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Q92583

- CCL17_HUMAN

UniProt

Q92583 - CCL17_HUMAN

Protein

C-C motif chemokine 17

Gene

CCL17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.1 Publication

    GO - Molecular functioni

    1. chemokine activity Source: ProtInc
    2. receptor binding Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell chemotaxis Source: GOC
    3. chemotaxis Source: ProtInc
    4. G-protein coupled receptor signaling pathway Source: ProtInc
    5. immune response Source: InterPro
    6. inflammatory response Source: UniProtKB-KW
    7. multicellular organismal development Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 17
    Alternative name(s):
    CC chemokine TARC
    Small-inducible cytokine A17
    Thymus and activation-regulated chemokine
    Gene namesi
    Name:CCL17
    Synonyms:SCYA17, TARC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:10615. CCL17.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35548.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 9471C-C motif chemokine 17PRO_0000005211Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 571 Publication
    Disulfide bondi34 ↔ 731 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ92583.
    PRIDEiQ92583.

    PTM databases

    PhosphoSiteiQ92583.

    Expressioni

    Tissue specificityi

    Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

    Inductioni

    By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

    Gene expression databases

    BgeeiQ92583.
    CleanExiHS_CCL17.
    GenevestigatoriQ92583.

    Organism-specific databases

    HPAiCAB002583.

    Interactioni

    Protein-protein interaction databases

    BioGridi112264. 1 interaction.
    DIPiDIP-5842N.
    MINTiMINT-1525198.
    STRINGi9606.ENSP00000219244.

    Structurei

    Secondary structure

    1
    94
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 293
    Beta strandi32 – 365
    Helixi44 – 463
    Beta strandi47 – 526
    Beta strandi57 – 593
    Beta strandi62 – 665
    Beta strandi71 – 744
    Helixi79 – 9012

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NR2X-ray2.18A/B24-94[»]
    1NR4X-ray1.72A/B/C/D/E/F/G/H24-94[»]
    ProteinModelPortaliQ92583.
    SMRiQ92583. Positions 26-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ92583.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45053.
    HOGENOMiHOG000036685.
    HOVERGENiHBG098492.
    InParanoidiQ92583.
    KOiK05514.
    OMAiCSDPKDT.
    OrthoDBiEOG7K0ZFZ.
    PhylomeDBiQ92583.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92583-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW   50
    YQTSEDCSRD AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS 94
    Length:94
    Mass (Da):10,507
    Last modified:February 1, 1997 - v1
    Checksum:i7959C56BA8FDAF08
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51K → N.
    Corresponds to variant rs34693308 [ dbSNP | Ensembl ].
    VAR_048708
    Natural varianti67 – 671V → M.
    Corresponds to variant rs34379253 [ dbSNP | Ensembl ].
    VAR_048709

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D43767 mRNA. Translation: BAA07824.1.
    EF064767 Genomic DNA. Translation: ABK41950.1.
    AC004382 Genomic DNA. Translation: AAC24308.1.
    CH471092 Genomic DNA. Translation: EAW82921.1.
    BC069107 mRNA. Translation: AAH69107.1.
    BC112066 mRNA. Translation: AAI12067.1.
    BC112068 mRNA. Translation: AAI12069.1.
    CCDSiCCDS10780.1.
    RefSeqiNP_002978.1. NM_002987.2.
    UniGeneiHs.546294.

    Genome annotation databases

    EnsembliENST00000219244; ENSP00000219244; ENSG00000102970.
    GeneIDi6361.
    KEGGihsa:6361.
    UCSCiuc002elj.1. human.

    Polymorphism databases

    DMDMi3024711.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL17 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D43767 mRNA. Translation: BAA07824.1 .
    EF064767 Genomic DNA. Translation: ABK41950.1 .
    AC004382 Genomic DNA. Translation: AAC24308.1 .
    CH471092 Genomic DNA. Translation: EAW82921.1 .
    BC069107 mRNA. Translation: AAH69107.1 .
    BC112066 mRNA. Translation: AAI12067.1 .
    BC112068 mRNA. Translation: AAI12069.1 .
    CCDSi CCDS10780.1.
    RefSeqi NP_002978.1. NM_002987.2.
    UniGenei Hs.546294.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NR2 X-ray 2.18 A/B 24-94 [» ]
    1NR4 X-ray 1.72 A/B/C/D/E/F/G/H 24-94 [» ]
    ProteinModelPortali Q92583.
    SMRi Q92583. Positions 26-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112264. 1 interaction.
    DIPi DIP-5842N.
    MINTi MINT-1525198.
    STRINGi 9606.ENSP00000219244.

    PTM databases

    PhosphoSitei Q92583.

    Polymorphism databases

    DMDMi 3024711.

    Proteomic databases

    PaxDbi Q92583.
    PRIDEi Q92583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219244 ; ENSP00000219244 ; ENSG00000102970 .
    GeneIDi 6361.
    KEGGi hsa:6361.
    UCSCi uc002elj.1. human.

    Organism-specific databases

    CTDi 6361.
    GeneCardsi GC16P057438.
    HGNCi HGNC:10615. CCL17.
    HPAi CAB002583.
    MIMi 601520. gene.
    neXtProti NX_Q92583.
    PharmGKBi PA35548.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45053.
    HOGENOMi HOG000036685.
    HOVERGENi HBG098492.
    InParanoidi Q92583.
    KOi K05514.
    OMAi CSDPKDT.
    OrthoDBi EOG7K0ZFZ.
    PhylomeDBi Q92583.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.

    Miscellaneous databases

    EvolutionaryTracei Q92583.
    GeneWikii CCL17.
    GenomeRNAii 6361.
    NextBioi 24716.
    PROi Q92583.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q92583.
    CleanExi HS_CCL17.
    Genevestigatori Q92583.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector."
      Imai T., Yoshida T., Baba M., Nishimura M., Kakizaki M., Yoshie O.
      J. Biol. Chem. 271:21514-21521(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-32.
      Tissue: Peripheral blood monocyte.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor."
      Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M., Menon S., Zlotnik A., Mantovani A., Santoni A., Napolitano M.
      Eur. J. Immunol. 28:582-588(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECEPTOR INTERACTION.
    7. "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8."
      Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W., Umland S.P.
      Eur. J. Immunol. 29:3210-3215(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Structures of thymus and activation-regulated chemokine (TARC)."
      Asojo O.A., Boulegue C., Hoover D.M., Lu W., Lubkowski J.
      Acta Crystallogr. D 59:1165-1173(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 24-94, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCCL17_HUMAN
    AccessioniPrimary (citable) accession number: Q92583
    Secondary accession number(s): A0N0Q9, Q2M287
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally thought to be a ligand for CCR8.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3