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Q92576

- PHF3_HUMAN

UniProt

Q92576 - PHF3_HUMAN

Protein

PHD finger protein 3

Gene

PHF3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (15 Aug 2003)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri717 – 77256PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB
    2. transcription, DNA-templated Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PHD finger protein 3
    Gene namesi
    Name:PHF3
    Synonyms:KIAA0244
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8921. PHF3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33261.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20392039PHD finger protein 3PRO_0000059292Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei283 – 2831Phosphoserine1 Publication
    Modified residuei299 – 2991Phosphoserine1 Publication
    Modified residuei680 – 6801Phosphoserine1 Publication
    Modified residuei1133 – 11331Phosphoserine2 Publications
    Modified residuei1148 – 11481Phosphoserine1 Publication
    Modified residuei1178 – 11781Phosphoserine2 Publications
    Modified residuei1642 – 16421Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ92576.
    PaxDbiQ92576.
    PeptideAtlasiQ92576.
    PRIDEiQ92576.

    PTM databases

    PhosphoSiteiQ92576.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell lines, anaplastic astrocytomas, and astrocytomas.1 Publication

    Gene expression databases

    ArrayExpressiQ92576.
    BgeeiQ92576.
    CleanExiHS_PHF3.
    GenevestigatoriQ92576.

    Organism-specific databases

    HPAiHPA024676.
    HPA025763.

    Interactioni

    Protein-protein interaction databases

    BioGridi117031. 5 interactions.
    IntActiQ92576. 3 interactions.
    STRINGi9606.ENSP00000262043.

    Structurei

    Secondary structure

    1
    2039
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi924 – 94320
    Turni944 – 9474
    Helixi952 – 97019
    Helixi975 – 98410
    Helixi986 – 9894
    Beta strandi990 – 9923
    Helixi996 – 10027
    Beta strandi1003 – 10053
    Helixi1009 – 10124
    Turni1015 – 10206
    Turni1024 – 10263

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DMENMR-A923-1029[»]
    ProteinModelPortaliQ92576.
    SMRiQ92576. Positions 723-774, 924-1029.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ92576.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini927 – 1046120TFIIS centralPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1797 – 186569Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
    Contains 1 TFIIS central domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri717 – 77256PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG255142.
    HOVERGENiHBG039623.
    InParanoidiQ92576.
    OMAiQMPCSTV.
    OrthoDBiEOG7NW685.
    PhylomeDBiQ92576.
    TreeFamiTF350578.

