated chemokine (TARC)."
    Asojo O.A., Boulegue C., Hoover D.M., Lu W., Lubkowski J.
    Acta Crystallogr. D 59:1165-1173(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 24-94, DISULFIDE BONDS.

Entry informationi

Entry nameiCCL17_HUMAN
AccessioniPrimary (citable) accession number: Q92583
Secondary accession number(s): A0N0Q9, Q2M287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally (1 Publication) thought to be a ligand for CCR8.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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