##gff-version 3
Q92581	UniProtKB	Chain	1	701	.	.	.	ID=PRO_0000052362;Note=Sodium/hydrogen exchanger 6	
Q92581	UniProtKB	Transmembrane	71	91	.	.	.	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	103	123	.	.	.	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	176	196	.	.	.	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	211	231	.	.	.	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	252	272	.	.	.	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	278	298	.	.	.	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	324	344	.	.	.	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	372	392	.	.	.	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	414	434	.	.	.	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	436	456	.	.	.	Note=Helical%3B Name%3D10;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	479	499	.	.	.	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Transmembrane	515	535	.	.	.	Note=Helical%3B Name%3D12;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q92581	UniProtKB	Glycosylation	128	128	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218	
Q92581	UniProtKB	Cross-link	475	475	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17370265;Dbxref=PMID:17370265	
Q92581	UniProtKB	Alternative sequence	1	52	.	.	.	ID=VSP_044868;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
Q92581	UniProtKB	Alternative sequence	144	175	.	.	.	ID=VSP_061774;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9039502,ECO:0000303|PubMed:9507001;Dbxref=PMID:9039502,PMID:9507001	
Q92581	UniProtKB	Natural variant	9	9	.	.	.	ID=VAR_087516;Note=Does not affect post-translational maturation%3B does not affect membrane sorting%3B does not affect pH homeostasis in recycling endosomes%3B does not affect cargo trafficking. A->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:31676550,ECO:0000269|PubMed:32277048;Dbxref=PMID:31676550,PMID:32277048	
Q92581	UniProtKB	Natural variant	188	188	.	.	.	ID=VAR_087517;Note=In MRXSCH%3B reduces oligosaccharide maturation%3B decreases protein stability%3B partially accumulated in the ER%3B impairs acidification of endosomes%3B reduces localization to recycling endosomes%3B impairs trafficking to plasma membrane%3B reduces uptake of recycling endosomal cargo. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25044251,ECO:0000269|PubMed:32277048;Dbxref=PMID:25044251,PMID:32277048	
Q92581	UniProtKB	Natural variant	218	218	.	.	.	ID=VAR_083536;Note=In MRXSCH%3B decreases protein stability%3B increased ubiquitination%3B impairs acidification of endosomes%3B reduces localization to recycling endosomes%3B impairs trafficking to plasma membrane%3B reduces uptake of recycling endosomal cargo. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30296617;Dbxref=PMID:30296617	
Q92581	UniProtKB	Natural variant	383	383	.	.	.	ID=VAR_087518;Note=In MRXSCH%3B reduces oligosaccharide maturation%3B decreases protein stability%3B partially accumulated in the ER%3B impairs acidification of endosomes%3B reduces localization to recycling endosomes%3B impairs trafficking to plasma membrane%3B reduces uptake of recycling endosomal cargo. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25044251,ECO:0000269|PubMed:32277048;Dbxref=PMID:25044251,PMID:32277048	
Q92581	UniProtKB	Natural variant	547	701	.	.	.	ID=VAR_087519;Note=In MRXSCH%3B reduces oligosaccharide maturation%3B largely retained in the ER%3B strongly reduces localization to recycling endosomes%3B strongly impairs trafficking to plasma membrane%3B strongly reduces uptake of recycling endosomal cargo. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24123876,ECO:0000269|PubMed:25044251,ECO:0000269|PubMed:32277048;Dbxref=PMID:24123876,PMID:25044251,PMID:32277048	
Q92581	UniProtKB	Natural variant	568	568	.	.	.	ID=VAR_087520;Note=Does not affect post-translational maturation%3B does not affect membrane sorting%2C does not affect pH homeostasis in recycling endosomes%2C does not affect cargo trafficking. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32277048;Dbxref=PMID:32277048	
Q92581	UniProtKB	Natural variant	570	701	.	.	.	ID=VAR_087521;Note=In MRXSCH%3B reduces oligosaccharide maturation%3B largely retained in the ER%3B strongly reduces localization to recycling endosomes%3B strongly impairs trafficking to plasma membrane%3B strongly reduces uptake of recycling endosomal cargo. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25044251,ECO:0000269|PubMed:32277048;Dbxref=PMID:25044251,PMID:32277048	
Q92581	UniProtKB	Sequence conflict	20	20	.	.	.	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q92581	UniProtKB	Sequence conflict	92	92	.	.	.	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q92581	UniProtKB	Sequence conflict	144	144	.	.	.	Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q92581	UniProtKB	Sequence conflict	339	339	.	.	.	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q92581	UniProtKB	Sequence conflict	404	404	.	.	.	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q92581	UniProtKB	Sequence conflict	405	405	.	.	.	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q92581	UniProtKB	Sequence conflict	666	666	.	.	.	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305