    Family and domain databases

    Gene3Di1.10.472.30. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR012921. SPOC_C.
    IPR003618. TFIIS_cen_dom.
    IPR017890. TFS2M.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    PF07744. SPOC. 1 hit.
    PF07500. TFIIS_M. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    SM00510. TFS2M. 1 hit.
    [Graphical view]
    SUPFAMiSSF46942. SSF46942. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51321. TFIIS_CENTRAL. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92576-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDIVDTFNHL IPTEHLDDAL FLGSNLENEV CEDFSASQNV LEDSLKNMLS     50
    DKDPMLGSAS NQFCLPVLDS NDPNFQMPCS TVVGLDDIMD EGVVKESGND 100
    TIDEEELILP NRNLRDKVEE NSVRSPRKSP RLMAQEQVRS LRQSTIAKRS 150
    NAAPLSNTKK ASGKTVSTAK AGVKQPERSQ VKEEVCMSLK PEYHKENRRC 200
    SRNSGQIEVV PEVSVSSSHS SVSSCLEMKD EDGLDSKHKC NNPGEIDVPS 250
    HELNCSLLSE TCVTIGEKKN EALMECKAKP VGSPLFKFSD KEEHEQNDSI 300
    SGKTGETVVE EMIATRKVEQ DSKETVKLSH EDDHILEDAG SSDISSDAAC 350
    TNPNKTENSL VGLPSCVDEV TECNLELKDT MGIADKTENT LERNKIEPLG 400
    YCEDAESNRQ LESTEFNKSN LEVVDTSTFG PESNILENAI CDVPDQNSKQ 450
    LNAIESTKIE SHETANLQDD RNSQSSSVSY LESKSVKSKH TKPVIHSKQN 500
    MTTDAPKKIV AAKYEVIHSK TKVNVKSVKR NTDVPESQQN FHRPVKVRKK 550
    QIDKEPKIQS CNSGVKSVKN QAHSVLKKTL QDQTLVQIFK PLTHSLSDKS 600
    HAHPGCLKEP HHPAQTGHVS HSSQKQCHKP QQQAPAMKTN SHVKEELEHP 650
    GVEHFKEEDK LKLKKPEKNL QPRQRRSSKS FSLDEPPLFI PDNIATIRRE 700
    GSDHSSSFES KYMWTPSKQC GFCKKPHGNR FMVGCGRCDD WFHGDCVGLS 750
    LSQAQQMGEE DKEYVCVKCC AEEDKKTEIL DPDTLENQAT VEFHSGDKTM 800
    ECEKLGLSKH TTNDRTKYID DTVKHKVKIL KRESGEGRNS SDCRDNEIKK 850
    WQLAPLRKMG QPVLPRRSSE EKSEKIPKES TTVTCTGEKA SKPGTHEKQE 900
    MKKKKVEKGV LNVHPAASAS KPSADQIRQS VRHSLKDILM KRLTDSNLKV 950
    PEEKAAKVAT KIEKELFSFF RDTDAKYKNK YRSLMFNLKD PKNNILFKKV 1000
    LKGEVTPDHL IRMSPEELAS KELAAWRRRE NRHTIEMIEK EQREVERRPI 1050
    TKITHKGEIE IESDAPMKEQ EAAMEIQEPA ANKSLEKPEG SEKQKEEVDS 1100
    MSKDTTSQHR QHLFDLNCKI CIGRMAPPVD DLSPKKVKVV VGVARKHSDN 1150
    EAESIADALS STSNILASEF FEEEKQESPK STFSPAPRPE MPGTVEVEST 1200
    FLARLNFIWK GFINMPSVAK FVTKAYPVSG SPEYLTEDLP DSIQVGGRIS 1250
    PQTVWDYVEK IKASGTKEIC VVRFTPVTEE DQISYTLLFA YFSSRKRYGV 1300
    AANNMKQVKD MYLIPLGATD KIPHPLVPFD GPGLELHRPN LLLGLIIRQK 1350
    LKRQHSACAS TSHIAETPES APPIALPPDK KSKIEVSTEE APEEENDFFN 1400
    SFTTVLHKQR NKPQQNLQED LPTAVEPLME VTKQEPPKPL RFLPGVLIGW 1450
    ENQPTTLELA NKPLPVDDIL QSLLGTTGQV YDQAQSVMEQ NTVKEIPFLN 1500
    EQTNSKIEKT DNVEVTDGEN KEIKVKVDNI SESTDKSAEI ETSVVGSSSI 1550
    SAGSLTSLSL RGKPPDVSTE AFLTNLSIQS KQEETVESKE KTLKRQLQED 1600
    QENNLQDNQT SNSSPCRSNV GKGNIDGNVS CSENLVANTA RSPQFINLKR 1650
    DPRQAAGRSQ PVTTSESKDG DSCRNGEKHM LPGLSHNKEH LTEQINVEEK 1700
    LCSAEKNSCV QQSDNLKVAQ NSPSVENIQT SQAEQAKPLQ EDILMQNIET 1750
    VHPFRRGSAV ATSHFEVGNT CPSEFPSKSI TFTSRSTSPR TSTNFSPMRP 1800
    QQPNLQHLKS SPPGFPFPGP PNFPPQSMFG FPPHLPPPLL PPPGFGFAQN 1850
    PMVPWPPVVH LPGQPQRMMG PLSQASRYIG PQNFYQVKDI RRPERRHSDP 1900
    WGRQDQQQLD RPFNRGKGDR QRFYSDSHHL KRERHEKEWE QESERHRRRD 1950
    RSQDKDRDRK SREEGHKDKE RARLSHGDRG TDGKASRDSR NVDKKPDKPK 2000
    SEDYEKDKER EKSKHREGEK DRDRYHKDRD HTDRTKSKR 2039
    Length:2,039
    Mass (Da):229,481
    Last modified:August 15, 2003 - v3
    Checksum:iFDAFF00576005E9B
    GO
    Isoform 2 (identifier: Q92576-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,951
    Mass (Da):219,808
    Checksum:iEC2F49C1B80A2ED5
    GO

    Sequence cautioni

    The sequence BAA13438.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1394 – 13941E → G in CAI56715. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti525 – 5251V → I.
    Corresponds to variant rs34288820 [ dbSNP | Ensembl ].
    VAR_051599
    Natural varianti1834 – 18341H → Y.
    Corresponds to variant rs3734881 [ dbSNP | Ensembl ].
    VAR_022040

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8888Missing in isoform 2. 1 PublicationVSP_026434Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF091622 mRNA. Translation: AAF21292.1.
    D87685 mRNA. Translation: BAA13438.2. Different initiation.
    BX648268 mRNA. Translation: CAI56715.1.
    AL050329, AL354719 Genomic DNA. Translation: CAM45842.1.
    BC113650 mRNA. Translation: AAI13651.1.
    BC113652 mRNA. Translation: AAI13653.1.
    CCDSiCCDS4966.1. [Q92576-1]
    RefSeqiNP_001277188.1. NM_001290259.1. [Q92576-2]
    NP_001277189.1. NM_001290260.1.
    NP_055968.1. NM_015153.3. [Q92576-1]
    XP_005248758.1. XM_005248701.1. [Q92576-1]
    XP_005248759.1. XM_005248702.1. [Q92576-2]
    XP_006715489.1. XM_006715426.1. [Q92576-1]
    UniGeneiHs.348921.
    Hs.731957.

    Genome annotation databases

    EnsembliENST00000262043; ENSP00000262043; ENSG00000118482. [Q92576-1]
    ENST00000393387; ENSP00000377048; ENSG00000118482. [Q92576-1]
    GeneIDi23469.
    KEGGihsa:23469.
    UCSCiuc003pen.2. human. [Q92576-1]

    Polymorphism databases

    DMDMi34098662.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF091622 mRNA. Translation: AAF21292.1 .
    D87685 mRNA. Translation: BAA13438.2 . Different initiation.
    BX648268 mRNA. Translation: CAI56715.1 .
    AL050329 , AL354719 Genomic DNA. Translation: CAM45842.1 .
    BC113650 mRNA. Translation: AAI13651.1 .
    BC113652 mRNA. Translation: AAI13653.1 .
    CCDSi CCDS4966.1. [Q92576-1 ]
    RefSeqi NP_001277188.1. NM_001290259.1. [Q92576-2 ]
    NP_001277189.1. NM_001290260.1.
    NP_055968.1. NM_015153.3. [Q92576-1 ]
    XP_005248758.1. XM_005248701.1. [Q92576-1 ]
    XP_005248759.1. XM_005248702.1. [Q92576-2 ]
    XP_006715489.1. XM_006715426.1. [Q92576-1 ]
    UniGenei Hs.348921.
    Hs.731957.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DME NMR - A 923-1029 [» ]
    ProteinModelPortali Q92576.
    SMRi Q92576. Positions 723-774, 924-1029.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117031. 5 interactions.
    IntActi Q92576. 3 interactions.
    STRINGi 9606.ENSP00000262043.

    PTM databases

    PhosphoSitei Q92576.

    Polymorphism databases

    DMDMi 34098662.

    Proteomic databases

    MaxQBi Q92576.
    PaxDbi Q92576.
    PeptideAtlasi Q92576.
    PRIDEi Q92576.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262043 ; ENSP00000262043 ; ENSG00000118482 . [Q92576-1 ]
    ENST00000393387 ; ENSP00000377048 ; ENSG00000118482 . [Q92576-1 ]
    GeneIDi 23469.
    KEGGi hsa:23469.
    UCSCi uc003pen.2. human. [Q92576-1 ]

    Organism-specific databases

    CTDi 23469.
    GeneCardsi GC06P064403.
    HGNCi HGNC:8921. PHF3.
    HPAi HPA024676.
    HPA025763.
    MIMi 607789. gene.
    neXtProti NX_Q92576.
    PharmGKBi PA33261.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255142.
    HOVERGENi HBG039623.
    InParanoidi Q92576.
    OMAi QMPCSTV.
    OrthoDBi EOG7NW685.
    PhylomeDBi Q92576.
    TreeFami TF350578.

    Miscellaneous databases

    ChiTaRSi PHF3. human.
    EvolutionaryTracei Q92576.
    GeneWikii PHF3.
    GenomeRNAii 23469.
    NextBioi 45797.
    PROi Q92576.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92576.
    Bgeei Q92576.
    CleanExi HS_PHF3.
    Genevestigatori Q92576.

    Family and domain databases

    Gene3Di 1.10.472.30. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR012921. SPOC_C.
    IPR003618. TFIIS_cen_dom.
    IPR017890. TFS2M.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    PF07744. SPOC. 1 hit.
    PF07500. TFIIS_M. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    SM00510. TFS2M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46942. SSF46942. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51321. TFIIS_CENTRAL. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PHF3 expression is frequently reduced in glioma."
      Fischer U., Struss A.-K., Hemmer D., Michel A., Henn W., Steudel W.-I., Meese E.
      Cytogenet. Cell Genet. 94:131-136(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Fetal kidney.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cerebellum.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1178, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-299; SER-680; SER-1133; SER-1178 AND SER-1642, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Solution structure of the TFIIS domain II of human PHD finger protein 3."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 923-1029.

    Entry informationi

    Entry nameiPHF3_HUMAN
    AccessioniPrimary (citable) accession number: Q92576
    Secondary accession number(s): A3KFI8
    , Q14CR5, Q5CZI1, Q5T1T6, Q9NQ16, Q9UI45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: August 15, 2003
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3